Observing a DNA Polymerase Choose Right from Wrong
Freudenthal, Bret D., Beard, William A., Shock, David D., Wilson, Samuel H.
Published in Cell (03.07.2013)
Published in Cell (03.07.2013)
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Journal Article
Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide
Freudenthal, Bret D., Beard, William A., Perera, Lalith, Shock, David D., Kim, Taejin, Schlick, Tamar, Wilson, Samuel H.
Published in Nature (London) (29.01.2015)
Published in Nature (London) (29.01.2015)
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Journal Article
Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints
Jamsen, Joonas A., Shock, David D., Wilson, Samuel H.
Published in Nature communications (09.06.2022)
Published in Nature communications (09.06.2022)
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Journal Article
Substrate Channeling in Mammalian Base Excision Repair Pathways: Passing the Baton
Prasad, Rajendra, Shock, David D., Beard, William A., Wilson, Samuel H.
Published in The Journal of biological chemistry (24.12.2010)
Published in The Journal of biological chemistry (24.12.2010)
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Journal Article
Time-lapse crystallography snapshots of a double-strand break repair polymerase in action
Jamsen, Joonas A., Beard, William A., Pedersen, Lars C., Shock, David D., Moon, Andrea F., Krahn, Juno M., Bebenek, Katarzyna, Kunkel, Thomas A., Wilson, Samuel H.
Published in Nature communications (15.08.2017)
Published in Nature communications (15.08.2017)
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Journal Article
Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
Jamsen, Joonas A., Sassa, Akira, Shock, David D., Beard, William A., Wilson, Samuel H.
Published in Nature communications (06.04.2021)
Published in Nature communications (06.04.2021)
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Journal Article
Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse
Perera, Lalith, Freudenthal, Bret D., Beard, William A., Shock, David D., Pedersen, Lee G., Wilson, Samuel H.
Published in Proceedings of the National Academy of Sciences - PNAS (22.09.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (22.09.2015)
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Journal Article
Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction
Shock, David D, Freudenthal, Bret D, Beard, William A, Wilson, Samuel H
Published in Nature chemical biology (01.10.2017)
Published in Nature chemical biology (01.10.2017)
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Journal Article
A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition
Smith, Mallory R, Shock, David D, Beard, William A, Greenberg, Marc M, Freudenthal, Bret D, Wilson, Samuel H
Published in Nucleic acids research (08.04.2019)
Published in Nucleic acids research (08.04.2019)
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Journal Article
Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion
Batra, Vinod K, Shock, David D, Beard, William A, McKenna, Charles E, Wilson, Samuel H
Published in Proceedings of the National Academy of Sciences - PNAS (03.01.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (03.01.2012)
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Journal Article
DNA polymerase β nucleotide-stabilized template misalignment fidelity depends on local sequence context
Howard, Michael J., Cavanaugh, Nisha A., Batra, Vinod K., Shock, David D., Beard, William A., Wilson, Samuel H.
Published in The Journal of biological chemistry (10.01.2020)
Published in The Journal of biological chemistry (10.01.2020)
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Journal Article
Magnesium-Induced Assembly of a Complete DNA Polymerase Catalytic Complex
Batra, Vinod K., Beard, William A., Shock, David D., Krahn, Joseph M., Pedersen, Lars C., Wilson, Samuel H.
Published in Structure (London) (01.04.2006)
Published in Structure (London) (01.04.2006)
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Journal Article
Substrate-induced DNA Polymerase β Activation
Beard, William A., Shock, David D., Batra, Vinod K., Prasad, Rajendra, Wilson, Samuel H.
Published in The Journal of biological chemistry (07.11.2014)
Published in The Journal of biological chemistry (07.11.2014)
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Journal Article
Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction
Batra, Vinod K, Perera, Lalith, Lin, Ping, Shock, David D, Beard, William A, Pedersen, Lars C, Pedersen, Lee G, Wilson, Samuel H
Published in Journal of the American Chemical Society (29.05.2013)
Published in Journal of the American Chemical Society (29.05.2013)
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Journal Article
Coordination of Steps in Single-nucleotide Base Excision Repair Mediated by Apurinic/Apyrimidinic Endonuclease 1 and DNA Polymerase β
Liu, Yuan, Prasad, Rajendra, Beard, William A., Kedar, Padmini S., Hou, Esther W., Shock, David D., Wilson, Samuel H.
Published in The Journal of biological chemistry (04.05.2007)
Published in The Journal of biological chemistry (04.05.2007)
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Journal Article
DNA polymerase beta substrate specificity: side chain modulation of the "A-rule"
Beard, William A, Shock, David D, Batra, Vinod K, Pedersen, Lars C, Wilson, Samuel H
Published in The Journal of biological chemistry (13.11.2009)
Published in The Journal of biological chemistry (13.11.2009)
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Journal Article
Substrate Rescue of DNA Polymerase β Containing a Catastrophic L22P Mutation
Kirby, Thomas W, DeRose, Eugene F, Beard, William A, Shock, David D, Wilson, Samuel H, London, Robert E
Published in Biochemistry (Easton) (15.04.2014)
Published in Biochemistry (Easton) (15.04.2014)
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