11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
Hermanowski-Vosatka, Anne, Balkovec, James M., Cheng, Kang, Chen, Howard Y., Hernandez, Melba, Koo, Gloria C., Le Grand, Cheryl B., Li, Zhihua, Metzger, Joseph M., Mundt, Steven S., Noonan, Heather, Nunes, Christian N., Olson, Steven H., Pikounis, Bill, Ren, Ning, Robertson, Nancy, Schaeffer, James M., Shah, Kashmira, Springer, Martin S., Strack, Alison M., Strowski, Matthias, Wu, Kenneth, Wu, TsueiJu, Xiao, Jianying, Zhang, Bei B., Wright, Samuel D., Thieringer, Rolf
Published in The Journal of experimental medicine (15.08.2005)
Published in The Journal of experimental medicine (15.08.2005)
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Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis
Zhang, Ji, Muise, Eric S., Han, Seongah, Kutchukian, Peter S., Costet, Philippe, Zhu, Yonghua, Kan, Yanqing, Zhou, Haihong, Shah, Vinit, Huang, Yongcheng, Saigal, Ashmita, Akiyama, Taro E., Shen, Xiao-Lan, Cai, Tian-Quan, Shah, Kashmira, Carballo-Jane, Ester, Zycband, Emanuel, Yi, Lan, Tian, Ye, Chen, Ying, Imbriglio, Jason, Smith, Elizabeth, Devito, Kristine, Conway, James, Ma, Li-Jun, Hoek, Maarten, Sebhat, Iyassu K., Peier, Andrea M., Talukdar, Saswata, McLaren, David G., Previs, Stephen F., Jensen, Kristian K., Pinto, Shirly
Published in Cell reports. Medicine (21.07.2020)
Published in Cell reports. Medicine (21.07.2020)
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Potent Kv1.3 inhibitors from correolide—modification of the C18 position
Bao, Jianming, Miao, Shouwu, Kayser, Frank, Kotliar, Andrew J., Baker, Robert K., Doss, George A., Felix, John P., Bugianesi, Randal M., Slaughter, Robert S., Kaczorowski, Gregory J., Garcia, Maria L., Ha, Sookhee N., Castonguay, Laurie, Koo, Gloria C., Shah, Kashmira, Springer, Marty S., Staruch, Mary Jo, Parsons, William H., Rupprecht, Kathleen M.
Published in Bioorganic & medicinal chemistry letters (17.01.2005)
Published in Bioorganic & medicinal chemistry letters (17.01.2005)
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Journal Article
11 beta -HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
Hermanowski-Vosatka, Anne, Balkovec, James M, Cheng, Kang, Chen, Howard Y, Hernandez, Melba, Koo, Gloria C, Le Grand, Cheryl B, Li, Zhihua, Metzger, Joseph M, Mundt, Steven S, Noonan, Heather, Nunes, Christian N, Olson, Steven H, Pikounis, Bill, Ren, Ning, Robertson, Nancy, Schaeffer, James M, Shah, Kashmira, Springer, Martin S, Strack, Alison M, Strowski, Matthias, Wu, Kenneth, Wu, TsueiJu, Xiao, Jianying, Zhang, Bei B, Wright, Samuel D, Thieringer, Rolf
Published in The Journal of experimental medicine (15.08.2005)
Published in The Journal of experimental medicine (15.08.2005)
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Use of Microcomputed Tomography to Measure the Relaxin-induced Expansion of Intrapubic Ligaments in Mice
Zimmerman, Heather A, Kennan, Richard P, Zhang, Chunlian, Shah, Kashmira, Johns, Douglas G, Lynch, Joseph J, Dajee, Maya
Published in Comparative medicine (01.08.2017)
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Published in Comparative medicine (01.08.2017)
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Identification and validation of genes affecting aortic lesions in mice
Yang, Xia, Peterson, Larry, Thieringer, Rolf, Deignan, Joshua L, Wang, Xuping, Zhu, Jun, Wang, Susanna, Zhong, Hua, Stepaniants, Serguei, Beaulaurier, John, Wang, I-Ming, Rosa, Ray, Cumiskey, Anne-Marie, Luo, Jane Ming-Juan, Luo, Qi, Shah, Kashmira, Xiao, Jianying, Nickle, David, Plump, Andrew, Schadt, Eric E, Lusis, Aldons J, Lum, Pek Yee
Published in The Journal of clinical investigation (01.07.2010)
Published in The Journal of clinical investigation (01.07.2010)
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Evaluation of selective inhibitors of 11β-HSD1 for the treatment of hypertension
Bauman, David R., Whitehead, Alan, Contino, Lisa C., Cui, Jisong, Garcia-Calvo, Margarita, Gu, Xin, Kevin, Nancy, Ma, Xiuying, Pai, Lee-yuh, Shah, Kashmira, Shen, Xiaolan, Stribling, Sloan, Zokian, Hratch J., Metzger, Joe, Shevell, Diane E., Waddell, Sherman T.
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
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The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotype
Hampton, Caryn, Zhou, Xiaoyan, Priest, Birgit T, Pai, Lee-Yuh, Felix, John P, Thomas-Fowlkes, Brande, Liu, Jessica, Kohler, Martin, Xiao, Jianying, Corona, Aaron, Price, Olga, Gill, Charles, Shah, Kashmira, Rasa, Cordelia, Tong, Vince, Owens, Karen, Ormes, James, Tang, Haifeng, Roy, Sophie, Sullivan, Kathleen A, Metzger, Joseph M, Alonso-Galicia, Magdalena, Kaczorowski, Gregory J, Pasternak, Alexander, Garcia, Maria L
Published in The Journal of pharmacology and experimental therapeutics (01.10.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2016)
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11 beta -HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature
Luo, Mingjuan J, Thieringer, Rolf, Springer, Martin S, Wright, Samuel D, Hermanowski-Vosatka, Anne, Plump, Andrew, Balkovec, James M, Cheng, Kang, Ding, Gloria J, Kawka, Douglas W
Published in Physiological genomics (01.01.2013)
Published in Physiological genomics (01.01.2013)
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Substituted phenyl triazoles as selective inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1
Sun, Wanying, Maletic, Milana, Mundt, Steven S., Shah, Kashmira, Zokian, Hratch, Lyons, Kathy, Waddell, Sherman T., Balkovec, James
Published in Bioorganic & medicinal chemistry letters (01.04.2011)
Published in Bioorganic & medicinal chemistry letters (01.04.2011)
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Phenylcyclobutyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I
Zhu, Yuping, Olson, Steven H., Graham, Donald, Patel, Gool, Hermanowski-Vosatka, Anne, Mundt, Steven, Shah, Kashmira, Springer, Marty, Thieringer, Rolf, Wright, Samuel, Xiao, Jianying, Zokian, Hratch, Dragovic, Jasminka, Balkovec, James M.
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature
Luo, Mingjuan J, Thieringer, Rolf, Springer, Martin S, Wright, Samuel D, Hermanowski-Vosatka, Anne, Plump, Andrew, Balkovec, James M, Cheng, Kang, Ding, Gloria J, Kawka, Douglas W, Koo, Gloria C, Grand, Cheryl B Le, Luo, Qi, Maletic, Milana M, Malkowitz, Lorraine, Shah, Kashmira, Singer, Irwin, Waddell, Sherman T, Wu, Kenneth K, Yuan, Jeffrey, Zhu, Jun, Stepaniants, Serguei, Yang, Xia, Lum, Pek Yee, Wang, I-Ming
Published in Physiological genomics (07.01.2013)
Published in Physiological genomics (07.01.2013)
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Bicyclo[2.2.2]octyltriazole inhibitors of 11β-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome
Maletic, Milana, Leeman, Aaron, Szymonifka, Michael, Mundt, Steven S., Zokian, Hratch J., Shah, Kashmira, Dragovic, Jasminka, Lyons, Kathy, Thieringer, Rolf, Vosatka, Anne H., Balkovec, James, Waddell, Sherman T.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation
Walsh, Shawn P, Shahripour, Aurash, Tang, Haifeng, Teumelsan, Nardos, Frie, Jessica, Zhu, Yuping, Priest, Birgit T, Swensen, Andrew M, Liu, Jessica, Margulis, Michael, Visconti, Richard, Weinglass, Adam, Felix, John P, Brochu, Richard M, Bailey, Timothy, Thomas-Fowlkes, Brande, Alonso-Galicia, Magdalena, Zhou, Xiaoyan, Pai, Lee-Yuh, Corona, Aaron, Hampton, Caryn, Hernandez, Melba, Bentley, Ross, Chen, Jing, Shah, Kashmira, Metzger, Joseph, Forrest, Michael, Owens, Karen, Tong, Vincent, Ha, Sookhee, Roy, Sophie, Kaczorowski, Gregory J, Yang, Lihu, Parmee, Emma, Garcia, Maria L, Sullivan, Kathleen, Pasternak, Alexander
Published in ACS medicinal chemistry letters (09.07.2015)
Published in ACS medicinal chemistry letters (09.07.2015)
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Evaluation of selective inhibitors of 11[beta]-HSD1 for the treatment of hypertension
Bauman, David R, Whitehead, Alan, Contino, Lisa C, Cui, Jisong, Garcia-Calvo, Margarita, Gu, Xin, Kevin, Nancy, Ma, Xiuying, Pai, Lee-yuh, Shah, Kashmira, Shen, Xiaolan, Stribling, Sloan, Zokian, Hratch J, Metzger, Joe, Shevell, Diane E, Waddell, Sherman T
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
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Published in Bioorganic & medicinal chemistry letters (15.06.2013)
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4-Methyl-5-phenyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I
Zhu, Yuping, Olson, Steven H., Hermanowski-Vosatka, Anne, Mundt, Steven, Shah, Kashmira, Springer, Marty, Thieringer, Rolf, Wright, Samuel, Xiao, Jianying, Zokian, Hratch, Balkovec, James M.
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome
Gu, Xin, Dragovic, Jasminka, Koo, Gloria C., Koprak, Sam L., LeGrand, Cheryl, Mundt, Steven S., Shah, Kashmira, Springer, Marty S., Tan, Eugene Y., Thieringer, Rolf, Hermanowski-Vosatka, Anne, Zokian, Hratch J., Balkovec, James M., Waddell, Sherman T.
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
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Bis-aryl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1
Aster, Susan D., Graham, Donald W., Kharbanda, Divya, Patel, Gool, Ponpipom, Mitree, Santorelli, Gina M., Szymonifka, Michael J., Mundt, Steven S., Shah, Kashmira, Springer, Marty S., Thieringer, Rolf, Hermanowski-Vosatka, Anne, Wright, Samuel D., Xiao, Jianying, Zokian, Hratch, Balkovec, James M.
Published in Bioorganic & medicinal chemistry (01.05.2008)
Published in Bioorganic & medicinal chemistry (01.05.2008)
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Abstract 17305: Activation of Soluble Guanylate Cyclase Ameliorates the Progression of Glucose Intolerance and Nephropathy in Obese ZSF1 Rats
da Cunha, Valdeci, Shah, Kashmira, Price, Olga, Sinz, Christopher J, Kim, Ronald M
Published in Circulation (New York, N.Y.) (11.11.2016)
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Published in Circulation (New York, N.Y.) (11.11.2016)
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