Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry
Dong, Jiajia, Krasnova, Larissa, Finn, M. G., Sharpless, K. Barry
Published in Angewandte Chemie (International ed.) (01.09.2014)
Published in Angewandte Chemie (International ed.) (01.09.2014)
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Journal Article
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
Liu, Zilei, Li, Jie, Li, Suhua, Li, Gencheng, Sharpless, K. Barry, Wu, Peng
Published in Journal of the American Chemical Society (28.02.2018)
Published in Journal of the American Chemical Society (28.02.2018)
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Journal Article
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
Zheng, Qinheng, Woehl, Jordan L., Kitamura, Seiya, Santos-Martins, Diogo, Smedley, Christopher J., Li, Gencheng, Forli, Stefano, Moses, John E., Wolan, Dennis W., Sharpless, K. Barry
Published in Proceedings of the National Academy of Sciences - PNAS (17.09.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (17.09.2019)
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Journal Article
A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope
Guo, Taijie, Meng, Genyi, Zhan, Xiongjie, Yang, Qian, Ma, Tiancheng, Xu, Long, Sharpless, K. Barry, Dong, Jiajia
Published in Angewandte Chemie International Edition (01.03.2018)
Published in Angewandte Chemie International Edition (01.03.2018)
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Journal Article
Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery
Brighty, Gabriel J, Botham, Rachel C, Li, Suhua, Nelson, Luke, Mortenson, David E, Li, Gencheng, Morisseau, Christophe, Wang, Hua, Hammock, Bruce D, Sharpless, K Barry, Kelly, Jeffery W
Published in Nature chemistry (01.10.2020)
Published in Nature chemistry (01.10.2020)
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Journal Article
Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins
Liu, Feng, Wang, Hua, Li, Suhua, Bare, Grant A. L., Chen, Xuemin, Wang, Chu, Moses, John E., Wu, Peng, Sharpless, K. Barry
Published in Angewandte Chemie International Edition (11.06.2019)
Published in Angewandte Chemie International Edition (11.06.2019)
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Journal Article
SuFEx‐Based Polysulfonate Formation from Ethenesulfonyl Fluoride–Amine Adducts
Wang, Hua, Zhou, Feng, Ren, Gerui, Zheng, Qinheng, Chen, Hongli, Gao, Bing, Klivansky, Liana, Liu, Yi, Wu, Bin, Xu, Qingfeng, Lu, Jianmei, Sharpless, K. Barry, Wu, Peng
Published in Angewandte Chemie (International ed.) (04.09.2017)
Published in Angewandte Chemie (International ed.) (04.09.2017)
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Journal Article
Copper(I)‐Catalyzed Cycloaddition of Organic Azides and 1‐Iodoalkynes
Hein, Jason E., Tripp, Jonathan C., Krasnova, Larissa B., Sharpless, K. Barry, Fokin, Valery V.
Published in Angewandte Chemie International Edition (01.01.2009)
Published in Angewandte Chemie International Edition (01.01.2009)
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Journal Article
Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
Smedley, Christopher J., Li, Gencheng, Barrow, Andrew S., Gialelis, Timothy L., Giel, Marie‐Claire, Ottonello, Alessandra, Cheng, Yunfei, Kitamura, Seiya, Wolan, Dennis W., Sharpless, K. Barry, Moses, John E.
Published in Angewandte Chemie International Edition (20.07.2020)
Published in Angewandte Chemie International Edition (20.07.2020)
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Journal Article
Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification
Hong, Senlian, Shi, Yujie, Wu, Nicholas C, Grande, Geramie, Douthit, Lacey, Wang, Hua, Zhou, Wen, Sharpless, K Barry, Wilson, Ian A, Xie, Jia, Wu, Peng
Published in Nature communications (17.04.2019)
Published in Nature communications (17.04.2019)
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Journal Article
Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure
Sit, Rakesh K, Kovarik, Zrinka, Maček Hrvat, Nikolina, Žunec, Suzana, Green, Carol, Fokin, Valery V, Sharpless, K Barry, Radić, Zoran, Taylor, Palmer
Published in The Journal of pharmacology and experimental therapeutics (01.11.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2018)
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Journal Article
SuFEx-based chemical diversification for the systematic discovery of CRBN molecular glues
Carter, Trever R., Milosevich, Natalia, Dada, Lucas, Shaum, James B., Barry Sharpless, K., Kitamura, Seiya, Erb, Michael A.
Published in Bioorganic & medicinal chemistry (15.04.2024)
Published in Bioorganic & medicinal chemistry (15.04.2024)
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Journal Article
Copper(I)-Catalyzed Synthesis of Azoles. DFT Study Predicts Unprecedented Reactivity and Intermediates
Himo, Fahmi, Lovell, Timothy, Hilgraf, Robert, Rostovtsev, Vsevolod V, Noodleman, Louis, Sharpless, K. Barry, Fokin, Valery V
Published in Journal of the American Chemical Society (12.01.2005)
Published in Journal of the American Chemical Society (12.01.2005)
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Journal Article
Quantitative and Orthogonal Formation and Reactivity of SuFEx Platforms
Gahtory, Digvijay, Sen, Rickdeb, Pujari, Sidharam, Li, Suhua, Zheng, Qinheng, Moses, John E., Sharpless, K. Barry, Zuilhof, Han
Published in Chemistry : a European journal (20.07.2018)
Published in Chemistry : a European journal (20.07.2018)
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Journal Article
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
Baranczak, Aleksandra, Liu, Yu, Connelly, Stephen, Du, Wen-Ge Han, Greiner, Erin R, Genereux, Joseph C, Wiseman, R. Luke, Eisele, Yvonne S, Bradbury, Nadine C, Dong, Jiajia, Noodleman, Louis, Sharpless, K. Barry, Wilson, Ian A, Encalada, Sandra E, Kelly, Jeffery W
Published in Journal of the American Chemical Society (17.06.2015)
Published in Journal of the American Chemical Society (17.06.2015)
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Journal Article
Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition
Wang, Qian, Chan, Timothy R, Hilgraf, Robert, Fokin, Valery V, Sharpless, K. Barry, Finn, M. G
Published in Journal of the American Chemical Society (19.03.2003)
Published in Journal of the American Chemical Society (19.03.2003)
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Journal Article
Mechanistic Studies on the Cu-Catalyzed Three-Component Reactions of Sulfonyl Azides, 1-Alkynes and Amines, Alcohols, or Water: Dichotomy via a Common Pathway
Yoo, Eun Jeong, Ahlquist, Mårten, Bae, Imhyuck, Sharpless, K. Barry, Fokin, Valery V, Chang, Sukbok
Published in Journal of organic chemistry (18.07.2008)
Published in Journal of organic chemistry (18.07.2008)
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Journal Article