Mesenchymal stem cells: From regeneration to cancer
Li, Peishan, Gong, Zheng, Shultz, Leonard D., Ren, Guangwen
Published in Pharmacology & therapeutics (Oxford) (01.08.2019)
Published in Pharmacology & therapeutics (Oxford) (01.08.2019)
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Journal Article
Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice
Saito, Yoriko, Shultz, Leonard D., Ishikawa, Fumihiko
Published in Trends in immunology (01.08.2020)
Published in Trends in immunology (01.08.2020)
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Journal Article
Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment
Gong, Zheng, Li, Qing, Shi, Jiayuan, Wei, Jian, Li, Peishan, Chang, Chih-Hao, Shultz, Leonard D., Ren, Guangwen
Published in Immunity (Cambridge, Mass.) (09.08.2022)
Published in Immunity (Cambridge, Mass.) (09.08.2022)
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Journal Article
Humanized Mouse Models of Clinical Disease
Walsh, Nicole C, Kenney, Laurie L, Jangalwe, Sonal, Aryee, Ken-Edwin, Greiner, Dale L, Brehm, Michael A, Shultz, Leonard D
Published in Annual review of pathology (24.01.2017)
Published in Annual review of pathology (24.01.2017)
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Journal Article
MEK Guards Proteome Stability and Inhibits Tumor-Suppressive Amyloidogenesis via HSF1
Tang, Zijian, Dai, Siyuan, He, Yishu, Doty, Rosalinda A., Shultz, Leonard D., Sampson, Stephen Byers, Dai, Chengkai
Published in Cell (12.02.2015)
Published in Cell (12.02.2015)
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Journal Article
Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status
Li, Peishan, Lu, Ming, Shi, Jiayuan, Hua, Li, Gong, Zheng, Li, Qing, Shultz, Leonard D., Ren, Guangwen
Published in Nature communications (01.09.2020)
Published in Nature communications (01.09.2020)
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Journal Article
Humanized mouse models for immuno-oncology research
Chuprin, Jane, Buettner, Hannah, Seedhom, Mina O., Greiner, Dale L., Keck, James G., Ishikawa, Fumihiko, Shultz, Leonard D., Brehm, Michael A.
Published in Nature reviews. Clinical oncology (01.03.2023)
Published in Nature reviews. Clinical oncology (01.03.2023)
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Journal Article
Humanized mice in translational biomedical research
Shultz, Leonard D, Ishikawa, Fumihiko, Greiner, Dale L
Published in Nature Reviews: Immunology (01.02.2007)
Published in Nature Reviews: Immunology (01.02.2007)
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Journal Article
Humanized mice for immune system investigation: progress, promise and challenges
Shultz, Leonard D., Brehm, Michael A., Garcia-Martinez, J. Victor, Greiner, Dale L.
Published in Nature reviews. Immunology (01.11.2012)
Published in Nature reviews. Immunology (01.11.2012)
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Journal Article
Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma
Crescenzo, Ramona, Abate, Francesco, Lasorsa, Elena, Tabbo’, Fabrizio, Gaudiano, Marcello, Chiesa, Nicoletta, Di Giacomo, Filomena, Spaccarotella, Elisa, Barbarossa, Luigi, Ercole, Elisabetta, Todaro, Maria, Boi, Michela, Acquaviva, Andrea, Ficarra, Elisa, Novero, Domenico, Rinaldi, Andrea, Tousseyn, Thomas, Rosenwald, Andreas, Kenner, Lukas, Cerroni, Lorenzo, Tzankov, Alexander, Ponzoni, Maurilio, Paulli, Marco, Weisenburger, Dennis, Chan, Wing C., Iqbal, Javeed, Piris, Miguel A., Zamo’, Alberto, Ciardullo, Carmela, Rossi, Davide, Gaidano, Gianluca, Pileri, Stefano, Tiacci, Enrico, Falini, Brunangelo, Shultz, Leonard D., Mevellec, Laurence, Vialard, Jorge E., Piva, Roberto, Bertoni, Francesco, Rabadan, Raul, Inghirami, Giorgio
Published in Cancer cell (13.04.2015)
Published in Cancer cell (13.04.2015)
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Journal Article
Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain
Svoboda, Devon S., Barrasa, M. Inmaculada, Shu, Jian, Rietjens, Rosalie, Zhang, Shupei, Mitalipova, Maya, Berube, Peter, Fu, Dongdong, Shultz, Leonard D., Bell, George W., Jaenisch, Rudolf
Published in Proceedings of the National Academy of Sciences - PNAS (10.12.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (10.12.2019)
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Journal Article
AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice
Youngblood, Bradford A., Brock, Emily C., Leung, John, Falahati, Rustom, Bryce, Paul J., Bright, Jessica, Williams, Jason, Shultz, Leonard D., Greiner, Dale L., Brehm, Michael A., Bebbington, Christopher, Tomasevic, Nenad
Published in International archives of allergy and immunology (01.09.2019)
Published in International archives of allergy and immunology (01.09.2019)
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Journal Article
Humanized mice in studying efficacy and mechanisms of PD‐1‐targeted cancer immunotherapy
Wang, Minan, Yao, Li‐Chin, Cheng, Mingshan, Cai, Danying, Martinek, Jan, Pan, Chong‐Xian, Shi, Wei, Ma, Ai‐Hong, Vere White, Ralph W., Airhart, Susan, Liu, Edison T., Banchereau, Jacques, Brehm, Michael A., Greiner, Dale L., Shultz, Leonard D., Palucka, Karolina, Keck, James G.
Published in The FASEB journal (01.03.2018)
Published in The FASEB journal (01.03.2018)
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Journal Article
Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis
Li, Peishan, Lu, Ming, Shi, Jiayuan, Gong, Zheng, Hua, Li, Li, Qing, Lim, Bora, Zhang, Xiang H.-F., Chen, Xiaowen, Li, Sheng, Shultz, Leonard D., Ren, Guangwen
Published in Nature immunology (01.11.2020)
Published in Nature immunology (01.11.2020)
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Journal Article
Humanized mouse models of immunological diseases and precision medicine
Shultz, Leonard D., Keck, James, Burzenski, Lisa, Jangalwe, Sonal, Vaidya, Shantashri, Greiner, Dale L., Brehm, Michael A.
Published in Mammalian genome (01.06.2019)
Published in Mammalian genome (01.06.2019)
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Journal Article
Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice
Shultz, Leonard D, Saito, Yoriko, Najima, Yuho, Tanaka, Satoshi, Ochi, Toshiki, Tomizawa, Mariko, Doi, Takehiko, Sone, Akiko, Suzuki, Nahoko, Fujiwara, Hiroshi, Yasukawa, Masaki, Ishikawa, Fumihiko
Published in Proceedings of the National Academy of Sciences - PNAS (20.07.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (20.07.2010)
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Journal Article
Overcoming Current Limitations in Humanized Mouse Research
Brehm, Michael A., Shultz, Leonard D., Luban, Jeremy, Greiner, Dale L.
Published in The Journal of infectious diseases (15.11.2013)
Published in The Journal of infectious diseases (15.11.2013)
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Journal Article
Conference Proceeding
Generation of improved humanized mouse models for human infectious diseases
Brehm, Michael A., Wiles, Michael V., Greiner, Dale L., Shultz, Leonard D.
Published in Journal of immunological methods (01.08.2014)
Published in Journal of immunological methods (01.08.2014)
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Journal Article
Humanized mouse model of mast cell–mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis
Bryce, Paul J., PhD, Falahati, Rustom, PhD, Kenney, Laurie L., PhD, Leung, John, BS, Bebbington, Christopher, PhD, Tomasevic, Nenad, PhD, Krier, Rebecca A., MS, Hsu, Chia-Lin, PhD, Shultz, Leonard D., PhD, Greiner, Dale L., PhD, Brehm, Michael A., PhD
Published in Journal of allergy and clinical immunology (01.09.2016)
Published in Journal of allergy and clinical immunology (01.09.2016)
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Journal Article