KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells
Etchin, J, Berezovskaya, A, Conway, A S, Galinsky, I A, Stone, R M, Baloglu, E, Senapedis, W, Landesman, Y, Kauffman, M, Shacham, S, Wang, J C Y, Look, A T
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Published in Leukemia (01.01.2017)
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CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications
Tai, Y-T, Landesman, Y, Acharya, C, Calle, Y, Zhong, M Y, Cea, M, Tannenbaum, D, Cagnetta, A, Reagan, M, Munshi, A A, Senapedis, W, Saint-Martin, J-R, Kashyap, T, Shacham, S, Kauffman, M, Gu, Y, Wu, L, Ghobrial, I, Zhan, F, Kung, A L, Schey, S A, Richardson, P, Munshi, N C, Anderson, K C
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Published in Leukemia (01.01.2014)
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Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies
Hing, Z A, Fung, H Y J, Ranganathan, P, Mitchell, S, El-Gamal, D, Woyach, J A, Williams, K, Goettl, V M, Smith, J, Yu, X, Meng, X, Sun, Q, Cagatay, T, Lehman, A M, Lucas, D M, Baloglu, E, Shacham, S, Kauffman, M G, Byrd, J C, Chook, Y M, Garzon, R, Lapalombella, R
Published in Leukemia (01.12.2016)
Published in Leukemia (01.12.2016)
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KPT-330 has antitumour activity against non-small cell lung cancer
Sun, H, Hattori, N, Chien, W, Sun, Q, Sudo, M, E-Ling, G L, Ding, L, Lim, S L, Shacham, S, Kauffman, M, Nakamaki, T, Koeffler, H P
Published in British journal of cancer (15.07.2014)
Published in British journal of cancer (15.07.2014)
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Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells
Etchin, J, Sun, Q, Kentsis, A, Farmer, A, Zhang, Z C, Sanda, T, Mansour, M R, Barcelo, C, McCauley, D, Kauffman, M, Shacham, S, Christie, A L, Kung, A L, Rodig, S J, Chook, Y M, Look, A T
Published in Leukemia (01.01.2013)
Published in Leukemia (01.01.2013)
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Phase 2 study of the Exportin 1 inhibitor selinexor in patients with recurrent gynecological malignancies
Vergote, I.B., Lund, B., Peen, U., Umajuridze, Z., Mau-Sorensen, M., Kranich, A., Van Nieuwenhuysen, E., Haslund, C., Nottrup, T., Han, S.N., Concin, N., Unger, T.J., Chai, Y., Au, N., Rashal, T., Joshi, A., Crochiere, M., Landesman, Y., Shah, J., Shacham, S., Kauffman, M., Mirza, M.R.
Published in Gynecologic oncology (01.02.2020)
Published in Gynecologic oncology (01.02.2020)
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Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276
Schmidt, J, Braggio, E, Kortuem, K M, Egan, J B, Zhu, Y X, Xin, C S, Tiedemann, R E, Palmer, S E, Garbitt, V M, McCauley, D, Kauffman, M, Shacham, S, Chesi, M, Bergsagel, P L, Stewart, A K
Published in Leukemia (01.12.2013)
Published in Leukemia (01.12.2013)
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Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells
Zhong, Y, El-Gamal, D, Dubovsky, J A, Beckwith, K A, Harrington, B K, Williams, K E, Goettl, V M, Jha, S, Mo, X, Jones, J A, Flynn, J M, Maddocks, K J, Andritsos, L A, McCauley, D, Shacham, S, Kauffman, M, Byrd, J C, Lapalombella, R
Published in Leukemia (01.05.2014)
Published in Leukemia (01.05.2014)
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Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice
Etchin, J, Montero, J, Berezovskaya, A, Le, B T, Kentsis, A, Christie, A L, Conway, A S, Chen, W C, Reed, C, Mansour, M R, Ng, C E L, Adamia, S, Rodig, S J, Galinsky, I A, Stone, R M, Klebanov, B, Landesman, Y, Kauffman, M, Shacham, S, Kung, A L, Wang, J C Y, Letai, A, Look, A T
Published in Leukemia (01.01.2016)
Published in Leukemia (01.01.2016)
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Selective inhibitors of nuclear export for the treatment of non-Hodgkin’s lymphomas
Azmi, A. S., Al-Katib, A., Aboukameel, A., McCauley, D., Kauffman, M., Shacham, S., Mohammad, R. M.
Published in Haematologica (Roma) (01.07.2013)
Published in Haematologica (Roma) (01.07.2013)
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Eltanexor (KPT-8602), a second-generation selective inhibitor of nuclear export (SINE) compound, in patients with metastatic colorectal cancer (mCRC)
Hays, J., Zhang, J., Berlin, J.D., O'Hara, M., Shah, M.A., Reichmann, W., Senapedis, W., Achour, H., Baloglu, E., Shacham, S., Kauffman, M.
Published in Annals of oncology (01.10.2018)
Published in Annals of oncology (01.10.2018)
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THU0263 Kpt-350, A Selective Inhibitor of Nuclear Export (SINE) Compound, Effectively Reduces Interferon-Alpha Activation and Autoreactive Plasma Cells in Murine Lupus
Rangel-Moreno, J., Wang, W., Owen, T., Barnard, J., Klebanov, B., Landesman, Y., Tamir, S., Shacham, S., Anolik, J.
Published in Annals of the rheumatic diseases (01.06.2016)
Published in Annals of the rheumatic diseases (01.06.2016)
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305 Selinexor, a novel selective inhibitor of nuclear export, potentiates the antitumor activity of gemcitabine against pancreatic cancer by nuclear retention of p27
Amit, M, Kazim, S, Kazim, H, Shacham, S, Kauffman, M, Malafa, M.P
Published in European journal of cancer (1990) (01.11.2014)
Published in European journal of cancer (1990) (01.11.2014)
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480 Identification of novel small molecules as selective PAK4 allosteric modulators (PAMs) by stable isotope labeling of amino acids in cells (SILAC)
Senapedis, W, Landesman, Y, Schenone, M, Karger, B, Wu, S, Shacham, S, Baloglu, E
Published in European journal of cancer (1990) (01.11.2014)
Published in European journal of cancer (1990) (01.11.2014)
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220 Overcoming drug-resistance in multiple myeloma by XPO1 inhibitor combination therapy
Turner, J, Dawson, J, Grant, S, Shain, K, Cubitt, C, Dai, Y, Zhoui, L, Kauffman, M, Shacham, S, Sullivan, D
Published in European journal of cancer (1990) (01.11.2014)
Published in European journal of cancer (1990) (01.11.2014)
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492 Quantification of exportin-1 (XPO1) occupancy by selective inhibitors of nuclear export (SINE)
Crochiere, M, Klebanov, B, Baloglu, E, Kalid, O, Kashyap, T, Senapedis, W, del Alamo, D, Tamir, S, McCauley, D, Carlson, R, Kauffman, M, Shacham, S, Landesman, Y
Published in European journal of cancer (1990) (01.11.2014)
Published in European journal of cancer (1990) (01.11.2014)
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247 Selective inhibitors of nuclear export (SINE) block the expression of DNA damage repair proteins and sensitize cancer cells to DNA damage therapeutic agents
Kashyap, T, Crochiere, M, Friedlander, S, Klebanov, B, Senapedis, W, Baloglu, E, del Alamo, D, Tamir, S, Rashal, T, McCauley, D, Carlson, R, Kauffman, M, Shacham, S, Landesman, Y
Published in European journal of cancer (1990) (01.11.2014)
Published in European journal of cancer (1990) (01.11.2014)
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974 Selective Inhibitors of Nuclear Export (SINE) CRM1 (XPO1) Antagonists Activate Multiple Tumor Suppressor Pathways and Kill Prostate Cancer (PrCa) Cells
Festuccia, C, Gravina, G.L, Mancini, A, D'Alessandro, A, Chin, L, Shechter, S, Sandanayaka, V, McCauley, D, Kauffman, M, Shacham, S
Published in European journal of cancer (1990) (01.07.2012)
Published in European journal of cancer (1990) (01.07.2012)
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A PHASE 2B RANDOMIZED STUDY OF SINGLE AGENT SELINEXOR IN PATIENTS WITH RELAPSED/REFRACTORY DIFFUSE LARGE B‐CELL LYMPHOMA (DLBCL)
Casasnovas, R., Westin, J., Thieblemont, C., Zijlstra, J., Hill, B., De La Cruz Vicente, F., Choquet, S., Caimi, P., Kaplan, J., Canales, M., Kuruvilla, J., Follows, G., Neste, E., Meade, J., Wrigley, B., Devlin, M., Saint‐Martin, J., Nippgen, C., Gardner, H., Shacham, S., Kauffman, M., Maerevoet, M.
Published in Hematological oncology (01.06.2017)
Published in Hematological oncology (01.06.2017)
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Bulging fontanelle in febrile infants: is lumbar puncture mandatory?
Shacham, S, Kozer, E, Bahat, H, Mordish, Y, Goldman, M
Published in Archives of disease in childhood (01.09.2009)
Published in Archives of disease in childhood (01.09.2009)
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