Theoretical Studies of Chemical Reactivity of Metabolically Activated Forms of Aromatic Amines toward DNA
Shamovsky, Igor, Ripa, Lena, Blomberg, Niklas, Eriksson, Leif A, Hansen, Peter, Mee, Christine, Tyrchan, Christian, O'Donovan, Mike, Sjö, Peter
Published in Chemical research in toxicology (15.10.2012)
Published in Chemical research in toxicology (15.10.2012)
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Journal Article
Theoretical Studies on the Origin of β-sheet Twisting
Shamovsky, Igor L, Ross, Gregory M, Riopelle, Richard J
Published in The journal of physical chemistry. B (30.11.2000)
Published in The journal of physical chemistry. B (30.11.2000)
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Journal Article
Theoretical Studies of the Mechanism of Carbamoylation of Nucleobases by Isocyanates
Liljenberg, Magnus, Ripa, Lena, Shamovsky, Igor
Published in Chemical research in toxicology (16.11.2020)
Published in Chemical research in toxicology (16.11.2020)
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Journal Article
Mechanism-Based Insights into Removing the Mutagenicity of Aromatic Amines by Small Structural Alterations
Shamovsky, Igor, Ripa, Lena, Narjes, Frank, Bonn, Britta, Schiesser, Stefan, Terstiege, Ina, Tyrchan, Christian
Published in Journal of medicinal chemistry (24.06.2021)
Published in Journal of medicinal chemistry (24.06.2021)
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Journal Article
Zinc alters conformation and inhibits biological activities of nerve growth factor and related neurotrophins
Ross, G M, Shamovsky, I L, Lawrance, G, Solc, M, Dostaler, S M, Jimmo, S L, Weaver, D F, Riopelle, R J
Published in Nature medicine (01.08.1997)
Published in Nature medicine (01.08.1997)
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Journal Article
The binding of zinc and copper ions to nerve growth factor is differentially affected by pH: implications for cerebral acidosis
Ross, Gregory M., Shamovsky, Igor L., Woo, Sang B., Post, Joan I., Vrkljan, Philip N., Lawrance, Gail, Solc, Mark, Dostaler, Suzanne M., Neet, Kenneth E., Riopelle, Richard J.
Published in Journal of neurochemistry (01.08.2001)
Published in Journal of neurochemistry (01.08.2001)
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Journal Article
Selective and Bioavailable HDAC6 2‑(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism
Ripa, Lena, Sandmark, Jenny, Hughes, Glyn, Shamovsky, Igor, Gunnarsson, Anders, Johansson, Julia, Llinas, Antonio, Collins, Mia, Jung, Bomi, Novén, Anna, Pemberton, Nils, Mogemark, Mickael, Xiong, Yao, Li, Qing, Tångefjord, Stefan, Ek, Margareta, Åstrand, Annika
Published in Journal of medicinal chemistry (26.10.2023)
Published in Journal of medicinal chemistry (26.10.2023)
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Journal Article
Discovery and Early Clinical Development of an Inhibitor of 5‑Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease
Pettersen, Daniel, Broddefalk, Johan, Emtenäs, Hans, Hayes, Martin A, Lemurell, Malin, Swanson, Marianne, Ulander, Johan, Whatling, Carl, Amilon, Carl, Ericsson, Hans, Westin Eriksson, Annika, Granberg, Kenneth, Plowright, Alleyn T, Shamovsky, Igor, Dellsèn, Anita, Sundqvist, Monica, Någård, Mats, Lindstedt, Eva-Lotte
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Journal Article
Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full Agonists
Cooper, Martin, Llinas, Antonio, Hansen, Peter, Caffrey, Moya, Ray, Asim, Sjödin, Stina, Shamovsky, Igor, Wada, Hiroki, Jellesmark Jensen, Tina, Sivars, Ulf, Hultin, Leif, Andersson, Ulf, Lundqvist, Sara, Gedda, Karin, Jinton, Lisa, Krutrök, Nina, Lewis, Richard, Jansson, Paul, Gardelli, Cristina
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Journal Article
Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin
Narjes, Frank, Edfeldt, Fredrik, Petersen, Jens, Öster, Linda, Hamblet, Corinne, Bird, James, Bold, Peter, Rae, Rebecca, Bäck, Elisabeth, Stomilovic, Stina, Zlatoidsky, Pavol, Svensson, Tor, Hidestål, Lotta, Kunalingam, Lavaniya, Shamovsky, Igor, De Maria, Leonardo, Gordon, Euan, Lewis, Richard J., Watcham, Sophie, van Rietschoten, Katerine, Mudd, Gemma E., Harrison, Helen, Chen, Liuhong, Skynner, Michael J.
Published in Journal of medicinal chemistry (08.02.2024)
Published in Journal of medicinal chemistry (08.02.2024)
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Journal Article
Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling
Shamovsky, Igor, Belfield, Graham, Lewis, Richard, Narjes, Frank, Ripa, Lena, Tyrchan, Christian, Öberg, Lisa, Sjö, Peter
Published in Journal of inorganic biochemistry (01.04.2018)
Published in Journal of inorganic biochemistry (01.04.2018)
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Journal Article
Differential effects of transition metal cations on the conformation and biological activities of nerve growth factor
Maitra, Rajatavo, Shamovsky, Igor L., Wang, Wei, Solc, Mark, Lawrance, Gail, Dostaler, Suzanne M., Ross, Gregory M., Riopelle, Richard J.
Published in Neurotoxicity research (01.12.2000)
Published in Neurotoxicity research (01.12.2000)
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Journal Article
Differential Activity of the Nerve Growth Factor (NGF) Antagonist PD90780 [7-(Benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic Acid] Suggests Altered NGF-p75NTR Interactions in the Presence of TrkA
Colquhoun, Amy, Lawrance, Gail M, Shamovsky, Igor L, Riopelle, Richard J, Ross, Gregory M
Published in The Journal of pharmacology and experimental therapeutics (01.08.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2004)
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Journal Article
Explanation for Main Features of Structure–Genotoxicity Relationships of Aromatic Amines by Theoretical Studies of Their Activation Pathways in CYP1A2
Shamovsky, Igor, Ripa, Lena, Börjesson, Lena, Mee, Christine, Nordén, Bo, Hansen, Peter, Hasselgren, Catrin, O’Donovan, Mike, Sjö, Peter
Published in Journal of the American Chemical Society (12.10.2011)
Published in Journal of the American Chemical Society (12.10.2011)
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Journal Article
Identification and Pharmacological Profile of an Indane Based Series of Ghrelin Receptor Full Agonists
Gardelli, Cristina, Wada, Hiroki, Ray, Asim, Caffrey, Moya, Llinas, Antonio, Shamovsky, Igor, Tholander, Joakim, Larsson, Joakim, Sivars, Ulf, Hultin, Leif, Andersson, Ulf, Sanganee, Hitesh J, Stenvall, Kristina, Leidvik, Brith, Gedda, Karin, Jinton, Lisa, Rydén Landergren, Marie, Karabelas, Kostas
Published in Journal of medicinal chemistry (26.07.2018)
Published in Journal of medicinal chemistry (26.07.2018)
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Journal Article
Overcoming Undesirable hERG Potency of Chemokine Receptor Antagonists Using Baseline Lipophilicity Relationships
Shamovsky, Igor, Connolly, Stephen, David, Laurent, Ivanova, Svetlana, Nordén, Bo, Springthorpe, Brian, Urbahns, Klaus
Published in Journal of medicinal chemistry (13.03.2008)
Published in Journal of medicinal chemistry (13.03.2008)
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Journal Article
Fragment-Based Discovery of Novel Allosteric MEK1 Binders
Di Fruscia, Paolo, Edfeldt, Fredrik, Shamovsky, Igor, Collie, Gavin W, Aagaard, Anna, Barlind, Louise, Börjesson, Ulf, Hansson, Eva L, Lewis, Richard J, Nilsson, Magnus K, Öster, Linda, Pemberton, Josefine, Ripa, Lena, Storer, R. Ian, Käck, Helena
Published in ACS medicinal chemistry letters (11.02.2021)
Published in ACS medicinal chemistry letters (11.02.2021)
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