Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)
Vadas, Oscar, Dbouk, Hashem A., Shymanets, Aliaksei, Perisic, Olga, Burke, John E., Saab, Widian F. Abi, Khalil, Bassem D., Harteneck, Christian, Bresnick, Anne R., Nürnberg, Bernd, Backer, Jonathan M., Williams, Roger L.
Published in Proceedings of the National Academy of Sciences - PNAS (19.11.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (19.11.2013)
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Journal Article
Nanodiscs for INPHARMA NMR Characterization of GPCRs: Ligand Binding to the Human A2A Adenosine Receptor
Fredriksson, Kai, Lottmann, Philip, Hinz, Sonja, Onila, Iounut, Shymanets, Aliaksei, Harteneck, Christian, Müller, Christa E., Griesinger, Christian, Exner, Thomas E.
Published in Angewandte Chemie International Edition (15.05.2017)
Published in Angewandte Chemie International Edition (15.05.2017)
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Journal Article
Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase
Dbouk, Hashem A, Khalil, Bassem D, Wu, Haiyan, Shymanets, Aliaksei, Nürnberg, Bernd, Backer, Jonathan M
Published in PloS one (29.05.2013)
Published in PloS one (29.05.2013)
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Journal Article
p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase
Barrows, Douglas, Schoenfeld, Sarah M., Hodakoski, Cindy, Silkov, Antonina, Honig, Barry, Couvillon, Anthony, Shymanets, Aliaksei, Nürnberg, Bernd, Asara, John M., Parsons, Ramon
Published in The Journal of biological chemistry (27.11.2015)
Published in The Journal of biological chemistry (27.11.2015)
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Journal Article
Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110γ
Kurig, Barbara, Shymanets, Aliaksei, Bohnacker, Thomas, Prajwal, Brock, Carsten, Ahmadian, Mohammad Reza, Schaefer, Michael, Gohla, Antje, Harteneck, Christian, Wymann, Matthias P, Jeanclos, Elisabeth, Nürnberg, Bernd
Published in Proceedings of the National Academy of Sciences - PNAS (01.12.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (01.12.2009)
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Journal Article
Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins
Brink, Thorsten, Leiss, Veronika, Siegert, Peter, Jehle, Doris, Ebner, Julia K, Schwan, Carsten, Shymanets, Aliaksei, Wiese, Sebastian, Nürnberg, Bernd, Hensel, Michael, Aktories, Klaus, Orth, Joachim H C
Published in PLoS pathogens (01.08.2018)
Published in PLoS pathogens (01.08.2018)
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Journal Article
Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1
Zhang, Si-Cai, Gremer, Lothar, Heise, Henrike, Janning, Petra, Shymanets, Aliaksei, Cirstea, Ion C, Krause, Eberhard, Nürnberg, Bernd, Ahmadian, Mohammad Reza
Published in PloS one (11.07.2014)
Published in PloS one (11.07.2014)
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Journal Article
Don't Let Gluten-Related Issues Slow You Down--Read on to Learn More
Matthias, Torsten, Wusterhausen, Patricia, Shymanets, Aliaksei, Kammermeier, Robert, Orth, Jennifer
Published in European journal of rheumatology (11.05.2024)
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Published in European journal of rheumatology (11.05.2024)
Journal Article
Don't Let Gluten-Related Issues Slow You Down--Read on to Learn More
Matthias, Torsten, Wusterhausen, Patricia, Shymanets, Aliaksei, Kammermeier, Robert, Orth, Jennifer
Published in European journal of rheumatology (01.05.2024)
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Published in European journal of rheumatology (01.05.2024)
Journal Article
Rac1-stimulated macropinocytosis enhances Gβγ activation of PI3Kβ
Erami, Zahra, Khalil, Bassem D, Salloum, Gilbert, Yao, Yanhua, LoPiccolo, Jaclyn, Shymanets, Aliaksei, Nürnberg, Bernd, Bresnick, Anne R, Backer, Jonathan M
Published in Biochemical journal (16.11.2017)
Published in Biochemical journal (16.11.2017)
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Journal Article
Development of First Lead Structures for Phosphoinositide 3-Kinase-C27 gamma Inhibitors
Freitag, Anne, Prajwal, Prajwal, Shymanets, Aliaksei, Harteneck, Christian, Nuernberg, Bernd, Schaechtele, Christoph, Kubbutat, Michael, Totzke, Frank, Laufer, Stefan A.
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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Journal Article
Development of First Lead Structures for Phosphoinositide 3‑Kinase-C2γ Inhibitors
Freitag, Anne, Prajwal, Prajwal, Shymanets, Aliaksei, Harteneck, Christian, Nürnberg, Bernd, Schächtele, Christoph, Kubbutat, Michael, Totzke, Frank, Laufer, Stefan A.
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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Journal Article
Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric G.sub.i proteins
Brink, Thorsten, Leiss, Veronika, Siegert, Peter, Jehle, Doris, Ebner, Julia K, Schwan, Carsten, Shymanets, Aliaksei, Wiese, Sebastian, Nürnberg, Bernd, Hensel, Michael, Aktories, Klaus, Orth, Joachim H. C
Published in PLoS pathogens (13.08.2018)
Published in PLoS pathogens (13.08.2018)
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Journal Article
Ras is an indispensable coregulator of the class I B phosphoinositide 3-kinase p87/p110γ
Kurig, Barbara, Shymanets, Aliaksei, Bohnacker, Thomas, Prajwal, Brock, Carsten, Ahmadian, Mohammad Reza, Schaefer, Michael, Gohla, Antje, Harteneck, Christian, Wymann, Matthias P., Jeanclos, Elisabeth, Nürnberg, Bernd
Published in Proceedings of the National Academy of Sciences - PNAS (01.12.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (01.12.2009)
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Journal Article
Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity
Shymanets, Aliaksei, Prajwal, Vadas, Oscar, Czupalla, Cornelia, LoPiccolo, Jaclyn, Brenowitz, Michael, Ghigo, Alessandra, Hirsch, Emilio, Krause, Eberhard, Wetzker, Reinhard, Williams, Roger L, Harteneck, Christian, Nürnberg, Bernd
Published in Biochemical journal (01.07.2015)
Published in Biochemical journal (01.07.2015)
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Journal Article
A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion
Heitz, Samantha D., Hamelin, David J., Hoffmann, Reece M., Greenberg, Nili, Salloum, Gilbert, Erami, Zahra, Khalil, Bassem D., Shymanets, Aliaksei, Steidle, Elizabeth A., Gong, Grace Q., Nürnberg, Bernd, Burke, John E., Flanagan, Jack U., Bresnick, Anne R., Backer, Jonathan M.
Published in The Journal of biological chemistry (22.03.2019)
Published in The Journal of biological chemistry (22.03.2019)
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