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Ozcan, Lale, Kasikara, Canan, Yurdagul, Jr, Arif, Kuriakose, George, Hubbard, Brian, Serrano-Wu, Michael H, Tabas, Ira
Published in PloS one (13.05.2021)
Published in PloS one (13.05.2021)
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Identification of Hepatitis C Virus NS5A Inhibitors
LEMM, Julie A, O'BOYLE, Donald, ROMINE, Jeffrey L, MEANWELL, Nicholas A, MIN GAO, MENGPING LIU, NOWER, Peter T, COLONNO, Richard, DESHPANDE, Milind S, SNYDER, Lawrence B, MARTIN, Scott W, LAURENT, Denis R. St, SERRANO-WU, Michael H
Published in Journal of Virology (01.01.2010)
Published in Journal of Virology (01.01.2010)
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High-Throughput Melanin-Binding Affinity and In Silico Methods to Aid in the Prediction of Drug Exposure in Ocular Tissue
Reilly, John, Williams, Sarah L., Forster, Cornelia J., Kansara, Viral, End, Peter, Serrano-Wu, Michael H.
Published in Journal of pharmaceutical sciences (01.12.2015)
Published in Journal of pharmaceutical sciences (01.12.2015)
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A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1
Clifton, Matthew C, Dranow, David M, Leed, Alison, Fulroth, Ben, Fairman, James W, Abendroth, Jan, Atkins, Kateri A, Wallace, Ellen, Fan, Dazhong, Xu, Guoping, Ni, Z J, Daniels, Doug, Van Drie, John, Wei, Guo, Burgin, Alex B, Golub, Todd R, Hubbard, Brian K, Serrano-Wu, Michael H
Published in PloS one (24.04.2015)
Published in PloS one (24.04.2015)
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Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes
Romine, Jeffrey L, St. Laurent, Denis R, Leet, John E, Martin, Scott W, Serrano-Wu, Michael H, Yang, Fukang, Gao, Min, O’Boyle, Donald R, Lemm, Julie A, Sun, Jin-Hua, Nower, Peter T, Huang, Xiaohua (Stella), Deshpande, Milind S, Meanwell, Nicholas A, Snyder, Lawrence B
Published in ACS medicinal chemistry letters (10.03.2011)
Published in ACS medicinal chemistry letters (10.03.2011)
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Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)
Fang, Chao, D’Souza, Brendan, Thompson, Christopher F, Clifton, Matthew C, Fairman, James W, Fulroth, Ben, Leed, Alison, McCarren, Patrick, Wang, Lili, Wang, Yikai, Feau, Clementine, Kaushik, Virendar K, Palmer, Michelle, Wei, Guo, Golub, Todd R, Hubbard, Brian K, Serrano-Wu, Michael H
Published in ACS medicinal chemistry letters (11.12.2014)
Published in ACS medicinal chemistry letters (11.12.2014)
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Discovery of Potent Hepatitis C Virus NS5A Inhibitors with Dimeric Structures
Lemm, Julie A, Leet, John E, O'Boyle, 2nd, Donald R, Romine, Jeffrey L, Huang, Xiaohua Stella, Schroeder, Daniel R, Alberts, Jeffrey, Cantone, Joseph L, Sun, Jin-Hua, Nower, Peter T, Martin, Scott W, Serrano-Wu, Michael H, Meanwell, Nicholas A, Snyder, Lawrence B, Gao, Min
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
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Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes
Johnson, Eachan O, LaVerriere, Emily, Office, Emma, Stanley, Mary, Meyer, Elisabeth, Kawate, Tomohiko, Gomez, James E, Audette, Rebecca E, Bandyopadhyay, Nirmalya, Betancourt, Natalia, Delano, Kayla, Da Silva, Israel, Davis, Joshua, Gallo, Christina, Gardner, Michelle, Golas, Aaron J, Guinn, Kristine M, Kennedy, Sofia, Korn, Rebecca, McConnell, Jennifer A, Moss, Caitlin E, Murphy, Kenan C, Nietupski, Raymond M, Papavinasasundaram, Kadamba G, Pinkham, Jessica T, Pino, Paula A, Proulx, Megan K, Ruecker, Nadine, Song, Naomi, Thompson, Matthew, Trujillo, Carolina, Wakabayashi, Shoko, Wallach, Joshua B, Watson, Christopher, Ioerger, Thomas R, Lander, Eric S, Hubbard, Brian K, Serrano-Wu, Michael H, Ehrt, Sabine, Fitzgerald, Michael, Rubin, Eric J, Sassetti, Christopher M, Schnappinger, Dirk, Hung, Deborah T
Published in Nature (London) (01.07.2019)
Published in Nature (London) (01.07.2019)
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Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
Meanwell, Nicholas A, Gao, Min, Nettles, Richard E, Belema, Makonen, Snyder, Lawrence B, Nguyen, Van N, Fridell, Robert A, Serrano-Wu, Michael H, Langley, David R, Sun, Jin-Hua, O’Boyle II, Donald R, Lemm, Julie A, Wang, Chunfu, Knipe, Jay O, Chien, Caly, Colonno, Richard J, Grasela, Dennis M, Hamann, Lawrence G
Published in Nature (London) (06.05.2010)
Published in Nature (London) (06.05.2010)
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Chemical Screen for Vancomycin Antagonism Uncovers Probes of the Gram-Negative Outer Membrane
Klobucar, Kristina, Côté, Jean-Philippe, French, Shawn, Borrillo, Louis, Guo, Amelia Bing Ya, Serrano-Wu, Michael H, Lee, Katie K, Hubbard, Brian, Johnson, Jarrod W, Gaulin, Jeffrey L, Magolan, Jakob, Hung, Deborah T, Brown, Eric D
Published in ACS chemical biology (21.05.2021)
Published in ACS chemical biology (21.05.2021)
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Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity
Ozcan, Lale, Xu, Xiaoming, Deng, Shi-Xian, Ghorpade, Devram S, Thomas, Tiffany, Cremers, Serge, Hubbard, Brian, Serrano-Wu, Michael H, Gaestel, Matthias, Landry, Donald W, Tabas, Ira
Published in Diabetes (New York, N.Y.) (01.10.2015)
Published in Diabetes (New York, N.Y.) (01.10.2015)
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Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors
Fang, Chao, Lee, Katie K., Nietupski, Raymond, Bates, Robert H., Fernandez-Menendez, Raquel, Lopez-Roman, Eva Maria, Guijarro-Lopez, Laura, Yin, Yunxing, Peng, Zuozhong, Gomez, James E., Fisher, Stewart, Barros-Aguirre, David, Hubbard, Brian K., Serrano-Wu, Michael H., Hung, Deborah T.
Published in Bioorganic & medicinal chemistry letters (01.12.2018)
Published in Bioorganic & medicinal chemistry letters (01.12.2018)
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Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Triglycerides in Humans
Nakajima, Katsumasa, Chatelain, Ricardo, Clairmont, Kevin B, Commerford, Renee, Coppola, Gary M, Daniels, Thomas, Forster, Cornelia J, Gilmore, Thomas A, Gong, Yongjin, Jain, Monish, Kanter, Aaron, Kwak, Youngshin, Li, Jingzhou, Meyers, Charles D, Neubert, Alan D, Szklennik, Paul, Tedesco, Vivienne, Thompson, James, Truong, David, Yang, Qing, Hubbard, Brian K, Serrano-Wu, Michael H
Published in Journal of medicinal chemistry (08.06.2017)
Published in Journal of medicinal chemistry (08.06.2017)
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Preclinical Development of Pentamidine Analogs Identifies a Potent and Nontoxic Antibiotic Adjuvant
MacNair, Craig R, Farha, Maya A, Serrano-Wu, Michael H, Lee, Katie K, Hubbard, Brian, Côté, Jean-Philippe, Carfrae, Lindsey A, Tu, Megan M, Gaulin, Jeffrey L, Hunt, Diana K, Hung, Deborah T, Brown, Eric D
Published in ACS infectious diseases (08.04.2022)
Published in ACS infectious diseases (08.04.2022)
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Discovery of diamide compounds as diacylglycerol acyltransferase 1 (DGAT1) inhibitors
Nakajima, Katsumasa, April, Myriam, Brewer, Jason T., Daniels, Thomas, Forster, Cornelia J., Gilmore, Thomas A., Jain, Monish, Kanter, Aaron, Kwak, Youngshin, Li, Jingzhou, McQuire, Les, Serrano-Wu, Michael H., Streeper, Ryan, Szklennik, Paul, Thompson, James, Wang, Bing
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
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HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies
Lopez, Omar D, Nguyen, Van N, St. Laurent, Denis R, Belema, Makonen, Serrano-Wu, Michael H, Goodrich, Jason T, Yang, Fukang, Qiu, Yuping, Ripka, Amy S, Nower, Peter T, Valera, Lourdes, Liu, Mengping, O’Boyle, Donald R., II, Sun, Jin-Hua, Fridell, Robert A, Lemm, Julie A, Gao, Min, Good, Andrew C, Meanwell, Nicholas A, Snyder, Lawrence B
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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HCV NS5A replication complex inhibitors. Part 2: Investigation of stilbene prolinamides
St. Laurent, Denis R., Belema, Makonen, Gao, Min, Goodrich, Jason, Kakarla, Ramesh, Knipe, Jay O., Lemm, Julie A., Liu, Mengping, Lopez, Omar D., Nguyen, Van N., Nower, Peter T., O’Boyle, Donald, Qiu, Yuping, Romine, Jeffrey L., Serrano-Wu, Michael H., Sun, Jin-Hua, Valera, Lourdes, Yang, Fukang, Yang, Xuejie, Meanwell, Nicholas A., Snyder, Lawrence B.
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
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HCV NS5A Replication Complex Inhibitors. Part 4. Optimization for Genotype 1a Replicon Inhibitory Activity
St. Laurent, Denis R., Serrano-Wu, Michael H., Belema, Makonen, Ding, Min, Fang, Hua, Gao, Min, Goodrich, Jason T., Krause, Rudolph G., Lemm, Julie A., Liu, Mengping, Lopez, Omar D., Nguyen, Van N., Nower, Peter T., O’Boyle, Donald R., Pearce, Bradley C., Romine, Jeffrey L., Valera, Lourdes, Sun, Jin-Hua, Wang, Ying-Kai, Yang, Fukang, Yang, Xuejie, Meanwell, Nicholas A., Snyder, Lawrence B.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Intestinally Targeted Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors Robustly Suppress Postprandial Triglycerides
Serrano-Wu, Michael H, Coppola, Gary M, Gong, Yongjin, Neubert, Alan D, Chatelain, Ricardo, Clairmont, Kevin B, Commerford, Renee, Cosker, Theresa, Daniels, Thomas, Hou, Ying, Jain, Monish, Juedes, Marlene, Li, Lisha, Mullarkey, Tara, Rocheford, Erik, Sung, Moo Je, Tyler, Andrew, Yang, Qing, Yoon, Taeyoung, Hubbard, Brian K
Published in ACS medicinal chemistry letters (10.05.2012)
Published in ACS medicinal chemistry letters (10.05.2012)
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A new structural alert for benzimidazoles: 2,6-Dimethylphenyl substituents increase mutagenic potential and time-dependent CYP3A4 inhibition risk
Kwak, Youngshin, Coppola, Gary, Forster, Cornelia J., Gilmore, Thomas A., Gong, Yongjin, Kanter, Aaron, Neubert, Alan, Stroup, Bryan, Szklennik, Paul, Glowienke, Susanne, Stadelmann, Pascal, Bell, Leslie, Bickford, Shari, Gangl, Eric, Gunduz, Mithat, Jain, Monish, Zhan, Jenny, Serrano-Wu, Michael H.
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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