mCRY1 and mCRY2 Are Essential Components of the Negative Limb of the Circadian Clock Feedback Loop
Kume, Kazuhiko, Zylka, Mark J, Sriram, Sathyanarayanan, Shearman, Lauren P, Weaver, David R, Jin, Xiaowei, Maywood, Elizabeth S, Hastings, Michael H, Reppert, Steven M
Published in Cell (23.07.1999)
Published in Cell (23.07.1999)
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Journal Article
Interacting Molecular Loops in the Mammalian Circadian Clock
Shearman, Lauren P., Sriram, Sathyanarayanan, Weaver, David R., Maywood, Elizabeth S., Chaves, Inẽs, Zheng, Binhai, Kume, Kazuhiko, Lee, Cheng Chi, Gijsbertus T. J. van der Horst, Hastings, Michael H., Reppert, Steven M.
Published in Science (American Association for the Advancement of Science) (12.05.2000)
Published in Science (American Association for the Advancement of Science) (12.05.2000)
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Journal Article
Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice
Qian, Su, Chen, Howard, Weingarth, Drew, Trumbauer, Myrna E., Novi, Dawn E., Guan, Xiaoming, Yu, Hong, Shen, Zhu, Feng, Yue, Frazier, Easter, Chen, Airu, Camacho, Ramon E., Shearman, Lauren P., Gopal-Truter, Shobhna, MacNeil, Douglas J., Van der Ploeg, Lex H. T., Marsh, Donald J.
Published in Molecular and Cellular Biology (01.07.2002)
Published in Molecular and Cellular Biology (01.07.2002)
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Journal Article
Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats
Shearman, Lauren P., Camacho, Ramon E., Sloan Stribling, D., Zhou, Dan, Bednarek, Maria A., Hreniuk, Donna L., Feighner, Scott D., Tan, Carina P., Howard, Andrew D., Van der Ploeg, Lex H.T., MacIntyre, D.Euan, Hickey, Gerard J., Strack, Alison M.
Published in European journal of pharmacology (15.08.2003)
Published in European journal of pharmacology (15.08.2003)
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Journal Article
Enhanced running wheel activity of both Mch1r- and Pmch-deficient mice
Zhou, Dan, Shen, Zhu, Strack, Alison M., Marsh, Donald J., Shearman, Lauren P.
Published in Regulatory peptides (15.01.2005)
Published in Regulatory peptides (15.01.2005)
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Journal Article
A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock
Jin, Xiaowei, Shearman, Lauren P., Weaver, David R., Zylka, Mark J., De Vries, Geert J., Reppert, Steven M.
Published in Cell (08.01.1999)
Published in Cell (08.01.1999)
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Journal Article
Melanin-Concentrating Hormone 1 Receptor-Deficient Mice are Lean, Hyperactive, and Hyperphagic and Have Altered Metabolism
Marsh, Donald J., Weingarth, Drew T., Novi, Dawn E., Chen, Howard Y., Trumbauer, Myrna E., Chen, Airu S., Guan, Xiao-Ming, Jiang, Michael M., Feng, Yue, Camacho, Ramon E., Shen, Zhu, Frazier, Easter G., Yu, Hong, Metzger, Joseph M., Kuca, Stephanie J., Shearman, Lauren P., Gopal-Truter, Shobhna, MacNeil, Douglas J., Strack, Alison M., MacIntyre, D. Euan, Lex H. T. Van der Ploeg, Qian, Su
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2002)
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Journal Article
CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP
Ripperger, J A, Shearman, L P, Reppert, S M, Schibler, U
Published in Genes & development (15.03.2000)
Published in Genes & development (15.03.2000)
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Journal Article
Ghrelin Neutralization by a Ribonucleic Acid-SPM Ameliorates Obesity in Diet-Induced Obese Mice
Shearman, Lauren P, Wang, Sheng-Ping, Helmling, Steffen, Stribling, D. Sloan, Mazur, Paul, Ge, Lan, Wang, Liyang, Klussmann, Sven, Macintyre, D. Euan, Howard, Andrew D, Strack, Alison M
Published in Endocrinology (Philadelphia) (01.03.2006)
Published in Endocrinology (Philadelphia) (01.03.2006)
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Journal Article
Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist
Guan, Xiao-Ming, Metzger, Joseph M, Yang, Liming, Raustad, Kate A, Wang, Sheng-Ping, Spann, Stephanie K, Kosinski, Jennifer A, Yu, Hong, Shearman, Lauren P, Faidley, Terry D, Palyha, Oksana, Kan, Yanqing, Kelly, Theresa M, Sebhat, Iyassu, Lin, Linus S, Dragovic, Jasminka, Lyons, Kathy A, Craw, Stephanie, Nargund, Ravi P, Marsh, Donald J, Strack, Alison M, Reitman, Marc L
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
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Journal Article
Antiobesity Efficacy of a Novel Cannabinoid-1 Receptor Inverse Agonist, N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), in Rodents
Fong, Tung M., Guan, Xiao-Ming, Marsh, Donald J., Shen, Chun-Pyn, Stribling, D. Sloan, Rosko, Kim M., Lao, Julie, Yu, Hong, Feng, Yue, Xiao, Jing C., Van der Ploeg, Lex H. T., Goulet, Mark T., Hagmann, Williams K., Lin, Linus S., Lanza, Thomas J., Jewell, James P., Liu, Ping, Shah, Shrenik K., Qi, Hongbo, Tong, Xinchun, Wang, Junying, Xu, Suoyu S., Francis, Barbara, Strack, Alison M., MacIntyre, D. Euan, Shearman, Lauren P.
Published in The Journal of pharmacology and experimental therapeutics (01.06.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2007)
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Journal Article
Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei
Shearman, L P, Zylka, M J, Weaver, D R, Kolakowski, Jr, L F, Reppert, S M
Published in Neuron (Cambridge, Mass.) (01.12.1997)
Published in Neuron (Cambridge, Mass.) (01.12.1997)
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Journal Article
Targeted Disruption of the mPer3 Gene: Subtle Effects on Circadian Clock Function
Shearman, Lauren P., Jin, Xiaowei, Lee, Choogon, Reppert, Steven M., Weaver, David R.
Published in Molecular and Cellular Biology (01.09.2000)
Published in Molecular and Cellular Biology (01.09.2000)
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Journal Article
Discovery of N-[(4R)-6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a Novel Cannabinoid-1 Receptor (CB1R) Inverse Agonist for the Treatment of Obesity
Yan, Lin, Huo, Pei, Debenham, John S, Madsen-Duggan, Christina B, Lao, Julie, Chen, Richard Z, Xiao, Jing Chen, Shen, Chun-Pyn, Stribling, D. Sloan, Shearman, Lauren P, Strack, Alison M, Tsou, Nancy, Ball, Richard G, Wang, Junying, Tong, Xinchun, Bateman, Thomas J, Reddy, Vijay B. G, Fong, Tung M, Hale, Jeffrey J
Published in Journal of medicinal chemistry (27.05.2010)
Published in Journal of medicinal chemistry (27.05.2010)
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Journal Article
Furo[2,3- b]pyridine-based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation. Part 1
Debenham, John S., Madsen-Duggan, Christina B., Toupence, Richard B., Walsh, Thomas F., Wang, Junying, Tong, Xinchun, Kumar, Sanjeev, Lao, Julie, Fong, Tung M., Xiao, Jing Chen, Huang, Cathy R.-R.C., Shen, Chun-Pyn, Feng, Yue, Marsh, Donald J., Stribling, D. Sloan, Shearman, Lauren P., Strack, Alison M., Goulet, Mark T.
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
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Journal Article
Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: Synthesis, SAR and biological evaluation
Madsen-Duggan, Christina B., Debenham, John S., Walsh, Thomas F., Yan, Lin, Huo, Pei, Wang, Junying, Tong, Xinchun, Lao, Julie, Fong, Tung M., Xiao, Jing Chen, Huang, Cathy R.-R.C., Shen, Chun-Pyn, Stribling, D.Sloan, Shearman, Lauren P., Strack, Alison M., Goulet, Mark T., Hale, Jeffrey J.
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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