Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases
Bacioglu, Mehtap, Maia, Luis F., Preische, Oliver, Schelle, Juliane, Apel, Anja, Kaeser, Stephan A., Schweighauser, Manuel, Eninger, Timo, Lambert, Marius, Pilotto, Andrea, Shimshek, Derya R., Neumann, Ulf, Kahle, Philipp J., Staufenbiel, Matthias, Neumann, Manuela, Maetzler, Walter, Kuhle, Jens, Jucker, Mathias
Published in Neuron (Cambridge, Mass.) (06.07.2016)
Published in Neuron (Cambridge, Mass.) (06.07.2016)
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Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease
Hijazi, Sara, Heistek, Tim S., Scheltens, Philip, Neumann, Ulf, Shimshek, Derya R., Mansvelder, Huibert D., Smit, August B., van Kesteren, Ronald E.
Published in Molecular psychiatry (01.12.2020)
Published in Molecular psychiatry (01.12.2020)
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G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice
Novello, Salvatore, Arcuri, Ludovico, Dovero, Sandra, Dutheil, Nathalie, Shimshek, Derya R., Bezard, Erwan, Morari, Michele
Published in Neurobiology of disease (01.12.2018)
Published in Neurobiology of disease (01.12.2018)
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Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo
Albanese, Federica, Mercatelli, Daniela, Finetti, Luca, Lamonaca, Giulia, Pizzi, Sara, Shimshek, Derya R., Bernacchia, Giovanni, Morari, Michele
Published in Neurobiology of disease (01.11.2021)
Published in Neurobiology of disease (01.11.2021)
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The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease
Neumann, Ulf, Ufer, Mike, Jacobson, Laura H, Rouzade‐Dominguez, Marie‐Laure, Huledal, Gunilla, Kolly, Carine, Lüönd, Rainer M, Machauer, Rainer, Veenstra, Siem J, Hurth, Konstanze, Rueeger, Heinrich, Tintelnot‐Blomley, Marina, Staufenbiel, Matthias, Shimshek, Derya R, Perrot, Ludovic, Frieauff, Wilfried, Dubost, Valerie, Schiller, Hilmar, Vogg, Barbara, Beltz, Karen, Avrameas, Alexandre, Kretz, Sandrine, Pezous, Nicole, Rondeau, Jean‐Michel, Beckmann, Nicolau, Hartmann, Andreas, Vormfelde, Stefan, David, Olivier J, Galli, Bruno, Ramos, Rita, Graf, Ana, Lopez Lopez, Cristina
Published in EMBO molecular medicine (01.11.2018)
Published in EMBO molecular medicine (01.11.2018)
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Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945
Beckmann, Nicolau, Giorgetti, Elisa, Neuhaus, Anna, Zurbruegg, Stefan, Accart, Nathalie, Smith, Paul, Perdoux, Julien, Perrot, Ludovic, Nash, Mark, Desrayaud, Sandrine, Wipfli, Peter, Frieauff, Wilfried, Shimshek, Derya R
Published in Acta neuropathologica communications (15.02.2018)
Published in Acta neuropathologica communications (15.02.2018)
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Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging
Longo, Francesco, Russo, Isabella, Shimshek, Derya R, Greggio, Elisa, Morari, Michele
Published in Neurobiology of disease (01.11.2014)
Published in Neurobiology of disease (01.11.2014)
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Synaptic Inhibition in the Olfactory Bulb Accelerates Odor Discrimination in Mice
Abraham, Nixon M., Egger, Veronica, Shimshek, Derya R., Renden, Robert, Fukunaga, Izumi, Sprengel, Rolf, Seeburg, Peter H., Klugmann, Matthias, Margrie, Troy W., Schaefer, Andreas T., Kuner, Thomas
Published in Neuron (Cambridge, Mass.) (11.02.2010)
Published in Neuron (Cambridge, Mass.) (11.02.2010)
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Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units
Giorgetti, Elisa, Panesar, Moh, Zhang, Yunyu, Joller, Stefanie, Ronco, Marie, Obrecht, Michael, Lambert, Christian, Accart, Nathalie, Beckmann, Nicolau, Doelemeyer, Arno, Perrot, Ludovic, Fruh, Isabelle, Mueller, Matthias, Pierrel, Eliane, Summermatter, Serge, Bidinosti, Michael, Shimshek, Derya R., Brachat, Sophie, Nash, Mark
Published in Cell reports (Cambridge) (05.11.2019)
Published in Cell reports (Cambridge) (05.11.2019)
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In vivo susceptibility to energy failure parkinsonism and LRRK2 kinase activity
Novello, Salvatore, Mercatelli, Daniela, Albanese, Federica, Domenicale, Chiara, Brugnoli, Alberto, D'Aversa, Elisabetta, Vantaggiato, Silvia, Dovero, Sandra, Murtaj, Valentina, Presotto, Luca, Borgatti, Monica, Shimshek, Derya R., Bezard, Erwan, Moresco, Rosa Maria, Belloli, Sara, Morari, Michele
Published in Neurobiology of disease (01.01.2022)
Published in Neurobiology of disease (01.01.2022)
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Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model
Beckmann, Nicolau, Neuhaus, Anna, Zurbruegg, Stefan, Volkmer, Pia, Patino, Claudia, Joller, Stefanie, Feuerbach, Dominik, Doelemeyer, Arno, Schweizer, Tatjana, Rudin, Stefan, Neumann, Ulf, Berth, Ramon, Frieauff, Wilfried, Gasparini, Fabrizio, Shimshek, Derya R
Published in Journal of neuroinflammation (08.02.2023)
Published in Journal of neuroinflammation (08.02.2023)
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Imaging of cerebrovascular pathology in animal models of Alzheimer's disease
Klohs, Jan, Rudin, Markus, Shimshek, Derya R, Beckmann, Nicolau
Published in Frontiers in aging neuroscience (13.03.2014)
Published in Frontiers in aging neuroscience (13.03.2014)
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Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures
Barth, Melanie, Bacioglu, Mehtap, Schwarz, Niklas, Novotny, Renata, Brandes, Janine, Welzer, Marc, Mazzitelli, Sonia, Häsler, Lisa M, Schweighauser, Manuel, Wuttke, Thomas V, Kronenberg-Versteeg, Deborah, Fog, Karina, Ambjørn, Malene, Alik, Ania, Melki, Ronald, Kahle, Philipp J, Shimshek, Derya R, Koch, Henner, Jucker, Mathias, Tanriöver, Gaye
Published in Molecular neurodegeneration (11.08.2021)
Published in Molecular neurodegeneration (11.08.2021)
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Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition
Schelle, Juliane, Häsler, Lisa M, Göpfert, Jens C, Joos, Thomas O, Vanderstichele, Hugo, Stoops, Erik, Mandelkow, Eva-Maria, Neumann, Ulf, Shimshek, Derya R, Staufenbiel, Matthias, Jucker, Mathias, Kaeser, Stephan A
Published in Alzheimer's & dementia (01.06.2017)
Published in Alzheimer's & dementia (01.06.2017)
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High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain
Herzig, Martin C, Bidinosti, Michael, Schweizer, Tatjana, Hafner, Thomas, Stemmelen, Christine, Weiss, Andreas, Danner, Simone, Vidotto, Nella, Stauffer, Daniela, Barske, Carmen, Mayer, Franziska, Schmid, Peter, Rovelli, Giorgio, van der Putten, P Herman, Shimshek, Derya R
Published in PloS one (15.05.2012)
Published in PloS one (15.05.2012)
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Neuropathology in mice expressing mouse alpha-synuclein
Rieker, Claus, Dev, Kumlesh K, Lehnhoff, Katja, Barbieri, Samuel, Ksiazek, Iwona, Kauffmann, Sabine, Danner, Simone, Schell, Heinrich, Boden, Cindy, Ruegg, Markus A, Kahle, Philipp J, van der Putten, Herman, Shimshek, Derya R
Published in PloS one (26.09.2011)
Published in PloS one (26.09.2011)
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Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions
Tanriöver, Gaye, Bacioglu, Mehtap, Schweighauser, Manuel, Mahler, Jasmin, Wegenast-Braun, Bettina M., Skodras, Angelos, Obermüller, Ulrike, Barth, Melanie, Kronenberg-Versteeg, Deborah, Nilsson, K. Peter R., Shimshek, Derya R., Kahle, Philipp J., Eisele, Yvonne S., Jucker, Mathias
Published in Acta neuropathologica communications (12.08.2020)
Published in Acta neuropathologica communications (12.08.2020)
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LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
HERZIG, Martin C, KOLLY, Carine, SCHNELL, Christian R, MUELLER, Matthias, KINZEL, Bernd, GREVOT, Armelle, BOLOGNANI, Federico, STIRN, Martina, KUHN, Rainer R, KAUPMANN, Klemens, VAN DER PUTTEN, P. Herman, ROVELLI, Giorgio, PERSOHN, Elke, SHIMSHEK, Derya R, THEIL, Diethilde, SCHWEIZER, Tatjana, HAFNER, Thomas, STEMMELEN, Christine, TROXLER, Thomas J, SCHMID, Peter, DANNER, Simone
Published in Human molecular genetics (01.11.2011)
Published in Human molecular genetics (01.11.2011)
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Mutant huntingtin gene-dose impacts on aggregate deposition, DARPP32 expression and neuroinflammation in HdhQ150 mice
Young, Douglas, Mayer, Franziska, Vidotto, Nella, Schweizer, Tatjana, Berth, Ramon, Abramowski, Dorothee, Shimshek, Derya R, van der Putten, P Herman, Schmid, Peter
Published in PloS one (23.09.2013)
Published in PloS one (23.09.2013)
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