K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
Ostrem, Jonathan M., Peters, Ulf, Sos, Martin L., Wells, James A., Shokat, Kevan M.
Published in Nature (London) (29.11.2013)
Published in Nature (London) (29.11.2013)
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Drugging MYCN through an Allosteric Transition in Aurora Kinase A
Gustafson, William Clay, Meyerowitz, Justin Gabriel, Nekritz, Erin A., Chen, Justin, Benes, Cyril, Charron, Elise, Simonds, Erin F., Seeger, Robert, Matthay, Katherine K., Hertz, Nicholas T., Eilers, Martin, Shokat, Kevan M., Weiss, William A.
Published in Cancer cell (08.09.2014)
Published in Cancer cell (08.09.2014)
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A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1
Hertz, Nicholas T., Berthet, Amandine, Sos, Martin L., Thorn, Kurt S., Burlingame, Al L., Nakamura, Ken, Shokat, Kevan M.
Published in Cell (15.08.2013)
Published in Cell (15.08.2013)
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Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A
White, Kris M, Rosales, Romel, Yildiz, Soner, Kehrer, Thomas, Miorin, Lisa, Moreno, Elena, Jangra, Sonia, Uccellini, Melissa B, Rathnasinghe, Raveen, Coughlan, Lynda, Martinez-Romero, Carles, Batra, Jyoti, Rojc, Ajda, Bouhaddou, Mehdi, Fabius, Jacqueline M, Obernier, Kirsten, Dejosez, Marion, Guillén, María José, Losada, Alejandro, Avilés, Pablo, Schotsaert, Michael, Zwaka, Thomas, Vignuzzi, Marco, Shokat, Kevan M, Krogan, Nevan J, García-Sastre, Adolfo
Published in Science (26.02.2021)
Published in Science (26.02.2021)
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Chemical genetic discovery of targets and anti-targets for cancer polypharmacology
Dar, Arvin C., Das, Tirtha K., Shokat, Kevan M., Cagan, Ross L.
Published in Nature (London) (07.06.2012)
Published in Nature (London) (07.06.2012)
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Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2
Tummino, Tia A, Rezelj, Veronica V, Fischer, Benoit, Fischer, Audrey, O'Meara, Matthew J, Monel, Blandine, Vallet, Thomas, White, Kris M, Zhang, Ziyang, Alon, Assaf, Schadt, Heiko, O'Donnell, Henry R, Lyu, Jiankun, Rosales, Romel, McGovern, Briana L, Rathnasinghe, Raveen, Jangra, Sonia, Schotsaert, Michael, Galarneau, Jean-René, Krogan, Nevan J, Urban, Laszlo, Shokat, Kevan M, Kruse, Andrew C, García-Sastre, Adolfo, Schwartz, Olivier, Moretti, Francesca, Vignuzzi, Marco, Pognan, Francois, Shoichet, Brian K
Published in Science (30.07.2021)
Published in Science (30.07.2021)
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Site-specific incorporation of phosphotyrosine using an expanded genetic code
Hoppmann, Christian, Wong, Allison, Yang, Bing, Li, Shuwei, Hunter, Tony, Shokat, Kevan M, Wang, Lei
Published in Nature chemical biology (01.08.2017)
Published in Nature chemical biology (01.08.2017)
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EGFR Phosphorylates Tumor-Derived EGFRvIII Driving STAT3/5 and Progression in Glioblastoma
Fan, Qi-Wen, Cheng, Christine K., Gustafson, W. Clay, Charron, Elizabeth, Zipper, Petra, Wong, Robyn A., Chen, Justin, Lau, Jasmine, Knobbe-Thomsen, Christiane, Weller, Michael, Jura, Natalia, Reifenberger, Guido, Shokat, Kevan M., Weiss, William A.
Published in Cancer cell (14.10.2013)
Published in Cancer cell (14.10.2013)
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Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II
Larochelle, Stéphane, Amat, Ramon, Glover-Cutter, Kira, Sansó, Miriam, Zhang, Chao, Allen, Jasmina J, Shokat, Kevan M, Bentley, David L, Fisher, Robert P
Published in Nature structural & molecular biology (01.11.2012)
Published in Nature structural & molecular biology (01.11.2012)
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Evolutionarily divergent mTOR remodels translatome for tissue regeneration
Zhulyn, Olena, Rosenblatt, Hannah D., Shokat, Leila, Dai, Shizhong, Kuzuoglu-Öztürk, Duygu, Zhang, Zijian, Ruggero, Davide, Shokat, Kevan M., Barna, Maria
Published in Nature (London) (03.08.2023)
Published in Nature (London) (03.08.2023)
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A Cdk7-Cdk4 T-Loop Phosphorylation Cascade Promotes G1 Progression
Schachter, Miriam Merzel, Merrick, Karl A., Larochelle, Stéphane, Hirschi, Alexander, Zhang, Chao, Shokat, Kevan M., Rubin, Seth M., Fisher, Robert P.
Published in Molecular cell (25.04.2013)
Published in Molecular cell (25.04.2013)
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Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction
Schaffer, Bethany E., Levin, Rebecca S., Hertz, Nicholas T., Maures, Travis J., Schoof, Michael L., Hollstein, Pablo E., Benayoun, Bérénice A., Banko, Max R., Shaw, Reuben J., Shokat, Kevan M., Brunet, Anne
Published in Cell metabolism (03.11.2015)
Published in Cell metabolism (03.11.2015)
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Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis
Banko, Max R., Allen, Jasmina J., Schaffer, Bethany E., Wilker, Erik W., Tsou, Peiling, White, Jamie L., Villén, Judit, Wang, Beatrice, Kim, Sara R., Sakamoto, Kei, Gygi, Steven P., Cantley, Lewis C., Yaffe, Michael B., Shokat, Kevan M., Brunet, Anne
Published in Molecular cell (23.12.2011)
Published in Molecular cell (23.12.2011)
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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
Feldman, Morris E, Apsel, Beth, Uotila, Aino, Loewith, Robbie, Knight, Zachary A, Ruggero, Davide, Shokat, Kevan M
Published in PLoS biology (01.02.2009)
Published in PLoS biology (01.02.2009)
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Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers
Pourdehnad, Michael, Truitt, Morgan L., Siddiqi, Imran N., Ducker, Gregory S., Shokat, Kevan M., Ruggero, Davide
Published in Proceedings of the National Academy of Sciences - PNAS (16.07.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (16.07.2013)
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A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma
Fan, QiWen, Aksoy, Ozlem, Wong, Robyn A., Ilkhanizadeh, Shirin, Novotny, Chris J., Gustafson, William C., Truong, Albert Yi-Que, Cayanan, Geraldine, Simonds, Erin F., Haas-Kogan, Daphne, Phillips, Joanna J., Nicolaides, Theodore, Okaniwa, Masanori, Shokat, Kevan M., Weiss, William A.
Published in Cancer cell (13.03.2017)
Published in Cancer cell (13.03.2017)
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