Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules
Hamulakova, Slavka, Poprac, Patrik, Jomova, Klaudia, Brezova, Vlasta, Lauro, Peter, Drostinova, Lenka, Jun, Daniel, Sepsova, Vendula, Hrabinova, Martina, Soukup, Ondrej, Kristian, Pavol, Gazova, Zuzana, Bednarikova, Zuzana, Kuca, Kamil, Valko, Marian
Published in Journal of inorganic biochemistry (01.08.2016)
Published in Journal of inorganic biochemistry (01.08.2016)
Get full text
Journal Article
A resurrection of 7-MEOTA: a comparison with tacrine
Soukup, Ondrej, Jun, Daniel, Zdarova-Karasova, Jana, Patocka, Jiri, Musilek, Kamil, Korabecny, Jan, Krusek, Jan, Kaniakova, Martina, Sepsova, Vendula, Mandikova, Jana, Trejtnar, Frantisek, Pohanka, Miroslav, Drtinova, Lucie, Pavlik, Michal, Tobin, Gunnar, Kuca, Kamil
Published in Current Alzheimer research (01.10.2013)
Published in Current Alzheimer research (01.10.2013)
Get more information
Journal Article
7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment
Korabecny, Jan, Andrs, Martin, Nepovimova, Eugenie, Dolezal, Rafael, Babkova, Katerina, Horova, Anna, Malinak, David, Mezeiova, Eva, Gorecki, Lukas, Sepsova, Vendula, Hrabinova, Martina, Soukup, Ondrej, Jun, Daniel, Kuca, Kamil
Published in Molecules (Basel, Switzerland) (10.12.2015)
Published in Molecules (Basel, Switzerland) (10.12.2015)
Get full text
Journal Article
Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy
Mezeiova, Eva, Korabecny, Jan, Sepsova, Vendula, Hrabinova, Martina, Jost, Petr, Muckova, Lubica, Kucera, Tomas, Dolezal, Rafael, Misik, Jan, Spilovska, Katarina, Pham, Ngoc Lam, Pokrievkova, Lucia, Roh, Jaroslav, Jun, Daniel, Soukup, Ondrej, Kaping, Daniel, Kuca, Kamil
Published in Molecules (Basel, Switzerland) (28.07.2017)
Published in Molecules (Basel, Switzerland) (28.07.2017)
Get full text
Journal Article
Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier
Hamulakova, Slavka, Janovec, Ladislav, Soukup, Ondrej, Jun, Daniel, Janockova, Jana, Hrabinova, Martina, Sepsova, Vendula, Kuca, Kamil
Published in Current Alzheimer research (01.01.2018)
Published in Current Alzheimer research (01.01.2018)
Get more information
Journal Article
Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy
Dgachi, Youssef, Martin, Hélène, Malek, Rim, Jun, Daniel, Janockova, Jana, Sepsova, Vendula, Soukup, Ondrej, Iriepa, Isabel, Moraleda, Ignacio, Maalej, Emna, Carreiras, M. Carmo, Refouvelet, Bernard, Chabchoub, Fakher, Marco-Contelles, José, Ismaili, Lhassane
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2019)
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2019)
Get full text
Journal Article
The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats-A Comparison with Trimedoxime and the Oxime K203
Kassa, Jiri, Misik, Jan, Hatlapatkova, Jana, Zdarova Karasova, Jana, Sepsova, Vendula, Caisberger, Filip, Pejchal, Jaroslav
Published in Molecules (Basel, Switzerland) (11.07.2017)
Published in Molecules (Basel, Switzerland) (11.07.2017)
Get full text
Journal Article
Oximes: inhibitors of human recombinant acetylcholinesterase. A structure-activity relationship (SAR) study
Sepsova, Vendula, Karasova, Jana Zdarova, Korabecny, Jan, Dolezal, Rafael, Zemek, Filip, Bennion, Brian J, Kuca, Kamil
Published in International journal of molecular sciences (16.08.2013)
Published in International journal of molecular sciences (16.08.2013)
Get full text
Journal Article
Acetylcholinesterase reactivators (HI-6, obidoxime, trimedoxime, K027, K075, K127, K203, K282): structural evaluation of human serum albumin binding and absorption kinetics
Zemek, Filip, Zdarova, Jana Karasova, Sepsova, Vendula, Kuca, Kamil
Published in International journal of molecular sciences (02.08.2013)
Published in International journal of molecular sciences (02.08.2013)
Get full text
Journal Article
A comparison of the reactivating and therapeutic efficacy of the newly developed bispyridinium oxime K203 with currently available oximes, in sarin poisoned rats and mice
Kassa, Jiří, Karasová, Jana Žd'árová, Šepsová, Vendula, Bajgar, Jiří
Published in Journal of applied biomedicine (01.01.2011)
Published in Journal of applied biomedicine (01.01.2011)
Get full text
Journal Article
Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity
Nepovimova, Eugenie, Korabecny, Jan, Dolezal, Rafael, Babkova, Katerina, Ondrejicek, Ales, Jun, Daniel, Sepsova, Vendula, Horova, Anna, Hrabinova, Martina, Soukup, Ondrej, Bukum, Neslihan, Jost, Petr, Muckova, Lubica, Kassa, Jiri, Malinak, David, Andrs, Martin, Kuca, Kamil
Published in Journal of medicinal chemistry (25.11.2015)
Published in Journal of medicinal chemistry (25.11.2015)
Get full text
Journal Article
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease
Jeřábek, Jakub, Uliassi, Elisa, Guidotti, Laura, Korábečný, Jan, Soukup, Ondřej, Sepsova, Vendula, Hrabinova, Martina, Kuča, Kamil, Bartolini, Manuela, Peña-Altamira, Luis Emiliano, Petralla, Sabrina, Monti, Barbara, Roberti, Marinella, Bolognesi, Maria Laura
Published in European journal of medicinal chemistry (15.02.2017)
Published in European journal of medicinal chemistry (15.02.2017)
Get full text
Journal Article
The Antioxidant Additive Approach for Alzheimer’s Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators
Benchekroun, Mohamed, Romero, Alejandro, Egea, Javier, León, Rafael, Michalska, Patrycja, Buendía, Izaskun, Jimeno, María Luisa, Jun, Daniel, Janockova, Jana, Sepsova, Vendula, Soukup, Ondrej, Bautista-Aguilera, Oscar M, Refouvelet, Bernard, Ouari, Olivier, Marco-Contelles, José, Ismaili, Lhassane
Published in Journal of medicinal chemistry (10.11.2016)
Published in Journal of medicinal chemistry (10.11.2016)
Get full text
Journal Article
Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation
Spilovska, Katarina, Korabecny, Jan, Sepsova, Vendula, Jun, Daniel, Hrabinova, Martina, Jost, Petr, Muckova, Lubica, Soukup, Ondrej, Janockova, Jana, Kucera, Tomas, Dolezal, Rafael, Mezeiova, Eva, Kaping, Daniel, Kuca, Kamil
Published in Molecules (Basel, Switzerland) (16.06.2017)
Published in Molecules (Basel, Switzerland) (16.06.2017)
Get full text
Journal Article
7-MEOTA–donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies
Korabecny, Jan, Dolezal, Rafael, Cabelova, Pavla, Horova, Anna, Hruba, Eva, Ricny, Jan, Sedlacek, Lukas, Nepovimova, Eugenie, Spilovska, Katarina, Andrs, Martin, Musilek, Kamil, Opletalova, Veronika, Sepsova, Vendula, Ripova, Daniela, Kuca, Kamil
Published in European journal of medicinal chemistry (23.07.2014)
Published in European journal of medicinal chemistry (23.07.2014)
Get full text
Journal Article
Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment
Gazova, Zuzana, Soukup, Ondrej, Sepsova, Vendula, Siposova, Katarina, Drtinova, Lucie, Jost, Petr, Spilovska, Katarina, Korabecny, Jan, Nepovimova, Eugenie, Fedunova, Diana, Horak, Martin, Kaniakova, Martina, Wang, Ze-Jun, Hamouda, Ayman K., Kuca, Kamil
Published in Biochimica et biophysica acta. Molecular basis of disease (01.02.2017)
Published in Biochimica et biophysica acta. Molecular basis of disease (01.02.2017)
Get full text
Journal Article
A Comparison of the Reactivating and Therapeutic Efficacy of Two Newly Developed Oximes (K727 and K733) with Oxime K203 and Trimedoxime in Tabun‐Poisoned Rats and Mice
Kassa, Jiri, Sepsova, Vendula, Tumova, Martina, Horova, Anna, Musilek, Kamil
Published in Basic & clinical pharmacology & toxicology (01.04.2015)
Published in Basic & clinical pharmacology & toxicology (01.04.2015)
Get full text
Journal Article
Design, Synthesis, and Biological Evaluation of 1‑Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer’s Agents
Panek, Dawid, Więckowska, Anna, Jończyk, Jakub, Godyń, Justyna, Bajda, Marek, Wichur, Tomasz, Pasieka, Anna, Knez, Damijan, Pišlar, Anja, Korabecny, Jan, Soukup, Ondrej, Sepsova, Vendula, Sabaté, Raimon, Kos, Janko, Gobec, Stanislav, Malawska, Barbara
Published in ACS chemical neuroscience (16.05.2018)
Published in ACS chemical neuroscience (16.05.2018)
Get full text
Journal Article
The Evaluation of Prophylactic Efficacy of Newly Developed Reversible Inhibitors of Acetylcholinesterase in Soman‐Poisoned Mice – A Comparison with Commonly Used Pyridostigmine
Kassa, Jiri, Korabecny, Jan, Sepsova, Vendula, Tumova, Martina
Published in Basic & clinical pharmacology & toxicology (01.12.2014)
Published in Basic & clinical pharmacology & toxicology (01.12.2014)
Get full text
Journal Article