From the Clinic to the Bench and Back Again in One Dog Year: How a Cross-Species Pipeline to Identify New Treatments for Sarcoma Illuminates the Path Forward in Precision Medicine
Rao, Sneha R, Somarelli, Jason A, Altunel, Erdem, Selmic, Laura E, Byrum, Mark, Sheth, Maya U, Cheng, Serene, Ware, Kathryn E, Kim, So Young, Prinz, Joseph A, Devos, Nicolas, Corcoran, David L, Moseley, Arthur, Soderblom, Erik, Hsu, S David, Eward, William C
Published in Frontiers in oncology (11.02.2020)
Published in Frontiers in oncology (11.02.2020)
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Journal Article
Bioengineering a Future Free of Marine Plastic Waste
Sheth, Maya U., Kwartler, Sarah K., Schmaltz, Emma R., Hoskinson, Sarah M., Martz, E. J., Dunphy-Daly, Meagan M., Schultz, Thomas F., Read, Andrew J., Eward, William C., Somarelli, Jason A.
Published in Frontiers in Marine Science (11.10.2019)
Published in Frontiers in Marine Science (11.10.2019)
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Journal Article
A Comparative Oncology Drug Discovery Pipeline to Identify and Validate New Treatments for Osteosarcoma
Somarelli, Jason A., Rupprecht, Gabrielle, Altunel, Erdem, Flamant, Etienne M., Rao, Sneha, Sivaraj, Dharshan, Lazarides, Alexander L., Hoskinson, Sarah M., Sheth, Maya U., Cheng, Serene, Kim, So Young, Ware, Kathryn E., Agarwal, Anika, Cullen, Mark M., Selmic, Laura E., Everitt, Jeffrey I., McCall, Shannon J., Eward, Cindy, Eward, William C., Hsu, David S.
Published in Cancers (01.11.2020)
Published in Cancers (01.11.2020)
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Journal Article
Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding
Bartholf DeWitt, Suzanne, Hoskinson Plumlee, Sarah, Brighton, Hailey E, Sivaraj, Dharshan, Martz, E J, Zand, Maryam, Kumar, Vardhman, Sheth, Maya U, Floyd, Warren, Spruance, Jacob V, Hawkey, Nathan, Varghese, Shyni, Ruan, Jianhua, Kirsch, David G, Somarelli, Jason A, Alman, Ben, Eward, William C
Published in JCI insight (08.09.2022)
Published in JCI insight (08.09.2022)
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Journal Article
A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK/STAT signaling as a therapeutic vulnerability in prostate cancer
Ware, Kathryn E, Thomas, Beatrice C, Olawuni, Pelumi D, Sheth, Maya U, Hawkey, Nathan, Yeshwanth, M, Miller, Brian C, Vietor, Katherine J, Jolly, Mohit Kumar, Kim, So Young, Armstrong, Andrew J, Somarelli, Jason A
Published in Frontiers in molecular biosciences (09.05.2023)
Published in Frontiers in molecular biosciences (09.05.2023)
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Journal Article
An Integrative Systems Biology and Experimental Approach Identifies Convergence of Epithelial Plasticity, Metabolism, and Autophagy to Promote Chemoresistance
Xu, Shengnan, Ware, Kathryn E, Ding, Yuantong, Kim, So Young, Sheth, Maya U, Rao, Sneha, Chan, Wesley, Armstrong, Andrew J, Eward, William C, Jolly, Mohit Kumar, Somarelli, Jason A
Published in Journal of clinical medicine (07.02.2019)
Published in Journal of clinical medicine (07.02.2019)
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Journal Article
Improving Cancer Drug Discovery by Studying Cancer across the Tree of Life
Somarelli, Jason A, Boddy, Amy M, Gardner, Heather L, DeWitt, Suzanne Bartholf, Tuohy, Joanne, Megquier, Kate, Sheth, Maya U, Hsu, Shiaowen David, Thorne, Jeffrey L, London, Cheryl A, Eward, William C
Published in Molecular biology and evolution (01.01.2020)
Published in Molecular biology and evolution (01.01.2020)
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Journal Article
Genetic and functional analysis of Raynaud’s syndrome implicates loci in vasculature and immunity
Tervi, Anniina, Ramste, Markus, Abner, Erik, Cheng, Paul, Lane, Jacqueline M., Maher, Matthew, Valliere, Jesse, Lammi, Vilma, Strausz, Satu, Riikonen, Juha, Nguyen, Trieu, Martyn, Gabriella E., Sheth, Maya U., Xia, Fan, Docampo, Mauro Lago, Gu, Wenduo, Esko, Tõnu, Saxena, Richa, Pirinen, Matti, Palotie, Aarno, Ripatti, Samuli, Sinnott-Armstrong, Nasa, Daly, Mark, Engreitz, Jesse M., Rabinovitch, Marlene, Heckman, Caroline A., Quertermous, Thomas, Jones, Samuel E., Ollila, Hanna M.
Published in Cell genomics (11.09.2024)
Published in Cell genomics (11.09.2024)
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Journal Article
High-throughput affinity measurements of direct interactions between activation domains and co-activators
DelRosso, Nicole, Suzuki, Peter H, Griffith, Daniel, Lotthammer, Jeffrey M, Novak, Borna, Kocalar, Selin, Sheth, Maya U, Holehouse, Alex S, Bintu, Lacramioara, Fordyce, Polly
Published in bioRxiv (20.08.2024)
Published in bioRxiv (20.08.2024)
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Journal Article
Cohesin-mediated 3D contacts tune enhancer-promoter regulation
Guckelberger, Philine, Doughty, Benjamin R, Munson, Glen, Rao, Suhas S P, Tan, Yingxuan, Cai, Xiangmeng Shawn, Fulco, Charles P, Nasser, Joseph, Mualim, Kristy S, Bergman, Drew T, Ray, Judhajeet, Jagoda, Evelyn, Munger, Chad J, Gschwind, Andreas R, Sheth, Maya U, Tan, Anthony S, Steinmetz, Lars M, Lander, Eric S, Meissner, Alexander, Aiden, Erez Lieberman, Engreitz, Jesse M
Published in bioRxiv (12.07.2024)
Published in bioRxiv (12.07.2024)
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Journal Article
Abstract B019: A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK/STAT signaling as a therapeutic vulnerability in prostate cancer
Ware, Kathryn E., Thomas, Beatrice C., Olawuni, Pelumi, Sheth, Maya U., Hawkey, Nathan, M, Yeshwanth, Miller, Brian C., Vietor, Katherine J., Jolly, Mohit Kumar, Kim, So Young, Armstrong, Andrew J., Somarelli, Jason A.
Published in Cancer research (Chicago, Ill.) (02.06.2023)
Published in Cancer research (Chicago, Ill.) (02.06.2023)
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Journal Article
Abstract 1061: Exportin 1 (XPO1) inhibition alone or in combination as a novel therapeutic strategy in osteosarcoma
Graves, Laurie, Rupprecht, Gabrielle, Altunel, Erdem, Flamant, Etienne M., Rao, Sneha, Sivara, Dharshan, Lazarides, Alexander L., Hoskinson, Sarah M., Sheth, Maya U., Cheng, Serene, Kim, So Young, Ware, Kathryn E., Agarwal, Anika, Cullen, Mark M., Syal, Casey, Selmic, Laura E., Everitt, Jeffrey I., McCall, Shannon J., Eward, Cindy, Kashyap, Trinayan, Maloof, Marie, Walker, Christopher J., Landesman, Yosef, Wagner, Lars, Eward, William C., Hsu, David S., Somarelli, Jason A.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
An encyclopedia of enhancer-gene regulatory interactions in the human genome
Gschwind, Andreas R, Mualim, Kristy S, Karbalayghareh, Alireza, Sheth, Maya U, Dey, Kushal K, Jagoda, Evelyn, Nurtdinov, Ramil N, Xi, Wang, Tan, Anthony S, Jones, Hank, Ma, X Rosa, Yao, David, Nasser, Joseph, Avsec, Žiga, James, Benjamin T, Shamim, Muhammad S, Durand, Neva C, Rao, Suhas S P, Mahajan, Ragini, Doughty, Benjamin R, Andreeva, Kalina, Ulirsch, Jacob C, Fan, Kaili, Perez, Elizabeth M, Nguyen, Tri C, Kelley, David R, Finucane, Hilary K, Moore, Jill E, Weng, Zhiping, Kellis, Manolis, Bassik, Michael C, Price, Alkes L, Beer, Michael A, Guigó, Roderic, Stamatoyannopoulos, John A, Lieberman Aiden, Erez, Greenleaf, William J, Leslie, Christina S, Steinmetz, Lars M, Kundaje, Anshul, Engreitz, Jesse M
Published in bioRxiv : the preprint server for biology (13.11.2023)
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Published in bioRxiv : the preprint server for biology (13.11.2023)
Journal Article
A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK/STAT signaling as a therapeutic vulnerability in prostate cancer
Ware, Kathryn E, Thomas, Beatrice C, Olawuni, Pelumi, Sheth, Maya U, Hawkey, Nathan, Yeshwanth, M, Miller, Brian C, Vietor, Kathryn, Jolly, Mohit Kumar, So Young Kim, Armstrong, Andrew J, Somarelli, Jason A
Published in bioRxiv (17.11.2022)
Published in bioRxiv (17.11.2022)
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Paper
Loss of the chromatin remodeler, ATRX, promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin receptor binding
Dewitt, Suzanne Bartholf, Sarah Hoskinson Plumlee, Brighton, Hailey E, Dharshan Sivaraj, Martz, E J, Zand, Maryam, Kumar, Vardhman, Sheth, Maya U, Floyd, Warren, Spruance, Jacob, Hawkey, Nathan, Varghese, Shyni, Ruan, Jianhua, Kirsch, David G, Somarelli, Jason, Alman, Benjamin, Eward, William C
Published in bioRxiv (25.04.2022)
Published in bioRxiv (25.04.2022)
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Paper
An encyclopedia of enhancer-gene regulatory interactions in the human genome
Gschwind, Andreas R, Mualim, Kristy S, Karbalayghareh, Alireza, Sheth, Maya U, Dey, Kushal K, Jagoda, Evelyn, Nurtdinov, Ramil N, Wang, Xi, Tan, Anthony S, Jones, Hank, X Rosa Ma, Yao, David, Nasser, Joseph, Avsec, Ziga, James, Benjamin T, Shamim, Muhammad S, Durand, Neva C, Rao, Suhas S P, Mahajan, Ragini, Doughty, Benjamin R, Andreeva, Kalina, Ulirsch, Jacob C, Fan, Kaili, Perez, Elizabeth M, Nguyen, Tri C, Kelley, David R, Finucane, Hilary K, Moore, Jill E, Weng, Zhiping, Kellis, Manolis, Bassik, Michael C, Price, Alkes L, Beer, Michael A, Guigo, Roderic, Stamatoyannopoulos, John A, Erez Lieberman Aiden, Greenleaf, William J, Leslie, Christina S, Steinmetz, Lars M, Kundaje, Anshul, Engreitz, Jesse M
Published in bioRxiv (13.11.2023)
Published in bioRxiv (13.11.2023)
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Paper
A cross-species drug discovery pipeline to identify and validate new treatments for osteosarcoma
Somarelli, Jason A, Rupprecht, Gabrielle, Erdem Altunel, Flamant, Etienne M, Rao, Sneha, Dharshan Sivaraj, Lazarides, Alexander L, Hoskinson, Sarah M, Sheth, Maya U, Cheng, Serene, So Young Kim, Ware, Kathryn E, Agarwal, Anika, Cullen, Mark M, Selmic, Laura E, Everitt, Jeffrey I, Mccall, Shannon J, Eward, Cindy, Eward, William C, Hsu, S David
Published in bioRxiv (21.10.2020)
Published in bioRxiv (21.10.2020)
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Paper
Convergent evolution of p38/MAPK activation in hormone resistant prostate cancer mediates pro-survival, immune evasive, and metastatic phenotypes
Ware, Kathryn E, Gupta, Santosh, Eng, Jared, Kemeny, Gabor, Puviindran, Bhairavy J, Wen-Chi, Foo, Crawford, Lorin A, R Garland Almquist, Runyambo, Daniella, Thomas, Beatrice C, Sheth, Maya U, Agarwal, Anika, Pierobon, Mariaelena, Petricoin, Emanueel F, Corcoran, David L, Freedman, Jennifer, Patierno, Steven R, Zhang, Tian, Simon, Gregory, Sychev, Zoi, Drake, Justin M, Armstrong, Andrew J, Somarelli, Jason
Published in bioRxiv (24.04.2020)
Published in bioRxiv (24.04.2020)
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Paper
From the clinic to the bench and back again in one dog year: identifying new treatments for sarcoma using a cross-species personalized medicine pipeline
Rao, Sneha, Somarelli, Jason A, Erdem Altunel, Selmic, Laura E, Byrum, Mark, Sheth, Maya U, Cheng, Serene, Ware, Kathryn E, So Young Kim, Prinz, Joseph A, Devos, Nicolas, Corcoran, David L, Moseley, Arthur, Soderblom, Erik, Hsu, S David, Eward, William C
Published in bioRxiv (10.01.2019)
Published in bioRxiv (10.01.2019)
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