Block of Peripheral Nerve Sodium Channels Selectively Inhibits Features of Neuropathic Pain in Rats
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Published in Molecular pharmacology (01.03.2006)
Published in Molecular pharmacology (01.03.2006)
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Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties
Vachal, Petr, Duffy, Joseph L, Campeau, Louis-Charles, Amin, Rupesh P, Mitra, Kaushik, Murphy, Beth Ann, Shao, Pengcheng P, Sinclair, Peter J, Ye, Feng, Katipally, Revathi, Lu, Zhijian, Ondeyka, Debra, Chen, Yi-Heng, Zhao, Kake, Sun, Wanying, Tyagarajan, Sriram, Bao, Jianming, Wang, Sheng-Ping, Cote, Josee, Lipardi, Concetta, Metzger, Daniel, Leung, Dennis, Hartmann, Georgy, Wollenberg, Gordon K, Liu, Jian, Tan, Lushi, Xu, Yingju, Chen, Qinghao, Liu, Guiquan, Blaustein, Robert O, Johns, Douglas G
Published in Journal of medicinal chemistry (23.09.2021)
Published in Journal of medicinal chemistry (23.09.2021)
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Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain
Shao, Pengcheng P., Ye, Feng, Weber, Ann E., Li, Xiaohua, Lyons, Kathryn A., Parsons, William H., Garcia, Maria L., Priest, Birgit T., Smith, McHardy M., Felix, John P., Williams, Brande S., Kaczorowski, Gregory J., McGowan, Erin, Abbadie, Catherine, Martin, William J., McMasters, Daniel R., Gao, Ying-Duo
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
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Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP‑4 Inhibition
Liu, Weiguo, Shao, Pengcheng P, Liang, Gui-Bai, Bawiec, John, He, Jiafang, Aster, Susan D, Wu, Margaret, Chicchi, Garry, Wang, John, Tsao, Kwei-Lan, Shang, Jin, Salituro, Gino, Zhou, Yun-Ping, Li, Cai, Akiyama, Taro E, Metzger, Daniel E, Murphy, Beth Ann, Howard, Andrew D, Weber, Ann E, Duffy, Joseph L
Published in ACS medicinal chemistry letters (08.11.2018)
Published in ACS medicinal chemistry letters (08.11.2018)
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Aminopiperidine Sulfonamide Cav2.2 Channel Inhibitors for the Treatment of Chronic Pain
Shao, Pengcheng P, Ye, Feng, Chakravarty, Prasun K, Varughese, Deepu J, Herrington, James B, Dai, Ge, Bugianesi, Randal M, Haedo, Rodolfo J, Swensen, Andrew M, Warren, Vivien A, Smith, McHardy M, Garcia, Maria L, McManus, Owen B, Lyons, Kathryn A, Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J, Duffy, Joseph L
Published in Journal of medicinal chemistry (26.11.2012)
Published in Journal of medicinal chemistry (26.11.2012)
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Journal Article
Improved Cav2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide
Shao, Pengcheng P, Ye, Feng, Chakravarty, Prasun K, Herrington, James B, Dai, Ge, Bugianesi, Randal M, Haedo, Rodolfo J, Swensen, Andrew M, Warren, Vivien A, Smith, McHardy M, Garcia, Maria L, McManus, Owen B, Lyons, Kathryn A, Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J, Duffy, Joseph L
Published in ACS medicinal chemistry letters (14.11.2013)
Published in ACS medicinal chemistry letters (14.11.2013)
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Journal Article
Discovery of a novel class of isoxazoline voltage gated sodium channel blockers
Shao, Pengcheng P., Ye, Feng, Weber, Ann E., Li, Xiaohua, Lyons, Kathryn A., Parsons, William H., Garcia, Maria L., Priest, Birgit T., Smith, McHardy M., Felix, John P., Williams, Brande S., Kaczorowski, Gregory J., McGowan, Erin, Abbadie, Catherine, Martin, William J., McMasters, Daniel R., Gao, Ying-Duo
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
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Journal Article
A Disubstituted Succinamide Is a Potent Sodium Channel Blocker with Efficacy in a Rat Pain Model
Priest, Birgit T, Garcia, Maria L, Middleton, Richard E, Brochu, Richard M, Clark, Samantha, Dai, Ge, Dick, Ivy E, Felix, John P, Liu, Chou J, Reiseter, Brita S, Schmalhofer, William A, Shao, Pengcheng P, Tang, Yui S, Chou, Margaret Z, Kohler, Martin G, Smith, McHardy M, Warren, Vivien A, Williams, Brande S, Cohen, Charles J, Martin, William J, Meinke, Peter T, Parsons, William H, Wafford, Keith A, Kaczorowski, Gregory J
Published in Biochemistry (Easton) (03.08.2004)
Published in Biochemistry (Easton) (03.08.2004)
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Journal Article
Aminopiperidine Sulfonamide Ca(v)2.2 Channel Inhibitors for the Treatment of Chronic Pain
Shao, Pengcheng P., Ye, Feng, Chakravarty, Prasun K., Varughese, Deepu J., Herrington, James B., Dai, Ge, Bugianesi, Randal M., Haedo, Rodolfo J., Swensen, Andrew M., Warren, Vivien A., Smith, McHardy M., Garcia, Maria L., McManus, Owen B., Lyons, Kathn A., Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J., Duffy, Joseph L.
Published in Journal of medicinal chemistry (22.11.2012)
Published in Journal of medicinal chemistry (22.11.2012)
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Journal Article
Improved Ca(v)2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide
Shao, Pengcheng P., Ye, Feng, Chakravarty, Prasun K., Herrington, James B., Dai, Ge, Bugianesi, Randal M., Haedo, Rodolfo J., Swensen, Andrew M., Warren, Vivien A., Smith, McHardy M., Garcia, Maria L., McManus, Owen B., Lyons, Kathryn A., Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J., Duffy, Joseph L.
Published in ACS medicinal chemistry letters (01.11.2013)
Published in ACS medicinal chemistry letters (01.11.2013)
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Journal Article
Aminopiperidine Sulfonamide Ca v 2.2 Channel Inhibitors for the Treatment of Chronic Pain
Shao, Pengcheng P., Ye, Feng, Chakravarty, Prasun K., Varughese, Deepu J., Herrington, James B., Dai, Ge, Bugianesi, Randal M., Haedo, Rodolfo J., Swensen, Andrew M., Warren, Vivien A., Smith, McHardy M., Garcia, Maria L., McManus, Owen B., Lyons, Kathryn A., Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J., Duffy, Joseph L.
Published in Journal of medicinal chemistry (26.11.2012)
Published in Journal of medicinal chemistry (26.11.2012)
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Journal Article
Improved Ca v 2.2 Channel Inhibitors through a gem -Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide
Shao, Pengcheng P., Ye, Feng, Chakravarty, Prasun K., Herrington, James B., Dai, Ge, Bugianesi, Randal M., Haedo, Rodolfo J., Swensen, Andrew M., Warren, Vivien A., Smith, McHardy M., Garcia, Maria L., McManus, Owen B., Lyons, Kathryn A., Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J., Duffy, Joseph L.
Published in ACS medicinal chemistry letters (14.11.2013)
Published in ACS medicinal chemistry letters (14.11.2013)
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Year of Publication 01.07.2020
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Year of Publication 01.07.2020
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NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES
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Year of Publication 20.05.2020
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Year of Publication 20.05.2020
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NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES
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Year of Publication 15.01.2020
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Year of Publication 15.01.2020
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Tricyclic compounds as inhibitors of mutant IDH enzymes
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Year of Publication 17.12.2019
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Year of Publication 17.12.2019
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Tricyclic compounds as inhibitors of mutant IDH enzymes
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Year of Publication 15.10.2019
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Year of Publication 15.10.2019
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Tricyclic compounds as inhibitors of mutant IDH enzymes
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Year of Publication 02.10.2018
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Year of Publication 02.10.2018
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