RGD-Binding Integrins in Prostate Cancer: Expression Patterns and Therapeutic Prospects against Bone Metastasis
Sutherland, Mark, Gordon, Andrew, Shnyder, Steven D, Patterson, Laurence H, Sheldrake, Helen M
Published in Cancers (26.10.2012)
Published in Cancers (26.10.2012)
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Journal Article
Book Review
RGD-Binding Integrins in Head and Neck Cancers
Ahmedah, Hanadi Talal, Patterson, Laurence H, Shnyder, Steven D, Sheldrake, Helen M
Published in Cancers (26.05.2017)
Published in Cancers (26.05.2017)
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Journal Article
Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds
Ortuzar, Natalia, Karu, Kersti, Presa, Daniela, Morais, Goreti R., Sheldrake, Helen M., Shnyder, Steve D., Barnieh, Francis M., Loadman, Paul M., Patterson, Laurence H., Pors, Klaus, Searcey, Mark
Published in Bioorganic & medicinal chemistry (15.06.2021)
Published in Bioorganic & medicinal chemistry (15.06.2021)
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Journal Article
Sidechain structure-activity relationships of cyclobutane-based small molecule αvβ3 antagonists
Throup, Adam, Zraikat, Manar Saleh, Gordon, Andrew, Jafarinejad Soumehsaraei, Shohreh, Haase, Kathrin D, Patterson, Laurence H, Cooper, Patricia A, Hanlon, Katherine, Loadman, Paul M, Sutherland, Mark, Shnyder, Steven D, Sheldrake, Helen M
Published in MedChemComm (17.10.2024)
Published in MedChemComm (17.10.2024)
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Journal Article
Synthesis and Biological Evaluation of Cyclobutane-Based β3 Integrin Antagonists: A Novel Approach to Targeting Integrins for Cancer Therapy
Sutherland, Mark, Gordon, Andrew, Al-Shammari, Fatemah O. F. O, Throup, Adam, Cilia La Corte, Amy, Philippou, Helen, Shnyder, Steven D, Patterson, Laurence H, Sheldrake, Helen M
Published in Cancers (01.08.2023)
Published in Cancers (01.08.2023)
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Journal Article
Physicochemical and biopharmaceutical characterization of new sulfonamide derivatives of gallic acid
Alhyari, Dania Hussein, Sheldrake, Helen Sheldrake, Kantamneni, Sriharsha, Isreb, Mohammad, Soumehsaraei, Shohreh Jafarinejad, Martin, William, Qinna, Nidal, Paluch, Krzysztof
Published in British Journal of Pharmacy (01.11.2022)
Published in British Journal of Pharmacy (01.11.2022)
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Journal Article
Colon Cancer―Specific Cytochrome P450 2W1 Converts Duocarmycin Analogues into Potent Tumor Cytotoxins
TRAVICA, Sandra, PORS, Klaus, LOADMAN, Paul M, SHNYDER, Steven D, JOHANSSON, Inger, ALANDAS, Mohammed N, SHELDRAKE, Helen M, MKRTCHIAN, Souren, PATTERSON, Laurence H, INGELMAN-SUNDBERG, Magnus
Published in Clinical cancer research (01.06.2013)
Published in Clinical cancer research (01.06.2013)
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The Changing Faces of Halogenated Marine Natural Products: Total Synthesis of the Reported Structures of Elatenyne and an Enyne from Laurencia majuscula
Sheldrake, Helen M., Jamieson, Craig, Burton, Jonathan W.
Published in Angewandte Chemie International Edition (06.11.2006)
Published in Angewandte Chemie International Edition (06.11.2006)
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Journal Article
Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder
Sutherland, Mark, Gill, Jason H, Loadman, Paul M, Laye, Jonathan P, Sheldrake, Helen M, Illingworth, Nicola A, Alandas, Mohammed N, Cooper, Patricia A, Searcey, Mark, Pors, Klaus, Shnyder, Steve D, Patterson, Laurence H
Published in Molecular cancer therapeutics (01.01.2013)
Published in Molecular cancer therapeutics (01.01.2013)
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Journal Article
Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity
Pors, Klaus, Loadman, Paul M., Shnyder, Steven D., Sutherland, Mark, Sheldrake, Helen M., Guino, Meritxell, Kiakos, Konstantinos, Hartley, John A., Searcey, Mark, Patterson, Laurence H.
Published in Chemical communications (Cambridge, England) (28.11.2011)
Published in Chemical communications (Cambridge, England) (28.11.2011)
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Journal Article
Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity
Sheldrake, Helen M, Travica, Sandra, Johansson, Inger, Loadman, Paul M, Sutherland, Mark, Elsalem, Lina, Illingworth, Nicola, Cresswell, Alexander J, Reuillon, Tristan, Shnyder, Steven D, Mkrtchian, Souren, Searcey, Mark, Ingelman-Sundberg, Magnus, Patterson, Laurence H, Pors, Klaus
Published in Journal of medicinal chemistry (08.08.2013)
Published in Journal of medicinal chemistry (08.08.2013)
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Journal Article
Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity
Santos, Ana R. N, Sheldrake, Helen M, Ibrahim, Ali I. M, Danta, Chhanda Charan, Bonanni, Davide, Daga, Martina, Oliaro-Bosso, Simonetta, Boschi, Donatella, Lolli, Marco L, Pors, Klaus
Published in MedChemComm (14.08.2019)
Published in MedChemComm (14.08.2019)
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Rapid stereoselective access to the tetracyclic core of puupehenone and related sponge metabolites using metal-free radical cyclisations of cyclohexenyl-substituted 3-bromochroman-4-ones
Pritchard, Robin G., Sheldrake, Helen M., Taylor, Isobel Z., Wallace, Timothy W.
Published in Tetrahedron letters (23.06.2008)
Published in Tetrahedron letters (23.06.2008)
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