228 Engineered human IL-2/IL-2Rß orthogonal pairs selectively enhance anti-GPC3 CAR T cells in vivo to drive complete responses in solid epithelial tumor models
Aspuria, Paul-Joseph, Semana, Marie, Cheng, Ivan, Ratti, Navneet, Ramadass, Mahalaksmi, Rokkam, Deepti, Ali, Mohammed, Bauer, Michele, Burgess, Ryan, Rosas, Henry, Vivona, Sandro, Zheng, George, Lupardus, Patrick, Oft, Martin
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Abstract 1512: OrthoCARs: Engineered human IL-2/IL-2Rb orthogonal pairs selectively enhance CAR T cell antitumor efficacy by driving T cell expansion and fitness
Aspuria, Paul-Joseph P., Vivona, Sandro, Bauer, Michele, Semana, Marie, Ratti, Navneet, McCauley, Scott, Riener, Romina, Malefyt, Rene de Waal, Rokkam, Deepti, Emmerich, Jan, Lupardus, Patrick J., Kastelein, Rob A., Oft, Martin
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Abstract 1744: STK-012, an alpha/beta selective IL-2 mutein for the activation of the antigen-activated T cells in solid tumor
Emmerich, Jan, Bauer, Michele, Semana, Marie, Jayaraman, Bhargavi, Vivona, Sandro, McCauley, Scott, Riener, Romina, Malefyt, Rene De Waal, Aspuria, Paul-Joseph, Rokkam, Deepti, Lupardus, Patrick, Kastelein, Rob, Oft, Martin
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CAR T cells and clearance of bulky lymphoma
Aspuria, Paul-Joseph, Vivona, Sandro, Bauer, Michele, Semana, Marie, Ratti, Navneet, McCauley, Scott, Riener, Romina, de Waal Malefyt, Rene, Rokkam, Deepti, Emmerich, Jan, Kastelein, Rob A, Lupardus, Patrick J, Oft, Martin
Published in Science translational medicine (22.12.2021)
Published in Science translational medicine (22.12.2021)
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GITR Agonism Enhances Cellular Metabolism to Support CD8 + T-cell Proliferation and Effector Cytokine Production in a Mouse Tumor Model
Sabharwal, Simran S, Rosen, David B, Grein, Jeff, Tedesco, Dana, Joyce-Shaikh, Barbara, Ueda, Roanna, Semana, Marie, Bauer, Michele, Bang, Kathy, Stevenson, Christopher, Cua, Daniel J, Zúñiga, Luis A
Published in Cancer immunology research (01.10.2018)
Published in Cancer immunology research (01.10.2018)
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Abstract 6312: Orthogonal IL-2/IL-2Rβ signaling selectively enhances and sustains a synthetic effector state via a novel mechanism and outperforms constitutive armoring approaches
Jung, Ethan, Silva, Helena, Semana, Marie, Cheng, Ivan, Singh, Somya, Bauer, Michele, Ali, Mohammed, Rosas, Henry, Burgess, Ryan, Zeng, George, Chang, Woei, Ratti, Navneet, Rokkam, Deepti, Lupardus, Patrick J., Oft, Martin, Aspuria, Paul-Joseph
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 586: Orthogonal IL-2/IL-2RB signaling in adoptively transferred T cells controls tumor growth without the need for lymphodepletion in a B16 tumor model
Kochel, Christina, Sun, Meng, Ratti, Navneet, Vivona, Sandro, Ramadass, Mahalaksmi, Semana, Marie, Bauer, Michele, Ali, Mohammed, Emmerich, Jan, Kastelein, Rob, Lupardus, Patrick J., Aspuria, Paul-Joseph, Oft, Martin
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Abstract 2824: Engineered human IL-2/IL-2Rb orthogonal pairs selectively enhance anti-GPC3 CAR T cells to drive complete responses in solid epithelial tumor models
Aspuria, Paul-Joseph, Semana, Marie, Vivona, Sandro, Ramadass, Mahalaksmi, Ratti, Navneet, Riener, Romina, Bauer, Michele, Ali, Mohammed, Rokkam, Deepti, Kastelein, Rob A., Lupardus, Patrick J., Oft, Martin
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Abstract 1801: STK-012, an a/b-selective IL-2 activates tumor antigen specific CD25+ CD8 T cells to reject tumors without acute vascular toxicity
Oft, Martin, Ratti, Navneet, Vivona, Sandro, Emmerich, Jan, Riener, Romina, Koliesnik, Ievgen O., McCauley, Scott, Bauer, Michele, Semana, Marie, Rokkam, Deepti, Jayaraman, Bhargavi, Malefyt, Rene de Waal, Aspuria, Paul-Joseph, Totagrande, Michael, Mehta-Damani, Anita, Lupardus, Patrick J., Kastelein, Rob A.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Awareness of Stroke among University Employees in Kigali, Rwanda: A Cross Sectional Study
Nsengimana, Emmanuel, Niyonambaza, Clarisse, Sindayigaya, Jean Pierre, Rutayisire, Tusale, Rukundo, Jean de Dieu, Semana, Jean Marie Vianney, Nshimiyimana, Jacques, Ndahiriwe, Christian Chance, Nuhu, Assuman, Seminega, Benoît, Hakizimana, Moussa, Urimubenshi, Gerard
Published in Rwanda journal of medicine and health sciences (28.03.2023)
Published in Rwanda journal of medicine and health sciences (28.03.2023)
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