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In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer
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Published in Nature (London) (14.11.2019)
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SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition
Mullen, Peter J., Garcia, Gustavo, Purkayastha, Arunima, Matulionis, Nedas, Schmid, Ernst W., Momcilovic, Milica, Sen, Chandani, Langerman, Justin, Ramaiah, Arunachalam, Shackelford, David B., Damoiseaux, Robert, French, Samuel W., Plath, Kathrin, Gomperts, Brigitte N., Arumugaswami, Vaithilingaraja, Christofk, Heather R.
Published in Nature communications (25.03.2021)
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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
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Published in Molecular cell (25.04.2008)
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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Egan, Daniel F, Shackelford, David B, Mihaylova, Maria M, Gelino, Sara, Kohnz, Rebecca A, Mair, William, Vasquez, Debbie S, Joshi, Aashish, Gwinn, Dana M, Taylor, Rebecca, Asara, John M, Fitzpatrick, James, Dillin, Andrew, Viollet, Benoit, Kundu, Mondira, Hansen, Malene, Shaw, Reuben J
Published in Science (American Association for the Advancement of Science) (28.01.2011)
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Sodium-glucose transporter 2 is a diagnostic and therapeutic target for early-stage lung adenocarcinoma
Scafoglio, Claudio R, Villegas, Brendon, Abdelhady, Gihad, Bailey, Sean T, Liu, Jie, Shirali, Aditya S, Wallace, W Dean, Magyar, Clara E, Grogan, Tristan R, Elashoff, David, Walser, Tonya, Yanagawa, Jane, Aberle, Denise R, Barrio, Jorge R, Dubinett, Steven M, Shackelford, David B
Published in Science translational medicine (14.11.2018)
Published in Science translational medicine (14.11.2018)
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Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α
Faubert, Brandon, Vincent, Emma E., Griss, Takla, Samborska, Bozena, Izreig, Said, Svensson, Robert U., Mamer, Orval A., Avizonis, Daina, Shackelford, David B., Shaw, Reuben J., Jones, Russell G.
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2014)
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The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition
Goodwin, Justin, Neugent, Michael L., Lee, Shin Yup, Choe, Joshua H., Choi, Hyunsung, Jenkins, Dana M. R., Ruthenborg, Robin J., Robinson, Maddox W., Jeong, Ji Yun, Wake, Masaki, Abe, Hajime, Takeda, Norihiko, Endo, Hiroko, Inoue, Masahiro, Xuan, Zhenyu, Yoo, Hyuntae, Chen, Min, Ahn, Jung-Mo, Minna, John D., Helke, Kristi L., Singh, Pankaj K., Shackelford, David B., Kim, Jung-whan
Published in Nature communications (26.05.2017)
Published in Nature communications (26.05.2017)
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Reply to: In vivo quantification of mitochondrial membrane potential
Momcilovic, Milica, Shirihai, Orian, Murphy, Michael P., Koehler, Carla M., Sadeghi, Saman, Shackelford, David B.
Published in Nature (London) (09.07.2020)
Published in Nature (London) (09.07.2020)
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Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer
Momcilovic, Milica, Bailey, Sean T., Lee, Jason T., Fishbein, Michael C., Magyar, Clara, Braas, Daniel, Graeber, Thomas, Jackson, Nicholas J., Czernin, Johannes, Emberley, Ethan, Gross, Matthew, Janes, Julie, Mackinnon, Andy, Pan, Alison, Rodriguez, Mirna, Works, Melissa, Zhang, Winter, Parlati, Francesco, Demo, Susan, Garon, Edward, Krysan, Kostyantyn, Walser, Tonya C., Dubinett, Steven M., Sadeghi, Saman, Christofk, Heather R., Shackelford, David B.
Published in Cell reports (Cambridge) (17.01.2017)
Published in Cell reports (Cambridge) (17.01.2017)
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mTOR and HIF-1α-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
Shackelford, David B, Vasquez, Debbie S, Corbeil, Jacqueline, Wu, Shulin, Leblanc, Mathias, Wu, Chin-Lee, Vera, David R, Shaw, Reuben J
Published in Proceedings of the National Academy of Sciences - PNAS (07.07.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (07.07.2009)
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p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas
Hsieh, Meng-Hsiung, Choe, Joshua H., Gadhvi, Jashkaran, Kim, Yoon Jung, Arguez, Marcus A., Palmer, Madison, Gerold, Haleigh, Nowak, Chance, Do, Hung, Mazambani, Simbarashe, Knighton, Jordan K., Cha, Matthew, Goodwin, Justin, Kang, Min Kyu, Jeong, Ji Yun, Lee, Shin Yup, Faubert, Brandon, Xuan, Zhenyu, Abel, E. Dale, Scafoglio, Claudio, Shackelford, David B., Minna, John D., Singh, Pankaj K., Shulaev, Vladimir, Bleris, Leonidas, Hoyt, Kenneth, Kim, James, Inoue, Masahiro, DeBerardinis, Ralph J., Kim, Tae Hoon, Kim, Jung-whan
Published in Cell reports (Cambridge) (13.08.2019)
Published in Cell reports (Cambridge) (13.08.2019)
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LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer
Murray, Christopher W., Brady, Jennifer J., Han, Mingqi, Cai, Hongchen, Tsai, Min K., Pierce, Sarah E., Cheng, Ran, Demeter, Janos, Feldser, David M., Jackson, Peter K., Shackelford, David B., Winslow, Monte M.
Published in Nature communications (28.02.2022)
Published in Nature communications (28.02.2022)
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Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung Cancers
Momcilovic, Milica, McMickle, Robert, Abt, Evan, Seki, Atsuko, Simko, Sarah A, Magyar, Clara, Stout, David B, Fishbein, Michael C, Walser, Tonya C, Dubinett, Steven M, Shackelford, David B
Published in Cancer research (Chicago, Ill.) (15.11.2015)
Published in Cancer research (Chicago, Ill.) (15.11.2015)
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Hypoxia induces a phase transition within a kinase signaling network in cancer cells
Wei, Wei, Shi, Qihui, Remacle, Francoise, Qin, Lidong, Shackelford, David B, Shin, Young Shik, Mischel, Paul S, Levine, R D, Heath, James R
Published in Proceedings of the National Academy of Sciences - PNAS (09.04.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (09.04.2013)
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Proteo-metabolomics and patient tumor slice experiments point to amino acid centrality for rewired mitochondria in fibrolamellar carcinoma
Long, Donald, Chan, Marina, Han, Mingqi, Kamdar, Zeal, Ma, Rosanna K., Tsai, Pei-Yin, Francisco, Adam B., Barrow, Joeva, Shackelford, David B., Yarchoan, Mark, McBride, Matthew J., Orre, Lukas M., Vacanti, Nathaniel M., Gujral, Taranjit S., Sethupathy, Praveen
Published in Cell reports. Medicine (17.09.2024)
Published in Cell reports. Medicine (17.09.2024)
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