Search Results - "Serafini, María-Teresa" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

4‑Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual μ‑Opioid Receptor Agonists and σ1 Receptor Antagonists for the Treatment of Pain

4‑Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual μ‑Opioid Receptor Agonists and σ1 Receptor Antagonists for the Treatment of Pain

by García, Mónica, Virgili, Marina, Alonso, Mònica, Alegret, Carles, Fernández, Begoña, Port, Adriana, Pascual, Rosalía, Monroy, Xavier, Vidal-Torres, Alba, Serafini, María-Teresa, Vela, José Miguel, Almansa, Carmen
Published in Journal of medicinal chemistry (12.03.2020)

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Journal Article

Preliminary in Vitro Assessment of the Potential of EST64454, a Sigma-1 Receptor Antagonist, for Pharmacokinetic Drug–Drug Interactions

Preliminary in Vitro Assessment of the Potential of EST64454, a Sigma-1 Receptor Antagonist, for Pharmacokinetic Drug–Drug Interactions

by Yeste, Sandra, Reinoso, Raquel F., Ayet, Eva, Pretel, Maria José, Balada, Ariadna, Serafini, Maria Teresa
Published in Biological & pharmaceutical bulletin (01.01.2020)

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Journal Article

Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of sigma(1) Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)

Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of sigma(1) Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)

by Luis Diaz, Jose, Cuberes, Rosa, Berrocal, Joana, Contijoch, Montserrat, Christmann, Ute, Fernandez, Ariadna, Port, Adriana, Holenz, Jorg, Buschmann, Helmut, Laggner, Christian, Teresa Serafini, Maria, Burgueno, Javier, Zamanillo, Daniel, Merlos, Manuel, Miguel Vela, Jose, Almansa, Carmen
Published in Journal of medicinal chemistry (11.10.2012)

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Journal Article

Synthesis and Biological Evaluation of the 1‑Arylpyrazole Class of σ1 Receptor Antagonists: Identification of 4‑{2-[5-Methyl-1-(naphthalen-2-yl)‑1H‑pyrazol-3-yloxy]ethyl}morpholine (S1RA, E‑52862)

Synthesis and Biological Evaluation of the 1‑Arylpyrazole Class of σ1 Receptor Antagonists: Identification of 4‑{2-[5-Methyl-1-(naphthalen-2-yl)‑1H‑pyrazol-3-yloxy]ethyl}morpholine (S1RA, E‑52862)

by Díaz, José Luis, Cuberes, Rosa, Berrocal, Joana, Contijoch, Montserrat, Christmann, Ute, Fernández, Ariadna, Port, Adriana, Holenz, Jörg, Buschmann, Helmut, Laggner, Christian, Serafini, Maria Teresa, Burgueño, Javier, Zamanillo, Daniel, Merlos, Manuel, Vela, José Miguel, Almansa, Carmen
Published in Journal of medicinal chemistry (11.10.2012)

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Journal Article

Comparative In vitro Metabolism of Enflicoxib in Dogs, Rats, and Humans: Main Metabolites and Proposed Metabolic Pathways

Comparative In vitro Metabolism of Enflicoxib in Dogs, Rats, and Humans: Main Metabolites and Proposed Metabolic Pathways

by Solà, Josep, Menargues, Àngel, Homedes, Josep, Salichs, Marta, Serafini, Maria Teresa, Encina, Gregorio
Published in Drug metabolism letters (2021)

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Journal Article

Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids

by Vidal-Torres, Alba, Fernández-Pastor, Begoña, García, Mónica, Ayet, Eva, Cabot, Anna, Burgueño, Javier, Monroy, Xavier, Aubel, Bertrand, Codony, Xavier, Romero, Luz, Pascual, Rosalía, Serafini, Maria Teresa, Encina, Gregorio, Almansa, Carmen, Zamanillo, Daniel, Merlos, Manuel, Vela, José Miguel
Published in Acta pharmaceutica Sinica. B (01.01.2023)

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Journal Article

4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual μ-Opioid Receptor Agonists and σ 1 Receptor Antagonists for the Treatment of Pain

4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual μ-Opioid Receptor Agonists and σ 1 Receptor Antagonists for the Treatment of Pain

by García, Mónica, Virgili, Marina, Alonso, Mònica, Alegret, Carles, Fernández, Begoña, Port, Adriana, Pascual, Rosalía, Monroy, Xavier, Vidal-Torres, Alba, Serafini, María-Teresa, Vela, José Miguel, Almansa, Carmen
Published in Journal of medicinal chemistry (12.03.2020)

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Journal Article

4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual mu-Opioid Receptor Agonists and sigma(1) Receptor Antagonists for the Treatment of Pain

4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual mu-Opioid Receptor Agonists and sigma(1) Receptor Antagonists for the Treatment of Pain

by Garcia, Monica, Virgili, Marina, Alonso, Monica, Alegret, Caries, Fernandez, Begona, Port, Adriana, Pascual, Rosalia, Monroy, Xavier, Vidal-Torres, Alba, Serafini, Maria-Teresa, Miguel Vela, Jose, Almansa, Carmen
Published in Journal of medicinal chemistry (12.03.2020)

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Journal Article

Preliminary in vitro approach to evaluate the drug-drug interaction potential of EST73502, a dual µ-opioid receptor partial agonist and σ1 receptor antagonist

Preliminary in vitro approach to evaluate the drug-drug interaction potential of EST73502, a dual µ-opioid receptor partial agonist and σ1 receptor antagonist

by Ayet, Eva, Yeste, Sandra, Reinoso, Raquel F., Pretel, María José, Balada, Ariadna, Serafini, Maria Teresa
Published in Xenobiotica (04.05.2021)

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Journal Article

Preliminary in vitro assessment of pharmacokinetic drug-drug interactions of EST64401 and EST64514, two sigma-1 receptor antagonists

Preliminary in vitro assessment of pharmacokinetic drug-drug interactions of EST64401 and EST64514, two sigma-1 receptor antagonists

by Reinoso, Raquel F., Yeste, Sandra, Ayet, Eva, Pretel, María José, Balada, Ariadna, Serafini, Maria Teresa
Published in Xenobiotica (03.04.2021)

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Journal Article

Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of σ 1 Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1 H -pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)

Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of σ 1 Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1 H -pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)

by Díaz, José Luis, Cuberes, Rosa, Berrocal, Joana, Contijoch, Montserrat, Christmann, Ute, Fernández, Ariadna, Port, Adriana, Holenz, Jörg, Buschmann, Helmut, Laggner, Christian, Serafini, Maria Teresa, Burgueño, Javier, Zamanillo, Daniel, Merlos, Manuel, Vela, José Miguel, Almansa, Carmen
Published in Journal of medicinal chemistry (11.10.2012)

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Journal Article

A Medicinal-Chemistry-Guided Approach to Selective and Druglike Sigma 1 Ligands

A Medicinal-Chemistry-Guided Approach to Selective and Druglike Sigma 1 Ligands

by Corbera, Jordi, Vaño, David, Martínez, Daniel, Vela, José M., Zamanillo, Daniel, Dordal, Alberto, Andreu, Francesc, Hernandez, Enric, Perez, Raquel, Escriche, Marisol, Salgado, Leonardo, Yeste, Sandra, Serafini, Maria Teresa, Pascual, Rosalia, Alegre, Júlia, Calvet, Maria Carme, Cano, Núria, Carro, Mónica, Buschmann, Helmut, Holenz, Jörg
Published in ChemMedChem (01.01.2006)

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Journal Article

A preliminary study of the metabolic stability of a series of benzoxazinone derivatives as potent neuropeptide Y5 antagonists: G-protein-coupled receptors in drug discovery

A preliminary study of the metabolic stability of a series of benzoxazinone derivatives as potent neuropeptide Y5 antagonists: G-protein-coupled receptors in drug discovery

by DORDAL, Alberto, LIPKIN, Mike, SPEARING, William, TORRENS, Antoni, YESTE, Sandra, MACRITCHIE, Jackie, MAS, Josep, PORT, Adriana, ROSE, Sally, SALGADO, Leonardo, SAVIC, Vladimir, SCHMIDT, Wolfgang, SERAFINI, Maria Teresa
Published in Bioorganic & medicinal chemistry letters (2005)

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Journal Article

A preliminary study of the metabolic stability of a series of benzoxazinone derivatives as potent neuropeptide Y5 antagonists

A preliminary study of the metabolic stability of a series of benzoxazinone derivatives as potent neuropeptide Y5 antagonists

by Dordal, Alberto, Lipkin, Mike, Macritchie, Jackie, Mas, Josep, Port, Adriana, Rose, Sally, Salgado, Leonardo, Savic, Vladimir, Schmidt, Wolfgang, Serafini, Maria Teresa, Spearing, William, Torrens, Antoni, Yeste, Sandra
Published in Bioorganic & medicinal chemistry letters (15.08.2005)

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Journal Article

Piperidine compounds having multimodal activity against pain

Piperidine compounds having multimodal activity against pain

by ALMANSA-ROSALES Carmen, CUEVAS-CORDOBÉS Félix, AYET GALCERA Eva Maria, SERAFINI CABANES María Teresa, GARCIA LOPEZ Monica
Year of Publication 05.01.2017

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Patent

PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN

PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN

by GARCIA LOPEZ, Monica, ALMANSA-ROSALES, Carmen, CUEVAS CORDOBES, Felix, SERAFINI CABANES, Maria Teresa, AYET GALCERA, Eva Maria
Year of Publication 27.05.2020

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Patent

Piperidine compounds having multimodal activity against pain

Piperidine compounds having multimodal activity against pain

by Almansa-Rosales Carmen, Serafini Cabanes Maria Teresa, Cuevas-Cordobés Félix, Garcia Lopez Monica, Ayet Galcera Eva Maria
Year of Publication 27.02.2018

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Patent

PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN

PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN

by GARCIA LOPEZ, Monica, ALMANSA-ROSALES, Carmen, CUEVAS CORDOBES, Felix, SERAFINI CABANES, Maria Teresa, AYET GALCERA, Eva Maria
Year of Publication 26.10.2016

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Patent

PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN

PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN

by AYET GALCERA, EVA MARIA, CUEVAS CORDOBES, FELIX, SERAFINI CABANES, MARIA TERESA, ALMANSA-ROSALES, CARMEN, GARCIA LOPEZ, MONICA
Year of Publication 25.06.2015

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Patent

PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN

PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN

by AYET GALCERA, EVA MARIA, CUEVAS CORDOBES, FELIX, SERAFINI CABANES, MARIA TERESA, ALMANSA-ROSALES, CARMEN, GARCIA LOPEZ, MONICA
Year of Publication 25.06.2015

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Patent