Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation
Panneer Selvam, Shanmugam, De Palma, Ryan M, Oaks, Joshua J, Oleinik, Natalia, Peterson, Yuri K, Stahelin, Robert V, Skordalakes, Emmanuel, Ponnusamy, Suriyan, Garrett-Mayer, Elizabeth, Smith, Charles D, Ogretmen, Besim
Published in Science signaling (16.06.2015)
Published in Science signaling (16.06.2015)
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Journal Article
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
Sentelle, R David, Senkal, Can E, Jiang, Wenhui, Ponnusamy, Suriyan, Gencer, Salih, Selvam, Shanmugam Panneer, Ramshesh, Venkat K, Peterson, Yuri K, Lemasters, John J, Szulc, Zdzislaw M, Bielawski, Jacek, Ogretmen, Besim
Published in Nature chemical biology (01.10.2012)
Published in Nature chemical biology (01.10.2012)
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Journal Article
TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis
Gencer, Salih, Oleinik, Natalia, Kim, Jisun, Panneer Selvam, Shanmugam, De Palma, Ryan, Dany, Mohammed, Nganga, Rose, Thomas, Raquela J, Senkal, Can E, Howe, Philip H, Ogretmen, Besim
Published in Science signaling (24.10.2017)
Published in Science signaling (24.10.2017)
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Journal Article
Balance between senescence and apoptosis is regulated by telomere damage–induced association between p16 and caspase-3
Panneer Selvam, Shanmugam, Roth, Braden M., Nganga, Rose, Kim, Jisun, Cooley, Marion A., Helke, Kristi, Smith, Charles D., Ogretmen, Besim
Published in The Journal of biological chemistry (22.06.2018)
Published in The Journal of biological chemistry (22.06.2018)
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Journal Article
Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells
Chakraborty, Paramita, Chatterjee, Shilpak, Kesarwani, Pravin, Thyagarajan, Krishnamurthy, Iamsawat, Supinya, Dalheim, Annika, Nguyen, Hung, Selvam, Shanmugam P., Nasarre, Patrick, Scurti, Gina, Hardiman, Gary, Maulik, Nilanjana, Ball, Lauren, Gangaraju, Vamsi, Rubinstein, Mark P., Klauber-DeMore, Nancy, Hill, Elizabeth G., Ogretmen, Besim, Yu, Xue-Zhong, Nishimura, Michael I., Mehrotra, Shikhar
Published in The Journal of biological chemistry (07.06.2019)
Published in The Journal of biological chemistry (07.06.2019)
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Journal Article
HPV/E7 induces chemotherapy‐mediated tumor suppression by ceramide‐dependent mitophagy
Thomas, Raquela J, Oleinik, Natalia, Panneer Selvam, Shanmugam, Vaena, Silvia G, Dany, Mohammed, Nganga, Rose N, Depalma, Ryan, Baron, Kyla D, Kim, Jisun, Szulc, Zdzislaw M, Ogretmen, Besim
Published in EMBO molecular medicine (01.08.2017)
Published in EMBO molecular medicine (01.08.2017)
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Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis
Saddoughi, Sahar A., Gencer, Salih, Peterson, Yuri K., Ward, Katherine E., Mukhopadhyay, Archana, Oaks, Joshua, Bielawski, Jacek, Szulc, Zdzislaw M., Thomas, Raquela J., Selvam, Shanmugam P., Senkal, Can E., Garrett‐Mayer, Elizabeth, De Palma, Ryan M., Fedarovich, Dzmitry, Liu, Angen, Habib, Amyn A., Stahelin, Robert V., Perrotti, Danilo, Ogretmen, Besim
Published in EMBO molecular medicine (01.01.2013)
Published in EMBO molecular medicine (01.01.2013)
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Journal Article
Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A
Salas, Arelis, Ponnusamy, Suriyan, Senkal, Can E., Meyers-Needham, Marisa, Selvam, Shanmugam Panneer, Saddoughi, Sahar A., Apohan, Elif, Sentelle, R. David, Smith, Charles, Gault, Christopher R., Obeid, Lina M., El-Shewy, Hesham M., Oaks, Joshua, Santhanam, Ramasamy, Marcucci, Guido, Baran, Yusuf, Mahajan, Sandeep, Fernandes, Daniel, Stuart, Robert, Perrotti, Danilo, Ogretmen, Besim
Published in Blood (02.06.2011)
Published in Blood (02.06.2011)
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Journal Article
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
Sentelle, R David, Senkal, Can E, Jiang, Wenhui, Ponnusamy, Suriyan, Gencer, Salih, Panneer Selvam, Shanmugam, Ramshesh, Venkat K, Peterson, Yuri K, Lemasters, John J, Szulc, Zdzislaw M, Bielawski, Jacek, Ogretmen, Besim
Published in Nature chemical biology (26.08.2012)
Published in Nature chemical biology (26.08.2012)
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Journal Article
Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity
Chakraborty, Paramita, Vaena, Silvia G., Thyagarajan, Krishnamurthy, Chatterjee, Shilpak, Al-Khami, Amir, Selvam, Shanmugam Panneer, Nguyen, Hung, Kang, Inhong, Wyatt, Megan W., Baliga, Uday, Hedley, Zachariah, Ngang, Rose N., Guo, Beichu, Beeson, Gyda C., Husain, Shahid, Paulos, Chrystal M., Beeson, Craig C., Zilliox, Michael J., Hill, Elizabeth G., Mehrotra, Meenal, Yu, Xue-Zhong, Ogretmen, Besim, Mehrotra, Shikhar
Published in Cell reports (Cambridge) (13.08.2019)
Published in Cell reports (Cambridge) (13.08.2019)
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Journal Article
Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance
Ponnusamy, Suriyan, Meyers-Needham, Marisa, Senkal, Can E, Saddoughi, Sahar A, Sentelle, David, Selvam, Shanmugam Panneer, Salas, Arelis, Ogretmen, Besim
Published in Future oncology (London, England) (01.10.2010)
Published in Future oncology (London, England) (01.10.2010)
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Journal Article
Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress
Oleinik, Natalia, Kim, Jisun, Roth, Braden M, Selvam, Shanmugam Panneer, Gooz, Monika, Johnson, Roger H, Lemasters, John J, Ogretmen, Besim
Published in Science advances (01.09.2019)
Published in Science advances (01.09.2019)
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Journal Article
CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response
Chatterjee, Shilpak, Daenthanasanmak, Anusara, Chakraborty, Paramita, Wyatt, Megan W., Dhar, Payal, Selvam, Shanmugam Panneer, Fu, Jianing, Zhang, Jinyu, Nguyen, Hung, Kang, Inhong, Toth, Kyle, Al-Homrani, Mazen, Husain, Mahvash, Beeson, Gyda, Ball, Lauren, Helke, Kristi, Husain, Shahid, Garrett-Mayer, Elizabeth, Hardiman, Gary, Mehrotra, Meenal, Nishimura, Michael I., Beeson, Craig C., Bupp, Melanie Gubbels, Wu, Jennifer, Ogretmen, Besim, Paulos, Chrystal M., Rathmell, Jeffery, Yu, Xue-Zhong, Mehrotra, Shikhar
Published in Cell metabolism (09.01.2018)
Published in Cell metabolism (09.01.2018)
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Journal Article
Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1‐phosphate signalling to regulate tumour metastasis
Ponnusamy, Suriyan, Selvam, Shanmugam Panneer, Mehrotra, Shikhar, Kawamori, Toshihiko, Snider, Ashley J., Obeid, Lina M., Shao, Yuan, Sabbadini, Roger, Ogretmen, Besim
Published in EMBO molecular medicine (01.08.2012)
Published in EMBO molecular medicine (01.08.2012)
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Journal Article
S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity
Lv, Zongyang, Rickman, Kimberly A., Yuan, Lingmin, Williams, Katelyn, Selvam, Shanmugam Panneer, Woosley, Alec N., Howe, Philip H., Ogretmen, Besim, Smogorzewska, Agata, Olsen, Shaun K.
Published in Molecular cell (16.02.2017)
Published in Molecular cell (16.02.2017)
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Journal Article
Thioredoxin-1 confines T cell alloresponse and pathogenicity in graft-versus-host disease
Sofi, M Hanief, Wu, Yongxia, Schutt, Steven D, Dai, Min, Daenthanasanmak, Anusara, Heinrichs Voss, Jessica, Nguyen, Hung, Bastian, David, Iamsawat, Supinya, Selvam, Shanmugam Panneer, Liu, Chen, Maulik, Nilanjana, Ogretmen, Besim, Jin, Junfei, Mehrotra, Shikhar, Yu, Xue-Zhong
Published in The Journal of clinical investigation (01.07.2019)
Published in The Journal of clinical investigation (01.07.2019)
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Journal Article
SphK1/S1P Axis Regulate PPARγ Levels to Program Metabolically Fit Anti-Tumor T Cells
Chakraborty, Paramita, Thyagarajan, Krishnamurthy, Chatterjee, Shilpak, Selvam, Shanmugam Panneer, Ogretmen, Besim, Mehrotra, Shikhar
Published in The Journal of immunology (1950) (01.05.2018)
Published in The Journal of immunology (1950) (01.05.2018)
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Journal Article
Abstract 5474: Sphingosine kinase 2/sphingosine 1-phosphate signaling regulates p16 mediated accelerated aging in normal somatic tissues and tcf21 mediated tumor suppression in lung cancer
Selvam, Shanmugam Panneer, Cooley, Marion, Helke, Kristi, Garrett-Mayer, Elizabeth, Smith, Charles D., Ogretmen, Besim
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
S1P/PPARγ axis metabolically reprograms the T cells to modulate their anti-tumor potential
Chakraborty, Paramita, Thyagarajan, Krishnamurthy, Chatterjee, Shilpak, Nganga, Rose Nithenya, Selvam, Shanmugam Panneer, Ogretmen, Besim, Mehrotra, Shikhar
Published in The Journal of immunology (1950) (01.05.2017)
Published in The Journal of immunology (1950) (01.05.2017)
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