Total Synthesis of (+)-Irciniastatin A (a.k.a. Psymberin) and (−)-Irciniastatin B
An, Chihui, Jurica, Jon A, Walsh, Shawn P, Hoye, Adam T, Smith, Amos B
Published in Journal of organic chemistry (03.05.2013)
Published in Journal of organic chemistry (03.05.2013)
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Total Syntheses of the Assigned Structures of Lituarines B and C
Smith, Amos B, Duffey, Matthew O, Basu, Kallol, Walsh, Shawn P, Suennemann, Hans W, Frohn, Michael
Published in Journal of the American Chemical Society (16.01.2008)
Published in Journal of the American Chemical Society (16.01.2008)
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Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics
Tang, Haifeng, Walsh, Shawn P, Yan, Yan, de Jesus, Reynalda K, Shahripour, Aurash, Teumelsan, Nardos, Zhu, Yuping, Ha, Sookhee, Owens, Karen A, Thomas-Fowlkes, Brande S, Felix, John P, Liu, Jessica, Kohler, Martin, Priest, Birgit T, Bailey, Timothy, Brochu, Richard, Alonso-Galicia, Magdalena, Kaczorowski, Gregory J, Roy, Sophie, Yang, Lihu, Mills, Sander G, Garcia, Maria L, Pasternak, Alexander
Published in ACS medicinal chemistry letters (10.05.2012)
Published in ACS medicinal chemistry letters (10.05.2012)
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Chronic Inhibition of Renal Outer Medullary Potassium Channel Not Only Prevented but Also Reversed Development of Hypertension and End-Organ Damage in Dahl Salt-Sensitive Rats
Zhou, Xiaoyan, Forrest, Michael J, Sharif-Rodriguez, Wanda, Forrest, Gail, Szeto, Daphne, Urosevic-Price, Olga, Zhu, Yonghua, Stevenson, Andra S, Zhou, Yuchen, Stribling, Sloan, Dajee, Maya, Walsh, Shawn P, Pasternak, Alexander, Sullivan, Kathleen A
Published in Hypertension (Dallas, Tex. 1979) (01.02.2017)
Published in Hypertension (Dallas, Tex. 1979) (01.02.2017)
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Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold
Zhu, Yuping, de Jesus, Reynalda K., Tang, Haifeng, Walsh, Shawn P., Jiang, Jinlong, Gu, Xin, Teumelsan, Nardos, Shahripour, Aurash, Pio, Barbara, Ding, Fa-Xiang, Ha, Sookhee, Priest, Birgit T., Swensen, Andrew M., Alonso-Galicia, Magdalena, Felix, John P., Brochu, Richard M., Bailey, Timothy, Thomas-Fowlkes, Brande, Zhou, Xiaoyan, Pai, Lee-Yuh, Hampton, Caryn, Hernandez, Melba, Owens, Karen, Ehrhart, Juliann, Roy, Sophie, Kaczorowski, Gregory J., Yang, Lihu, Parmee, Emma R., Sullivan, Kathleen, Garcia, Maria L., Pasternak, Alexander
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
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Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one
Tang, Haifeng, de Jesus, Reynald K., Walsh, Shawn P., Zhu, Yuping, Yan, Yan, Priest, Birgit T., Swensen, Andrew M., Alonso-Galicia, Magdalena, Felix, John P., Brochu, Richard M., Bailey, Timothy, Thomas-Fowlkes, Brande, Zhou, Xiaoyan, Pai, Lee-Yuh, Hampton, Caryn, Hernandez, Melba, Owens, Karen, Roy, Sophie, Kaczorowski, Gregory J., Yang, Lihu, Garcia, Maria L., Pasternak, Alexander
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
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Journal Article
Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure
Tang, Haifeng, Zhu, Yuping, Teumelsan, Nardos, Walsh, Shawn P, Shahripour, Aurash, Priest, Birgit T, Swensen, Andrew M, Felix, John P, Brochu, Richard M, Bailey, Timothy, Thomas-Fowlkes, Brande, Pai, Lee-Yuh, Hampton, Caryn, Corona, Aaron, Hernandez, Melba, Metzger, Joseph, Forrest, Michael, Zhou, Xiaoyan, Owens, Karen, Tong, Vincent, Parmee, Emma, Roy, Sophie, Kaczorowski, Gregory J, Yang, Lihu, Alonso-Galicia, Magdalena, Garcia, Maria L, Pasternak, Alexander
Published in ACS medicinal chemistry letters (14.07.2016)
Published in ACS medicinal chemistry letters (14.07.2016)
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Journal Article
Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation
Walsh, Shawn P., Shahripour, Aurash, Tang, Haifeng, de Jesus, Reynalda K., Teumelsan, Nardos, Zhu, Yuping, Frie, Jessica, Priest, Birgit T., Swensen, Andrew M., Alonso-Galicia, Magdalena, Felix, John P., Brochu, Richard M., Bailey, Timothy, Thomas-Fowlkes, Brande, Zhou, Xiaoyan, Pai, Lee-Yuh, Hampton, Caryn, Hernandez, Melba, Owens, Karen, Ehrhart, Juliann, Roy, Sophie, Kaczorowski, Gregory J., Yang, Lihu, Garcia, Maria L., Pasternak, Alexander
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
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Journal Article
3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists
Walsh, Shawn P., Severino, Alexandra, Zhou, Changyou, He, Jiafang, Liang, Gui-Bai, Tan, Carina P., Cao, Jin, Eiermann, George J., Xu, Ling, Salituro, Gino, Howard, Andrew D., Mills, Sander G., Yang, Lihu
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
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Journal Article
Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation
Walsh, Shawn P, Shahripour, Aurash, Tang, Haifeng, Teumelsan, Nardos, Frie, Jessica, Zhu, Yuping, Priest, Birgit T, Swensen, Andrew M, Liu, Jessica, Margulis, Michael, Visconti, Richard, Weinglass, Adam, Felix, John P, Brochu, Richard M, Bailey, Timothy, Thomas-Fowlkes, Brande, Alonso-Galicia, Magdalena, Zhou, Xiaoyan, Pai, Lee-Yuh, Corona, Aaron, Hampton, Caryn, Hernandez, Melba, Bentley, Ross, Chen, Jing, Shah, Kashmira, Metzger, Joseph, Forrest, Michael, Owens, Karen, Tong, Vincent, Ha, Sookhee, Roy, Sophie, Kaczorowski, Gregory J, Yang, Lihu, Parmee, Emma, Garcia, Maria L, Sullivan, Kathleen, Pasternak, Alexander
Published in ACS medicinal chemistry letters (09.07.2015)
Published in ACS medicinal chemistry letters (09.07.2015)
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Diversity-Oriented Synthesis of Polyketide Natural Products via Iterative Chemo- and Stereoselective Functionalization of Polyenoates: Development of a Unified Approach for the C(1−19) Segments of Lituarines A−C
Smith, Amos B, Walsh, Shawn P, Frohn, Michael, Duffey, Matthew O
Published in Organic letters (06.01.2005)
Published in Organic letters (06.01.2005)
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Furoyl and Benzofuroyl Pyrroloquinolones as Potent and Selective PDE5 Inhibitors for Treatment of Erectile Dysfunction
Jiang, Weiqin, Sui, Zhihua, Macielag, Mark J, Walsh, Shawn P, Fiordeliso, James J, Lanter, James C, Guan, Jihua, Qiu, Yuhong, Kraft, Patricia, Bhattacharjee, Sheela, Craig, Elizabeth, Haynes-Johnson, Donna, John, T. Matthew, Clancy, Joanna
Published in Journal of medicinal chemistry (30.01.2003)
Published in Journal of medicinal chemistry (30.01.2003)
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Abstract 068: Impact of Renal Outer Medullary Potassium Channel Inhibition on Afferent Arteriolar Tone in Rats With Type 1 Diabetes
Carmines, Pamela K, Zhou, Xiaoyan, Dajee, Maya, Sullivan, Kathleen A, Walsh, Shawn P, Pasternak, Alexander
Published in Hypertension (Dallas, Tex. 1979) (01.09.2017)
Published in Hypertension (Dallas, Tex. 1979) (01.09.2017)
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A novel domino reaction for the preparation of substituted non-racemic β-proline derivatives
Gilbert, Eric J., Brunskill, Andrew, Cai, Jiaqiang, Cai, Yaxian, Chu, Xin-Jie, Dai, Xing, Hao, Jinsong, Kuethe, Jeffrey T., Lai, Zhong, Liu, Hong, Mu, Cuizhi, Qi, Yan, Scott, Jack D., Taoka, Brandon, Truong, Quang, Walsh, Shawn P., Wu, Wen-Lian, Cumming, Jared N.
Published in Tetrahedron (06.10.2016)
Published in Tetrahedron (06.10.2016)
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Year of Publication 26.10.2023
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INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
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Year of Publication 07.08.2024
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TAN, Zheng, TONG, Ling, NEELAMKAVIL, Santhosh Francis, DONOFRIO, Anthony, SLUTSKYY, Yuriy, LIU, Weiguo, WALSH, Shawn P
Year of Publication 14.09.2023
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Year of Publication 14.09.2023
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3-HETEROARYL PYRROLIDINE AND PIPERIDINE OREXIN RECEPTOR AGONISTS
Rudd, Michael T, Wei, Lan, Huang, Xianhai, Walsh, Shawn P, Yang, Dexi, Chen, Ping, Bogen, Stephane L, Claussen, Dane James
Year of Publication 04.01.2024
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Year of Publication 04.01.2024
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