Discovery of 4-Aryl-4H-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-based High-Throughput Screening Assay. 1. Structure−Activity Relationships of the 4-Aryl Group
Kemnitzer, William, Drewe, John, Jiang, Songchun, Zhang, Hong, Wang, Yan, Zhao, Jianghong, Jia, Shaojuan, Herich, John, Labreque, Denis, Storer, Richard, Meerovitch, Karen, Bouffard, David, Rej, Rabindra, Denis, Real, Blais, Charles, Lamothe, Serge, Attardo, Giorgio, Gourdeau, Henriette, Tseng, Ben, Kasibhatla, Shailaja, Cai, Sui Xiong
Published in Journal of medicinal chemistry (02.12.2004)
Published in Journal of medicinal chemistry (02.12.2004)
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Journal Article
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions
KEMNITZER, William, KASIBHATLA, Shailaja, VAILLANCOURT, Louis, CHARRON, Sylvie, DODD, Jennifer, ATTARDO, Giorgio, LABRECQUE, Denis, LAMOTHE, Serge, GOURDEAU, Henriette, TSENG, Ben, DREWE, John, SUI XIONG CAI, SONGCHUN JIANG, HONG ZHANG, JIANGHONG ZHAO, SHAOJUAN JIA, LIFEN XU, CROGAN-GRUNDY, Candace, DENIS, Réal, BARRIAULT, Nancy
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
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Journal Article
Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship
Wishka, Donn G, Walker, Daniel P, Yates, Karen M, Reitz, Steven C, Jia, Shaojuan, Myers, Jason K, Olson, Kirk L, Jacobsen, E. Jon, Wolfe, Mark L, Groppi, Vincent E, Hanchar, Alexander J, Thornburgh, Bruce A, Cortes-Burgos, Luz A, Wong, Erik H. F, Staton, Brian A, Raub, Thomas J, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Walters, Rodney R, Hoffmann, William E, Hajos, Mihaly, Franklin, Stanley, Carey, Galen, Gold, Lisa H, Cook, Karen K, Sands, Steven B, Zhao, Sabrina X, Soglia, John R, Kalgutkar, Amit S, Arneric, Stephen P, Rogers, Bruce N
Published in Journal of medicinal chemistry (13.07.2006)
Published in Journal of medicinal chemistry (13.07.2006)
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Journal Article
Discovery of Substituted N-Phenyl Nicotinamides as Potent Inducers of Apoptosis Using a Cell- and Caspase-Based High Throughput Screening Assay
Cai, Sui Xiong, Nguyen, Bao, Jia, Shaojuan, Herich, John, Guastella, John, Reddy, Sanjeeva, Tseng, Ben, Drewe, John, Kasibhatla, Shailaja
Published in Journal of medicinal chemistry (05.06.2003)
Published in Journal of medicinal chemistry (05.06.2003)
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Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists
Walker, Daniel P., Wishka, Donn G., Piotrowski, David W., Jia, Shaojuan, Reitz, Steven C., Yates, Karen M., Myers, Jason K., Vetman, Tatiana N., Margolis, Brandon J., Jacobsen, E. Jon, Acker, Brad A., Groppi, Vincent E., Wolfe, Mark L., Thornburgh, Bruce A., Tinholt, Paula M., Cortes-Burgos, Luz A., Walters, Rodney R., Hester, Matthew R., Seest, Eric P., Dolak, Lester A., Han, Fusen, Olson, Barbara A., Fitzgerald, Laura, Staton, Brian A., Raub, Thomas J., Hajos, Mihaly, Hoffmann, William E., Li, Kai S., Higdon, Nicole R., Wall, Theron M., Hurst, Raymond S., Wong, Erik H.F., Rogers, Bruce N.
Published in Bioorganic & medicinal chemistry (01.12.2006)
Published in Bioorganic & medicinal chemistry (01.12.2006)
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Journal Article
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors : Peptidomimetic replacement of the P2 amino acid by 2-aminoaryl acids and other non-natural amino acids
YAN WANG, SHAOJUAN JIA, TSENG, Ben, DREWE, John, SUI XIONG CAI
Published in Bioorganic & medicinal chemistry letters (15.11.2007)
Published in Bioorganic & medicinal chemistry letters (15.11.2007)
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Journal Article
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 α-amino acid by a α-hydroxy acid
YAN WANG, LUFENG GUAN, SHAOJUAN JIA, BEN TSENG, DREWE, John, SUI XIONG CAI
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
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Journal Article
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: SAR of the N-protecting group
SUI XIONG CAI, LUFENG GUAN, SHAOJUAN JIA, YAN WANG, WU YANG, TSENG, Ben, DREWE, John
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
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Journal Article
Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha 7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: Synthesis and structure-activity relationship
Wishka, Donn G., Walker, Daniel P., Yates, Karen M., Reitz, Steven C., Jia, Shaojuan, Myers, Jason K., Olson, Kirk L., Jacobsen, E. Jon, Wolfe, Mark L., Groppi, Vincent E., Hanchar, Alexander J., Thornburgh, Bruce A., Cortes-Burgos, Luz A., Wong, Erik H. F., Staton, Brian A., Raub, Thomas J., Higdon, Nicole R., Wall, Theron M., Hurst, Raymond S., Walters, Rodney R., Hoffmann, William E., Hajos, Mihaly, Franklin, Stanley, Carey, Galen, Gold, Lisa H., Cook, Karen K., Sands, Steven B., Zhao, Sabrina X., Soglia, John R., Kalgutkar, Amit S., Arneric, Stephen P., Rogers, Bruce N.
Published in Journal of medicinal chemistry (13.07.2006)
Published in Journal of medicinal chemistry (13.07.2006)
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Journal Article
Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha 7 nicotinic acetylcholine receptor agonists
Walker, Daniel P, Wishka, Donn G, Piotrowski, David W, Jia, Shaojuan, Reitz, Steven C, Yates, Karen M, Myers, Jason K, Vetman, Tatiana N, Margolis, Brandon J, Jacobsen, EJon, Acker, Brad A, Groppi, Vincent E, Wolfe, Mark L, Thornburgh, Bruce A, Tinholt, Paula M, Cortes-Burgos, Luz A, Walters, Rodney R, Hester, Matthew R, Seest, Eric P, Dolak, Lester A, Han, Fusen, Olson, Barbara A, Fitzgerald, Laura, Staton, Brian A, Raub, Thomas J, Hajos, Mihaly, Hoffmann, William E, Li, Kai S, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Wong, Erik HF, Rogers, Bruce N
Published in Bioorganic & medicinal chemistry (15.12.2006)
Published in Bioorganic & medicinal chemistry (15.12.2006)
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Journal Article
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: Peptidomimetic replacement of the P 2 amino acid by 2-aminoaryl acids and other non-natural amino acids
Wang, Yan, Jia, Shaojuan, Tseng, Ben, Drewe, John, Cai, Sui Xiong
Published in Bioorganic & medicinal chemistry letters (15.11.2007)
Published in Bioorganic & medicinal chemistry letters (15.11.2007)
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Journal Article
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: Peptidomimetic replacement of the P sub(2) amino acid by 2-aminoaryl acids and other non-natural amino acids
Wang, Yan, Jia, Shaojuan, Tseng, Ben, Drewe, John, Cai, Sui Xiong
Published in Bioorganic & medicinal chemistry (01.11.2007)
Published in Bioorganic & medicinal chemistry (01.11.2007)
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Journal Article
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P(2) amino acid by 2-aminoaryl acids and other non-natural amino acids
Wang, Yan, Jia, Shaojuan, Tseng, Ben, Drewe, John, Cai, Sui Xiong
Published in Bioorganic & medicinal chemistry letters (15.11.2007)
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Published in Bioorganic & medicinal chemistry letters (15.11.2007)
Journal Article
Discovery of a Potent, Dual Serotonin and Norepinephrine Reuptake Inhibitor
Dreyfus, Nicolas, Myers, Jason K, Badescu, Valentina O, de Frutos, Oscar, de la Puente, Maria Luz, Ding, Chunjin, Filla, Sandra A, Fynboe, Karsten, Gernert, Douglas L, Heinz, Beverly A, Hemrick-Luecke, Susan K, Johnson, Kirk W, Johnson, Michael P, López, Pilar, Love, Patrick L, Martin, Laura J, Masquelin, Thierry, McCoy, Michael J, Mendiola, Javier, Morrow, Denise, Muhlhauser, Mark, Pascual, Gustavo, Perun, Thomas J, Pfeifer, Lance A, Phebus, Lee A, Richards, Simon J, Rincón, Juan Antonio, Seest, Eric P, Shah, Jikesh, Shaojuan, Jia, Simmons, Rosa Maria A, Stephenson, Gregory A, Tromiczak, Eric G, Thompson, Linda K, Walter, Magnus W, Weber, Wayne W, Zarrinmayeh, Hamideh, Thomas, Craig E, Joshi, Elizabeth, Iyengar, Smriti, Johansson, Anette M
Published in ACS medicinal chemistry letters (13.06.2013)
Published in ACS medicinal chemistry letters (13.06.2013)
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Journal Article
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P 2 α-amino acid by a α-hydroxy acid
Wang, Yan, Guan, Lufeng, Jia, Shaojuan, Tseng, Ben, Drewe, John, Cai, Sui Xiong
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
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Journal Article
Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship
Wishka, Donn G, Walker, Daniel P, Yates, Karen M, Reitz, Steven C, Jia, Shaojuan, Myers, Jason K, Olson, Kirk L, Jacobsen, E Jon, Wolfe, Mark L, Groppi, Vincent E, Hanchar, Alexander J, Thornburgh, Bruce A, Cortes-Burgos, Luz A, Wong, Erik H F, Staton, Brian A, Raub, Thomas J, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Walters, Rodney R, Hoffmann, William E, Hajos, Mihaly, Franklin, Stanley, Carey, Galen, Gold, Lisa H, Cook, Karen K, Sands, Steven B, Zhao, Sabrina X, Soglia, John R, Kalgutkar, Amit S, Arneric, Stephen P, Rogers, Bruce N
Published in Journal of medicinal chemistry (13.07.2006)
Get full text
Published in Journal of medicinal chemistry (13.07.2006)
Journal Article
Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 nicotinic acetylcholine receptor agonists
Walker, Daniel P, Wishka, Donn G, Piotrowski, David W, Jia, Shaojuan, Reitz, Steven C, Yates, Karen M, Myers, Jason K, Vetman, Tatiana N, Margolis, Brandon J, Jacobsen, E Jon, Acker, Brad A, Groppi, Vincent E, Wolfe, Mark L, Thornburgh, Bruce A, Tinholt, Paula M, Cortes-Burgos, Luz A, Walters, Rodney R, Hester, Matthew R, Seest, Eric P, Dolak, Lester A, Han, Fusen, Olson, Barbara A, Fitzgerald, Laura, Staton, Brian A, Raub, Thomas J, Hajos, Mihaly, Hoffmann, William E, Li, Kai S, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Wong, Erik H F, Rogers, Bruce N
Published in Bioorganic & medicinal chemistry (15.12.2006)
Get full text
Published in Bioorganic & medicinal chemistry (15.12.2006)
Journal Article
Discovery of 4-Aryl-4 H -chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-based High-Throughput Screening Assay. 1. Structure−Activity Relationships of the 4-Aryl Group
Kemnitzer, William, Drewe, John, Jiang, Songchun, Zhang, Hong, Wang, Yan, Zhao, Jianghong, Jia, Shaojuan, Herich, John, Labreque, Denis, Storer, Richard, Meerovitch, Karen, Bouffard, David, Rej, Rabindra, Denis, Real, Blais, Charles, Lamothe, Serge, Attardo, Giorgio, Gourdeau, Henriette, Tseng, Ben, Kasibhatla, Shailaja, Cai, Sui Xiong
Published in Journal of medicinal chemistry (01.12.2004)
Published in Journal of medicinal chemistry (01.12.2004)
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Journal Article