Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography
Orth, Peter, Xiao, Li, Hernandez, Lorraine D., Reichert, Paul, Sheth, Payal R., Beaumont, Maribel, Yang, Xiaoyu, Murgolo, Nicholas, Ermakov, Grigori, DiNunzio, Edward, Racine, Fred, Karczewski, Jerzy, Secore, Susan, Ingram, Richard N., Mayhood, Todd, Strickland, Corey, Therien, Alex G.
Published in The Journal of biological chemistry (27.06.2014)
Published in The Journal of biological chemistry (27.06.2014)
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Structural basis of CX-4945 binding to human protein kinase CK2
Ferguson, Andrew D., Sheth, Payal R., Basso, Andrea D., Paliwal, Sunil, Gray, Kimberly, Fischmann, Thierry O., Le, Hung V.
Published in FEBS letters (03.01.2011)
Published in FEBS letters (03.01.2011)
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Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab
Hernandez, Lorraine D., Kroh, Heather K., Hsieh, Edward, Yang, Xiaoyu, Beaumont, Maribel, Sheth, Payal R., DiNunzio, Edward, Rutherford, Stacey A., Ohi, Melanie D., Ermakov, Grigori, Xiao, Li, Secore, Susan, Karczewski, Jerzy, Racine, Fred, Mayhood, Todd, Fischer, Paul, Sher, Xinwei, Gupta, Pulkit, Lacy, D. Borden, Therien, Alex G.
Published in Journal of molecular biology (07.04.2017)
Published in Journal of molecular biology (07.04.2017)
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Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets
Mann, Paul A, Müller, Anna, Wolff, Kerstin A, Fischmann, Thierry, Wang, Hao, Reed, Patricia, Hou, Yan, Li, Wenjin, Müller, Christa E, Xiao, Jianying, Murgolo, Nicholas, Sher, Xinwei, Mayhood, Todd, Sheth, Payal R, Mirza, Asra, Labroli, Marc, Xiao, Li, McCoy, Mark, Gill, Charles J, Pinho, Mariana G, Schneider, Tanja, Roemer, Terry
Published in PLoS pathogens (01.05.2016)
Published in PLoS pathogens (01.05.2016)
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Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies
Satapati, Santhosh, Downes, Daniel P., Metzger, Daniel, Shankaran, Harish, Talukdar, Saswata, Zhou, Yingjiang, Ren, Zhao, Chen, Michelle, Lim, Yeon-Hee, Hatcher, Nathan G., Wen, Xiujuan, Sheth, Payal R., McLaren, David G., Previs, Stephen F.
Published in SLAS discovery (01.01.2022)
Published in SLAS discovery (01.01.2022)
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Novel Benzimidazole Inhibitors Bind to a Unique Site in the Kinesin Spindle Protein Motor Domain
Sheth, Payal R, Shipps, Gerald W, Seghezzi, Wolfgang, Smith, Catherine K, Chuang, Cheng-Chi, Sanden, David, Basso, Andrea D, Vilenchik, Lev, Gray, Kimberly, Annis, D. Allen, Nickbarg, Elliott, Ma, Yao, Lahue, Brian, Herbst, Ronald, Le, Hung V
Published in Biochemistry (Easton) (28.09.2010)
Published in Biochemistry (Easton) (28.09.2010)
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Selective small-molecule inhibition of an RNA structural element
Howe, John A., Wang, Hao, Fischmann, Thierry O., Balibar, Carl J., Xiao, Li, Galgoci, Andrew M., Malinverni, Juliana C., Mayhood, Todd, Villafania, Artjohn, Nahvi, Ali, Murgolo, Nicholas, Barbieri, Christopher M., Mann, Paul A., Carr, Donna, Xia, Ellen, Zuck, Paul, Riley, Dan, Painter, Ronald E., Walker, Scott S., Sherborne, Brad, de Jesus, Reynalda, Pan, Weidong, Plotkin, Michael A., Wu, Jin, Rindgen, Diane, Cummings, John, Garlisi, Charles G., Zhang, Rumin, Sheth, Payal R., Gill, Charles J., Tang, Haifeng, Roemer, Terry
Published in Nature (London) (29.10.2015)
Published in Nature (London) (29.10.2015)
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Expression, purification, stability optimization and characterization of human Aurora B kinase domain from E. coli
Sheth, Payal R., Ramanathan, Lata, Ranchod, Ashwin, Basso, Andrea D., Barrett, Dianah, Zhao, Jia, Gray, Kimberly, Liu, Yan-Hui, Zhang, Rumin, Le, Hung V.
Published in Archives of biochemistry and biophysics (15.11.2010)
Published in Archives of biochemistry and biophysics (15.11.2010)
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Direct Analysis from Phase-Separated Liquid Samples using ADE-OPI-MS: Applicability to High-Throughput Screening for Inhibitors of Diacylglycerol Acyltransferase 2
Wen, Xiujuan, Liu, Chang, Ghislain, Lucien, Tovar, Kiersten, Shah, Vinit, Stout, Steven J, Cifelli, Steven, Satapati, Santhosh, O’Donnell, Gregory, Sheth, Payal R, Wildey, Mary Jo, Datwani, Sammy S, Covey, Thomas R, Bateman, Kevin P, McLaren, David G
Published in Analytical chemistry (Washington) (20.04.2021)
Published in Analytical chemistry (Washington) (20.04.2021)
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TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci
Lee, Sang Ho, Wang, Hao, Labroli, Marc, Koseoglu, Sandra, Zuck, Paul, Mayhood, Todd, Gill, Charles, Mann, Paul, Sher, Xinwei, Ha, Sookhee, Yang, Shu-Wei, Mandal, Mihir, Yang, Christine, Liang, Lianzhu, Tan, Zheng, Tawa, Paul, Hou, Yan, Kuvelkar, Reshma, DeVito, Kristine, Wen, Xiujuan, Xiao, Jing, Batchlett, Michelle, Balibar, Carl J, Liu, Jenny, Xiao, Jianying, Murgolo, Nicholas, Garlisi, Charles G, Sheth, Payal R, Flattery, Amy, Su, Jing, Tan, Christopher, Roemer, Terry
Published in Science translational medicine (09.03.2016)
Published in Science translational medicine (09.03.2016)
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Broad coverage of genetically diverse strains of Clostridium difficile by actoxumab and bezlotoxumab predicted by in vitro neutralization and epitope modeling
Hernandez, Lorraine D, Racine, Fred, Xiao, Li, DiNunzio, Edward, Hairston, Nichelle, Sheth, Payal R, Murgolo, Nicholas J, Therien, Alex G
Published in Antimicrobial agents and chemotherapy (01.02.2015)
Published in Antimicrobial agents and chemotherapy (01.02.2015)
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Mapping Lipogenic Flux: A Gold LDI–MS Approach for Imaging Neutral Lipid Kinetics
Downes, Daniel P, Zhong, Wendy, Zhang, Ji, Chen, Bingming, Satapati, Santhosh, Metzger, Daniel, Godinez, Guillermo, Lao, Julie, Sheth, Payal R, McLaren, David G, Talukdar, Saswata, Previs, Stephen F
Published in Journal of the American Society for Mass Spectrometry (02.12.2020)
Published in Journal of the American Society for Mass Spectrometry (02.12.2020)
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Examining Targeted Protein Degradation from Physiological and Analytical Perspectives: Enabling Translation between Cells and Subjects
Daurio, Natalie A., Zhou, Haihong, Chen, Ying, Sheth, Payal R., Imbriglio, Jason E., McLaren, David G., Tawa, Paul, Rachdaoui, Nadia, Previs, Michael J., Kasumov, Takhar, O’Neil, Jennifer, Previs, Stephen F.
Published in ACS chemical biology (16.10.2020)
Published in ACS chemical biology (16.10.2020)
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Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS
Berejnaia, Olga, Wang, Hao, Labroli, Marc, Yang, Christine, Gill, Charles, Xiao, Jianying, Hesk, David, DeJesus, Reynalda, Su, Jing, Tan, Christopher M., Sheth, Payal R., Kavana, Michael, McLaren, David G.
Published in Analytical biochemistry (01.02.2017)
Published in Analytical biochemistry (01.02.2017)
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Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus
Yang, Shu-Wei, Pan, Jianping, Yang, Christine, Labroli, Marc, Pan, Weidong, Caldwell, John, Ha, Sookhee, Koseoglu, Sandra, Xiao, Jing C., Mayhood, Todd, Sheth, Payal R., Garlisi, Charles G., Wu, Jin, Lee, Sang Ho, Wang, Hao, Tan, Christopher M., Roemer, Terry, Su, Jing
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
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Isotope Fractionation during Gas Chromatography Can Enhance Mass Spectrometry-Based Measures of 2H-Labeling of Small Molecules
Downes, Daniel P., Kasumov, Takhar, Daurio, Natalie A., Wood, Neil B., Previs, Michael J., Sheth, Payal R., McLaren, David G., Previs, Stephen F.
Published in Metabolites (20.11.2020)
Published in Metabolites (20.11.2020)
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SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics
Basso, Andrea D, Liu, Ming, Dai, Chaoyang, Gray, Kimberly, Nale, Lissette, Tevar, Seema, Lee, Suining, Liang, Lianzhu, Ponery, Abdul, Yaremko, Bohdan, Smith, Elizabeth, Tang, Huadong, Sheth, Payal R, Siddiqui, M Arshad, Hicklin, Daniel J, Kirschmeier, Paul
Published in Molecular cancer therapeutics (01.11.2010)
Published in Molecular cancer therapeutics (01.11.2010)
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Thermodynamics of Nucleotide and Inhibitor Binding to Wild-Type and Ispinesib-Resistant Forms of Human Kinesin Spindle Protein
Sheth, Payal R, Basso, Andrea, Duca, José S, Lesburg, Charles A, Ogas, Polina, Gray, Kimberly, Nale, Lissette, Mannarino, Anthony F, Prongay, Andrew J, Le, Hung V
Published in Biochemistry (Easton) (24.11.2009)
Published in Biochemistry (Easton) (24.11.2009)
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