The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K
Gauthier, Jacques Yves, Chauret, Nathalie, Cromlish, Wanda, Desmarais, Sylvie, Duong, Le T., Falgueyret, Jean-Pierre, Kimmel, Donald B., Lamontagne, Sonia, Léger, Serge, LeRiche, Tammy, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Nicoll-Griffith, Deborah A., Oballa, Renata M., Palmer, James T., Percival, M. David, Riendeau, Denis, Robichaud, Joel, Rodan, Gideon A., Rodan, Sevgi B., Seto, Carmai, Thérien, Michel, Truong, Vouy-Linh, Venuti, Michael C., Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Black, W. Cameron
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
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Microdosing Assessment to Evaluate Pharmacokinetics and Drug Metabolism in Rats Using Liquid Chromatography-Tandem Mass Spectrometry
Ni, Jinsong, Ouyang, Hui, Aiello, Mauro, Seto, Carmai, Borbridge, Lisa, Sakuma, Takeo, Ellis, Robert, Welty, Devin, Acheampong, Andrew
Published in Pharmaceutical research (01.07.2008)
Published in Pharmaceutical research (01.07.2008)
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Effects of ionization mode on charge-site-remote and related fragmentation reactions of long-chain quaternary ammonium ions
Seto, Carmai, Grossert, J.Stuart, Waddell, David S., Curtis, Jonathan M., Boyd, Robert K.
Published in Journal of the American Society for Mass Spectrometry (01.05.2001)
Published in Journal of the American Society for Mass Spectrometry (01.05.2001)
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Discovery of a potent and selective prostaglandin D-2 receptor antagonist, [(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524)
Sturino, Claudio F., O'Neill, Gary, Lachance, Nicolas, Boyd, Michael, Berthelette, Carl, Labelle, Marc, Li, Lianhai, Roy, Bruno, Scheigetz, John, Tsou, Nancy, Aubin, Yves, Bateman, Kevin P., Chauret, Nathalie, Day, Stephen H., Levesque, Jean-Francois, Seto, Carmai, Silva, Jose H., Trimble, Laird A., Carriere, Marie-Claude, Denis, Danielle, Greig, Gillian, Kargman, Stacia, Lamontagne, Sonia, Mathieu, Marie-Claude, Sawyer, Nicole, Slipetz, Deborah, Abraham, William M., Jones, Tom, McAuliffe, Malia, Piechuta, Hana, Nicoll-Griffith, Deborah A., Wang, Zhaoyin, Zamboni, Robert, Young, Robert N., Metters, Kathleen M.
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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Discovery of a Potent and Selective Prostaglandin D2 Receptor Antagonist, [(3R)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic Acid (MK-0524)
Sturino, Claudio F, O'Neill, Gary, Lachance, Nicolas, Boyd, Michael, Berthelette, Carl, Labelle, Marc, Li, Lianhai, Roy, Bruno, Scheigetz, John, Tsou, Nancy, Aubin, Yves, Bateman, Kevin P, Chauret, Nathalie, Day, Stephen H, Lévesque, Jean-François, Seto, Carmai, Silva, Jose H, Trimble, Laird A, Carriere, Marie-Claude, Denis, Danielle, Greig, Gillian, Kargman, Stacia, Lamontagne, Sonia, Mathieu, Marie-Claude, Sawyer, Nicole, Slipetz, Deborah, Abraham, William M, Jones, Tom, McAuliffe, Malia, Piechuta, Hana, Nicoll-Griffith, Deborah A, Wang, Zhaoyin, Zamboni, Robert, Young, Robert N, Metters, Kathleen M
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor
Isabel, Elise, Bateman, Kevin P., Chauret, Nathalie, Cromlish, Wanda, Desmarais, Sylvie, Duong, Le T., Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Lamontagne, Sonia, Lau, Cheuk K., Léger, Serge, LeRiche, Tammy, Lévesque, Jean-François, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Mellon, Christophe, Nicoll-Griffith, Deborah A., Oballa, Renata M., Percival, M. David, Riendeau, Denis, Robichaud, Joël, Rodan, Gideon A., Rodan, Sevgi B., Seto, Carmai, Thérien, Michel, Truong, Vouy Linh, Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Black, W. Cameron
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Sensitivity and proportionality assessment of metabolites from microdose to high dose in rats using LC-MS/MS
Ni, Jinsong, Ouyang, Hui, Seto, Carmai, Sakuma, Takeo, Ellis, Robert, Rowe, Josh, Acheampong, Andrew, Welty, Devin, Szekely-Klepser, Gabriella
Published in Bioanalysis (01.03.2010)
Published in Bioanalysis (01.03.2010)
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Metabolic activation of indole-containing prostaglandin D2 receptor 1 antagonists: Impacts of glutathione trapping and glucuronide conjugation on covalent binding
Lévesque, Jean-François, Day, Stephen H., Chauret, Nathalie, Seto, Carmai, Trimble, Laird, Bateman, Kevin P., Silva, José M., Berthelette, Carl, Lachance, Nicolas, Boyd, Michael, Li, Lianhai, Sturino, Claudio F., Wang, Zhaoyin, Zamboni, Robert, Young, Robert N., Nicoll-Griffith, Deborah A.
Published in Bioorganic & medicinal chemistry letters (01.06.2007)
Published in Bioorganic & medicinal chemistry letters (01.06.2007)
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β-Substituted Cyclohexanecarboxamide: A Nonpeptidic Framework for the Design of Potent Inhibitors of Cathepsin K
Crane, Sheldon N, Black, W. Cameron, Palmer, James T, Davis, Dana E, Setti, Eduardo, Robichaud, Joel, Paquet, Julie, Oballa, Renata M, Bayly, Christopher I, McKay, Daniel J, Somoza, John R, Chauret, Natalie, Seto, Carmai, Scheigetz, John, Wesolowski, Greg, Massé, Frederic, Desmarais, Sylvie, Ouellet, Marc
Published in Journal of medicinal chemistry (09.02.2006)
Published in Journal of medicinal chemistry (09.02.2006)
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In vitro biotransformations of the prostaglandin D 2 (DP) antagonist MK-0524 and synthesis of metabolites
Nicoll-Griffith, Deborah A., Seto, Carmai, Aubin, Yves, Lévesque, Jean François, Chauret, Nathalie, Day, Stephen, Silva, José M., Trimble, Laird A., Truchon, Jean-François, Berthelette, Carl, Lachance, Nicolas, Wang, Zhaoyin, Sturino, Claudio, Braun, Matt, Zamboni, Robert, Young, Robert N.
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
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In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites
NICOLL-GRIFFITH, Deborah A, SETO, Carmai, LACHANCE, Nicolas, ZHAOYIN WANG, STURINO, Claudio, BRAUN, Matt, ZAMBONI, Robert, YOUNG, Robert N, AUBIN, Yves, LEVESQUE, Jean Francois, CHAURET, Nathalie, DAY, Stephen, SILVA, José M, TRIMBLE, Laird A, TRUCHON, Jean-Francois, BERTHELETTE, Carl
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
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Detection of Covalent Adducts to Cytochrome P450 3A4 Using Liquid Chromatography Mass Spectrometry
Bateman, Kevin P, Baker, Jennifer, Wilke, Mark, Lee, Justin, LeRiche, Tammy, Seto, Carmai, Day, Stephen, Chauret, Nathalie, Ouellet, Marc, Nicoll-Griffith, Deborah A
Published in Chemical research in toxicology (01.10.2004)
Published in Chemical research in toxicology (01.10.2004)
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Charge-remote fragmentation characteristics of functionalized alkanes in high-energy collision-induced dissociation
Denekamp, Chagit, Van den Heuvel, Hilde, Voinov, Valery G., Claeys, Magda, Seto, Carmai, Grossert, J. Stuart, Waddell, David S., Curtis, Jonathan M., Boyd, Robert K.
Published in Rapid communications in mass spectrometry (01.01.2000)
Published in Rapid communications in mass spectrometry (01.01.2000)
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