Multiple ligand-specific conformations of the β2-adrenergic receptor
Kahsai, Alem W, Xiao, Kunhong, Rajagopal, Sudarshan, Ahn, Seungkirl, Shukla, Arun K, Sun, Jinpeng, Oas, Terrence G, Lefkowitz, Robert J
Published in Nature chemical biology (21.08.2011)
Published in Nature chemical biology (21.08.2011)
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Loss of biased signaling at a G protein-coupled receptor in overexpressed systems
Li, Angus, Liu, Samuel, Huang, Rennica, Ahn, Seungkirl, Lefkowitz, Robert J
Published in PloS one (24.03.2023)
Published in PloS one (24.03.2023)
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Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
Staus, Dean P, Strachan, Ryan T, Manglik, Aashish, Pani, Biswaranjan, Kahsai, Alem W, Kim, Tae Hun, Wingler, Laura M, Ahn, Seungkirl, Chatterjee, Arnab, Masoudi, Ali, Kruse, Andrew C, Pardon, Els, Steyaert, Jan, Weis, William I, Prosser, R Scott, Kobilka, Brian K, Costa, Tommaso, Lefkowitz, Robert J
Published in Nature (London) (21.07.2016)
Published in Nature (London) (21.07.2016)
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Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9
Luttrell, Louis M, Wang, Jialu, Plouffe, Bianca, Smith, Jeffrey S, Yamani, Lama, Kaur, Suneet, Jean-Charles, Pierre-Yves, Gauthier, Christophe, Lee, Mi-Hye, Pani, Biswaranjan, Kim, Jihee, Ahn, Seungkirl, Rajagopal, Sudarshan, Reiter, Eric, Bouvier, Michel, Shenoy, Sudha K, Laporte, Stéphane A, Rockman, Howard A, Lefkowitz, Robert J
Published in Science signaling (25.09.2018)
Published in Science signaling (25.09.2018)
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Journal Article
β-Arrestin- but Not G Protein-Mediated Signaling by the "Decoy" Receptor CXCR7
Rajagopal, Sudarshan, Kim, Jihee, Ahn, Seungkirl, Craig, Stewart, Lam, Christopher M., Gerard, Norma P., Gerard, Craig, Lefkowitz, Robert J.
Published in Proceedings of the National Academy of Sciences - PNAS (12.01.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (12.01.2010)
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Journal Article
unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
Wisler, James W, DeWire, Scott M, Whalen, Erin J, Violin, Jonathan D, Drake, Matthew T, Ahn, Seungkirl, Shenoy, Sudha K, Lefkowitz, Robert J
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2007)
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Journal Article
Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection in asthma models
Ahn, Seungkirl, Maarsingh, Harm, Walker, Julia Kl, Liu, Samuel W, Hegde, Akhil, Sumajit, Hyeje C, Kahsai, Alem W, Lefkowitz, Robert J
Published in The Journal of clinical investigation (15.09.2023)
Published in The Journal of clinical investigation (15.09.2023)
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Journal Article
Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library
Ahn, Seungkirl, Kahsai, Alem W., Pani, Biswaranjan, Wang, Qin-Ting, Zhao, Shuai, Wall, Alissa L., Strachan, Ryan T., Staus, Dean P., Wingler, Laura M., Sun, Lillian D., Sinnaeve, Justine, Choi, Minjung, Cho, Ted, Xu, Thomas T., Hansen, Gwenn M., Burnett, Michael B., Lamerdin, Jane E., Bassoni, Daniel L., Gavino, Bryant J., Husemoen, Gitte, Olsen, Eva K., Franch, Thomas, Costanzi, Stefano, Chen, Xin, Lefkowitz, Robert J.
Published in Proceedings of the National Academy of Sciences - PNAS (14.02.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (14.02.2017)
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Journal Article
How carvedilol does not activate β2-adrenoceptors
Lefkowitz, Robert J, Rockman, Howard A, Shim, Paul J, Liu, Samuel, Ahn, Seungkirl, Pani, Biswaranjan, Rajagopal, Sudarshan, Shenoy, Sudha K, Bouvier, Michel, Benovic, Jeffrey L, Liggett, Stephen B, Ruffolo, Robert R, Bristow, Michael R, Packer, Milton
Published in Nature communications (30.11.2023)
Published in Nature communications (30.11.2023)
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β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
Shenoy, Sudha K, Modi, Aalok S, Shukla, Arun K, Xiao, Kunhong, Berthouze, Magali, Ahn, Seungkirl, Wilkinson, Keith D, Miller, William E, Lefkowitz, Robert J
Published in Proceedings of the National Academy of Sciences - PNAS (21.04.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (21.04.2009)
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Journal Article
Different G Protein-Coupled Receptor Kinases Govern G Protein and β-Arrestin-Mediated Signaling of V2 Vasopressin Receptor
Ren, Xiu-Rong, Reiter, Eric, Ahn, Seungkirl, Kim, Jihee, Chen, Wei, Lefkowitz, Robert J.
Published in Proceedings of the National Academy of Sciences - PNAS (01.02.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (01.02.2005)
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Journal Article
Independent β-Arrestin 2 and G Protein-Mediated Pathways for Angiotensin II Activation of Extracellular Signal-Regulated Kinases 1 and 2
Wei, Huijun, Ahn, Seungkirl, Shenoy, Sudha K., Karnik, Sadashiva S., Hunyady, László, Luttrell, Louis M., Lefkowitz, Robert J.
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.2003)
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Journal Article
Functional Antagonism of Different G Protein-Coupled Receptor Kinases for β-Arrestin-Mediated Angiotensin II Receptor Signaling
Kim, Jihee, Ahn, Seungkirl, Ren, Xiu-Rong, Whalen, Erin J., Reiter, Eric, Wei, Huijun, Lefkowitz, Robert J.
Published in Proceedings of the National Academy of Sciences - PNAS (01.02.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (01.02.2005)
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Journal Article
Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling
Ahn, Seungkirl, Maudsley, Stuart, Luttrell, Louis M., Lefkowitz, Robert J., Daaka, Yehia
Published in The Journal of biological chemistry (01.01.1999)
Published in The Journal of biological chemistry (01.01.1999)
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Desensitization, Internalization, and Signaling Functions of β-Arrestins Demonstrated by RNA Interference
Ahn, Seungkirl, Nelson, Christopher D., Garrison, Tiffany Runyan, Miller, William E., Lefkowitz, Robert J.
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2003)
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Journal Article
Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure
Liu, Xiangyu, Ahn, Seungkirl, Kahsai, Alem W., Meng, Kai-Cheng, Latorraca, Naomi R., Pani, Biswaranjan, Venkatakrishnan, A. J., Masoudi, Ali, Weis, William I., Dror, Ron O., Chen, Xin, Lefkowitz, Robert J., Kobilka, Brian K.
Published in Nature (London) (16.08.2017)
Published in Nature (London) (16.08.2017)
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Journal Article
Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor
Aristotelous, Tonia, Ahn, Seungkirl, Shukla, Arun K, Gawron, Sylwia, Sassano, Maria F, Kahsai, Alem W, Wingler, Laura M, Zhu, Xiao, Tripathi-Shukla, Prachi, Huang, Xi-Ping, Riley, Jennifer, Besnard, Jérémy, Read, Kevin D, Roth, Bryan L, Gilbert, Ian H, Hopkins, Andrew L, Lefkowitz, Robert J, Navratilova, Iva
Published in ACS medicinal chemistry letters (10.10.2013)
Published in ACS medicinal chemistry letters (10.10.2013)
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Journal Article
Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase
Daaka, Yehia, Luttrell, Louis M., Ahn, Seungkirl, Della Rocca, Gregory J., Ferguson, Stephen S.G., Caron, Marc G., Lefkowitz, Robert J.
Published in The Journal of biological chemistry (09.01.1998)
Published in The Journal of biological chemistry (09.01.1998)
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Journal Article
Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor
Kahsai, Alem W, Wisler, James W, Lee, Jungmin, Ahn, Seungkirl, Cahill Iii, Thomas J, Dennison, S Moses, Staus, Dean P, Thomsen, Alex R B, Anasti, Kara M, Pani, Biswaranjan, Wingler, Laura M, Desai, Hemant, Bompiani, Kristin M, Strachan, Ryan T, Qin, Xiaoxia, Alam, S Munir, Sullenger, Bruce A, Lefkowitz, Robert J
Published in Nature chemical biology (11.07.2016)
Published in Nature chemical biology (11.07.2016)
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Journal Article
Src-dependent Tyrosine Phosphorylation Regulates Dynamin Self-assembly and Ligand-induced Endocytosis of the Epidermal Growth Factor Receptor
Ahn, Seungkirl, Kim, Jihee, Lucaveche, Carmen L., Reedy, Mary C., Luttrell, Louis M., Lefkowitz, Robert J., Daaka, Yehia
Published in The Journal of biological chemistry (19.07.2002)
Published in The Journal of biological chemistry (19.07.2002)
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