CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma
Rioja-Blanco, Elisa, Arroyo-Solera, Irene, Álamo, Patricia, Casanova, Isolda, Gallardo, Alberto, Unzueta, Ugutz, Serna, Naroa, Sánchez-García, Laura, Quer, Miquel, Villaverde, Antonio, Vázquez, Esther, León, Xavier, Alba-Castellón, Lorena, Mangues, Ramon
Published in Journal of experimental & clinical cancer research (04.02.2022)
Published in Journal of experimental & clinical cancer research (04.02.2022)
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Journal Article
GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases
Sala, Rita, Rioja-Blanco, Elisa, Serna, Naroa, Sánchez-García, Laura, Álamo, Patricia, Alba-Castellón, Lorena, Casanova, Isolda, López-Pousa, Antonio, Unzueta, Ugutz, Céspedes, María Virtudes, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon
Published in Drug delivery (01.12.2022)
Published in Drug delivery (01.12.2022)
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Journal Article
Bioengineered PBGD variant improves the therapeutic index of gene therapy vectors for acute intermittent porphyria
Serrano-Mendioroz, Irantzu, Sampedro, Ana, Serna, Naroa, de Salamanca, Rafael Enríquez, Sanz-Parra, Arantza, Corrales, Fernando, Berraondo, Pedro, Millet, Oscar, Fontanellas, Antonio
Published in Human molecular genetics (01.11.2018)
Published in Human molecular genetics (01.11.2018)
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Journal Article
Lymphocyte infiltration and antitumoral effect promoted by cytotoxic inflammatory proteins formulated as self-assembling, protein-only nanoparticles
Martínez-Torró, Carlos, Alba-Castellón, Lorena, Carrasco-Díaz, Luis Miguel, Serna, Naroa, Imedio, Laura, Gallardo, Alberto, Casanova, Isolda, Unzueta, Ugutz, Vázquez, Esther, Mangues, Ramón, Villaverde, Antonio
Published in Biomedicine & pharmacotherapy (01.08.2023)
Published in Biomedicine & pharmacotherapy (01.08.2023)
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Journal Article
An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination
Pallarès, Victor, Unzueta, Ugutz, Falgàs, Aïda, Sánchez-García, Laura, Serna, Naroa, Gallardo, Alberto, Morris, Gordon A, Alba-Castellón, Lorena, Álamo, Patricia, Sierra, Jorge, Villaverde, Antonio, Vázquez, Esther, Casanova, Isolda, Mangues, Ramon
Published in Journal of hematology and oncology (15.04.2020)
Published in Journal of hematology and oncology (15.04.2020)
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Journal Article
An In Silico Methodology That Facilitates Decision Making in the Engineering of Nanoscale Protein Materials
Parladé, Eloi, Voltà-Durán, Eric, Cano-Garrido, Olivia, Sánchez, Julieta M, Unzueta, Ugutz, López-Laguna, Hèctor, Serna, Naroa, Cano, Montserrat, Rodríguez-Mariscal, Manuel, Vazquez, Esther, Villaverde, Antonio
Published in International journal of molecular sciences (29.04.2022)
Published in International journal of molecular sciences (29.04.2022)
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Journal Article
A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4+ lymphoma cells without toxicity in immunocompromised and immunocompetent mice
Falgàs, Aïda, Garcia-León, Annabel, Núñez, Yáiza, Serna, Naroa, Sánchez-Garcia, Laura, Unzueta, Ugutz, Voltà-Durán, Eric, Aragó, Marc, Álamo, Patricia, Alba-Castellón, Lorena, Sierra, Jorge, Gallardo, Alberto, Villaverde, Antonio, Vázquez, Esther, Mangues, Ramon, Casanova, Isolda
Published in Biomedicine & pharmacotherapy (01.06.2022)
Published in Biomedicine & pharmacotherapy (01.06.2022)
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Journal Article
Artificial Inclusion Bodies for Clinical Development
Sánchez, Julieta M., López‐Laguna, Hèctor, Álamo, Patricia, Serna, Naroa, Sánchez‐Chardi, Alejandro, Nolan, Verónica, Cano‐Garrido, Olivia, Casanova, Isolda, Unzueta, Ugutz, Vazquez, Esther, Mangues, Ramon, Villaverde, Antonio
Published in Advanced science (01.02.2020)
Published in Advanced science (01.02.2020)
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Journal Article
The Diphtheria Toxin Translocation Domain Impairs Receptor Selectivity in Cancer Cell-Targeted Protein Nanoparticles
Voltà-Durán, Eric, Sánchez, Julieta M, Parladé, Eloi, Serna, Naroa, Vazquez, Esther, Unzueta, Ugutz, Villaverde, Antonio
Published in Pharmaceutics (29.11.2022)
Published in Pharmaceutics (29.11.2022)
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Journal Article
Time-Prolonged Release of Tumor-Targeted Protein-MMAE Nanoconjugates from Implantable Hybrid Materials
Serna, Naroa, Falgàs, Aïda, García-León, Annabel, Unzueta, Ugutz, Núñez, Yáiza, Sánchez-Chardi, Alejandro, Martínez-Torró, Carlos, Mangues, Ramón, Vazquez, Esther, Casanova, Isolda, Villaverde, Antonio
Published in Pharmaceutics (14.01.2022)
Published in Pharmaceutics (14.01.2022)
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Journal Article
Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4+ head and neck squamous cell carcinoma tumors
Rioja-Blanco, Elisa, Arroyo-Solera, Irene, Álamo, Patricia, Casanova, Isolda, Gallardo, Alberto, Unzueta, Ugutz, Serna, Naroa, Sánchez-García, Laura, Quer, Miquel, Villaverde, Antonio, Vázquez, Esther, Mangues, Ramon, Alba-Castellón, Lorena, León, Xavier
Published in Acta pharmaceutica Sinica. B (01.05.2022)
Published in Acta pharmaceutica Sinica. B (01.05.2022)
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Journal Article
T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo
Núñez, Yáiza, Garcia-León, Annabel, Falgàs, Aïda, Serna, Naroa, Sánchez-García, Laura, Garrido, Ana, Sierra, Jorge, Gallardo, Alberto, Unzueta, Ugutz, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon, Casanova, Isolda
Published in Pharmaceutics (22.02.2023)
Published in Pharmaceutics (22.02.2023)
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Journal Article
Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles
Álamo, Patricia, Pallarès, Victor, Céspedes, María Virtudes, Falgàs, Aïda, Sanchez, Julieta M., Serna, Naroa, Sánchez-García, Laura, Voltà-Duràn, Eric, Morris, Gordon A., Sánchez-Chardi, Alejandro, Casanova, Isolda, Mangues, Ramón, Vazquez, Esther, Villaverde, Antonio, Unzueta, Ugutz
Published in Pharmaceutics (22.10.2020)
Published in Pharmaceutics (22.10.2020)
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Journal Article
The Poly-Histidine Tag H6 Mediates Structural and Functional Properties of Disintegrating, Protein-Releasing Inclusion Bodies
Sánchez, Julieta María, Carratalá, José Vicente, Serna, Naroa, Unzueta, Ugutz, Nolan, Verónica, Sánchez-Chardi, Alejandro, Voltà-Durán, Eric, López-Laguna, Hèctor, Ferrer-Miralles, Neus, Villaverde, Antonio, Vazquez, Esther
Published in Pharmaceutics (10.03.2022)
Published in Pharmaceutics (10.03.2022)
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Journal Article
Antibacterial Activity of T22, a Specific Peptidic Ligand of the Tumoral Marker CXCR4
Serna, Naroa, Carratalá, José Vicente, Conchillo-Solé, Oscar, Martínez-Torró, Carlos, Unzueta, Ugutz, Mangues, Ramón, Ferrer-Miralles, Neus, Daura, Xavier, Vázquez, Esther, Villaverde, Antonio
Published in Pharmaceutics (13.11.2021)
Published in Pharmaceutics (13.11.2021)
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Journal Article
Efficient Delivery of Antimicrobial Peptides in an Innovative, Slow-Release Pharmacological Formulation
Serna, Naroa, López-Laguna, Hèctor, Aceituno, Patricia, Rojas-Peña, Mauricio, Parladé, Eloi, Voltà-Durán, Eric, Martínez-Torró, Carlos, Sánchez, Julieta M, Di Somma, Angela, Carratalá, Jose Vicente, Livieri, Andrea L, Ferrer-Miralles, Neus, Vázquez, Esther, Unzueta, Ugutz, Roher, Nerea, Villaverde, Antonio
Published in Pharmaceutics (01.11.2023)
Published in Pharmaceutics (01.11.2023)
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Journal Article
A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model
Rioja-Blanco, Elisa, Gallardo, Alberto, Arroyo-Solera, Irene, Álamo, Patricia, Casanova, Isolda, Unzueta, Ugutz, Serna, Naroa, Sánchez-García, Laura, Quer, Miquel, Villaverde, Antonio, Vázquez, Esther, León, Xavier, Alba-Castellón, Lorena, Mangues, Ramon
Published in Pharmaceutics (18.04.2022)
Published in Pharmaceutics (18.04.2022)
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Journal Article
In Vivo Bactericidal Efficacy of GWH1 Antimicrobial Peptide Displayed on Protein Nanoparticles, a Potential Alternative to Antibiotics
Carratalá, Jose V, Brouillette, Eric, Serna, Naroa, Sánchez-Chardi, Alejandro, Sánchez, Julieta M, Villaverde, Antonio, Arís, Anna, Garcia-Fruitós, Elena, Ferrer-Miralles, Neus, Malouin, François
Published in Pharmaceutics (17.12.2020)
Published in Pharmaceutics (17.12.2020)
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Journal Article
Nanostructured antimicrobial peptides: The last push towards clinics
Carratalá, Jose Vicente, Serna, Naroa, Villaverde, Antonio, Vázquez, Esther, Ferrer-Miralles, Neus
Published in Biotechnology advances (15.11.2020)
Published in Biotechnology advances (15.11.2020)
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Journal Article
Protein-Based Therapeutic Killing for Cancer Therapies
Serna, Naroa, Sánchez-García, Laura, Unzueta, Ugutz, Díaz, Raquel, Vázquez, Esther, Mangues, Ramón, Villaverde, Antonio
Published in Trends in biotechnology (Regular ed.) (01.03.2018)
Published in Trends in biotechnology (Regular ed.) (01.03.2018)
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Journal Article