Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics
Elgaher, Walid A. M., Hamed, Mostafa M., Baumann, Sascha, Herrmann, Jennifer, Siebenbürger, Lorenz, Krull, Jana, Cirnski, Katarina, Kirschning, Andreas, Brönstrup, Mark, Müller, Rolf, Hartmann, Rolf W.
Published in Chemistry : a European journal (05.06.2020)
Published in Chemistry : a European journal (05.06.2020)
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Lead Optimization Generates CYP11B1 Inhibitors of Pyridylmethyl Isoxazole Type with Improved Pharmacological Profile for the Treatment of Cushing’s Disease
Emmerich, Juliette, van Koppen, Chris J, Burkhart, Jens L, Hu, Qingzhong, Siebenbürger, Lorenz, Boerger, Carsten, Scheuer, Claudia, Laschke, Matthias W, Menger, Michael D, Hartmann, Rolf W
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
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Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis
Abdelsamie, Ahmed S, Salah, Mohamed, Siebenbürger, Lorenz, Merabet, Ahmed, Scheuer, Claudia, Frotscher, Martin, Müller, Sebastian T, Zierau, Oliver, Vollmer, Günter, Menger, Michael D, Laschke, Matthias W, van Koppen, Chris J, Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W
Published in Journal of medicinal chemistry (08.08.2019)
Published in Journal of medicinal chemistry (08.08.2019)
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Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing
Abdelsamie, Ahmed S, Herath, Steven, Biskupek, Yannik, Börger, Carsten, Siebenbürger, Lorenz, Salah, Mohamed, Scheuer, Claudia, Marchais-Oberwinkler, Sandrine, Frotscher, Martin, Pohlemann, Tim, Menger, Michael D, Hartmann, Rolf W, Laschke, Matthias W, van Koppen, Chris J
Published in Journal of medicinal chemistry (14.02.2019)
Published in Journal of medicinal chemistry (14.02.2019)
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A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms
Schütz, Christian, Ho, Duy‐Khiet, Hamed, Mostafa Mohamed, Abdelsamie, Ahmed Saad, Röhrig, Teresa, Herr, Christian, Kany, Andreas Martin, Rox, Katharina, Schmelz, Stefan, Siebenbürger, Lorenz, Wirth, Marius, Börger, Carsten, Yahiaoui, Samir, Bals, Robert, Scrima, Andrea, Blankenfeldt, Wulf, Horstmann, Justus Constantin, Christmann, Rebekka, Murgia, Xabier, Koch, Marcus, Berwanger, Aylin, Loretz, Brigitta, Hirsch, Anna Katharina Herta, Hartmann, Rolf Wolfgang, Lehr, Claus‐Michael, Empting, Martin
Published in Advanced science (01.06.2021)
Published in Advanced science (01.06.2021)
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Pseudomonas aeruginosa Biofilm: A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms (Adv. Sci. 12/2021)
Schütz, Christian, Ho, Duy‐Khiet, Hamed, Mostafa Mohamed, Abdelsamie, Ahmed Saad, Röhrig, Teresa, Herr, Christian, Kany, Andreas Martin, Rox, Katharina, Schmelz, Stefan, Siebenbürger, Lorenz, Wirth, Marius, Börger, Carsten, Yahiaoui, Samir, Bals, Robert, Scrima, Andrea, Blankenfeldt, Wulf, Horstmann, Justus Constantin, Christmann, Rebekka, Murgia, Xabier, Koch, Marcus, Berwanger, Aylin, Loretz, Brigitta, Hirsch, Anna Katharina Herta, Hartmann, Rolf Wolfgang, Lehr, Claus‐Michael, Empting, Martin
Published in Advanced science (01.06.2021)
Published in Advanced science (01.06.2021)
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Human airway mucus alters susceptibility of Pseudomonas aeruginosa biofilms to tobramycin, but not colistin
Müller, Laura, Murgia, Xabier, Siebenbürger, Lorenz, Börger, Carsten, Schwarzkopf, Konrad, Sewald, Katherina, Häussler, Susanne, Braun, Armin, Lehr, Claus-Michael, Hittinger, Marius, Wronski, Sabine
Published in Journal of antimicrobial chemotherapy (01.10.2018)
Published in Journal of antimicrobial chemotherapy (01.10.2018)
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Cover Feature: Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics (Chem. Eur. J. 32/2020)
Elgaher, Walid A. M., Hamed, Mostafa M., Baumann, Sascha, Herrmann, Jennifer, Siebenbürger, Lorenz, Krull, Jana, Cirnski, Katarina, Kirschning, Andreas, Brönstrup, Mark, Müller, Rolf, Hartmann, Rolf W.
Published in Chemistry : a European journal (05.06.2020)
Published in Chemistry : a European journal (05.06.2020)
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Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17β-Hydroxysteroid dehydrogenases: Design, synthesis, and biological evaluation
Abdelsamie, Ahmed S., Salah, Mohamed, Siebenbürger, Lorenz, Hamed, Mostafa M., Börger, Carsten, van Koppen, Chris J., Frotscher, Martin, Hartmann, Rolf W.
Published in European journal of medicinal chemistry (15.09.2019)
Published in European journal of medicinal chemistry (15.09.2019)
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Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle study
Abdelsamie, Ahmed S., van Koppen, Chris J., Bey, Emmanuel, Salah, Mohamed, Börger, Carsten, Siebenbürger, Lorenz, Laschke, Matthias W., Menger, Michael D., Frotscher, Martin
Published in European journal of medicinal chemistry (15.02.2017)
Published in European journal of medicinal chemistry (15.02.2017)
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Journal Article
Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC 50 for a proof-of-principle study
Abdelsamie, Ahmed S, van Koppen, Chris J, Bey, Emmanuel, Salah, Mohamed, Börger, Carsten, Siebenbürger, Lorenz, Laschke, Matthias W, Menger, Michael D, Frotscher, Martin
Published in European journal of medicinal chemistry (15.02.2017)
Published in European journal of medicinal chemistry (15.02.2017)
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Inhibitors of 17Beta-hydroxysteroid dehydrogenases type 1 and type 2
Frotscher Martin, Oberwinkler-Marchais Sandrine, Hernández Olmos Victor, Siebenbürger Lorenz, Bey Emmanuel, Hartmann Rolf, van Koppen Chris J, Börger Carsten, Ahmed Ahmed Saad Abdelsamie
Year of Publication 06.02.2018
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Year of Publication 06.02.2018
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INHIBITORS OF 17BETA-HYDROXYSTEROID DEHYDROGENASES TYPE 1 AND TYPE 2
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Year of Publication 09.11.2016
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Year of Publication 09.11.2016
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Inhibitors of 17Beta-Hydroxysteroid Dehydrogenases Type 1 and Type 2
Frotscher Martin, Oberwinkler-Marchais Sandrine, Hernández Olmos Victor, Siebenbürger Lorenz, Bey Emmanuel, Hartmann Rolf, van Koppen Chris J, Börger Carsten, Ahmed Ahmed Saad Abdelsamie
Year of Publication 03.11.2016
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Year of Publication 03.11.2016
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INHIBITORS OF 17BETA-HYDROXYSTEROID DEHYDROGENASES TYPE 1 AND TYPE 2
FROTSCHER, MARTIN, OBERWINKLER-MARCHAIS, SANDRINE, HARTMANN, ROLF, BEY, EMMANUEL, BÖRGER, CARSTEN, HERNÁNDEZ OLMOS, VICTOR, VAN KOPPEN, CHRIS, J, SIEBENBÜRGER, LORENZ, AHMED, AHMED SAAD ABDELSAMIE
Year of Publication 03.12.2015
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Year of Publication 03.12.2015
Patent
INHIBITORS OF 17BETA-HYDROXYSTEROID DEHYDROGENASES TYPE 1 AND TYPE 2
FROTSCHER, MARTIN, OBERWINKLER-MARCHAIS, SANDRINE, HARTMANN, ROLF, BEY, EMMANUEL, BÖRGER, CARSTEN, HERNÁNDEZ OLMOS, VICTOR, VAN KOPPEN, CHRIS, J, SIEBENBÜRGER, LORENZ, AHMED, AHMED SAAD ABDELSAMIE
Year of Publication 09.07.2015
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Year of Publication 09.07.2015
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INIBIDORES DE 17BETA-HIDROXIESTEROIDE DESIDROGENASES TIPO 1 E TIPO 2
LORENZ SIEBENBÜRGER, EMMANUEL BEY, MARTIN FROTSCHER, AHMED SAAD ABDELSAMIE AHMED, SANDRINE OBERWINKLER-MARCHAIS, CARSTEN BÖRGER, CHRIS J. VAN KOPPEN, VICTOR HERNÁNDEZ OLMOS, ROLF HARTMANN
Year of Publication 08.08.2017
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Year of Publication 08.08.2017
Patent