CyTOF protocol for immune monitoring of solid tumors from mouse models
Shin, Sarah M., Hernandez, Alexei, Coyne, Erin, Munjal, Kabeer, Gross, Nicole E., Charmsaz, Soren, Yuan, Xuan, Yang, Hongqui, Ho, Won Jin
Published in STAR protocols (17.03.2023)
Published in STAR protocols (17.03.2023)
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Journal Article
Mapping the breast tumor microenvironment: proximity analysis reveals spatial relationships between macrophage subtypes and metastasis-initiating cancer cells
Grasset, Eloïse M, Deshpande, Atul, Lee, Jae W, Cho, Yeonju, Shin, Sarah M, Coyne, Erin M, Hernandez, Alexei, Yuan, Xuan, Zhang, Zhehao, Cimino-Mathews, Ashley, Ewald, Andrew J, Ho, Won Jin
Published in Oncogene (20.08.2024)
Published in Oncogene (20.08.2024)
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Journal Article
Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD-1 Therapy
Chen, Jiang, Amoozgar, Zohreh, Liu, Xin, Aoki, Shuichi, Liu, Zelong, Shin, Sarah M, Matsui, Aya, Hernandez, Alexei, Pu, Zhangya, Halvorsen, Stefan, Lei, Pin-Ji, Datta, Meenal, Zhu, Lingling, Ruan, Zhiping, Shi, Lei, Staiculescu, Daniel, Inoue, Koetsu, Munn, Lance L, Fukumura, Dai, Huang, Peigen, Sassi, Slim, Bardeesy, Nabeel, Ho, Won Jin, Jain, Rakesh K, Duda, Dan G
Published in Cancer immunology research (02.04.2024)
Published in Cancer immunology research (02.04.2024)
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Journal Article
PanIN and CAF transitions in pancreatic carcinogenesis revealed with spatial data integration
Bell, Alexander T.F., Mitchell, Jacob T., Kiemen, Ashley L., Lyman, Melissa, Fujikura, Kohei, Lee, Jae W., Coyne, Erin, Shin, Sarah M., Nagaraj, Sushma, Deshpande, Atul, Wu, Pei-Hsun, Sidiropoulos, Dimitrios N., Erbe, Rossin, Stern, Jacob, Chan, Rena, Williams, Stephen, Chell, James M., Ciotti, Lauren, Zimmerman, Jacquelyn W., Wirtz, Denis, Ho, Won Jin, Zaidi, Neeha, Thompson, Elizabeth, Jaffee, Elizabeth M., Wood, Laura D., Fertig, Elana J., Kagohara, Luciane T.
Published in Cell systems (21.08.2024)
Published in Cell systems (21.08.2024)
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Multimodal immune phenotyping reveals microbial-T cell interactions that shape pancreatic cancer
Li, Yan, Chang, Renee B., Stone, Meredith L., Delman, Devora, Markowitz, Kelly, Xue, Yuqing, Coho, Heather, Herrera, Veronica M., Li, Joey H., Zhang, Liti, Choi-Bose, Shaanti, Giannone, Michael, Shin, Sarah M., Coyne, Erin M., Hernandez, Alexei, Gross, Nicole E., Charmsaz, Soren, Ho, Won Jin, Lee, Jae W., Beatty, Gregory L.
Published in Cell reports. Medicine (20.02.2024)
Published in Cell reports. Medicine (20.02.2024)
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Journal Article
Entinostat, nivolumab and ipilimumab for women with advanced HER2-negative breast cancer: a phase Ib trial
Roussos Torres, Evanthia T, Ho, Won J, Danilova, Ludmila, Tandurella, Joseph A, Leatherman, James, Rafie, Christine, Wang, Chenguang, Brufsky, Adam, LoRusso, Patricia, Chung, Vincent, Yuan, Yuan, Downs, Melinda, O'Connor, Ashley, Shin, Sarah M, Hernandez, Alexei, Engle, Elizabeth L, Piekarz, Richard, Streicher, Howard, Talebi, Zahra, Rudek, Michelle A, Zhu, Qingfeng, Anders, Robert A, Cimino-Mathews, Ashley, Fertig, Elana J, Jaffee, Elizabeth M, Stearns, Vered, Connolly, Roisin M
Published in Nature cancer (01.06.2024)
Published in Nature cancer (01.06.2024)
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Journal Article
Phosphodiesterase-5 inhibition collaborates with vaccine-based immunotherapy to reprogram myeloid cells in pancreatic ductal adenocarcinoma
Gross, Nicole E., Zhang, Zhehao, Mitchell, Jacob T., Charmsaz, Soren, Hernandez, Alexei G., Coyne, Erin M., Shin, Sarah M., Vargas Carvajal, Diana Carolina, Sidiropoulos, Dimitrios N., Cho, Yeonju, Mo, Guanglan, Yuan, Xuan, Cannon, Courtney, Suresh Babu, Jayalaxmi, Lyman, Melissa R., Armstrong, Todd, Kagohara, Luciane T., Bever, Katherine M., Le, Dung T., Jaffee, Elizabeth M., Fertig, Elana J., Ho, Won Jin
Published in JCI insight (06.08.2024)
Published in JCI insight (06.08.2024)
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Journal Article
1245 Th17 and Type 2 CD8+ cytokine signatures predict irAEs in solid tumors
Kao, Chester J, Charmsaz, Soren, Brancati, Madalena, Alden, Stephanie L, Li, Howard L, Balaji, Aanika, Munjal, Kabeer, Tsai, Hua-Ling, Danilova, Ludmila, Hernandez, Alexei, Gross, Nicole, Coyne, Erin M, Shin, Sarah M, Durham, Jennifer, Christmas, Brian, Thoburn, Christopher, Konig, Maximilian F, Lipson, Evan J, Naidoo, Jarushka, Cappelli, Laura, Ged, Yasser, Barretti, Marina, Brahmer, Julie, Hoffman-Censits, Jean, Seiwert, Tanguy Y, Garonce-Hediger, Rachel, Bansal, Sanjay, Tang, Laura, Jaffee, Elizabeth M, Scott Chandler, G, Mohindra, Rajat, Ho, Won Jin, Yarchoan, Mark
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure
Kiemen, Ashley L, Almagro-Pérez, Cristina, Matos, Valentina, jaz, Andre, Braxton, Alicia M, Dequiedt, Lucie, Parksong, Jeeun, Cannon, Courtney D, Yuan, Xuan, Shin, Sarah M, Babu, Jaanvi Mahesh, Thompson, Elizabeth D, Cornish, Toby C, Ho, Won Jin, Wood, Laura D, Wu, Pei-Hsun, Barrutia, Arrate Muñoz, Hruban, Ralph H, Wirtz, Denis
Published in bioRxiv (06.08.2024)
Published in bioRxiv (06.08.2024)
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Journal Article
Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade
Shu, Daniel H, Ho, Won Jin, Kagohara, Luciane T, Girgis, Alexander, Shin, Sarah M, Danilova, Ludmila, Lee, Jae W, Sidiropoulos, Dimitrios N, Mitchell, Sarah, Munjal, Kabeer, Howe, Kathryn, Bendinelli, Kayla J, Qi, Hanfei, Mo, Guanglan, Montagne, Janelle, Leatherman, James M, Lopez-Vidal, Tamara Y, Zhu, Qingfeng, Huff, Amanda L, Yuan, Xuan, Hernandez, Alexei, Coyne, Erin M, Zaidi, Neeha, Zabransky, Daniel J, Engle, Logan L, Ogurtsova, Aleksandra, Baretti, Marina, Laheru, Daniel, Durham, Jennifer N, Wang, Hao, Anders, Robert, Jaffee, Elizabeth M, Fertig, Elana J, Yarchoan, Mark
Published in bioRxiv : the preprint server for biology (26.10.2023)
Published in bioRxiv : the preprint server for biology (26.10.2023)
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Journal Article
Abstract 6092: Three-dimensional multi-omic analysis of early invasion of human pancreatic ductal adenocarcinoma from IPMN
Datta, Shalini, Shin, Sarah M., Kanacharoen, Jessie, Pflüger, Michael Johannes, Hirose, Katsuya, Forjaz, André, Graham, Sarah, Wu, Pei-Hsun, Hruban, Ralph H., Wirtz, Denis, Ho, Won Jin, Kiemen, Ashley L., Wood, Laura D.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract 1384: Highly metastatic PDAC adopts mesenchymal morphology and spatially coordinates endothelial cells with macrophages
Gross, Nicole E., Charmsaz, Soren, Lee, Jae W., Huang, Cheng-Chieh, Hernandez, Alexei G., Shin, Sarah M., Coyne, Erin M., Cannon, Courtney, Yuan, Xuan, Wood, Laura D., Jaffee, Elizabeth M., Ho, Won Jin
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract 5306: PTPN22 targeting partners with 41BB/OX40 costimulation to overcome anti-PD1 resistance in pancreatic ductal adenocarcinoma
Charmsaz, Soren, Gross, Nicole E., Lee, Jae W., Lin, Jianping, Hernandez, Alexei G., Coyne, Erin M., Shin, Sarah M., Cannon, Courtney, Yuan, Xuan, Zhang, Zhong-Yin, Jaffee, Elizabeth M., Ho, Won Jin
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract PR-08: Reprogramming and selective recruitment of distinct neutrophil subpopulations restrain cancer metastasis
Lee, Jae W, Vargas Carvajal, Diana Caroline, Cho, Yeonju, Shin, Sarah M, Coyne, Erin M, Hernandez, Alexei, Cannon, Courtney D, Yuan, Xuan, Zhang, Zhehao, Gross, Nicole E, Charmsaz, Soren, Shu, Daniel H, Bever, Katherine M, Le, Dung T, Kagohara, Luciane T, Jaffee, Elizabeth M, Ho, Won Jin
Published in Cancer research (Chicago, Ill.) (15.09.2024)
Published in Cancer research (Chicago, Ill.) (15.09.2024)
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Journal Article
Abstract 2270: Combination of CXCR4 antagonist and anti-PD1 therapy results in significant mobilization and increased infiltration of myeloid cells into the metastatic liver microenvironment of PDAC
Shin, Sarah M., Hernandez, Alexei, Coyne, Erin, Zhang, Zhehao, Mitchell, Sarah, Durham, Jennifer, Yuan, Xuan, Yang, Hongqui, Fertig, Elana J., Jaffee, Elizabeth M., Bever, Katherine M., Le, Dung T., Ho, Won Jin
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 1159: Machine learning integrating spatial omics uncovers humoral immunity patterns in intratumoral tertiary lymphoid structures in pancreatic cancer pathologic responders
Sidiropoulos, Dimitrios N., Shin, Sarah M., Girgis, Alexander, Shu, Daniel H., Montagne, Janelle, Deshpande, Atul, Johnson, Jeanette A., Dequiedt, Lucie, Jacobs, Victoria, Ogurtsova, Aleksandra, Mo, Guanglan, Yuan, Xuan, Stein-O’Brien, Genevieve, Yarchoan, Mark, Zhu, Qingfeng, Kiemen, Ashley, Jaffee, Elizabeth M., Zheng, Lei, Ho, Won Jin, Anders, Robert, Fertig, Elana J., Kagohara, Luciane T.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract 6522: Epigenetic modulation decreases myeloid suppression to improve response to immune checkpoint inhibition in breast cancer
Baugh, Aaron G., Gonzalez, Edgar, Kreger, Jesse, Liu, Yingtong, Al-Zubeidy, Batul, Danilova, Ludmila, Shin, Sarah M., Narumi, Valerie H., Castanon, Sofi, Jang, Julie, Fertig, Elana J., Cimino-Mathews, Ashley, Jaffee, Elizabeth M., Stearns, Vered, Connolly, Roisin M., Ho, Won Jin, MacLean, Adam, Roussos Torres, Evanthia T.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract B107: Spatial transcriptomics analysis of PanIN reveals loss of pro-inflammatory signaling and the presence of cancer-associated fibroblasts
Bell, Alexander T.F., Mitchell, Jacob T., Kiemen, Ashley L., Lyman, Melissa, Fujikura, Kohei, Lee, Jae W., Coyne, Erin, Shin, Sarah M., Wu, Pei-Hsun, Zimmerman, Jacquelyn W., Wirtz, Denis, Ho, Won J., Zaidi, Neeha, Thompson, Elizabeth, Jaffee, Elizabeth M., Wood, Laura D., Fertig, Elana J., Kagohara, Luciane T.
Published in Cancer research (Chicago, Ill.) (16.01.2024)
Published in Cancer research (Chicago, Ill.) (16.01.2024)
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Journal Article
Abstract 2661: Identification of a novel morphology of tertiary lymphoid structure in patients with hepatocellular carcinoma treated with neoadjuvant immune checkpoint blockade
Shu, Daniel H., Ho, Won Jin, Kagohara, Luciane T., Girgis, Alexander, Shin, Sarah M., Danilova, Ludmila, Lee, Jae W., Sidiropoulos, Dimitrios N. N., Mitchell, Sarah, Munjal, Kabeer, Howe, Kathryn, Bendinelli, Kayla J., Qi, Hanfei, Mo, Guanglan, Montagne, Janelle, Lopez-Vidal, Tamara Y., Zhu, Qingfeng, Huff, Amanda L., Yuan, Xuan, Hernandez, Alexei, Coyne, Erin M., Zaidi, Neeha, Zabransky, Daniel J., Engle, Logan L., Ogurtsova, Aleksandra, Baretti, Marina, Laheru, Daniel, Durham, Jennifer N., Wang, Hao, Anders, Robert, Jaffee, Elizabeth M., Fertig, Elana J., Yarchoan, Mark
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract 3846: The obesity paradox in immune checkpoint blockade: A pan-tumor analysis
Alden, Stephanie Leigh, Charmsaz, Soren, Brancati, Madelena, Li, Howard L., Warner, Aanika, Munjal, Kabeer, Howe, Kathryn, Mitchell, Sarah, Griffin, Ervin, Nakazawa, Mari, Tsai, Hua-Ling, Danilova, Ludmila, Thoburn, Chris, Gizzi, Jennifer, Hernandez, Alexei, Gross, Nicole E., Coyne, Erin M., Shin, Sarah M., Durham, Jennifer, Konig, Maximilian F., Christmas, Brian J., Lipson, Evan J., Naidoo, Jarushka, Cappelli, Laura C., Pabani, Aliyah, Ged, Yasser, Baretti, Marina, Brahmer, Julie R., Hoffman-Censits, Jean, Seiwert, Tanguy Y., Bansal, Sanjay, Tang, Laura, Jaffee, Elizabeth, Chandler, G Scott, Mohindra, Rajat, Ho, Won Jin, Yarchoan, Mark, Kao, Chester
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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