Inhibitors of the HSP90 Molecular Chaperone: Current Status
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Book Chapter
Journal Article
Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)
Chessum, Nicola E. A, Sharp, Swee Y, Caldwell, John J, Pasqua, A. Elisa, Wilding, Birgit, Colombano, Giampiero, Collins, Ian, Ozer, Bugra, Richards, Meirion, Rowlands, Martin, Stubbs, Mark, Burke, Rosemary, McAndrew, P. Craig, Clarke, Paul A, Workman, Paul, Cheeseman, Matthew D, Jones, Keith
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Journal Article
Correction: Silencing of HSP90 Cochaperone AHA1 Expression Decreases Client Protein Activation and Increases Cellular Sensitivity to the HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin
Holmes, Joanna L, Sharp, Swee Y, Hobbs, Steve, Workman, Paul
Published in Cancer research (Chicago, Ill.) (01.01.2019)
Published in Cancer research (Chicago, Ill.) (01.01.2019)
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Journal Article
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis
Eccles, Suzanne A, Massey, Andy, Raynaud, Florence I, Sharp, Swee Y, Box, Gary, Valenti, Melanie, Patterson, Lisa, de Haven Brandon, Alexis, Gowan, Sharon, Boxall, Frances, Aherne, Wynne, Rowlands, Martin, Hayes, Angela, Martins, Vanessa, Urban, Frederique, Boxall, Kathy, Prodromou, Chrisostomos, Pearl, Laurence, James, Karen, Matthews, Thomas P, Cheung, Kwai-Ming, Kalusa, Andrew, Jones, Keith, McDonald, Edward, Barril, Xavier, Brough, Paul A, Cansfield, Julie E, Dymock, Brian, Drysdale, Martin J, Finch, Harry, Howes, Rob, Hubbard, Roderick E, Surgenor, Alan, Webb, Paul, Wood, Mike, Wright, Lisa, Workman, Paul
Published in Cancer research (Chicago, Ill.) (15.04.2008)
Published in Cancer research (Chicago, Ill.) (15.04.2008)
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Journal Article
Silencing of HSP90 Cochaperone AHA1 Expression Decreases Client Protein Activation and Increases Cellular Sensitivity to the HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin
HOLMES, Joanna L, SHARP, Swee Y, HOBBS, Steve, WORKMAN, Paul
Published in Cancer research (Chicago, Ill.) (15.02.2008)
Published in Cancer research (Chicago, Ill.) (15.02.2008)
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Journal Article
4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer
Brough, Paul A, Aherne, Wynne, Barril, Xavier, Borgognoni, Jenifer, Boxall, Kathy, Cansfield, Julie E, Cheung, Kwai-Ming J, Collins, Ian, Davies, Nicholas G. M, Drysdale, Martin J, Dymock, Brian, Eccles, Suzanne A, Finch, Harry, Fink, Alexandra, Hayes, Angela, Howes, Robert, Hubbard, Roderick E, James, Karen, Jordan, Allan M, Lockie, Andrea, Martins, Vanessa, Massey, Andrew, Matthews, Thomas P, McDonald, Edward, Northfield, Christopher J, Pearl, Laurence H, Prodromou, Chrisostomos, Ray, Stuart, Raynaud, Florence I, Roughley, Stephen D, Sharp, Swee Y, Surgenor, Allan, Walmsley, D. Lee, Webb, Paul, Wood, Mike, Workman, Paul, Wright, Lisa
Published in Journal of medicinal chemistry (24.01.2008)
Published in Journal of medicinal chemistry (24.01.2008)
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Journal Article
Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells
Ferraldeschi, Roberta, Welti, Jonathan, Powers, Marissa V, Yuan, Wei, Smyth, Tomoko, Seed, George, Riisnaes, Ruth, Hedayat, Somaieh, Wang, Hannah, Crespo, Mateus, Nava Rodrigues, Daniel, Figueiredo, Ines, Miranda, Susana, Carreira, Suzanne, Lyons, John F, Sharp, Swee, Plymate, Stephen R, Attard, Gerhardt, Wallis, Nicola, Workman, Paul, de Bono, Johann S
Published in Cancer research (Chicago, Ill.) (01.05.2016)
Published in Cancer research (Chicago, Ill.) (01.05.2016)
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Journal Article
Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells
Davenport, Emma L., Moore, Hannah E., Dunlop, Alan S., Sharp, Swee Y., Workman, Paul, Morgan, Gareth J., Davies, Faith E.
Published in Blood (01.10.2007)
Published in Blood (01.10.2007)
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Journal Article
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies
Pasqua, A. Elisa, Sharp, Swee Y., Chessum, Nicola E. A., Hayes, Angela, Pellegrino, Loredana, Tucker, Michael J., Miah, Asadh, Wilding, Birgit, Evans, Lindsay E., Rye, Carl S., Mok, N. Yi, Liu, Manjuan, Henley, Alan T., Gowan, Sharon, De Billy, Emmanuel, te Poele, Robert, Powers, Marissa, Eccles, Suzanne A., Clarke, Paul A., Raynaud, Florence I., Workman, Paul, Jones, Keith, Cheeseman, Matthew D.
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
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Journal Article
MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature
Gaspar, Nathalie, Marshall, Lynley, Perryman, Lara, Bax, Dorine A., Little, Suzanne E., Pereira, Marta Sofia Carvalho Ribeiro Viana, Sharp, Swee Y., Vassal, Gilles, Pearson, Andrew D. J., Reis, R. M., Hargrave, Darren, Workman, Paul, Jones, Chris
Published in Cancer research (Chicago, Ill.) (15.11.2010)
Published in Cancer research (Chicago, Ill.) (15.11.2010)
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Journal Article
Acquired Resistance to 17-Allylamino-17-Demethoxygeldanamycin (17-AAG, Tanespimycin) in Glioblastoma Cells
GASPAR, Nathalie, SHARP, Swee Y, PACEY, Simon, JONES, Chris, WALTON, Michael, VASSAL, Gilles, ECCLES, Suzanne, PARSON, Andrew, WORKMAN, Paul
Published in Cancer research (Chicago, Ill.) (01.03.2009)
Published in Cancer research (Chicago, Ill.) (01.03.2009)
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Journal Article
Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone
Brough, Paul A, Barril, Xavier, Borgognoni, Jenifer, Chene, Patrick, Davies, Nicholas G. M, Davis, Ben, Drysdale, Martin J, Dymock, Brian, Eccles, Suzanne A, Garcia-Echeverria, Carlos, Fromont, Christophe, Hayes, Angela, Hubbard, Roderick E, Jordan, Allan M, Jensen, Michael Rugaard, Massey, Andrew, Merrett, Angela, Padfield, Antony, Parsons, Rachel, Radimerski, Thomas, Raynaud, Florence I, Robertson, Alan, Roughley, Stephen D, Schoepfer, Joseph, Simmonite, Heather, Sharp, Swee Y, Surgenor, Allan, Valenti, Melanie, Walls, Steven, Webb, Paul, Wood, Mike, Workman, Paul, Wright, Lisa
Published in Journal of medicinal chemistry (13.08.2009)
Published in Journal of medicinal chemistry (13.08.2009)
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Journal Article
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen
Cheeseman, Matthew D, Chessum, Nicola E. A, Rye, Carl S, Pasqua, A. Elisa, Tucker, Michael J, Wilding, Birgit, Evans, Lindsay E, Lepri, Susan, Richards, Meirion, Sharp, Swee Y, Ali, Salyha, Rowlands, Martin, O’Fee, Lisa, Miah, Asadh, Hayes, Angela, Henley, Alan T, Powers, Marissa, te Poele, Robert, De Billy, Emmanuel, Pellegrino, Loredana, Raynaud, Florence, Burke, Rosemary, van Montfort, Rob L. M, Eccles, Suzanne A, Workman, Paul, Jones, Keith
Published in Journal of medicinal chemistry (12.01.2017)
Published in Journal of medicinal chemistry (12.01.2017)
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Journal Article
Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines
Patel, Alpa, Sharp, Swee Y., Hall, Katelan, Lewis, William, Stevens, Malcolm F. G., Workman, Paul, Moody, Christopher J.
Published in Organic & biomolecular chemistry (28.04.2016)
Published in Organic & biomolecular chemistry (28.04.2016)
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Journal Article
Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches
Darby, John F., Vidler, Lewis R., Simpson, Peter J., Al-Lazikani, Bissan, Matthews, Stephen J., Sharp, Swee Y., Pearl, Laurence H., Hoelder, Swen, Workman, Paul
Published in Scientific reports (29.09.2020)
Published in Scientific reports (29.09.2020)
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Journal Article
Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma
Gaspar, Nathalie, Sharp, Swee Y, Eccles, Suzanne A, Gowan, Sharon, Popov, Sergey, Jones, Chris, Pearson, Andrew, Vassal, Gilles, Workman, Paul
Published in Molecular cancer therapeutics (01.05.2010)
Published in Molecular cancer therapeutics (01.05.2010)
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Journal Article
Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors
Sharp, Swee Y, Roe, S Mark, Kazlauskas, Egidijus, Cikotienė, Inga, Workman, Paul, Matulis, Daumantas, Prodromou, Chrisostomos
Published in PloS one (11.09.2012)
Published in PloS one (11.09.2012)
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Journal Article
Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor
Whittaker, Steven R., Barlow, Clare, Martin, Mathew P., Mancusi, Caterina, Wagner, Steve, Self, Annette, Barrie, Elaine, Te Poele, Robert, Sharp, Swee, Brown, Nathan, Wilson, Stuart, Jackson, Wayne, Fischer, Peter M., Clarke, Paul A., Walton, Michael I., McDonald, Edward, Blagg, Julian, Noble, Martin, Garrett, Michelle D., Workman, Paul
Published in Molecular oncology (01.03.2018)
Published in Molecular oncology (01.03.2018)
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Journal Article
Correction: In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors
Sharp, Swee Y, Boxall, Kathy, Rowlands, Martin, Prodromou, Chrisostomos, Roe, S Mark, Maloney, Alison, Powers, Marissa, Clarke, Paul A, Box, Gary, Sanderson, Sharon, Patterson, Lisa, Matthews, Thomas P, Cheung, Kwai-Ming J, Ball, Karen, Hayes, Angela, Raynaud, Florence, Marais, Richard, Pearl, Laurence, Eccles, Sue, Aherne, Wynne, McDonald, Edward, Workman, Paul
Published in Cancer research (Chicago, Ill.) (01.01.2019)
Published in Cancer research (Chicago, Ill.) (01.01.2019)
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Journal Article