Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface
Lewis, Steven M, Wu, Xiufeng, Pustilnik, Anna, Sereno, Arlene, Huang, Flora, Rick, Heather L, Guntas, Gurkan, Leaver-Fay, Andrew, Smith, Eric M, Ho, Carolyn, Hansen-Estruch, Christophe, Chamberlain, Aaron K, Truhlar, Stephanie M, Conner, Elaine M, Atwell, Shane, Kuhlman, Brian, Demarest, Stephen J
Published in Nature biotechnology (01.02.2014)
Published in Nature biotechnology (01.02.2014)
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Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics
Froning, Karen, Maguire, Jack, Sereno, Arlene, Huang, Flora, Chang, Shawn, Weichert, Kenneth, Frommelt, Anton J, Dong, Jessica, Wu, Xiufeng, Austin, Heather, Conner, Elaine M, Fitchett, Jonathan R, Heng, Aik Roy, Balasubramaniam, Deepa, Hilgers, Mark T, Kuhlman, Brian, Demarest, Stephen J
Published in Nature communications (11.05.2020)
Published in Nature communications (11.05.2020)
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Generalizable design parameters for soluble T cell receptor-based T cell engagers
Froning, Karen J, Sereno, Arlene, Huang, Flora, Demarest, Stephen J
Published in Journal for immunotherapy of cancer (01.03.2022)
Published in Journal for immunotherapy of cancer (01.03.2022)
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Journal Article
Fab-based bispecific antibody formats with robust biophysical properties and biological activity
Wu, Xiufeng, Sereno, Arlene J, Huang, Flora, Lewis, Steven M, Lieu, Ricky L, Weldon, Caroline, Torres, Carina, Fine, Cody, Batt, Micheal A, Fitchett, Jonathan R, Glasebrook, Andrew L, Kuhlman, Brian, Demarest, Stephen J
Published in mAbs (04.05.2015)
Published in mAbs (04.05.2015)
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Dichotomous impact of affinity on the function of T cell engaging bispecific antibodies
Poussin, Mathilde, Sereno, Arlene, Wu, Xiufeng, Huang, Flora, Manro, Jason, Cao, Shanshan, Carpenito, Carmine, Glasebrook, Andrew, Powell Jr, Daniel J, Demarest, Stephen
Published in Journal for immunotherapy of cancer (01.07.2021)
Published in Journal for immunotherapy of cancer (01.07.2021)
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Protein design of IgG/TCR chimeras for the co-expression of Fab-like moieties within bispecific antibodies
Wu, Xiufeng, Sereno, Arlene J, Huang, Flora, Zhang, Kai, Batt, Micheal, Fitchett, Jonathan R, He, Dongmei, Rick, Heather L, Conner, Elaine M, Demarest, Stephen J
Published in mAbs (04.03.2015)
Published in mAbs (04.03.2015)
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Combination of two insulin-like growth factor-I receptor inhibitory antibodies targeting distinct epitopes leads to an enhanced antitumor response
Dong, Jianying, Demarest, Stephen J, Sereno, Arlene, Tamraz, Susan, Langley, Emma, Doern, Adam, Snipas, Tracey, Perron, Keli, Joseph, Ingrid, Glaser, Scott M, Ho, Steffan N, Reff, Mitchell E, Hariharan, Kandasamy
Published in Molecular cancer therapeutics (01.09.2010)
Published in Molecular cancer therapeutics (01.09.2010)
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Stable IgG-like Bispecific Antibodies Directed toward the Type I Insulin-like Growth Factor Receptor Demonstrate Enhanced Ligand Blockade and Anti-tumor Activity
Dong, Jianying, Sereno, Arlene, Snyder, William B., Miller, Brian R., Tamraz, Susan, Doern, Adam, Favis, Michael, Wu, Xiufeng, Tran, Hon, Langley, Emma, Joseph, Ingrid, Boccia, Antonio, Kelly, Rebecca, Wortham, Kathleen, Wang, Qin, Berquist, Lisa, Huang, Flora, Gao, Sharon X., Zhang, Ying, Lugovskoy, Alexey, Martin, Shelly, Gouvis, Heather, Berkowitz, Steven, Chiang, Gisela, Reff, Mitchell, Glaser, Scott M., Hariharan, Kandasamy, Demarest, Stephen J.
Published in The Journal of biological chemistry (11.02.2011)
Published in The Journal of biological chemistry (11.02.2011)
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A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity
Dong, Jianying, Sereno, Arlene, Aivazian, Dikran, Langley, Emma, Miller, Brian R., Snyder, William B, Chan, Eric, Cantele, Matt, Morena, Ronald, Joseph, Ingrid B.J.K., Boccia, Antonio, Virata, Cyrus, Gamez, James, Yco, Grace, Favis, Michael, Wu, Xiufeng, Graff, Christilyn P., Wang, Qin, Rohde, Ellen, Rennard, Rachel, Berquist, Lisa, Huang, Flora, Zhang, Ying, Gao, Sharon X., Ho, Steffan N., Demarest, Stephen J., Reff, Mitchell E., Hariharan, Kandasamy, Glaser, Scott M.
Published in mAbs (01.05.2011)
Published in mAbs (01.05.2011)
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Characterization of Inhibitory Anti-insulin-like Growth Factor Receptor Antibodies with Different Epitope Specificity and Ligand-blocking Properties
Doern, Adam, Cao, Xianjun, Sereno, Arlene, Reyes, Christopher L., Altshuler, Angelina, Huang, Flora, Hession, Cathy, Flavier, Albert, Favis, Michael, Tran, Hon, Ailor, Eric, Levesque, Melissa, Murphy, Tracey, Berquist, Lisa, Tamraz, Susan, Snipas, Tracey, Garber, Ellen, Shestowsky, William S., Rennard, Rachel, Graff, Christilyn P., Wu, Xiufeng, Snyder, William, Cole, Lindsay, Gregson, David, Shields, Michael, Ho, Steffan N., Reff, Mitchell E., Glaser, Scott M., Dong, Jianying, Demarest, Stephen J., Hariharan, Kandasamy
Published in The Journal of biological chemistry (10.04.2009)
Published in The Journal of biological chemistry (10.04.2009)
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Abstract 2956: TNRX-257, a novel multifunctional biologic effectively blocks LAG3 and conditionally delivers IL2Rg/b agonism to LAG3+ cells for robust anti-tumor immunity
Sharma, Rajesh K., Dong, Jianying, Cid, Natasha Del, Ghorbanian, Yasamine, Carnevale, Christina, Buetz, Christen, Lundberg, Matthew, Capodagli, Glenn, Hannah, Jayd, Hong, Gavin, Walters, Pricilla, Sereno, Arlene, Chai, Falene, Lin, Abby, Furney, James, Zhang, Wendy, Pigott, Craig, Kang, Paul, Gallo, Michael, Karow, Margaret, Demarest, Stephen
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Glu-96 of Basic Fibroblast Growth Factor Is Essential for High Affinity Receptor Binding
Zhu, Hengyi, Ramnarayan, K., Anchin, Jerry, Miao, Wendy Y., Sereno, Arlene, Millman, Linda, Zheng, Jinhua, Balaji, V.N., Wolff, Manfred E.
Published in The Journal of biological chemistry (15.09.1995)
Published in The Journal of biological chemistry (15.09.1995)
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Journal Article
Characterization of Inhibitory Anti-insulin-like Growth Factor Receptor Antibodies with Different Epitope Specificity and Ligand-blocking Properties: IMPLICATIONS FOR MECHANISM OF ACTION IN VIVO
Doern, Adam, Cao, Xianjun, Sereno, Arlene, Reyes, Christopher L, Altshuler, Angelina, Huang, Flora, Hession, Cathy, Flavier, Albert, Favis, Michael, Tran, Hon, Ailor, Eric, Levesque, Melissa, Murphy, Tracey, Berquist, Lisa, Tamraz, Susan, Snipas, Tracey, Garber, Ellen, Shestowsky, William S, Rennard, Rachel, Graff, Christilyn P, Wu, Xiufeng, Snyder, William, Cole, Lindsay, Gregson, David, Shields, Michael, Ho, Steffan N, Reff, Mitchell E, Glaser, Scott M, Dong, Jianying, Demarest, Stephen J, Hariharan, Kandasamy
Published in The Journal of biological chemistry (10.04.2009)
Published in The Journal of biological chemistry (10.04.2009)
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Journal Article
Glu-96 of basic fibroblast growth factor is essential for high affinity receptor binding. Identification by structure-based site-directed mutagenesis
Zhu, H, Ramnarayan, K, Anchin, J, Miao, W Y, Sereno, A, Millman, L, Zheng, J, Balaji, V N, Wolff, M E
Published in The Journal of biological chemistry (15.09.1995)
Published in The Journal of biological chemistry (15.09.1995)
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