RK‐287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model
Mizutani, Anna, Yashiroda, Yoko, Muramatsu, Yukiko, Yoshida, Haruka, Chikada, Tsubasa, Tsumura, Takeshi, Okue, Masayuki, Shirai, Fumiyuki, Fukami, Takehiro, Yoshida, Minoru, Seimiya, Hiroyuki
Published in Cancer science (01.12.2018)
Published in Cancer science (01.12.2018)
Get full text
Journal Article
A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression
Takase, Shohei, Hiroyama, Takashi, Shirai, Fumiyuki, Maemoto, Yuki, Nakata, Akiko, Arata, Mayumi, Matsuoka, Seiji, Sonoda, Takeshi, Niwa, Hideaki, Sato, Shin, Umehara, Takashi, Shirouzu, Mikako, Nishigaya, Yosuke, Sumiya, Tatsunobu, Hashimoto, Noriaki, Namie, Ryosuke, Usui, Masaya, Ohishi, Tomokazu, Ohba, Shun-Ichi, Kawada, Manabu, Hayashi, Yoshihiro, Harada, Hironori, Yamaguchi, Tokio, Shinkai, Yoichi, Nakamura, Yukio, Yoshida, Minoru, Ito, Akihiro
Published in Nature communications (12.01.2023)
Published in Nature communications (12.01.2023)
Get full text
Journal Article
Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer
Shirai, Fumiyuki, Mizutani, Anna, Yashiroda, Yoko, Tsumura, Takeshi, Kano, Yuko, Muramatsu, Yukiko, Chikada, Tsubasa, Yuki, Hitomi, Niwa, Hideaki, Sato, Shin, Washizuka, Kenichi, Koda, Yasuko, Mazaki, Yui, Jang, Myung-Kyu, Yoshida, Haruka, Nagamori, Akiko, Okue, Masayuki, Watanabe, Takashi, Kitamura, Kouichi, Shitara, Eiki, Honma, Teruki, Umehara, Takashi, Shirouzu, Mikako, Fukami, Takehiro, Seimiya, Hiroyuki, Yoshida, Minoru, Koyama, Hiroo
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
Get full text
Journal Article
Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors
Shirai, Fumiyuki, Tsumura, Takeshi, Yashiroda, Yoko, Yuki, Hitomi, Niwa, Hideaki, Sato, Shin, Chikada, Tsubasa, Koda, Yasuko, Washizuka, Kenichi, Yoshimoto, Nobuko, Abe, Masako, Onuki, Tetsuo, Mazaki, Yui, Hirama, Chizuko, Fukami, Takehiro, Watanabe, Hirofumi, Honma, Teruki, Umehara, Takashi, Shirouzu, Mikako, Okue, Masayuki, Kano, Yuko, Watanabe, Takashi, Kitamura, Kouichi, Shitara, Eiki, Muramatsu, Yukiko, Yoshida, Haruka, Mizutani, Anna, Seimiya, Hiroyuki, Yoshida, Minoru, Koyama, Hiroo
Published in Journal of medicinal chemistry (11.04.2019)
Published in Journal of medicinal chemistry (11.04.2019)
Get full text
Journal Article
Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents
Nishigaya, Yosuke, Takase, Shohei, Sumiya, Tatsunobu, Kikuzato, Ko, Sato, Tomohiro, Niwa, Hideaki, Sato, Shin, Nakata, Akiko, Sonoda, Takeshi, Hashimoto, Noriaki, Namie, Ryosuke, Honma, Teruki, Umehara, Takashi, Shirouzu, Mikako, Koyama, Hiroo, Yoshida, Minoru, Ito, Akihiro, Shirai, Fumiyuki
Published in Journal of medicinal chemistry (23.03.2023)
Published in Journal of medicinal chemistry (23.03.2023)
Get full text
Journal Article
An ex vivo screening using mouse brain mitochondria identified seco-cycline D as an inhibitor of mitochondrial permeability transition pore
Kubota-Sakashita, Mie, Kawakami, Hirochika, Kikuzato, Ko, Shirai, Fumiyuki, Nakamura, Takemichi, Kato, Tadafumi
Published in Biochemical and biophysical research communications (08.01.2024)
Published in Biochemical and biophysical research communications (08.01.2024)
Get full text
Journal Article
BET protein–dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer
Morino, Shun, Mashima, Tetsuo, Shirai, Fumiyuki, Nagayama, Satoshi, Katayama, Ryohei, Seimiya, Hiroyuki
Published in Cancer letters (01.03.2024)
Published in Cancer letters (01.03.2024)
Get full text
Journal Article
Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents
Nishigaya, Yosuke, Takase, Shohei, Sumiya, Tatsunobu, Kikuzato, Ko, Sato, Tomohiro, Niwa, Hideaki, Sato, Shin, Nakata, Akiko, Sonoda, Takeshi, Hashimoto, Noriaki, Namie, Ryosuke, Honma, Teruki, Umehara, Takashi, Shirouzu, Mikako, Koyama, Hiroo, Yoshida, Minoru, Ito, Akihiro, Shirai, Fumiyuki
Published in Journal of medicinal chemistry (23.03.2023)
Published in Journal of medicinal chemistry (23.03.2023)
Get full text
Journal Article
Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment
Nishigaya, Yosuke, Takase, Shohei, Sumiya, Tatsunobu, Sato, Tomohiro, Niwa, Hideaki, Sato, Shin, Nakata, Akiko, Matsuoka, Seiji, Maemoto, Yuki, Hashimoto, Noriaki, Namie, Ryosuke, Honma, Teruki, Umehara, Takashi, Shirouzu, Mikako, Koyama, Hiroo, Yoshida, Minoru, Ito, Akihiro, Shirai, Fumiyuki
Published in Bioorganic & medicinal chemistry letters (15.09.2024)
Published in Bioorganic & medicinal chemistry letters (15.09.2024)
Get full text
Journal Article
Synthesis and antibacterial activity of novel 4-pyrrolidinylthio carbapenems Part IV. 2-Alkyl substituents containing cationic heteroaromatics linked via a C–C bond
Azami, Hidenori, Barrett, David, Tanaka, Akira, Sasaki, Hiroshi, Matsuda, Keiji, Sakurai, Minoru, Terasawa, Takeshi, Shirai, Fumiyuki, Chiba, Toshiyuki, Matsumoto, Yoshimi, Tawara, Shuichi
Published in Bioorganic & medicinal chemistry (01.04.2001)
Published in Bioorganic & medicinal chemistry (01.04.2001)
Get full text
Journal Article
APC/PIK3CA mutations and β-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells
Chen, Mingjue, Mashima, Tetsuo, Oishi, Taichi, Muramatsu, Yukiko, Seto, Yosuke, Takamatsu, Manabu, Kawata, Naomi, Morino, Shun, Nakamura, Ayane, Inaba, Saori, Yuan, Xunmei, Maruyama, Kohei, Suzuki, Mai, Sato, Ayana, Yoshida, Haruka, Jang, Myung-Kyu, Mizutani, Anna, Takeuchi, Kengo, Yamaguchi, Kensei, Shirai, Fumiyuki, Nagayama, Satoshi, Katayama, Ryohei, Seimiya, Hiroyuki
Published in British journal of cancer (31.01.2024)
Published in British journal of cancer (31.01.2024)
Get full text
Journal Article
Reduction of H3K9 methylation by G9a inhibitors improves the development of mouse SCNT embryos
Matoba, Shogo, Shikata, Daiki, Shirai, Fumiyuki, Tatebe, Takaki, Hirose, Michiko, Nakata, Akiko, Watanabe, Naomi, Hasegawa, Ayumi, Ito, Akihiro, Yoshida, Minoru, Ogura, Atsuo
Published in Stem cell reports (11.06.2024)
Published in Stem cell reports (11.06.2024)
Get full text
Journal Article
Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug–drug interactions and P-gp liability
Kunikawa, Shigeki, Tanaka, Akira, Mukoyoshi, Koichiro, Nagashima, Shinya, Tominaga, Hiroaki, Chida, Noboru, Tasaki, Mamoru, Shirai, Fumiyuki
Published in Bioorganic & medicinal chemistry (01.07.2015)
Published in Bioorganic & medicinal chemistry (01.07.2015)
Get full text
Journal Article
Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen
Yuki, Hitomi, Kikuzato, Ko, Koda, Yasuko, Mikuni, Junko, Tomabechi, Yuri, Kukimoto-Niino, Mutsuko, Tanaka, Akiko, Shirai, Fumiyuki, Shirouzu, Mikako, Koyama, Hiroo, Honma, Teruki
Published in Bioorganic & medicinal chemistry (15.08.2017)
Published in Bioorganic & medicinal chemistry (15.08.2017)
Get full text
Journal Article
Identification of pyrrolo[2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors
Koda, Yasuko, Kikuzato, Ko, Mikuni, Junko, Tanaka, Akiko, Yuki, Hitomi, Honma, Teruki, Tomabechi, Yuri, Kukimoto-Niino, Mutsuko, Shirouzu, Mikako, Shirai, Fumiyuki, Koyama, Hiroo
Published in Bioorganic & medicinal chemistry letters (15.11.2017)
Published in Bioorganic & medicinal chemistry letters (15.11.2017)
Get full text
Journal Article
Novel tankyrase inhibitors suppress TDP-43 aggregate formation
Tanji, Kunikazu, Mori, Fumiaki, Shirai, Fumiyuki, Fukami, Takehiro, Seimiya, Hiroyuki, Utsumi, Jun, Kakita, Akiyoshi, Wakabayashi, Koichi
Published in Biochemical and biophysical research communications (22.01.2021)
Published in Biochemical and biophysical research communications (22.01.2021)
Get full text
Journal Article
G9a INHIBITOR
SHIRAI Fumiyuki, NAMIE Ryosuke, YOSHIDA Minoru, ITO Akihiro, SUMIYA Tatsunobu, KIKUZATO Ko, HASHIMOTO Noriaki, NISHIGAYA Yosuke
Year of Publication 03.06.2021
Get full text
Year of Publication 03.06.2021
Patent