Soluble epoxide hydrolase inhibitor trifluoromethoxyphenyl‐3‐(1‐propionylpiperidin‐4‐yl)urea prevents hyperalgesia through regulating NLRC4 inflammasome‐related pro‐inflammatory and anti‐inflammatory signaling pathways in the lipopolysaccharide‐induced pain mouse model
Cagli, Ali, Senol, Sefika Pinar, Temiz‐Resitoglu, Meryem, Guden, Demet Sinem, Sari, Ayse Nihal, Sahan‐Firat, Seyhan, Tunctan, Bahar
Published in Drug development research (01.09.2021)
Published in Drug development research (01.09.2021)
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Journal Article
NF‐κB activation mediates LPS‐or zymosan‐induced hypotension and inflammation reversed by BAY61‐3606, a selective Syk inhibitor, in rat models of septic and non‐septic shock
Sahan‐Firat, Seyhan, Temiz‐Resitoglu, Meryem, Guden, Demet Sinem, Senol, Sefika Pinar, Sari, Ayse Nihal, Cil, Meltem, Unsal, Demet, Korkmaz, Belma, Tunctan, Bahar, Malik, Kafait U., Buharalioglu, Cuneyt Kemal
Published in Clinical and experimental pharmacology & physiology (01.02.2019)
Published in Clinical and experimental pharmacology & physiology (01.02.2019)
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Contribution of RhoA/Rho-kinase/MEK1/ERK1/2/iNOS pathway to ischemia/reperfusion-induced oxidative/nitrosative stress and inflammation leading to distant and target organ injury in rats
Sari, A. Nihal, Kacan, Meltem, Unsal, Demet, Sahan Firat, Seyhan, Kemal Buharalioglu, C., Vezir, Ozden, Korkmaz, Belma, Cuez, Tuba, Canacankatan, Necmiye, Sucu, Nehir, Ayaz, Lokman, Tamer Gumus, Lulufer, Gorur, Aysegul, Tunctan, Bahar
Published in European journal of pharmacology (15.01.2014)
Published in European journal of pharmacology (15.01.2014)
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Journal Article
NLRX1 ligand, docosahexaenoic acid, ameliorates LPS-induced inflammatory hyperalgesia by decreasing TRAF6/IKK/IκB-α/NF-κB signaling pathway activity
Dilsah Ezgi Yilmaz, Sefika Pinar Senol, Meryem Temiz-Resitoglu, Seyhan Sahan-Firat, Bahar Tunctan
Published in Cellular and Molecular Biology (08.10.2023)
Published in Cellular and Molecular Biology (08.10.2023)
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mTORC2 inhibition by JR-AB2-011 improves IL-1β-induced inflammation, catabolic response, and apoptosis in human chondrocytes through IκB-α/NF-κB p65
Temiz-Resitoglu, Meryem, Sabrie, Zainab, Tiftik, Rukiye Nalan, Kalkan, Taskın, Aktas-Sukuroglu, Ayca, Malik, Kafait U, Sahan-Firat, Seyhan
Published in Cellular and Molecular Biology (08.10.2024)
Published in Cellular and Molecular Biology (08.10.2024)
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Pro-inflammatory GPR75 and anti-apoptotic phospholipase signaling pathways contribute to the ameliorating effect of soluble epoxide hydrolase inhibition on chronic experimental autoimmune encephalomyelitis in mice
Horat, Mehmet Furkan, Senol, Sefika Pinar, Bahceli, Omer, Temiz-Resitoglu, Meryem, Sahan-Firat, Seyhan, Sevim, Serhan, Tunctan, Bahar
Published in Cellular and Molecular Biology (31.10.2023)
Published in Cellular and Molecular Biology (31.10.2023)
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Journal Article
Suppression of TLR4/MyD88/TAK1/NF-κB/COX-2 Signaling Pathway in the Central Nervous System by Bexarotene, a Selective RXR Agonist, Prevents Hyperalgesia in the Lipopolysaccharide-Induced Pain Mouse Model
Senol, Sefika Pinar, Temiz-Resitoglu, Meryem, Guden, Demet Sinem, Sari, Ayse Nihal, Sahan-Firat, Seyhan, Tunctan, Bahar
Published in Neurochemical research (01.03.2021)
Published in Neurochemical research (01.03.2021)
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Journal Article
Eicosanoids derived from cytochrome P450 pathway of arachidonic acid and inflammatory shock
Tunctan, Bahar, Senol, Sefika Pinar, Temiz-Resitoglu, Meryem, Guden, Demet Sinem, Sahan-Firat, Seyhan, Falck, John R., Malik, Kafait U.
Published in Prostaglandins & other lipid mediators (01.12.2019)
Published in Prostaglandins & other lipid mediators (01.12.2019)
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Journal Article
mTOR inhibition as a possible pharmacological target in the management of systemic inflammatory response and associated neuroinflammation by lipopolysaccharide challenge in rats
Guden, Demet Sinem, Temiz-Resitoglu, Meryem, Senol, Sefika Pinar, Kibar, Deniz, Yilmaz, Sakir Necat, Tunctan, Bahar, Malik, Kafait U, Sahan-Firat, Seyhan
Published in Canadian journal of physiology and pharmacology (01.09.2021)
Published in Canadian journal of physiology and pharmacology (01.09.2021)
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Journal Article
The role of Syk/IĸB‐α/NF‐ĸB pathway activation in the reversal effect of BAY 61‐3606, a selective Syk inhibitor, on hypotension and inflammation in a rat model of zymosan‐induced non‐septic shock
Unsal, Demet, Kacan, Meltem, Temiz‐Resitoglu, Meryem, Guden, Demet S, Korkmaz, Belma, Sari, Ayse N, Buharalioglu, Cuneyt K, Yildirim‐Yaroglu, Hatice, Tamer‐Gumus, Lulufer, Tunctan, Bahar, Malik, Kafait U, Sahan‐Firat, Seyhan
Published in Clinical and experimental pharmacology & physiology (01.02.2018)
Published in Clinical and experimental pharmacology & physiology (01.02.2018)
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Journal Article
Cytochrome P450 1B1 Contributes to Angiotensin II-Induced Hypertension and Associated Pathophysiology
Jennings, Brett L, Sahan-Firat, Seyhan, Estes, Anne M, Das, Kanak, Farjana, Nasreen, Fang, Xiao R, Gonzalez, Frank J, Malik, Kafait U
Published in Hypertension (Dallas, Tex. 1979) (01.10.2010)
Published in Hypertension (Dallas, Tex. 1979) (01.10.2010)
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Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock
Sari, A. Nihal, Korkmaz, Belma, Serin, Mehmet Sami, Kacan, Meltem, Unsal, Demet, Buharalioglu, C. Kemal, Sahan Firat, Seyhan, Manthati, Vijay L., Falck, John R., Malik, Kafait U., Tunctan, Bahar
Published in Inflammation research (01.09.2014)
Published in Inflammation research (01.09.2014)
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Journal Article
2,3',4,5'-Tetramethoxystilbene prevents deoxycorticosterone-salt-induced hypertension: contribution of cytochrome P-450 1B1
Sahan-Firat, Seyhan, Jennings, Brett L, Yaghini, Fariborz A, Song, Chi Young, Estes, Anne M, Fang, Xiao R, Farjana, Nasreen, Khan, Amir I, Malik, Kafait U
Published in American journal of physiology. Heart and circulatory physiology (01.12.2010)
Published in American journal of physiology. Heart and circulatory physiology (01.12.2010)
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Journal Article
Role of ACE I/D gene polymorphisms on the effect of ramipril in inflammatory response and myocardial injury in patients undergoing coronary artery bypass grafts
Urhan Küçük, Meral, Sucu, Nehir, Şahan Firat, Seyhan, Aytaçoğlu, Barlas Naim, Vezir, Özden, Bozali, Caner, Canacankatan, Necmiye, Kul, Seval, Tunçtan, Bahar
Published in European journal of clinical pharmacology (01.12.2014)
Published in European journal of clinical pharmacology (01.12.2014)
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Journal Article
Inhibition of mTOR protects against skeletal muscle and kidney injury following hindlimb ischemia-reperfusion in rats by regulating MEK1/ERK1/2 activity
AKINCI UYSAL, Çağla, TEMİZ REŞİTOĞLU, Meryem, GÜDEN, Demet Sinem, ŞENOL, Sefika Pınar, VEZİR, Özden, SUCU, Nehir, TUNÇTAN, Bahar, MALİK, Kafait U., FIRAT, Seyhan
Published in Cukurova Medical Journal (01.01.2022)
Published in Cukurova Medical Journal (01.01.2022)
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Journal Article
A Synthetic Analogue of 20‐HETE, 5,14‐HEDGE, Reverses Endotoxin‐Induced Hypotension via Increased 20‐HETE Levels Associated with Decreased iNOS Protein Expression and Vasodilator Prostanoid Production in Rats
Cuez, Tuba, Korkmaz, Belma, Buharalioglu, C. Kemal, Sahan‐Firat, Seyhan, Falck, John, Malik, Kafait U., Tunctan, Bahar
Published in Basic & clinical pharmacology & toxicology (01.05.2010)
Published in Basic & clinical pharmacology & toxicology (01.05.2010)
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Journal Article
Experimental Models Used in Hypertension Research
Temiz Resitoglu, Meryem, Guden, Demet Sinem, Sahan Firat, Seyhan
Published in Clinical and experimental health sciences (Online) (06.05.2016)
Published in Clinical and experimental health sciences (Online) (06.05.2016)
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Journal Article
Contribution of Vasoactive Eicosanoids and Nitric Oxide Production to the Effect of Selective Cyclooxygenase‐2 Inhibitor, NS‐398, on Endotoxin‐Induced Hypotension in Rats
Tunctan, Bahar, Korkmaz, Belma, Cuez, Tuba, Kemal Buharalioglu, C., Sahan‐Firat, Seyhan, Falck, John, Malik, Kafait U.
Published in Basic & clinical pharmacology & toxicology (01.11.2010)
Published in Basic & clinical pharmacology & toxicology (01.11.2010)
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Journal Article
Piroxicam Reverses Endotoxin‐Induced Hypotension in Rats: Contribution of Vasoactive Eicosanoids and Nitric Oxide
Buharalioglu, C. Kemal, Korkmaz, Belma, Cuez, Tuba, Sahan‐Firat, Seyhan, Sari, Ayse Nihal, Malik, Kafait U., Tunctan, Bahar
Published in Basic & clinical pharmacology & toxicology (01.09.2011)
Published in Basic & clinical pharmacology & toxicology (01.09.2011)
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Journal Article
Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats
Temiz-Resitoglu, Meryem, Kucukkavruk, Sefika Pinar, Guden, Demet Sinem, Cecen, Pelin, Sari, Ayse Nihal, Tunctan, Bahar, Gorur, Aysegul, Tamer-Gumus, Lulufer, Buharalioglu, Cuneyt Kemal, Malik, Kafait U., Sahan-Firat, Seyhan
Published in European journal of pharmacology (05.05.2017)
Published in European journal of pharmacology (05.05.2017)
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