Reconstitution of a Type II Polyketide Synthase that Catalyzes Polyene Formation
Du, Danyao, Katsuyama, Yohei, Shin‐ya, Kazuo, Ohnishi, Yasuo
Published in Angewandte Chemie International Edition (12.02.2018)
Published in Angewandte Chemie International Edition (12.02.2018)
Get full text
Journal Article
Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters
Ikeda, Haruo, Shin-ya, Kazuo, Omura, Satoshi
Published in Journal of industrial microbiology & biotechnology (01.02.2014)
Published in Journal of industrial microbiology & biotechnology (01.02.2014)
Get full text
Journal Article
Bacterial Avenalumic Acid Biosynthesis Includes Substitution of an Aromatic Amino Group for Hydride by Nitrous Acid Dependent Diazotization
Kawai, Seiji, Hagihara, Ryota, Shin‐ya, Kazuo, Katsuyama, Yohei, Ohnishi, Yasuo
Published in Angewandte Chemie International Edition (07.11.2022)
Published in Angewandte Chemie International Edition (07.11.2022)
Get full text
Journal Article
Identification of the Cirratiomycin Biosynthesis Gene Cluster in Streptomyces Cirratus: Elucidation of the Biosynthetic Pathways for 2,3‐Diaminobutyric Acid and Hydroxymethylserine
Sakata, Shunki, Li, Jiafeng, Yasuno, Yoko, Shinada, Tetsuro, Shin‐ya, Kazuo, Katsuyama, Yohei, Ohnishi, Yasuo
Published in Chemistry : a European journal (17.05.2024)
Published in Chemistry : a European journal (17.05.2024)
Get full text
Journal Article
In Vitro Module Editing Of NRPS Enables Production Of Highly Potent Gq‐Signaling Inhibitor FR900359 Derived From Unculturable Plant Symbiont
Hashimoto, Takuya, Suenaga, Hikaru, Amagai, Keita, Hashimoto, Junko, Kozone, Ikuko, Takahashi, Shunji, Shin‐ya, Kazuo
Published in Angewandte Chemie International Edition (04.03.2024)
Published in Angewandte Chemie International Edition (04.03.2024)
Get full text
Journal Article
Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy
Bastola, Soniya, Pavlyukov, Marat S., Yamashita, Daisuke, Ghosh, Sadashib, Cho, Heejin, Kagaya, Noritaka, Zhang, Zhuo, Minata, Mutsuko, Lee, Yeri, Sadahiro, Hirokazu, Yamaguchi, Shinobu, Komarova, Svetlana, Yang, Eddy, Markert, James, Nabors, Louis B., Bhat, Krishna, Lee, James, Chen, Qin, Crossman, David K., Shin-Ya, Kazuo, Nam, Do-Hyun, Nakano, Ichiro
Published in Nature communications (16.09.2020)
Published in Nature communications (16.09.2020)
Get full text
Journal Article
Structural and Functional Analyses of the Tridomain‐Nonribosomal Peptide Synthetase FmoA3 for 4‐Methyloxazoline Ring Formation
Katsuyama, Yohei, Sone, Kaoru, Harada, Ayaka, Kawai, Seiji, Urano, Naoki, Adachi, Naruhiko, Moriya, Toshio, Kawasaki, Masato, Shin‐ya, Kazuo, Senda, Toshiya, Ohnishi, Yasuo
Published in Angewandte Chemie International Edition (21.06.2021)
Published in Angewandte Chemie International Edition (21.06.2021)
Get full text
Journal Article
Acyltransferase Domain Exchange between Two Independent Type I Polyketide Synthases in the Same Producer Strain of Macrolide Antibiotics
Kudo, Fumitaka, Kishikawa, Kosuke, Tsuboi, Kazuma, Kido, Takafusa, Usui, Takeo, Hashimoto, Junko, Shin‐ya, Kazuo, Miyanaga, Akimasa, Eguchi, Tadashi
Published in Chembiochem : a European journal of chemical biology (14.03.2023)
Published in Chembiochem : a European journal of chemical biology (14.03.2023)
Get full text
Journal Article
Structural and Molecular Basis of the Catalytic Mechanism of Geranyl Pyrophosphate C6‐Methyltransferase: Creation of an Unprecedented Farnesyl Pyrophosphate C6‐Methyltransferase
Tsutsumi, Hayama, Moriwaki, Yoshitaka, Terada, Tohru, Shimizu, Kentaro, Shin‐ya, Kazuo, Katsuyama, Yohei, Ohnishi, Yasuo
Published in Angewandte Chemie International Edition (03.01.2022)
Published in Angewandte Chemie International Edition (03.01.2022)
Get full text
Journal Article
Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma
Khaledian, Behnoush, Taguchi, Ayumu, Shin‐ya, Kazuo, Kondo‐Ida, Lisa, Kagaya, Noritaka, Suzuki, Motoshi, Kajino, Taisuke, Yamaguchi, Tomoya, Shimada, Yukako, Takahashi, Takashi
Published in Cancer science (01.03.2021)
Published in Cancer science (01.03.2021)
Get full text
Journal Article
Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi
Ye, Ying, Minami, Atsushi, Igarashi, Yuya, Izumikawa, Miho, Umemura, Myco, Nagano, Nozomi, Machida, Masayuki, Kawahara, Teppei, Shin-ya, Kazuo, Gomi, Katsuya, Oikawa, Hideaki
Published in Angewandte Chemie International Edition (04.07.2016)
Published in Angewandte Chemie International Edition (04.07.2016)
Get full text
Journal Article
Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity
Lin, Weiqiang, Sampathi, Shilpa, Dai, Huifang, Liu, Changwei, Zhou, Mian, Hu, Jenny, Huang, Qin, Campbell, Judith, Shin-Ya, Kazuo, Zheng, Li, Chai, Weihang, Shen, Binghui
Published in The EMBO journal (15.05.2013)
Published in The EMBO journal (15.05.2013)
Get full text
Journal Article
In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives
Kudo, Kei, Hashimoto, Takuya, Hashimoto, Junko, Kozone, Ikuko, Kagaya, Noritaka, Ueoka, Reiko, Nishimura, Takehiro, Komatsu, Mamoru, Suenaga, Hikaru, Ikeda, Haruo, Shin-ya, Kazuo
Published in Nature communications (11.08.2020)
Published in Nature communications (11.08.2020)
Get full text
Journal Article
Structural Basis for the Prenylation Reaction of Carbazole‐Containing Natural Products Catalyzed by Squalene Synthase‐Like Enzymes
Nagata, Ryuhei, Suemune, Hironori, Kobayashi, Masaya, Shinada, Tetsuro, Shin‐ya, Kazuo, Nishiyama, Makoto, Hino, Tomoya, Sato, Yusuke, Kuzuyama, Tomohisa, Nagano, Shingo
Published in Angewandte Chemie International Edition (09.05.2022)
Published in Angewandte Chemie International Edition (09.05.2022)
Get full text
Journal Article
An Atypical Arginine Dihydrolase Involved in the Biosynthesis of Cyclic Hexapeptide Longicatenamides
Liu, Chao, Hashimoto, Junko, Kudo, Kei, Shin‐ya, Kazuo, Kakeya, Hideaki
Published in Chemistry, an Asian journal (01.06.2021)
Published in Chemistry, an Asian journal (01.06.2021)
Get full text
Journal Article
Neothioviridamide, a Polythioamide Compound Produced by Heterologous Expression of a Streptomyces sp. Cryptic RiPP Biosynthetic Gene Cluster
Kawahara, Teppei, Izumikawa, Miho, Kozone, Ikuko, Hashimoto, Junko, Kagaya, Noritaka, Koiwai, Hanae, Komatsu, Mamoru, Fujie, Manabu, Sato, Noriyuki, Ikeda, Haruo, Shin-ya, Kazuo
Published in Journal of natural products (Washington, D.C.) (23.02.2018)
Published in Journal of natural products (Washington, D.C.) (23.02.2018)
Get full text
Journal Article