Quinolinone-based agonists of S1P1: Use of a N-scan SAR strategy to optimize in vitro and in vivo activity
Pennington, Lewis D., Croghan, Michael D., Sham, Kelvin K.C., Pickrell, Alexander J., Harrington, Paul E., Frohn, Michael J., Lanman, Brian A., Reed, Anthony B., Lee, Matthew R., Xu, Han, McElvain, Michele, Xu, Yang, Zhang, Xuxia, Fiorino, Michael, Horner, Michelle, Morrison, Henry G., Arnett, Heather A., Fotsch, Christopher, Tasker, Andrew S., Wong, Min, Cee, Victor J.
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Journal Article
Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups
Reed, Anthony B., Lanman, Brian A., Neira, Susana, Harrington, Paul E., Sham, Kelvin K.C., Frohn, Mike, Pickrell, Alexander J., Tasker, Andrew S., Gore, Anu, Fiorino, Mike, Itano, Andrea, McElvain, Michele, Middleton, Scot, Morrison, Henry, Xu, Han, Xu, Yang, Wong, Min, Cee, Victor J.
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
4-Methoxy- N -[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P 1
Pennington, Lewis D., Sham, Kelvin K. C., Pickrell, Alexander J., Harrington, Paul E., Frohn, Michael J., Lanman, Brian A., Reed, Anthony B., Croghan, Michael D., Lee, Matthew R., Xu, Han, McElvain, Michele, Xu, Yang, Zhang, Xuxia, Fiorino, Michael, Horner, Michelle, Morrison, Henry G., Arnett, Heather A., Fotsch, Christopher, Wong, Min, Cee, Victor J.
Published in ACS medicinal chemistry letters (13.10.2011)
Published in ACS medicinal chemistry letters (13.10.2011)
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Journal Article
Synthesis of Aromatic Heterocycles via Palladium-Catalyzed Annulation of Internal Alkynes
Larock, Richard C, Yum, Eul K, Doty, Mark J, Sham, Kelvin K. C
Published in Journal of organic chemistry (01.06.1995)
Published in Journal of organic chemistry (01.06.1995)
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Journal Article
Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core
Harrington, Paul E, Croghan, Michael D, Fotsch, Christopher, Frohn, Mike, Lanman, Brian A, Pennington, Lewis D, Pickrell, Alexander J, Reed, Anthony B, Sham, Kelvin K. C, Tasker, Andrew, Arnett, Heather A, Fiorino, Michael, Lee, Matthew R, McElvain, Michele, Morrison, Henry G, Xu, Han, Xu, Yang, Zhang, Xuxia, Wong, Min, Cee, Victor J
Published in ACS medicinal chemistry letters (12.01.2012)
Published in ACS medicinal chemistry letters (12.01.2012)
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Journal Article
Quinine analogs as non-peptide calcitonin gene-related peptide (CGRP) receptor antagonists
Daines, Robert A., Sham, Kelvin K.C., Taggart, Jack J., Kingsbury, William D., Chan, James, Breen, Ann, Disa, Jyoti, Aiyar, Nambi
Published in Bioorganic & medicinal chemistry letters (21.10.1997)
Published in Bioorganic & medicinal chemistry letters (21.10.1997)
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Journal Article
(E)-3-[6-[[(2,6-Dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2-pyridinyl]-2- propenoic Acid: A High-Affinity Leukotriene B4 Receptor Antagonist with Oral Antiinflammatory Activity
Daines, Robert A, Chambers, Pamela A, Foley, James J, Griswold, Don E, Kingsbury, William D, Martin, Lenox D, Schmidt, Dulcie B, Sham, Kelvin K. C, Sarau, Henry M
Published in Journal of medicinal chemistry (13.09.1996)
Published in Journal of medicinal chemistry (13.09.1996)
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Journal Article
PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE
XU, SHIMIN, REED, ANTHONY, SHAM, KELVIN K.C, CAO, GUO-QIANG, HERBERICH, BRADLEY J, THAMAN, MAYA C, RZASA, ROBERT M, HUNGATE, RANDALL W, PETTUS, LIPING H, CHAKRABARTI, PARTHA PRATIM, TASKER, ANDREW, FALSEY, JAMES RICHARD, ZHANG, DAWEI
Year of Publication 03.09.2014
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Year of Publication 03.09.2014
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PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND MEDICINAL USES THEREOF
XU, SHIMIN, PETTUS, LIPING H, SHAM, KELVIN K.C, CHAKRABARTI, PARTHA PRATIM, TASKER, ANDREW, RZASA, ROBERT M, ZHANG, DAWEI
Year of Publication 03.01.2012
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Year of Publication 03.01.2012
Patent
Phthalazine, AZA- and diaza-phthalazine compounds and methods of use
XU, SHIMIN, PETTUS, LIPING H, SHAM, KELVIN K.C, CHAKRABARTI, PARTHA PRATIM, TASKER, ANDREW, RZASA, ROBERT M, ZHANG, DAWEI
Year of Publication 18.08.2011
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Year of Publication 18.08.2011
Patent
PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE
XU, SHIMIN, PETTUS, LIPING, H, TASKER, ANDREW, SHAM, KELVIN, K.C, RZASA, ROBERT, M, CHAKRABARTI, PARTHA, PRATIM, ZHANG, DAWEI
Year of Publication 09.03.2011
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Year of Publication 09.03.2011
Patent
HETEROARYLOXYCARBOCYCLYL COMPOUNDS AS PDE10 INHIBITORS
SHAM, KELVIN K.C, ALLEN, JENNIFER R, HARRINGTON, PAUL E, FROHN, MICHAEL J, HARRINGTON, ESSA HU, RZASA, ROBERT M, PICKRELL, ALEXANDER J
Year of Publication 17.11.2011
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Year of Publication 17.11.2011
Patent
S1P1 receptor agonists and use thereof
NEIRA SUSANA C, SHAM KELVIN K.C, CEE VICTOR J, FROHN MICHAEL J, LANMAN BRIAN ALAN, REED ANTHONY B
Year of Publication 04.02.2010
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Year of Publication 04.02.2010
Patent
PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE
XU, SHIMIN, PETTUS, LIPING, H, TASKER, ANDREW, SHAM, KELVIN, K.C, RZASA, ROBERT, M, CHAKRABARTI, PARTHA, PRATIM, ZHANG, DAWEI
Year of Publication 15.07.2009
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Year of Publication 15.07.2009
Patent
PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE
XU, SHIMIN, REED, ANTHONY, SHAM, KELVIN K.C, CAO, GUO-QIANG, HERBERICH, BRADLEY J, THAMAN, MAYA C, RZASA, ROBERT M, HUNGATE, RANDALL W, PETTUS, LIPING H, CHAKRABARTI, PARTHA PRATIM, TASKER, ANDREW, FALSEY, JAMES RICHARD, ZHANG, DAWEI
Year of Publication 04.10.2011
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Year of Publication 04.10.2011
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