The Role of Efflux and Uptake Transporters in N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, Lapatinib) Disposition and Drug Interactions
POLLI, Joseph W, HUMPHREYS, Joan E, HARMON, Kelly A, CASTELLINO, Stephen, O'MARA, Michael J, OLSON, Katie L, JOHN-WILLIAMS, Lisa St, KOCH, Kevin M, SERABJIT-SINGH, Cosette J
Published in Drug metabolism and disposition (01.04.2008)
Published in Drug metabolism and disposition (01.04.2008)
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P‐glycoprotein Influences the Brain Concentrations of Cetirizine (Zyrtec®), a Second‐Generation Non‐Sedating Antihistamine
Polli, Joseph W., Baughman, Todd M., Humphreys, Joan E., Jordan, Kelly H., Mote, Angela L., Salisbury, Jo A., Tippin, Timothy K., Serabjit‐Singh, Cosette J.
Published in Journal of pharmaceutical sciences (01.10.2003)
Published in Journal of pharmaceutical sciences (01.10.2003)
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IN VITRO P-GLYCOPROTEIN INHIBITION ASSAYS FOR ASSESSMENT OF CLINICAL DRUG INTERACTION POTENTIAL OF NEW DRUG CANDIDATES: A RECOMMENDATION FOR PROBE SUBSTRATES
Rautio, Jarkko, Humphreys, Joan E, Webster, Lindsey O, Balakrishnan, Anand, Keogh, John P, Kunta, Jeevan R, Serabjit-Singh, Cosette J, Polli, Joseph W
Published in Drug metabolism and disposition (01.05.2006)
Published in Drug metabolism and disposition (01.05.2006)
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Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs
Mahar Doan, Kelly M, Humphreys, Joan E, Webster, Lindsey O, Wring, Stephen A, Shampine, Larry J, Serabjit-Singh, Cosette J, Adkison, Kimberly K, Polli, Joseph W
Published in The Journal of pharmacology and experimental therapeutics (01.12.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2002)
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In Vitro absorption and secretory quotients: Practical criteria derived from a study of 331 compounds to assess for the impact of P-glycoprotein-mediated efflux on drug candidates
Thiel-Demby, Victoria E., Tippin, Timothy K., Humphreys, Joan E., Serabjit-Singh, Cosette J., Polli, Joseph W.
Published in Journal of pharmaceutical sciences (01.10.2004)
Published in Journal of pharmaceutical sciences (01.10.2004)
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THE SYSTEMIC EXPOSURE OF AN N-METHYL-d-ASPARTATE RECEPTOR ANTAGONIST IS LIMITED IN MICE BY THE P-GLYCOPROTEIN AND BREAST CANCER RESISTANCE PROTEIN EFFLUX TRANSPORTERS
POLLI, Joseph W, BAUGHMAN, Todd M, SERABJIT-SINGH, Cosette J, HUMPHREYS, Joan E, JORDAN, Kelly H, MOTE, Angela L, WEBSTER, Lindsey O, BARNABY, Robert J, VITULLI, Giovanni, BERTOLOTTI, Luigina, READ, Kevin D
Published in Drug metabolism and disposition (01.07.2004)
Published in Drug metabolism and disposition (01.07.2004)
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St. John's Wort Induces Hepatic Drug Metabolism through Activation of the Pregnane X Receptor
Moore, Linda B., Goodwin, Bryan, Jones, Stacey A., Wisely, G. Bruce, Serabjit-Singh, Cosette J., Willson, Timothy M., Collins, Jon L., Kliewer, Steven A.
Published in Proceedings of the National Academy of Sciences - PNAS (20.06.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (20.06.2000)
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Steady-State Brain Concentrations of Antihistamines in Rats
Doan, Kelly Mahar, Wring, Stephen A., Shampine, Larry J., Jordan, Kelly H., Bishop, James P., Kratz, John, Yang, Eric, Serabjit-Singh, Cosette J., Adkison, Kimberly K., Polli, Joseph W.
Published in Pharmacology (01.10.2004)
Published in Pharmacology (01.10.2004)
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Steady-state brain concentrations of antihistamines in rats: interplay of membrane permeability, P-glycoprotein efflux and plasma protein binding
Mahar Doan, Kelly M, Wring, Stephen A, Shampine, Larry J, Jordan, Kelly H, Bishop, James P, Kratz, John, Yang, Eric, Serabjit-Singh, Cosette J, Adkison, Kimberly K, Polli, Joseph W
Published in Pharmacology (01.10.2004)
Published in Pharmacology (01.10.2004)
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Identification of cytochrome P-450 isozymes in nonciliated bronchiolar epithelial (Clara) and alveolar type II cells isolated from rabbit lung
Devereux, T R, Serabjit-Singh, C J, Slaughter, S R, Wolf, C R, Philpot, R M, Fouts, J R
Published in Experimental lung research (1981)
Published in Experimental lung research (1981)
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CYP3A4 Expressed by Insect Cells Infected with a Recombinant Baculovirus Containing Both CYP3A4 and Human NADPH-Cytochrome P450 Reductase Is Catalytically Similar to Human Liver Microsomal CYP3A4
Lee, C.A., Kadwell, S.H., Kost, T.A., Serabjitsingh, C.J.
Published in Archives of biochemistry and biophysics (10.05.1995)
Published in Archives of biochemistry and biophysics (10.05.1995)
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The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions
Polli, Joseph W, Humphreys, Joan E, Harmon, Kelly A, Castellino, Stephen, O'Mara, Michael J, Olson, Katie L, John-Williams, Lisa St, Koch, Kevin M, Serabjit-Singh, Cosette J
Published in Drug metabolism and disposition (01.04.2008)
Published in Drug metabolism and disposition (01.04.2008)
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Quantitation of rabbit cytochrome P-450, form 2, in microsomal preparations bound directly to nitrocellulose paper using a modified peroxidase-immunostaining procedure
Domin, Barbara A., Serabjit-Singh, Cosette J., Philpot, Richard M.
Published in Analytical biochemistry (01.02.1984)
Published in Analytical biochemistry (01.02.1984)
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Cytochrome P-450: Localization in Rabbit Lung
Serabjit-Singh, Cosette J., Wolf, C. Roland, Philpot, Richard M., Plopper, Charles G.
Published in Science (American Association for the Advancement of Science) (28.03.1980)
Published in Science (American Association for the Advancement of Science) (28.03.1980)
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Applications of molecular biology and in vitro technology to drug metabolism studies: an industrial perspective
Tarbit, M H, Bayliss, M K, Herriott, D, Hood, S R, Hutson, J L, Park, G R, Serabjit-Singh, C J
Published in Biochemical Society transactions (01.11.1993)
Published in Biochemical Society transactions (01.11.1993)
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