Human cell surface-AAV interactomes identify LRP6 as blood-brain barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder
Shay, Timothy F., Jang, Seongmin, Brittain, Tyler J., Chen, Xinhong, Walker, Beth, Tebbutt, Claire, Fan, Yujie, Wolfe, Damien A., Arokiaraj, Cynthia M., Sullivan, Erin E., Ding, Xiaozhe, Wang, Ting-Yu, Lei, Yaping, Chuapoco, Miguel R., Chou, Tsui-Fen, Gradinaru, Viviana
Published in Nature communications (08.09.2024)
Published in Nature communications (08.09.2024)
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Fast, accurate ranking of engineered proteins by target-binding propensity using structure modeling
Ding, Xiaozhe, Chen, Xinhong, Sullivan, Erin E., Shay, Timothy F., Gradinaru, Viviana
Published in Molecular therapy (05.06.2024)
Published in Molecular therapy (05.06.2024)
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Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain
Chuapoco, Miguel R., Flytzanis, Nicholas C., Goeden, Nick, Christopher Octeau, J., Roxas, Kristina M., Chan, Ken Y., Scherrer, Jon, Winchester, Janet, Blackburn, Roy J., Campos, Lillian J., Man, Kwun Nok Mimi, Sun, Junqing, Chen, Xinhong, Lefevre, Arthur, Singh, Vikram Pal, Arokiaraj, Cynthia M., Shay, Timothy F., Vendemiatti, Julia, Jang, Min J., Mich, John K., Bishaw, Yemeserach, Gore, Bryan B., Omstead, Victoria, Taskin, Naz, Weed, Natalie, Levi, Boaz P., Ting, Jonathan T., Miller, Cory T., Deverman, Benjamin E., Pickel, James, Tian, Lin, Fox, Andrew S., Gradinaru, Viviana
Published in Nature nanotechnology (01.10.2023)
Published in Nature nanotechnology (01.10.2023)
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Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration
Lawrence, Jessica A, Aguilar-Calvo, Patricia, Ojeda-Juárez, Daniel, Khuu, Helen, Soldau, Katrin, Pizzo, Donald P, Wang, Jin, Malik, Adela, Shay, Timothy F, Sullivan, Erin E, Aulston, Brent, Song, Seung Min, Callender, Julia A, Sanchez, Henry, Geschwind, Michael D, Roy, Subhojit, Rissman, Robert A, Trejo, JoAnn, Tanaka, Nobuyuki, Wu, Chengbiao, Chen, Xu, Patrick, Gentry N, Sigurdson, Christina J
Published in The Journal of neuroscience (24.05.2023)
Published in The Journal of neuroscience (24.05.2023)
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Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors
Shay, Timothy F, Sullivan, Erin E, Ding, Xiaozhe, Chen, Xinhong, Ravindra Kumar, Sripriya, Goertsen, David, Brown, David, Crosby, Anaya, Vielmetter, Jost, Borsos, Máté, Wolfe, Damien A, Lam, Annie W, Gradinaru, Viviana
Published in Science advances (21.04.2023)
Published in Science advances (21.04.2023)
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Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates
Chen, Xinhong, Wolfe, Damien A, Dhanesh Sivadasan Bindu, Zhang, Mengying, Naz Taskin, Goertsen, David, Shay, Timothy F, Sullivan, Erin, Sripriya Ravindra Kumar, Sheng-Fu, Huang, Arokiaraj, Cynthia M, Plattner, Viktor, Campos, Lillian J, Mich, John K, Deja Monet, Ngo, Victoria, Ding, Xiaozhe, Omstead, Victoria, Weed, Natalie, Bishaw, Yeme, Gore, Bryan B, Lein, Ed S, Akrami, Athena, Miller, Cory, Levi, Boaz P, Keller, Annika, Ting, Jonathan T, Fox, Andrew S, Eroglu, Cagla, Gradinaru, Viviana
Published in bioRxiv (13.01.2023)
Published in bioRxiv (13.01.2023)
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Journal Article
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates
Chen, Xinhong, Wolfe, Damien A., Bindu, Dhanesh Sivadasan, Zhang, Mengying, Taskin, Naz, Goertsen, David, Shay, Timothy F., Sullivan, Erin E., Huang, Sheng-Fu, Ravindra Kumar, Sripriya, Arokiaraj, Cynthia M., Plattner, Viktor M., Campos, Lillian J., Mich, John K., Monet, Deja, Ngo, Victoria, Ding, Xiaozhe, Omstead, Victoria, Weed, Natalie, Bishaw, Yeme, Gore, Bryan B., Lein, Ed S., Akrami, Athena, Miller, Cory, Levi, Boaz P., Keller, Annika, Ting, Jonathan T., Fox, Andrew S., Eroglu, Cagla, Gradinaru, Viviana
Published in Nature communications (08.06.2023)
Published in Nature communications (08.06.2023)
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Journal Article
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates
Chen, Xinhong, Wolfe, Damien A, Bindu, Dhanesh Sivadasan, Zhang, Mengying, Taskin, Naz, Goertsen, David, Shay, Timothy F, Sullivan, Erin, Huang, Sheng-Fu, Kumar, Sripriya Ravindra, Arokiaraj, Cynthia M, Plattner, Viktor, Campos, Lillian J, Mich, John, Monet, Deja, Ngo, Victoria, Ding, Xiaozhe, Omstead, Victoria, Weed, Natalie, Bishaw, Yeme, Gore, Bryan, Lein, Ed S, Akrami, Athena, Miller, Cory, Levi, Boaz P, Keller, Annika, Ting, Jonathan T, Fox, Andrew S, Eroglu, Cagla, Gradinaru, Viviana
Published in bioRxiv : the preprint server for biology (13.01.2023)
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Published in bioRxiv : the preprint server for biology (13.01.2023)
Journal Article
Human cell surface-AAV interactomes identify LRP6 as blood-brain-barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder
Shay, Timothy F, Jang, Seongmin, Chen, Xinhong, Walker, Beth, Tebbutt, Claire, Wolfe, Damien A, Brittain, Tyler J, Arokiaraj, Cynthia M, Sullivan, Erin E, Ding, Xiaozhe, Ting-Yu, Wang, Lei, Yaping, Chuapoco, Miguel R, Chou, Tsui-Fen, Gradinaru, Viviana
Published in bioRxiv (05.01.2024)
Published in bioRxiv (05.01.2024)
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Primate-conserved Carbonic Anhydrase IV and murine-restricted Ly6c1 are new targets for crossing the blood-brain barrier
Shay, Timothy F, Sullivan, Erin E, Ding, Xiaozhe, Chen, Xinhong, Sripriya Ravindra Kumar, Goertsen, David, Brown, David, Jost Vielmetter, Máté Borsos, Lam, Annie W, Gradinaru, Viviana
Published in bioRxiv (13.01.2023)
Published in bioRxiv (13.01.2023)
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Adeno-Associated Viral Tools to Trace Neural Development and Connectivity Across Amphibians
Jaeger, Eliza Cb, Vijatovic, David, Deryckere, Astrid, Zorin, Nikol, Nguyen, Akemi L, Ivanian, Georgiy, Woych, Jamie, Arnold, Rebecca C, Alonso Ortega Gurrola, Shvartsman, Arik, Barbieri, Francesca, Toma, Florina A, Gorbsky, Gary J, Horb, Marko E, Cline, Hollis T, Shay, Timothy F, Kelley, Darcy B, Yamaguchi, Ayako, Shein-Idelson, Mark, Tosches, Maria Antonietta, Sweeney, Lora B
Published in bioRxiv (16.02.2024)
Published in bioRxiv (16.02.2024)
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