A Physiologically Based Pharmacokinetic Model Relates the Subcutaneous Bioavailability of Monoclonal Antibodies to the Saturation of FcRn-Mediated Recycling in Injection-Site-Draining Lymph Nodes
Stader, Felix, Liu, Cong, Derbalah, Abdallah, Momiji, Hiroshi, Pan, Xian, Gardner, Iain, Jamei, Masoud, Sepp, Armin
Published in Antibodies (Basel) (01.09.2024)
Published in Antibodies (Basel) (01.09.2024)
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Journal Article
Pharmacokinetic characteristics, pharmacodynamic effect and in vivo antiviral efficacy of liver-targeted interferon alpha
Rycroft, Daniel, Sosabowski, Jane, Coulstock, Edward, Davies, Marie, Morrey, John, Friel, Sarah, Kelly, Fiona, Hamatake, Robert, Ovečka, Milan, Prince, Rob, Goodall, Laura, Sepp, Armin, Walker, Adam
Published in PloS one (17.02.2015)
Published in PloS one (17.02.2015)
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Journal Article
Liver-targeting of interferon-alpha with tissue-specific domain antibodies
Coulstock, Edward, Sosabowski, Jane, Ovečka, Milan, Prince, Rob, Goodall, Laura, Mudd, Clare, Sepp, Armin, Davies, Marie, Foster, Julie, Burnet, Jerome, Dunlevy, Gráinne, Walker, Adam
Published in PloS one (25.02.2013)
Published in PloS one (25.02.2013)
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Journal Article
The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans
Thorneloe, Kevin S., Sepp, Armin, Zhang, Sean, Galinanes-Garcia, Laura, Galette, Paul, Al-Azzam, Wasfi, Vugts, Danielle J., van Dongen, Guus, Elsinga, Phillip, Wiegers, Johan, Glaudemans, Andor W. J. M., Vincent, Veena, Renaux, Jessica, Szapacs, Matt, Birchler, Mary, Cleveland, Matthew, Bergstrom, Mats, Davies, Marie
Published in EJNMMI research (21.05.2019)
Published in EJNMMI research (21.05.2019)
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Journal Article
Novel Selection Approaches to Identify Antibodies Targeting Neoepitopes on the C5b6 Intermediate Complex to Inhibit Membrane Attack Complex Formation
Stach, Lasse, Dinley, Emily K. H., Tournier, Nadia, Bingham, Ryan P., Gormley, Darren A., Bramhall, Jo L., Taylor, Adam, Clarkson, Jane E., Welbeck, Katherine A., Harris, Claire L., Feeney, Maria, Hughes, Jane P., Sepp, Armin, Batuwangala, Thil D., Kitchen, Semra J., Nichols, Eva-Maria
Published in Antibodies (Basel) (12.10.2021)
Published in Antibodies (Basel) (12.10.2021)
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Journal Article
Computer-assembled cross-species/cross-modalities two-pore physiologically based pharmacokinetic model for biologics in mice and rats
Sepp, Armin, Meno-Tetang, Guy, Weber, Andrew, Sanderson, Andrew, Schon, Oliver, Berges, Alienor
Published in Journal of pharmacokinetics and pharmacodynamics (01.08.2019)
Published in Journal of pharmacokinetics and pharmacodynamics (01.08.2019)
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Journal Article
Toward systems-informed models for biologics disposition: covariates of the abundance of the neonatal Fc Receptor (FcRn) in human tissues and implications for pharmacokinetic modelling
Barber, Jill, Al-Majdoub, Zubida M., Couto, Narciso, Howard, Martyn, Elmorsi, Yasmine, Scotcher, Daniel, Alizai, Naved, de Wildt, Saskia, Stader, Felix, Sepp, Armin, Rostami-Hodjegan, Amin, Achour, Brahim
Published in European journal of pharmaceutical sciences (01.03.2023)
Published in European journal of pharmaceutical sciences (01.03.2023)
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Journal Article
Application of physiologically based pharmacokinetic models for therapeutic proteins and other novel modalities
Rose, Rachel H., Sepp, Armin, Stader, Felix, Gill, Katherine L., Liu, Cong, Gardner, Iain
Published in Xenobiotica (03.08.2022)
Published in Xenobiotica (03.08.2022)
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Journal Article
In vivo biodistribution and pharmacokinetics of sotrovimab, a SARS-CoV-2 monoclonal antibody, in healthy cynomolgus monkeys
Aweda, Tolulope A., Cheng, Shih-Hsun, Lenhard, Stephen C., Sepp, Armin, Skedzielewski, Tinamarie, Hsu, Chih-Yang, Marshall, Shelly, Haag, Heather, Kehler, Jonathan, Jagdale, Prabhas, Peter, Alessia, Schmid, Michael A., Gehman, Andrew, Doan, Minh, Mayer, Andrew P., Gorycki, Peter, Fanget, Marie, Colas, Christophe, Smith, Brenda, Maier, Curtis C., Alsaid, Hasan
Published in European journal of nuclear medicine and molecular imaging (01.02.2023)
Published in European journal of nuclear medicine and molecular imaging (01.02.2023)
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Journal Article
Next generation immunotherapeutics—honing the magic bullet
Enever, Carrie, Batuwangala, Thil, Plummer, Chris, Sepp, Armin
Published in Current opinion in biotechnology (01.08.2009)
Published in Current opinion in biotechnology (01.08.2009)
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Journal Article
Modeling bispecific monoclonal antibody interaction with two cell membrane targets indicates the importance of surface diffusion
Sengers, Bram G, McGinty, Sean, Nouri, Fatma Z, Argungu, Maryam, Hawkins, Emma, Hadji, Aymen, Weber, Andrew, Taylor, Adam, Sepp, Armin
Published in mAbs (03.07.2016)
Published in mAbs (03.07.2016)
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Journal Article