Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancer
Sunaga, N, Kaira, K, Imai, H, Shimizu, K, Nakano, T, Shames, D S, Girard, L, Soh, J, Sato, M, Iwasaki, Y, Ishizuka, T, Gazdar, A F, Minna, J D, Mori, M
Published in Oncogene (22.08.2013)
Published in Oncogene (22.08.2013)
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NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition
Osborne, J K, Larsen, J E, Gonzales, J X, Shames, D S, Sato, M, Wistuba, I I, Girard, L, Minna, J D, Cobb, M H
Published in Oncogenesis (New York, NY) (19.08.2013)
Published in Oncogenesis (New York, NY) (19.08.2013)
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DNA methylation-associated inactivation of TGFβ-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers
Suzuki, M, Shigematsu, H, Shames, D S, Sunaga, N, Takahashi, T, Shivapurkar, N, Iizasa, T, Frenkel, E P, Minna, J D, Fujisawa, T, Gazdar, A F
Published in British journal of cancer (31.10.2005)
Published in British journal of cancer (31.10.2005)
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Randomized, phase II, placebo-controlled trial of onartuzumab and/or bevacizumab in combination with weekly paclitaxel in patients with metastatic triple-negative breast cancer
Diéras, V., Campone, M., Yardley, D.A., Romieu, G., Valero, V., Isakoff, S.J., Koeppen, H., Wilson, T.R., Xiao, Y., Shames, D.S., Mocci, S., Chen, M., Schmid, P.
Published in Annals of oncology (01.09.2015)
Published in Annals of oncology (01.09.2015)
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Journal Article
Primary efficacy results from B-F1RST, a prospective phase II trial evaluating blood-based tumour mutational burden (bTMB) as a predictive biomarker for atezolizumab (atezo) in 1L non-small cell lung cancer (NSCLC)
Kim, E.S., Velcheti, V., Mekhail, T., Leal, T.A., Dowell, J.E., Tsai, M.L., Dakhil, C.S.R., Stella, P., Shen, V., Hu, S., Paul, S.M., Shames, D.S., Schleifman, E., Fabrizio, D.A., Yun, C., Phan, S., Socinski, M.A.
Published in Annals of oncology (01.10.2018)
Published in Annals of oncology (01.10.2018)
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Prevalence and clinical association of gene mutations through multiplex mutation testing in patients with NSCLC: results from the ETOP Lungscape Project
Kerr, K.M., Dafni, U., Schulze, K., Thunnissen, E., Bubendorf, L., Hager, H., Finn, S., Biernat, W., Vliegen, L., Losa, J.H., Marchetti, A., Cheney, R., Warth, A., Speel, E.-J., Blackhall, F., Monkhorst, K., Jantus Lewintre, E., Tischler, V., Clark, C., Bertran-Alamillo, J., Meldgaard, P., Gately, K., Wrona, A., Vandenberghe, P., Felip, E., De Luca, G., Savic, S., Muley, T., Smit, E.F., Dingemans, A.-M.C., Priest, L., Baas, P., Camps, C., Weder, W., Polydoropoulou, V., Geiger, T.R., Kammler, R., Sumiyoshi, T., Molina, M.A., Shames, D.S., Stahel, R.A., Peters, S.
Published in Annals of oncology (01.01.2018)
Published in Annals of oncology (01.01.2018)
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IMpower133: Primary efficacy and safety + CNS-related adverse events in a phase I/III study of first-line (1L) atezolizumab + carboplatin + etoposide in extensive-stage SCLC (ES-SCLC)
Mok, T.S.K., Reck, M., Horn, L., Lam, S., Shames, D.S., Liu, J., Kabbinavar, F., Lin, W., Sandler, A., Liu, S.V.
Published in Annals of oncology (01.11.2018)
Published in Annals of oncology (01.11.2018)
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Journal Article
DNA methylation-associated inactivation of TGFβ-related genes, DRM/Gremlin, RUNX3, and HPP1 in human cancers
Suzuki, M, Shigematsu, H, Shames, D S, Sunaga, N, Takahashi, T, Shivapurkar, N, Iizasa, T, Frenkel, E P, Minna, J D, Fujisawa, T, Gazdar, A F
Published in British journal of cancer (10.12.2013)
Published in British journal of cancer (10.12.2013)
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RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells
SUZUKI, Makoto, SUNAGA, Noriaki, SHAMES, David S, TOYOOKA, Shinichi, GAZDAR, Adi F, MINNA, John D
Published in Cancer research (Chicago, Ill.) (01.05.2004)
Published in Cancer research (Chicago, Ill.) (01.05.2004)
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First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer
Horn, Leora, Mansfield, Aaron S, Szczęsna, Aleksandra, Havel, Libor, Krzakowski, Maciej, Hochmair, Maximilian J, Huemer, Florian, Losonczy, György, Johnson, Melissa L, Nishio, Makoto, Reck, Martin, Mok, Tony, Lam, Sivuonthanh, Shames, David S, Liu, Juan, Ding, Beiying, Lopez-Chavez, Ariel, Kabbinavar, Fairooz, Lin, Wei, Sandler, Alan, Liu, Stephen V
Published in The New England journal of medicine (06.12.2018)
Published in The New England journal of medicine (06.12.2018)
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LBA1IMpower133: Primary efficacy and safety + CNS-related adverse events in a phase I/III study of first-line (1L) atezolizumab + carboplatin + etoposide in extensive-stage SCLC (ES-SCLC)
Mok, T S K, Reck, M, Horn, L, Lam, S, Shames, D S, Liu, J, Kabbinavar, F, Lin, W, Sandler, A, Liu, S V
Published in Annals of oncology (01.11.2018)
Published in Annals of oncology (01.11.2018)
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Journal Article
Tumor mutation load assessed by FoundationOne (FM1) is associated with improved efficacy of atezolizumab (atezo) in patients with advanced NSCLC
Kowanetz, M., Zou, W., Shames, D.S., Cummings, C., Rizvi, N., Spira, A.I., Frampton, G.M., Leveque, V., Flynn, S., Mocci, S., Shankar, G., Funke, R., Ballinger, M., Waterkamp, D., Sandler, A., Hampton, G., Amler, L., Hegde, P.S., Hellmann, M.
Published in Annals of oncology (01.10.2016)
Published in Annals of oncology (01.10.2016)
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Journal Article
LBA83Final efficacy results from B-F1RST, a prospective phase II trial evaluating blood-based tumour mutational burden (bTMB) as a predictive biomarker for atezolizumab (atezo) in 1L non-small cell lung cancer (NSCLC)
Socinski, M, Velcheti, V, Mekhail, T, Chae, Y K, Leal, T A, Dowell, J E, Tsai, M L, Dakhil, C S, Stella, P, Shen, V, Hu, S, Paul, S M, Shames, D S, Schleifman, E, Fabrizio, D A, Nowicki, M, Yun, C, Phan, S, Kim, E S
Published in Annals of oncology (01.10.2019)
Published in Annals of oncology (01.10.2019)
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Clinical activity, safety and predictive biomarkers results from a phase Ia atezolizumab (atezo) trial in extensive-stage small cell lung cancer (ES-SCLC)
Sequist, L.V., Chiang, A., Gilbert, J., Gordon, M., Conkling, P.R., Thompson, D., Marcoux, J.P., Antonia, S.J., Liu, B., Shames, D.S., Lopez-Chavez, A., O'Hear, C., Fasso, M., Gettinger, S.
Published in Annals of oncology (01.10.2016)
Published in Annals of oncology (01.10.2016)
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Journal Article
LBA55Primary efficacy results from B-F1RST, a prospective phase II trial evaluating blood-based tumour mutational burden (bTMB) as a predictive biomarker for atezolizumab (atezo) in 1L non-small cell lung cancer (NSCLC)
Kim, E S, Velcheti, V, Mekhail, T, Leal, T A, Dowell, J E, Tsai, M L, Dakhil, C S R, Stella, P, Shen, V, Hu, S, Paul, S M, Shames, D S, Schleifman, E, Fabrizio, D A, Yun, C, Phan, S, Socinski, M A
Published in Annals of oncology (01.10.2018)
Published in Annals of oncology (01.10.2018)
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Journal Article
DNA methylation-associated inactivation of TGF[beta]-related genes, DRM/Gremlin, RUNX3, and HPP1 in human cancers
Suzuki, M, Shigematsu, H, Shames, D S, Sunaga, N, Takahashi, T, Shivapurkar, N, Iizasa, T, Frenkel, E P, Minna, J D, Fujisawa, T, Gazdar, A F
Published in British journal of cancer (10.12.2013)
Published in British journal of cancer (10.12.2013)
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Journal Article
Retraction Note: DNA methylation-associated inactivation of TGFβ-related genes, DRM/Gremlin, RUNX3, and HPP1 in human cancers
Suzuki, M, Shigematsu, H, Shames, D S, Sunaga, N, Takahashi, T, Shivapurkar, N, Iizasa, T, Frenkel, E P, Minna, J D, Fujisawa, T, Gazdar, A F
Published in British journal of cancer (10.12.2013)
Published in British journal of cancer (10.12.2013)
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Journal Article
Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells
Sato, Mitsuo, Vaughan, Melville B, Girard, Luc, Peyton, Michael, Lee, Woochang, Shames, David S, Ramirez, Ruben D, Sunaga, Noriaki, Gazdar, Adi F, Shay, Jerry W, Minna, John D
Published in Cancer research (Chicago, Ill.) (15.02.2006)
Published in Cancer research (Chicago, Ill.) (15.02.2006)
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Journal Article
Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs
Corey, David R, Janowski, Bethany A, Huffman, Kenneth E, Schwartz, Jacob C, Ram, Rosalyn, Hardy, Daniel, Shames, David S, Minna, John D
Published in Nature chemical biology (01.09.2005)
Published in Nature chemical biology (01.09.2005)
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Journal Article
DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers
Suzuki, M, Shigematsu, H, Shames, D S, Sunaga, N, Takahashi, T, Shivapurkar, N, Iizasa, T, Frenkel, E P, Minna, J D, Fujisawa, T, Gazdar, A F
Published in British journal of cancer (31.10.2005)
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Published in British journal of cancer (31.10.2005)
Journal Article