Cloning, expression, and characterization of the human eosinophil eotaxin receptor
Daugherty, B L, Siciliano, S J, DeMartino, J A, Malkowitz, L, Sirotina, A, Springer, M S
Published in The Journal of experimental medicine (01.05.1996)
Published in The Journal of experimental medicine (01.05.1996)
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Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection
Veazey, Ronald S, Klasse, Per Johan, Ketas, Thomas J, Reeves, Jacqueline D, Piatak, Jr, Michael, Kunstman, Kevin, Kuhmann, Shawn E, Marx, Preston A, Lifson, Jeffrey D, Dufour, Jason, Mefford, Megan, Pandrea, Ivona, Wolinsky, Steven M, Doms, Robert W, DeMartino, Julie A, Siciliano, Salvatore J, Lyons, Kathy, Springer, Martin S, Moore, John P
Published in The Journal of experimental medicine (17.11.2003)
Published in The Journal of experimental medicine (17.11.2003)
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CCR5, CXCR4, and CD4 Are Clustered and Closely Apposed on Microvilli of Human Macrophages and T Cells
Singer, I I, Scott, S, Kawka, D W, Chin, J, Daugherty, B L, DeMartino, J A, DiSalvo, J, Gould, S L, Lineberger, J E, Malkowitz, L, Miller, M D, Mitnaul, L, Siciliano, S J, Staruch, M J, Williams, H R, Zweerink, H J, Springer, M S
Published in Journal of Virology (01.04.2001)
Published in Journal of Virology (01.04.2001)
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Binding and Functional Properties of Recombinant and Endogenous CXCR3 Chemokine Receptors
Weng, Y, Siciliano, S J, Waldburger, K E, Sirotina-Meisher, A, Staruch, M J, Daugherty, B L, Gould, S L, Springer, M S, DeMartino, J A
Published in The Journal of biological chemistry (17.07.1998)
Published in The Journal of biological chemistry (17.07.1998)
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 1: Discovery and initial structure-activity relationships for 1-amino-2-phenyl-4-(piperidin-1-yl)butanes
DORN, Conrad P, FINKE, Paul E, DEMARTINO, Julie A, SICILIANO, Salvatore J, CARELLA, Anthony, CARVER, Gwen, HOLMES, Karen, DANZEISEN, Renee, HAZUDA, Daria, KESSLER, Joseph, LINEBERGER, Janet, MILLER, Michael, OATES, Bryan, SCHLEIF, William A, EMINI, Emilio A, BUDHU, Richard J, MILLS, Sander G, MACCOSS, Malcolm, MALKOWITZ, Lorraine, SPRINGER, Martin S, DAUGHERTY, Bruce L, GOULD, Sandra L
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
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Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and sar study of 4-pyrazolylpiperidine side chains
SHEN, Dong-Ming, MIN SHU, CARELLA, Anthony, CARVER, Gwen, HOLMES, Karen, SCHLEIF, William A, DANZEISEN, Renee, HAZUDA, Daria, KESSLER, Joseph, LINEBERGER, Janet, MILLER, Michael D, EMINI, Emilio A, MILLS, Sander G, CHAPMAN, Kevin T, MALKOWITZ, Lorraine, SPRINGER, Martin S, GOULD, Sandra L, DEMARTINO, Julie A, SICILIANO, Salvatore J, KWEI, Gloria Y
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
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A Critical Site in the Core of the CCR5 Chemokine Receptor Required for Binding and Infectivity of Human Immunodeficiency Virus Type 1
Siciliano, Salvatore J., Kuhmann, Shawn E., Weng, Youmin, Madani, Navid, Springer, Martin S., Lineberger, Janet E., Danzeisen, Renee, Miller, Michael D., Kavanaugh, Michael P., DeMartino, Julie A., Kabat, David
Published in The Journal of biological chemistry (22.01.1999)
Published in The Journal of biological chemistry (22.01.1999)
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains
Lynch, Christopher L., Willoughby, Christopher A., Hale, Jeffrey J., Holson, Edward J., Budhu, Richard J., Gentry, Amy L., Rosauer, Keith G., Caldwell, Charles G., Chen, Ping, Mills, Sander G., MacCoss, Malcolm, Berk, Scott, Chen, Liya, Chapman, Kevin T., Malkowitz, Lorraine, Springer, Martin S., Gould, Sandra L., DeMartino, Julie A., Siciliano, Salvatore J., Cascieri, Margaret A., Carella, Anthony, Carver, Gwen, Holmes, Karen, Schleif, William A., Danzeisen, Renee, Hazuda, Daria, Kessler, Joseph, Lineberger, Janet, Miller, Michael, Emini, Emilio A.
Published in Bioorganic & medicinal chemistry letters (06.01.2003)
Published in Bioorganic & medicinal chemistry letters (06.01.2003)
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: Structure-activity relationships for substituted 2-aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes
FINKE, Paul E, MEURER, Laura C, SICILIANO, Salvatore J, CARELLA, Anthony, CARVER, Gwen, HOLMES, Karen, DANZEISEN, Renee, HAZUDA, Daria, KESSLER, Joseph, LINEBERGER, Janet, MILLER, Michael, SCHLEIF, William A, OATES, Bryan, EMINI, Emilio A, MILLS, Sander G, MACCOSS, Malcolm, MALKOWITZ, Lorraine, SPRINGER, Martin S, DAUGHERTY, Bruce L, GOULD, Sandra L, DEMARTINO, Julie A
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
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Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds
SHEN, Dong-Ming, MIN SHU, GOULD, Sandra L, DEMARTINO, Julie A, SICILIANO, Salvatore J, LYONS, Kathy, PIVNICHNY, James V, KWEI, Gloria Y, CARELLA, Anthony, CARVER, Gwen, HOLMES, Karen, SCHLEIF, William A, WILLOUGHBY, Christopher A, DANZEISEN, Renee, HAZUDA, Daria, KESSLER, Joseph, LINEBERGER, Janet, MILLER, Michael D, EMINI, Emilio A, SHAH, Shrenik, LYNCH, Christopher L, HALE, Jeffrey J, MILLS, Sander G, CHAPMAN, Kevin T, MALKOWITZ, Lorraine, SPRINGER, Martin S
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
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Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment
MIN SHU, LOEBACH, Jennifer L, SICILIANO, Salvatore J, DI SALVO, Jerry, LYONS, Kathy, PIVNICHNY, James V, KWEI, Gloria Y, CARELLA, Anthony, CARVER, Gwen, HOLMES, Karen, SCHLEIF, William A, DANZEISEN, Renee, PARKER, Kerry A, HAZUDA, Daria, KESSLER, Joseph, LINEBERGER, Janet, MILLER, Michael D, EMINI, Emilio A, MILLS, Sander G, CHAPMAN, Kevin T, SHEN, Dong-Ming, MALKOWITZ, Lorraine, SPRINGER, Martin S, GOULD, Sandra L, DEMARTINO, Julie A
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: Synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV
LYNCH, Christopher L, HALE, Jeffrey J, DEMARTINO, Julie A, SICILIANO, Salvatore J, CASCIERI, Margaret A, CARELLA, Anthony, CARVER, Gwen, HOLMES, Karen, SCHLEIF, William A, DANZEISEN, Renee, HAZUDA, Daria, KESSLER, Joseph, BUDHU, Richard J, LINEBERGER, Janet, MILLER, Michael, EMINI, Emilio A, GENTRY, Amy L, MILLS, Sander G, CHAPMAN, Kevin T, MACCOSS, Malcolm, MALKOWITZ, Lorraine, SPRINGER, Martin S, GOULD, Sandra L
Published in Bioorganic & medicinal chemistry letters (21.10.2002)
Published in Bioorganic & medicinal chemistry letters (21.10.2002)
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Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor
Shankaran, K., Donnelly, Karla L., Shah, Shrenik K., Guthikonda, Ravindra N., MacCoss, Malcolm, Mills, Sander G., Gould, Sandra L., Malkowitz, Lorraine, Siciliano, Salvatore J., Springer, Martin S., Carella, Anthony, Carver, Gwen, Hazuda, Daria, Holmes, Karen, Kessler, Joseph, Lineberger, Janet, Miller, Michael D., Emini, Emilio A., Schleif, William A.
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
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1,3,4 trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains
Willoughby, Christopher A, Rosauer, Keith G, Hale, Jeffery J, Budhu, Richard J, Mills, Sander G, Chapman, Kevin T, MacCoss, Malcolm, Malkowitz, Lorraine, Springer, Martin S, Gould, Sandra L, DeMartino, Julie A, Siciliano, Salvatore J, Cascieri, Margaret A, Carella, Anthony, Carver, Gwen, Holmes, Karen, Schleif, William A, Danzeisen, Renee, Hazuda, Daria, Kessler, Joseph, Lineberger, Janet, Miller, Michael, Emini, Emilio A
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
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Journal Article
Development of C5a receptor antagonists. Differential loss of functional responses
Konteatis, ZD, Siciliano, SJ, Van Riper, G, Molineaux, CJ, Pandya, S, Fischer, P, Rosen, H, Mumford, RA, Springer, MS
Published in The Journal of immunology (1950) (01.11.1994)
Published in The Journal of immunology (1950) (01.11.1994)
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CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines
Lynch, Christopher L, Gentry, Amy L, Hale, Jeffrey J, Mills, Sander G, MacCoss, Malcolm, Malkowitz, Lorraine, Springer, Martin S, Gould, Sandra L, DeMartino, Julie A, Siciliano, Salvatore J, Cascieri, Margaret A, Doss, George, Carella, Anthony, Carver, Gwen, Holmes, Karen, Schleif, William A, Danzeisen, Renee, Hazuda, Daria, Kessler, Joseph, Lineberger, Janet, Miller, Michael, Emini, Emilio A
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: Polar functionality and its effect on anti-HIV-1 activity
HALE, Jeffrey J, BUDHU, Richard J, HAZUDA, Daria, MILLER, Michael, KESSLER, Joseph, DANZEISEN, Renee, HOLMES, Karen, LINEBERGER, Janet, CARELLA, Anthony, CARVER, Gwen, EMINI, Emilio A, MILLS, Sander G, MACCOSS, Malcolm, GOULD, Sandra L, DEMARTINO, Julie A, SPRINGER, Martin S, SICILIANO, Salvatore J, MALKOWITZ, Lorraine, SCHLEIF, William A
Published in Bioorganic & medicinal chemistry letters (21.10.2002)
Published in Bioorganic & medicinal chemistry letters (21.10.2002)
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CCR5 Antagonists: 3-(Pyrrolidin-1-yl)propionic Acid Analogues with Potent Anti-HIV Activity
Lynch, Christopher L, Hale, Jeffrey J, Budhu, Richard J, Gentry, Amy L, Finke, Paul E, Caldwell, Charles G, Mills, Sander G, MacCoss, Malcolm, Shen, Dong-Ming, Chapman, Kevin T, Malkowitz, Lorraine, Springer, Martin S, Gould, Sandra L, DeMartino, Julie A, Siciliano, Salvatore J, Cascieri, Margaret A, Carella, Anthony, Carver, Gwen, Holmes, Karen, Schleif, William A, Danzeisen, Renee, Hazuda, Daria, Kessler, Joseph, Lineberger, Janet, Miller, Michael, Emini, Emilio
Published in Organic letters (10.07.2003)
Published in Organic letters (10.07.2003)
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The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs
DEMARTINO, J. A, VAN RIPER, G, SICILIANO, S. J, MOLINEAUX, C. J, KONTEATIS, Z. D, ROSEN, H, SPRINGER, M. S
Published in The Journal of biological chemistry (20.05.1994)
Published in The Journal of biological chemistry (20.05.1994)
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Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists
Shankaran, K., Donnelly, Karla L., Shah, Shrenik K., Caldwell, Charles G., Chen, Ping, Finke, Paul E., Oates, Bryan, MacCoss, Malcolm, Mills, Sander G., DeMartino, Julie A., Gould, Sandra L., Malkowitz, Lorraine, Siciliano, Salvatore J., Springer, Martin S., Kwei, Gloria, Carella, Anthony, Carver, Gwen, Danzeisen, Renee, Hazuda, Daria, Holmes, Karen, Kessler, Joseph, Lineberger, Janet, Miller, Michael D., Emini, Emilio A., Schleif, William A.
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
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