Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2
Drayman, Nir, DeMarco, Jennifer K, Jones, Krysten A, Azizi, Saara-Anne, Froggatt, Heather M, Tan, Kemin, Maltseva, Natalia Ivanovna, Chen, Siquan, Nicolaescu, Vlad, Dvorkin, Steve, Furlong, Kevin, Kathayat, Rahul S, Firpo, Mason R, Mastrodomenico, Vincent, Bruce, Emily A, Schmidt, Madaline M, Jedrzejczak, Robert, Muñoz-Alía, Miguel Á, Schuster, Brooke, Nair, Vishnu, Han, Kyu-Yeon, O'Brien, Amornrat, Tomatsidou, Anastasia, Meyer, Bjoern, Vignuzzi, Marco, Missiakas, Dominique, Botten, Jason W, Brooke, Christopher B, Lee, Hyun, Baker, Susan C, Mounce, Bryan C, Heaton, Nicholas S, Severson, William E, Palmer, Kenneth E, Dickinson, Bryan C, Joachimiak, Andrzej, Randall, Glenn, Tay, Savaş
Published in Science (20.08.2021)
Published in Science (20.08.2021)
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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes
Schreiber, Stuart L., Kotz, Joanne D., Li, Min, Aubé, Jeffrey, Austin, Christopher P., Reed, John C., Rosen, Hugh, White, E. Lucile, Sklar, Larry A., Lindsley, Craig W., Alexander, Benjamin R., Bittker, Joshua A., Clemons, Paul A., de Souza, Andrea, Foley, Michael A., Palmer, Michelle, Shamji, Alykhan F., Wawer, Mathias J., McManus, Owen, Wu, Meng, Zou, Beiyan, Yu, Haibo, Golden, Jennifer E., Schoenen, Frank J., Simeonov, Anton, Jadhav, Ajit, Jackson, Michael R., Pinkerton, Anthony B., Chung, Thomas D.Y., Griffin, Patrick R., Cravatt, Benjamin F., Hodder, Peter S., Roush, William R., Roberts, Edward, Chung, Dong-Hoon, Jonsson, Colleen B., Noah, James W., Severson, William E., Ananthan, Subramaniam, Edwards, Bruce, Oprea, Tudor I., Conn, P. Jeffrey, Hopkins, Corey R., Wood, Michael R., Stauffer, Shaun R., Emmitte, Kyle A., Brady, Linda S., Driscoll, Jamie, Li, Ingrid Y., Loomis, Carson R., Margolis, Ronald N., Michelotti, Enrique, Perry, Mary E., Pillai, Ajay, Yao, Yong
Published in Cell (04.06.2015)
Published in Cell (04.06.2015)
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Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses
Nguyen, Long Chi, Yang, Dongbo, Nicolaescu, Vlad, Best, Thomas J, Gula, Haley, Saxena, Divyasha, Gabbard, Jon D, Chen, Shao-Nong, Ohtsuki, Takashi, Friesen, John Brent, Drayman, Nir, Mohamed, Adil, Dann, Christopher, Silva, Diane, Robinson-Mailman, Lydia, Valdespino, Andrea, Stock, Letícia, Suárez, Eva, Jones, Krysten A, Azizi, Saara-Anne, Demarco, Jennifer K, Severson, William E, Anderson, Charles D, Millis, James Michael, Dickinson, Bryan C, Tay, Savaş, Oakes, Scott A, Pauli, Guido F, Palmer, Kenneth E, Meltzer, David O, Randall, Glenn, Rosner, Marsha Rich
Published in Science advances (25.02.2022)
Published in Science advances (25.02.2022)
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Validated Preclinical Mouse Model for Therapeutic Testing against Multidrug-Resistant Pseudomonas aeruginosa Strains
Warawa, Jonathan M, Duan, Xiaoxian, Anderson, Charles D, Sotsky, Julie B, Cramer, Daniel E, Pfeffer, Tia L, Guo, Haixun, Adcock, Scott, Lepak, Alexander J, Andes, David R, Slone, Stacey A, Stromberg, Arnold J, Gabbard, Jon D, Severson, William E, Lawrenz, Matthew B
Published in Microbiology spectrum (26.10.2022)
Published in Microbiology spectrum (26.10.2022)
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Optimization of Potent and Selective Quinazolinediones: Inhibitors of Respiratory Syncytial Virus That Block RNA-Dependent RNA-Polymerase Complex Activity
Matharu, Daljit S, Flaherty, Daniel P, Simpson, Denise S, Schroeder, Chad E, Chung, Donghoon, Yan, Dan, Noah, James W, Jonsson, Colleen B, White, E. Lucile, Aubé, Jeffrey, Plemper, Richard K, Severson, William E, Golden, Jennifer E
Published in Journal of medicinal chemistry (26.12.2014)
Published in Journal of medicinal chemistry (26.12.2014)
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CoV-RBD121-NP Vaccine Candidate Protects against Symptomatic Disease following SARS-CoV-2 Challenge in K18-hACE2 Mice and Induces Protective Responses That Prevent COVID-19-Associated Immunopathology
DeMarco, Jennifer K, Royal, Joshua M, Severson, William E, Gabbard, Jon D, Hume, Steve, Morton, Josh, Swope, Kelsi, Simpson, Carrie A, Shepherd, John W, Bratcher, Barry, Palmer, Kenneth E, Pogue, Gregory P
Published in Vaccines (Basel) (17.11.2021)
Published in Vaccines (Basel) (17.11.2021)
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Ribavirin Causes Error Catastrophe during Hantaan Virus Replication
Severson, William E, Schmaljohn, Connie S, Javadian, Ali, Jonsson, Colleen B
Published in Journal of Virology (01.01.2003)
Published in Journal of Virology (01.01.2003)
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A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus
Chung, Dong-Hoon, Moore, Blake P, Matharu, Daljit S, Golden, Jennifer E, Maddox, Clinton, Rasmussen, Lynn, Sosa, Melinda I, Ananthan, Subramaniam, White, E Lucile, Jia, Fuli, Jonsson, Colleen B, Severson, William E
Published in Virology journal (10.01.2013)
Published in Virology journal (10.01.2013)
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Development and validation of a high-throughput screen for inhibitors of SARS CoV and its application in screening of a 100,000-compound library
Severson, William E, Shindo, Nice, Sosa, Mindy, Fletcher, 3rd, Thomas, White, E Lucile, Ananthan, Subramaniam, Jonsson, Colleen B
Published in Journal of biomolecular screening (01.02.2007)
Published in Journal of biomolecular screening (01.02.2007)
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(S)‑N‑(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a Small Molecule Inhibitor Probe for the Study of Respiratory Syncytial Virus Infection
Moore, Blake P, Chung, Dong Hoon, Matharu, Daljit S, Golden, Jennifer E, Maddox, Clinton, Rasmussen, Lynn, Noah, James W, Sosa, Melinda I, Ananthan, Subramaniam, Tower, Nichole, A, White, E. Lucile, Jia, Fuli, Prisinzano, Thomas E, Aubé, Jeffrey, Jonsson, Colleen B, Severson, William E
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
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Discovery of novel benzoquinazolinones and thiazoloimidazoles, inhibitors of influenza H5N1 and H1N1 viruses, from a cell-based high-throughput screen
Maddry, Joseph A, Chen, Xi, Jonsson, Colleen B, Ananthan, Subramaniam, Hobrath, Judith, Smee, Donald F, Noah, James W, Noah, Diana, Xu, Xiaolin, Jia, Fuli, Maddox, Clinton, Sosa, Melinda I, White, E Lucile, Severson, William E
Published in Journal of biomolecular screening (01.01.2011)
Published in Journal of biomolecular screening (01.01.2011)
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High-throughput screening of a 100,000-compound library for inhibitors of influenza A virus (H3N2)
Severson, William E, McDowell, Michael, Ananthan, Subramaniam, Chung, Dong-Hoon, Rasmussen, Lynn, Sosa, Melinda I, White, E Lucile, Noah, James, Jonsson, Colleen B
Published in Journal of biomolecular screening (01.10.2008)
Published in Journal of biomolecular screening (01.10.2008)
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Essential Amino Acids of the Hantaan Virus N Protein in Its Interaction with RNA
SEVERSON, William, XIAOLIN XU, KUHN, Michaela, SENUTOVITCH, Nina, THOKALA, Mercy, FERRON, Francois, LONGHI, Sonia, CANARD, Bruno, JONSSON, Colleen B
Published in Journal of Virology (01.08.2005)
Published in Journal of Virology (01.08.2005)
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The RNA Binding Domain of the Hantaan Virus N Protein Maps to a Central, Conserved Region
Xu, Xiaolin, Severson, William, Villegas, Noah, Schmaljohn, Connie S, Jonsson, Colleen B
Published in Journal of Virology (01.04.2002)
Published in Journal of Virology (01.04.2002)
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Characterization of the Hantaan Nucleocapsid Protein-Ribonucleic Acid Interaction
Severson, William, Partin, Laurel, Schmaljohn, Connie S., Jonsson, Colleen B.
Published in The Journal of biological chemistry (19.11.1999)
Published in The Journal of biological chemistry (19.11.1999)
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Insights into the transcriptome of oenocytes from Aedes aegypti pupae
Martins, Gustavo Ferreira, Ramalho-Ortigão, José Marcelo, Lobo, Neil Francis, Severson, David William, McDowell, Mary Ann, Pimenta, Paulo Filemon Paolucci
Published in Memórias do Instituto Oswaldo Cruz (01.05.2011)
Published in Memórias do Instituto Oswaldo Cruz (01.05.2011)
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507. Activation of Macrophages Enhances Susceptibility to SARS-CoV-2 Antibody-Dependent Enhancement and Promotes Damage to Downstream Epithelial Cells
DeMarco, Jennifer K, Severson, William E, DeMarco, Daniel R, Gabbard, Jon, Palmer, Kenneth E
Published in Open Forum Infectious Diseases (31.12.2020)
Published in Open Forum Infectious Diseases (31.12.2020)
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