A Mutant Ataxin-3 Putative-Cleavage Fragment in Brains of Machado-Joseph Disease Patients and Transgenic Mice Is Cytotoxic above a Critical Concentration
Goti, Daniel, Katzen, Scott M, Mez, Jesse, Kurtis, Noam, Kiluk, Jennifer, Ben-Haiem, Lea, Jenkins, Nancy A, Copeland, Neal G, Kakizuka, Akira, Sharp, Alan H, Ross, Christopher A, Mouton, Peter R, Colomer, Veronica
Published in The Journal of neuroscience (10.11.2004)
Published in The Journal of neuroscience (10.11.2004)
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Journal Article
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
Davies, S W, Turmaine, M, Cozens, B A, DiFiglia, M, Sharp, A H, Ross, C A, Scherzinger, E, Wanker, E E, Mangiarini, L, Bates, G P
Published in Cell (08.08.1997)
Published in Cell (08.08.1997)
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Inhibiting Caspase Cleavage of Huntingtin Reduces Toxicity and Aggregate Formation in Neuronal and Nonneuronal Cells
Wellington, Cheryl L., Singaraja, Roshni, Ellerby, Lisa, Savill, Jane, Roy, Sophie, Leavitt, Blair, Cattaneo, Elena, Hackam, Abigail, Sharp, Alan, Thornberry, Nancy, Nicholson, Donald W., Bredesen, Dale E., Hayden, Michael R.
Published in The Journal of biological chemistry (30.06.2000)
Published in The Journal of biological chemistry (30.06.2000)
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Journal Article
Intranuclear Inclusions and Neuritic Aggregates in Transgenic Mice Expressing a Mutant N-Terminal Fragment of Huntingtin
Schilling, Gabriele, Becher, Mark W., Sharp, Alan H., Jinnah, Hyder A., Duan, Kui, Kotzuk, Joyce A., Slunt, Hilda H., Ratovitski, Tamara, Cooper, Jillian K., Jenkins, Nancy A., Copeland, Neal G., Price, Donald L., Ross, Christopher A., Borchelt, David R.
Published in Human molecular genetics (01.03.1999)
Published in Human molecular genetics (01.03.1999)
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Journal Article
Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization
Snyder, Solomon H, Sawa, Akira, Wiegand, Gordon W, Cooper, Jillian, Margolis, Russell L, Sharp, Alan H, Lawler, Joseph F, Greenamyre, J. Timothy, Ross, Christopher A
Published in Nature medicine (01.10.1999)
Published in Nature medicine (01.10.1999)
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Journal Article
Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions
Sharp, Alan H, Troncoso, Juan C, Amaravi, Ravi K, Guo, Xin, Kleiderlein, John J, Engelender, Simone, Worley, Paul F, Kaminsky, Zachary, Lanahan, Anthony A, Dawson, Valina L, Margolis, Russell L, Ross, Christopher A, Dawson, Ted M
Published in Nature genetics (01.05.1999)
Published in Nature genetics (01.05.1999)
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Journal Article
A huntingtin-associated protein enriched in brain with implications for pathology
Li, Xiao-Jiang, Li, Shi-Hua, Sharp, Alan H, Nucifora, Frederick C, Schilling, Gabriele, Lanahan, Anthony, Worley, Paul, Snyder, Solomon H, Ross, Christopher A
Published in Nature (London) (23.11.1995)
Published in Nature (London) (23.11.1995)
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Journal Article
Lymphocyte Apoptosis: Mediation by Increased Type 3 Inositol 1,4,5- Trisphosphate Receptor
Khan, Adil A., Soloski, Mark J., Sharp, Alan H., Schilling, Gabriele, Sabatini, David M., Li, Shi-Hua, Ross, Christopher A., Snyder, Solomon H.
Published in Science (American Association for the Advancement of Science) (26.07.1996)
Published in Science (American Association for the Advancement of Science) (26.07.1996)
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Journal Article
Widespread expression of Huntington's disease gene (IT15) protein product
Sharp, Alan H, Loev, Scott J, Schilling, Gabriele, Li, Shi-Hua, Li, Xiao-Jiang, Bao, Jun, Wagster, Molly V, Kotzuk, Joyce A, Steiner, Joseph P, Lo, Amy, Hedreen, John, Sisodia, Sangram, Snyder, Solomon H, Dawson, Ted M, Ryugo, David K, Ross, Christopher A
Published in Neuron (Cambridge, Mass.) (01.05.1995)
Published in Neuron (Cambridge, Mass.) (01.05.1995)
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Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis
PASSANI, L. A, BEDFORD, M. T, FABER, P. W, MCGINNIS, K. M, SHARP, A. H, GUSELLA, J. F, VONSATTEL, J.-P, MACDONALD, M. E
Published in Human molecular genetics (01.09.2000)
Published in Human molecular genetics (01.09.2000)
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Journal Article
Expansion of Polyglutamine Repeat in Huntingtin Leads to Abnormal Protein Interactions Involving Calmodulin
Bao, Jun, Sharp, Alan H., Wagster, Molly V., Becher, Mark, Schilling, Gabriele, Ross, Christopher A., Dawson, Valina L., Dawson, Ted M.
Published in Proceedings of the National Academy of Sciences - PNAS (14.05.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (14.05.1996)
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Journal Article
Huntingtin-Associated Protein (HAP1): Discrete Neuronal Localizations in the Brain Resemble those of Neuronal Nitric Oxide Synthase
Li, Xiao-Jiang, Sharp, Alan H., Li, Shi-Hua, Dawson, Ted M., Snyder, Solomon H., Ross, Christopher A.
Published in Proceedings of the National Academy of Sciences - PNAS (14.05.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (14.05.1996)
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Journal Article
Differential cellular expression of isoforms of inositol 1,4,5-triphosphate receptors in neurons and glia in brain
Sharp, Alan H., Nucifora Jr, Frederick C., Blondel, Olivier, Sheppard, Carol A., Zhang, Chuanyi, Snyder, Solomon H., Russell, James T., Ryugoand, David K., Ross, Christopher A.
Published in Journal of comparative neurology (1911) (05.04.1999)
Published in Journal of comparative neurology (1911) (05.04.1999)
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