Origanum vulgare mediated biosynthesis of silver nanoparticles for its antibacterial and anticancer activity
Sankar, Renu, Karthik, Arunachalam, Prabu, Annamalai, Karthik, Selvaraju, Shivashangari, Kanchi Subramanian, Ravikumar, Vilwanathan
Published in Colloids and surfaces, B, Biointerfaces (01.08.2013)
Published in Colloids and surfaces, B, Biointerfaces (01.08.2013)
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Journal Article
The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells
Wang, Xin, Mazurkiewicz, Magdalena, Hillert, Ellin-Kristina, Olofsson, Maria Hägg, Pierrou, Stefan, Hillertz, Per, Gullbo, Joachim, Selvaraju, Karthik, Paulus, Aneel, Akhtar, Sharoon, Bossler, Felicitas, Khan, Asher Chanan, Linder, Stig, D’Arcy, Padraig
Published in Scientific reports (06.06.2016)
Published in Scientific reports (06.06.2016)
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Journal Article
Identification of proteasome inhibitors using analysis of gene expression profiles
Mofers, Arjan, Selvaraju, Karthik, Gubat, Johannes, D'Arcy, Padraig, Linder, Stig
Published in European journal of pharmacology (15.12.2020)
Published in European journal of pharmacology (15.12.2020)
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Journal Article
Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation
Hillert, Ellin-Kristina, Brnjic, Slavica, Zhang, Xiaonan, Mazurkiewicz, Magdalena, Saei, Amir Ata, Mofers, Arjan, Selvaraju, Karthik, Zubarev, Roman, Linder, Stig, D'Arcy, Padraig
Published in Cancer letters (28.04.2019)
Published in Cancer letters (28.04.2019)
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Journal Article
Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15
Mofers, Arjan, Perego, Paola, Selvaraju, Karthik, Gatti, Laura, Gullbo, Joachim, Linder, Stig, D'Arcy, Padraig
Published in PloS one (22.10.2019)
Published in PloS one (22.10.2019)
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Journal Article
Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570
Pellegrini, Paola, Selvaraju, Karthik, Faustini, Elena, Mofers, Arjan, Zhang, Xiaonan, Ternerot, Jens, Schubert, Alice, Linder, Stig, D Arcy, Pádraig
Published in International journal of molecular sciences (04.07.2020)
Published in International journal of molecular sciences (04.07.2020)
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Journal Article
Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain
García-Cuesta, Eva M, Martínez, Pablo, Selvaraju, Karthik, Ulltjärn, Gabriel, Gómez Pozo, Adrián Miguel, D'Agostino, Gianluca, Gardeta, Sofia, Quijada-Freire, Adriana, Blanco Gabella, Patricia, Roca, Carlos, Hoyo, Daniel Del, Jiménez-Saiz, Rodrigo, García-Rubia, Alfonso, Soler Palacios, Blanca, Lucas, Pilar, Ayala-Bueno, Rosa, Santander Acerete, Noelia, Carrasco, Yolanda, Oscar Sorzano, Carlos, Martinez, Ana, Campillo, Nuria E, Jensen, Lasse D, Rodriguez Frade, Jose Miguel, Santiago, César, Mellado, Mario
Published in eLife (09.09.2024)
Published in eLife (09.09.2024)
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Journal Article
Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action
Gubat, Johannes, Selvaraju, Karthik, Sjöstrand, Linda, Kumar Singh, Dhananjay, Turkina, Maria V, Schmierer, Bernhard, Sabatier, Pierre, Zubarev, Roman A, Linder, Stig, D'Arcy, Pádraig
Published in Frontiers in oncology (2022)
Published in Frontiers in oncology (2022)
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Journal Article
Sensitivity of Acute Myelocytic Leukemia Cells to the Dienone Compound VLX1570 Is Associated with Inhibition of the Ubiquitin-Proteasome System
Selvaraju, Karthik, Lotfi, Kourosh, Gubat, Johannes, Miquel, Maria, Nilsson, Amanda, Hill, Julia, Jensen, Lasse D, Linder, Stig, D'Arcy, Pádraig
Published in Biomolecules (Basel, Switzerland) (10.09.2021)
Published in Biomolecules (Basel, Switzerland) (10.09.2021)
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Journal Article
Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition
Mazurkiewicz, Magdalena, Hillert, Ellin-Kristina, Wang, Xin, Pellegrini, Paola, Olofsson, Maria Hägg, Selvaraju, Karthik, D’Arcy, Padraig, Linder, Stig
Published in Oncotarget (2017)
Published in Oncotarget (2017)
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Journal Article
Tideglusib induces apoptosis in human neuroblastoma IMR32 cells, provoking sub-G 0 /G 1 accumulation and ROS generation
Mathuram, Theodore Lemuel, Ravikumar, Vilwanathan, Reece, Lisa M., Karthik, Selvaraju, Sasikumar, Changam Sheela, Cherian, Kotturathu Mammen
Published in Environmental toxicology and pharmacology (01.09.2016)
Published in Environmental toxicology and pharmacology (01.09.2016)
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Journal Article
Romidepsin induces cell cycle arrest, apoptosis, histone hyperacetylation and reduces matrix metalloproteinases 2 and 9 expression in bortezomib sensitized non-small cell lung cancer cells
Karthik, Selvaraju, Sankar, Renu, Varunkumar, Krishnamoorthy, Ravikumar, Vilwanathan
Published in Biomedicine & pharmacotherapy (01.04.2014)
Published in Biomedicine & pharmacotherapy (01.04.2014)
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Journal Article
Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug
Zhang, Xiaonan, Selvaraju, Karthik, Saei, Amir Ata, D'Arcy, Padraig, Zubarev, Roman A., Arnér, Elias SJ, Linder, Stig
Published in Biochimie (01.07.2019)
Published in Biochimie (01.07.2019)
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Journal Article
Blocking NF-κB sensitizes non-small cell lung cancer cells to histone deacetylase inhibitor induced extrinsic apoptosis through generation of reactive oxygen species
Karthik, Selvaraju, Sankar, Renu, Varunkumar, Krishnamoorthy, Anusha, Chidambaram, Ravikumar, Vilwanathan
Published in Biomedicine & pharmacotherapy (01.02.2015)
Published in Biomedicine & pharmacotherapy (01.02.2015)
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Journal Article
Tideglusib induces apoptosis in Human Neuroblastoma IMR32 cells, provoking sub-G0 /G1 accumulation and ROS generation
Mathuram, Theodore Lemuel, Ravikumar, Vilwanathan, Reece, Lisa M, Karthik, Selvaraju, Sasikumar, Changam Sheela, Cherian, Kotturathu Mammen
Published in Environmental toxicology and pharmacology (01.09.2016)
Published in Environmental toxicology and pharmacology (01.09.2016)
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Journal Article