The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models
Zhang, Sen, Anjum, Rana, Squillace, Rachel, Nadworny, Sara, Zhou, Tianjun, Keats, Jeff, Ning, Yaoyu, Wardwell, Scott D, Miller, David, Song, Youngchul, Eichinger, Lindsey, Moran, Lauren, Huang, Wei-Sheng, Liu, Shuangying, Zou, Dong, Wang, Yihan, Mohemmad, Qurish, Jang, Hyun Gyung, Ye, Emily, Narasimhan, Narayana, Wang, Frank, Miret, Juan, Zhu, Xiaotian, Clackson, Tim, Dalgarno, David, Shakespeare, William C, Rivera, Victor M
Published in Clinical cancer research (15.11.2016)
Published in Clinical cancer research (15.11.2016)
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Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
Katayama, Ryohei, Khan, Tahsin M., Benes, Cyril, Lifshits, Eugene, Ebi, Hiromichi, Rivera, Victor M., Shakespeare, William C., Iafrate, A. John, Engelman, Jeffrey A., Shaw, Alice T., Vogt, Peter K.
Published in Proceedings of the National Academy of Sciences - PNAS (03.05.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (03.05.2011)
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Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase
Huang, Wei-Sheng, Liu, Shuangying, Zou, Dong, Thomas, Mathew, Wang, Yihan, Zhou, Tianjun, Romero, Jan, Kohlmann, Anna, Li, Feng, Qi, Jiwei, Cai, Lisi, Dwight, Timothy A, Xu, Yongjin, Xu, Rongsong, Dodd, Rory, Toms, Angela, Parillon, Lois, Lu, Xiaohui, Anjum, Rana, Zhang, Sen, Wang, Frank, Keats, Jeffrey, Wardwell, Scott D, Ning, Yaoyu, Xu, Qihong, Moran, Lauren E, Mohemmad, Qurish K, Jang, Hyun Gyung, Clackson, Tim, Narasimhan, Narayana I, Rivera, Victor M, Zhu, Xiaotian, Dalgarno, David, Shakespeare, William C
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Mobocertinib (TAK-788): A Targeted Inhibitor of EGFR Exon 20 Insertion Mutants in Non-Small Cell Lung Cancer
Gonzalvez, Francois, Vincent, Sylvie, Baker, Theresa E, Gould, Alexandra E, Li, Shuai, Wardwell, Scott D, Nadworny, Sara, Ning, Yaoyu, Zhang, Sen, Huang, Wei-Sheng, Hu, Yongbo, Li, Feng, Greenfield, Matthew T, Zech, Stephan G, Das, Biplab, Narasimhan, Narayana I, Clackson, Tim, Dalgarno, David, Shakespeare, William C, Fitzgerald, Michael, Chouitar, Johara, Griffin, Robert J, Liu, Shengwu, Wong, Kwok-Kin, Zhu, Xiaotian, Rivera, Victor M
Published in Cancer discovery (01.07.2021)
Published in Cancer discovery (01.07.2021)
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Ponatinib (AP24534), a multitargeted pan-FGFR inhibitor with activity in multiple FGFR-amplified or mutated cancer models
Gozgit, Joseph M, Wong, Matthew J, Moran, Lauren, Wardwell, Scott, Mohemmad, Qurish K, Narasimhan, Narayana I, Shakespeare, William C, Wang, Frank, Clackson, Tim, Rivera, Victor M
Published in Molecular cancer therapeutics (01.03.2012)
Published in Molecular cancer therapeutics (01.03.2012)
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Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance
Zhou, Tianjun, Commodore, Lois, Huang, Wei-Sheng, Wang, Yihan, Thomas, Mathew, Keats, Jeff, Xu, Qihong, Rivera, Victor M, Shakespeare, William C, Clackson, Tim, Dalgarno, David C, Zhu, Xiaotian
Published in Chemical biology & drug design (01.01.2011)
Published in Chemical biology & drug design (01.01.2011)
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Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies
Gozgit, Joseph M, Wong, Matthew J, Wardwell, Scott, Tyner, Jeffrey W, Loriaux, Marc M, Mohemmad, Qurish K, Narasimhan, Narayana I, Shakespeare, William C, Wang, Frank, Druker, Brian J, Clackson, Tim, Rivera, Victor M
Published in Molecular cancer therapeutics (01.06.2011)
Published in Molecular cancer therapeutics (01.06.2011)
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Crizotinib-Resistant Mutants of EML4-ALK Identified Through an Accelerated Mutagenesis Screen
Zhang, Sen, Wang, Frank, Keats, Jeffrey, Zhu, Xiaotian, Ning, Yaoyu, Wardwell, Scott D., Moran, Lauren, Mohemmad, Qurish K., Anjum, Rana, Wang, Yihan, Narasimhan, Narayana I., Dalgarno, David, Shakespeare, William C., Miret, Juan J., Clackson, Tim, Rivera, Victor M.
Published in Chemical biology & drug design (01.12.2011)
Published in Chemical biology & drug design (01.12.2011)
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Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non–small cell lung cancer
Huang, Wei-Sheng, Li, Feng, Gong, Yongjin, Zhang, Yun, Youngsaye, Willmen, Xu, Yongjin, Zhu, Xiaotian, Greenfield, Matthew T., Kohlmann, Anna, Taslimi, Paul M., Toms, Angela, Zech, Stephan G., Zhou, Tianjun, Das, Biplab, Jang, Hyun G., Tugnait, Meera, Ye, Yihua E., Gonzalvez, Francois, Baker, Theresa E., Nadworny, Sara, Ning, Yaoyu, Wardwell, Scott D., Zhang, Sen, Gould, Alexandra E., Hu, Yongbo, Lane, Weston, Skene, Robert J., Zou, Hua, Clackson, Tim, Narasimhan, Narayana I., Rivera, Victor M., Dalgarno, David C., Shakespeare, William C.
Published in Bioorganic & medicinal chemistry letters (15.01.2023)
Published in Bioorganic & medicinal chemistry letters (15.01.2023)
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Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery
Zech, Stephan G, Kohlmann, Anna, Zhou, Tianjun, Li, Feng, Squillace, Rachel M, Parillon, Lois E, Greenfield, Matthew T, Miller, David P, Qi, Jiwei, Thomas, R. Mathew, Wang, Yihan, Xu, Yongjin, Miret, Juan J, Shakespeare, William C, Zhu, Xiaotian, Dalgarno, David C
Published in Journal of medicinal chemistry (28.01.2016)
Published in Journal of medicinal chemistry (28.01.2016)
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