The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma
Spagnuolo, Paul A., Hu, Jiayi, Hurren, Rose, Wang, Xiaoming, Gronda, Marcela, Sukhai, Mahadeo A., Di Meo, Ashley, Boss, Jonathan, Ashali, Iman, Beheshti Zavareh, Reza, Fine, Noah, Simpson, Craig D., Sharmeen, Sumaiya, Rottapel, Rob, Schimmer, Aaron D.
Published in Blood (10.06.2010)
Published in Blood (10.06.2010)
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The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells
Sharmeen, Sumaiya, Skrtic, Marko, Sukhai, Mahadeo A., Hurren, Rose, Gronda, Marcela, Wang, Xiaoming, Fonseca, Sonali B., Sun, Hong, Wood, Tabitha E., Ward, Richard, Minden, Mark D., Batey, Robert A., Datti, Alessandro, Wrana, Jeff, Kelley, Shana O., Schimmer, Aaron D.
Published in Blood (04.11.2010)
Published in Blood (04.11.2010)
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Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors
Sukhai, Mahadeo A, Prabha, Swayam, Hurren, Rose, Rutledge, Angela C, Lee, Anna Y, Sriskanthadevan, Shrivani, Sun, Hong, Wang, Xiaoming, Skrtic, Marko, Seneviratne, Ayesh, Cusimano, Maria, Jhas, Bozhena, Gronda, Marcela, MacLean, Neil, Cho, Eunice E, Spagnuolo, Paul A, Sharmeen, Sumaiya, Gebbia, Marinella, Urbanus, Malene, Eppert, Kolja, Dissanayake, Dilan, Jonet, Alexia, Dassonville-Klimpt, Alexandra, Li, Xiaoming, Datti, Alessandro, Ohashi, Pamela S, Wrana, Jeff, Rogers, Ian, Sonnet, Pascal, Ellis, William Y, Corey, Seth J, Eaves, Connie, Minden, Mark D, Wang, Jean C Y, Dick, John E, Nislow, Corey, Giaever, Guri, Schimmer, Aaron D
Published in The Journal of clinical investigation (01.01.2013)
Published in The Journal of clinical investigation (01.01.2013)
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Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain
Page, Brent D.G., Fletcher, Steven, Yue, Peibin, Li, Zhihua, Zhang, Xiaolei, Sharmeen, Sumaiya, Datti, Alessandro, Wrana, Jeffrey L., Trudel, Suzanne, Schimmer, Aaron D., Turkson, James, Gunning, Patrick T.
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Journal Article
Disruption of Transcriptionally Active Stat3 Dimers with Non-phosphorylated, Salicylic Acid-Based Small Molecules: Potent in vitro and Tumor Cell Activities
Fletcher, Steven, Singh, Jardeep, Zhang, Xiaolei, Yue, Peibin, Page, Brent D.G, Sharmeen, Sumaiya, Shahani, Vijay M, Zhao, Wei, Schimmer, Aaron D, Turkson, James, Gunning, Patrick T
Published in Chembiochem : a European journal of chemical biology (17.08.2009)
Published in Chembiochem : a European journal of chemical biology (17.08.2009)
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Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein-protein interactions
Drewry, Joel A, Fletcher, Steven, Yue, Peibin, Marushchak, Denys, Zhao, Wei, Sharmeen, Sumaiya, Zhang, Xiaolei, Schimmer, Aaron D, Gradinaru, Claudiu, Turkson, James, Gunning, Patrick T
Published in Chemical communications (Cambridge, England) (01.01.2010)
Published in Chemical communications (Cambridge, England) (01.01.2010)
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Antagonism of the Stat3-Stat3 Protein Dimer with Salicylic Acid Based Small Molecules
Fletcher, Steven, Page, Brent D. G., Zhang, Xialoei, Yue, Peibin, Li, Zhi Hua, Sharmeen, Sumaiya, Singh, Jagdeep, Zhao, Wei, Schimmer, Aaron D., Trudel, Suzanne, Turkson, James, Gunning, Patrick T.
Published in ChemMedChem (01.08.2011)
Published in ChemMedChem (01.08.2011)
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Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein
Shahani, Vijay M., Yue, Peibin, Fletcher, Steven, Sharmeen, Sumaiya, Sukhai, Mahadeo A., Luu, Diana P., Zhang, Xiaolei, Sun, Hong, Zhao, Wei, Schimmer, Aaron D., Turkson, James, Gunning, Patrick T.
Published in Bioorganic & medicinal chemistry (01.03.2011)
Published in Bioorganic & medicinal chemistry (01.03.2011)
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Abstract 3684: Developing STAT3 protein inhibitors as adjuvant therapeutics: Promising synergistic effects in human cancers
Fletcher, Steven, Page, Brent D. G., Yue, Piebin, Zhang, Xiaolei, Sharmeen, Sumaiya, Schimmer, Aaron D., Turkson, James, Gunning, Patrick T.
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Identification of a Nonphosphorylated, Cell Permeable, Small Molecule Ligand for the Stat3 SH2 Domain
Page, Brent D. G., Fletcher, Steven, Yue, Peibin, Li, Zhihua, Zhang, Xiaolei, Sharmeen, Sumaiya, Trudel, Suzanne, Schimmer, Aaron D., Turkson, James, Gunning, Patrick T.
Published in Bioorganic & medicinal chemistry letters (30.06.2011)
Published in Bioorganic & medicinal chemistry letters (30.06.2011)
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Journal Article
The Antihelmintic Flubendazole Inhibits Microtubules through a Mechanism Distinct From Vinca Alkaloids and Displays Preclinical Activity in Leukemia and Myeloma
Spagnuolo, Paul A., Hu, Jiayi, Hurren, Rose, Di Meo, Ashley, Boss, Jonathan, Ashali, Iman, Gronda, Marcela, Wang, Xiaoming, Zavareh, Reza Behesti, Sharmeen, Sumaiya, Fine, Noah, Simpson, Craig D, Rottapel, Robert, Schimmer, Aaron D.
Published in Blood (20.11.2009)
Published in Blood (20.11.2009)
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Journal Article
Activation of Chloride Channels with the Anti-Parasitic Agent Ivermectin Induces Membrane Hyperpolarization and Cell Death in Leukemia Cells
Sharmeen, Sumaiya, Skrtic, Marko, Sukhai, Mahadeo, Sun, Joyce, Hurren, Rose, Gronda, Marcela, Wang, Xiaoming, Wood, Tabitha E, Batey, Robert A., Fonesca, Sonali, Kelley, Shana, Datti, Alessandro, Wrana, Jeff, Schimmer, Aaron D.
Published in Blood (20.11.2009)
Published in Blood (20.11.2009)
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Journal Article
Inside Cover: Disruption of Transcriptionally Active Stat3 Dimers with Non-phosphorylated, Salicylic Acid-Based Small Molecules: Potent in vitro and Tumor Cell Activities (ChemBioChem 12/2009)
Fletcher, Steven, Singh, Jardeephi, Zhang, Xiaolei, Yue, Peibin, Page, Brent D. G., Sharmeen, Sumaiya, Shahani, Vijay M., Zhao, Wei, Schimmer, Aaron D., Turkson, James, Gunning, Patrick T.
Published in Chembiochem : a European journal of chemical biology (17.08.2009)
Published in Chembiochem : a European journal of chemical biology (17.08.2009)
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