HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism
Seong, Ihn Sik, Ivanova, Elena, Lee, Jong-Min, Choo, Yeun Su, Fossale, Elisa, Anderson, MaryAnne, Gusella, James F., Laramie, Jason M., Myers, Richard H., Lesort, Mathieu, MacDonald, Marcy E.
Published in Human molecular genetics (01.10.2005)
Published in Human molecular genetics (01.10.2005)
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Journal Article
Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice
Gines, Silvia, Seong, Ihn Sik, Fossale, Elisa, Ivanova, Elena, Trettel, Flavia, Gusella, James F., Wheeler, Vanessa C., Persichetti, Francesca, MacDonald, Marcy E.
Published in Human molecular genetics (01.03.2003)
Published in Human molecular genetics (01.03.2003)
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Translocations Disrupting PHF21A in the Potocki-Shaffer-Syndrome Region Are Associated with Intellectual Disability and Craniofacial Anomalies
Kim, Hyung-Goo, Kim, Hyun-Taek, Leach, Natalia T., Lan, Fei, Ullmann, Reinhard, Silahtaroglu, Asli, Kurth, Ingo, Nowka, Anja, Seong, Ihn Sik, Shen, Yiping, Talkowski, Michael E., Ruderfer, Douglas, Lee, Ji-Hyun, Glotzbach, Caron, Ha, Kyungsoo, Kjaergaard, Susanne, Levin, Alex V., Romeike, Bernd F., Kleefstra, Tjitske, Bartsch, Oliver, Elsea, Sarah H., Jabs, Ethylin Wang, MacDonald, Marcy E., Harris, David J., Quade, Bradley J., Ropers, Hans-Hilger, Shaffer, Lisa G., Kutsche, Kerstin, Layman, Lawrence C., Tommerup, Niels, Kalscheuer, Vera M., Shi, Yang, Morton, Cynthia C., Kim, Cheol-Hee, Gusella, James F.
Published in American journal of human genetics (13.07.2012)
Published in American journal of human genetics (13.07.2012)
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Journal Article
Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism
Lee, Jong-Min, Ivanova, Elena V, Seong, Ihn Sik, Cashorali, Tanya, Kohane, Isaac, Gusella, James F, MacDonald, Marcy E
Published in PLoS genetics (01.08.2007)
Published in PLoS genetics (01.08.2007)
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Journal Article
Enhanced Akt Signaling Is an Early Pro-survival Response That Reflects N-Methyl-D-aspartate Receptor Activation in Huntington's Disease Knock-in Striatal Cells
Gines, Silvia, Ivanova, Elena, Seong, Ihn-Sik, Saura, Carlos A., MacDonald, Marcy E.
Published in The Journal of biological chemistry (12.12.2003)
Published in The Journal of biological chemistry (12.12.2003)
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Journal Article
Disruption of Neurexin 1 Associated with Autism Spectrum Disorder
Kim, Hyung-Goo, Kishikawa, Shotaro, Higgins, Anne W., Seong, Ihn-Sik, Donovan, Diana J., Shen, Yiping, Lally, Eric, Weiss, Lauren A., Najm, Juliane, Kutsche, Kerstin, Descartes, Maria, Holt, Lynn, Braddock, Stephen, Troxell, Robin, Kaplan, Lee, Volkmar, Fred, Klin, Ami, Tsatsanis, Katherine, Harris, David J., Noens, Ilse, Pauls, David L., Daly, Mark J., MacDonald, Marcy E., Morton, Cynthia C., Quade, Bradley J., Gusella, James F.
Published in American journal of human genetics (01.01.2008)
Published in American journal of human genetics (01.01.2008)
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Journal Article
Huntingtin facilitates polycomb repressive complex 2
Seong, Ihn Sik, Woda, Juliana M., Song, Ji-Joon, Lloret, Alejandro, Abeyrathne, Priyanka D., Woo, Caroline J., Gregory, Gillian, Lee, Jong-Min, Wheeler, Vanessa C., Walz, Thomas, Kingston, Robert E., Gusella, James F., Conlon, Ronald A., MacDonald, Marcy E.
Published in Human molecular genetics (15.02.2010)
Published in Human molecular genetics (15.02.2010)
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Journal Article
Hypomorphic mutation of the mouse Huntington's disease gene orthologue
Murthy, Vidya, Tebaldi, Toma, Yoshida, Toshimi, Erdin, Serkan, Calzonetti, Teresa, Vijayvargia, Ravi, Tripathi, Takshashila, Kerschbamer, Emanuela, Seong, Ihn Sik, Quattrone, Alessandro, Talkowski, Michael E, Gusella, James F, Georgopoulos, Katia, MacDonald, Marcy E, Biagioli, Marta
Published in PLoS genetics (21.03.2019)
Published in PLoS genetics (21.03.2019)
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Journal Article
HD CAG-correlated gene expression changes support a simple dominant gain of function
Jacobsen, Jessie C., Gregory, Gillian C., Woda, Juliana M., Thompson, Morgan N., Coser, Kathryn R., Murthy, Vidya, Kohane, Isaac S., Gusella, James F., Seong, Ihn Sik, MacDonald, Marcy E., Shioda, Toshi, Lee, Jong-Min
Published in Human molecular genetics (15.07.2011)
Published in Human molecular genetics (15.07.2011)
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Journal Article
Huntingtin's spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function
Vijayvargia, Ravi, Epand, Raquel, Leitner, Alexander, Jung, Tae-Yang, Shin, Baehyun, Jung, Roy, Lloret, Alejandro, Singh Atwal, Randy, Lee, Hyeongseok, Lee, Jong-Min, Aebersold, Ruedi, Hebert, Hans, Song, Ji-Joon, Seong, Ihn Sik
Published in eLife (22.03.2016)
Published in eLife (22.03.2016)
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Journal Article
Allele-specific silencing of the gain-of-function mutation in Huntington's disease using CRISPR/Cas9
Shin, Jun Wan, Hong, Eun Pyo, Park, Seri S, Choi, Doo Eun, Seong, Ihn Sik, Whittaker, Madelynn N, Kleinstiver, Benjamin P, Chen, Richard Z, Lee, Jong-Min
Published in JCI insight (10.10.2022)
Published in JCI insight (10.10.2022)
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Journal Article
Full sequence of mutant huntingtin 3'-untranslated region and modulation of its gene regulatory activity by endogenous microRNA
Kim, Kyung-Hee, Abu Elneel, Kawther, Shin, Jun Wan, Keum, Jae Whan, Seong, David, Kwak, Seung, Lee, Ramee, Gusella, James F, MacDonald, Marcy E, Seong, Ihn Sik, Lee, Jong-Min
Published in Journal of human genetics (01.10.2019)
Published in Journal of human genetics (01.10.2019)
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Journal Article
Purification of full-length recombinant human huntingtin proteins with allelic series of polyglutamine lengths
Kim, Hyeongju, Hyun, Kyung-gi, Lloret, Alejandro, Seong, Ihn Sik, Song, Ji-Joon
Published in STAR protocols (17.12.2021)
Published in STAR protocols (17.12.2021)
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Journal Article
Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity
Shin, Baehyun, Jung, Roy, Oh, Hyejin, Owens, Gwen E., Lee, Hyeongseok, Kwak, Seung, Lee, Ramee, Cotman, Susan L., Lee, Jong-Min, MacDonald, Marcy E., Song, Ji-Joon, Vijayvargia, Ravi, Seong, Ihn Sik
Published in Molecular therapy. Nucleic acids (01.06.2018)
Published in Molecular therapy. Nucleic acids (01.06.2018)
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Journal Article
Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis
REIS, Surya A, THOMPSON, Morgan N, MACDONALD, Marcy E, SIK SEONG, Ihn, LEE, Jong-Min, FOSSALE, Elisa, KIM, Hyung-Hwan, LIAO, James K, MOSKOWITZ, Michael A, SHAW, Stanley Y, LINDA DONG, HAGGARTY, Stephen J
Published in Human molecular genetics (15.06.2011)
Published in Human molecular genetics (15.06.2011)
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Journal Article
Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative
Fossale, Elisa, Seong, Ihn Sik, Coser, Kathryn R., Shioda, Toshi, Kohane, Isaac S., Wheeler, Vanessa C., Gusella, James F., MacDonald, Marcy E., Lee, Jong-Min
Published in Human molecular genetics (01.11.2011)
Published in Human molecular genetics (01.11.2011)
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Journal Article
HD CAGnome: a search tool for huntingtin CAG repeat length-correlated genes
Galkina, Ekaterina I, Shin, Aram, Coser, Kathryn R, Shioda, Toshi, Kohane, Isaac S, Seong, Ihn Sik, Wheeler, Vanessa C, Gusella, James F, Macdonald, Marcy E, Lee, Jong-Min
Published in PloS one (01.04.2014)
Published in PloS one (01.04.2014)
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Journal Article
Role of the GYVG Pore Motif of HslU ATPase in Protein Unfolding and Translocation for Degradation by HslV Peptidase
Park, Eunyong, Rho, Young Min, Koh, Ohn-Jo, Ahn, Sung Won, Seong, Ihn Sik, Song, Ji-Joon, Bang, Oksun, Seol, Jae Hong, Wang, Jimin, Eom, Soo Hyun, Chung, Chin Ha
Published in The Journal of biological chemistry (17.06.2005)
Published in The Journal of biological chemistry (17.06.2005)
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Journal Article
N-terminal Processing Is Essential for Release of Epithin, a Mouse Type II Membrane Serine Protease
Cho, E G, Kim, M G, Kim, C, Kim, S R, Seong, I S, Chung, C, Schwartz, R H, Park, D
Published in The Journal of biological chemistry (30.11.2001)
Published in The Journal of biological chemistry (30.11.2001)
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Journal Article
Crystal structure of Bacillus subtilis CodW, a noncanonical HslV-like peptidase with an impaired catalytic apparatus
Rho, Seong-Hwan, Park, Hyun Ho, Kang, Gil Bu, Im, Young Jun, Kang, Min Suk, Lim, Byung Kook, Seong, Ihn Sik, Seol, Jaehong, Chung, Chin Ha, Wang, Jimin, Eom, Soo Hyun
Published in Proteins, structure, function, and bioinformatics (01.05.2008)
Published in Proteins, structure, function, and bioinformatics (01.05.2008)
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