Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator
Surapaneni, Sekhar, Yerramilli, Usha, Bai, April, Dalvie, Deepak, Brooks, Jennifer, Wang, Xiaomin, Selkirk, Julie V, Yan, Yingzhuo Grace, Zhang, Peijin, Hargreaves, Richard, Kumar, Gondi, Palmisano, Maria, Tran, Jonathan Q
Published in Drug metabolism and disposition (01.05.2021)
Published in Drug metabolism and disposition (01.05.2021)
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Journal Article
In vitro assessment of the binding and functional responses of ozanimod and its plasma metabolites across human sphingosine 1-phosphate receptors
Selkirk, Julie V., Yan, Yingzhuo Grace, Ching, Nathan, Paget, Kate, Hargreaves, Richard
Published in European journal of pharmacology (15.02.2023)
Published in European journal of pharmacology (15.02.2023)
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Journal Article
Investigation into MAO B-Mediated Formation of CC112273, a Major Circulating Metabolite of Ozanimod, in Humans and Preclinical Species: Stereospecific Oxidative Deamination of ( S )-Enantiomer of Indaneamine (RP101075) by MAO B
Bai, April, Shanmugasundaram, Veerabahu, Selkirk, Julie V, Surapaneni, Sekhar, Dalvie, Deepak
Published in Drug metabolism and disposition (01.08.2021)
Published in Drug metabolism and disposition (01.08.2021)
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Journal Article
Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine 1-Phosphate Receptor Subtypes 1 and 5
Selkirk, Julie V, Dines, Kevin C, Yan, Yingzhuo Grace, Ching, Nathan, Dalvie, Deepak, Biswas, Shameek, Bortolato, Andrea, Schkeryantz, Jeffrey M, Lopez, Carlos, Ruiz, Iliana, Hargreaves, Richard
Published in The Journal of pharmacology and experimental therapeutics (01.12.2021)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2021)
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Journal Article
A novel cell-based assay for G-protein-coupled receptor-mediated cyclic adenosine monophosphate response element binding protein phosphorylation
Selkirk, Julie V, Nottebaum, Lisa M, Ford, Ian C, Santos, Mark, Malany, Siobhan, Foster, Alan C, Lechner, Sandra M
Published in Journal of biomolecular screening (01.06.2006)
Published in Journal of biomolecular screening (01.06.2006)
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Journal Article
Elucidation of cardiovascular effects mediated by blockade of the PI3K/mTOR/Akt pathway using selective inhibitors
Nottebaum, Lisa M., Hemkens, Michelle D., Blasi, Eileen, Selkirk, Julie V., McHarg, Aileen D.
Published in Journal of pharmacological and toxicological methods (01.07.2011)
Published in Journal of pharmacological and toxicological methods (01.07.2011)
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Journal Article
N-cadherin monoclonal antibody 12E3 blocks action potential conduction in human isolated Purkinje fibers
Selkirk, Julie V., McHarg, Aileen D., Trajkovik, Dusko, Lappin, Patrick D., LaPorte, Sherry, Dilley, Jeanette, Page, Guy, Stous, Shanon, Truong, Ky, Miller, Paul, Guia, Antonio, Ghetti, Andrea
Published in Journal of pharmacological and toxicological methods (01.07.2011)
Published in Journal of pharmacological and toxicological methods (01.07.2011)
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Journal Article
Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus
Selkirk, Julie V., Nottebaum, Lisa M., Vana, Alicia M., Verge, Gail M., Mackay, Kenneth B., Stiefel, Theodore H., Naeve, Greg S., Pomeroy, Jordan E., Petroski, Robert E., Moyer, John, Dunlop, John, Foster, Alan C.
Published in The European journal of neuroscience (01.06.2005)
Published in The European journal of neuroscience (01.06.2005)
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Journal Article
Over-expression of the human EAAT2 glutamate transporter within neurons of mouse organotypic hippocampal slice cultures leads to increased vulnerability of CA1 pyramidal cells
Selkirk, Julie V., Stiefel, Theodore H., Stone, Ida M., Naeve, Greg S., Foster, Alan C., Poulsen, David J.
Published in The European journal of neuroscience (01.04.2005)
Published in The European journal of neuroscience (01.04.2005)
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Journal Article
Manipulation of small-molecule inhibitory kinetics modulates MCH-R1 function
Schwarz, David A., Allen, Molly M., Petroski, Robert E., Pomeroy, Jordan E., Heise, Christopher E., Mistry, Monica S., Selkirk, Julie V., Nottebaum, Lisa M., Grey, Jonathan, Zhang, Mingzhu, Goodfellow, Val S., Maki, Richard A.
Published in Molecular and cellular endocrinology (19.10.2006)
Published in Molecular and cellular endocrinology (19.10.2006)
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Journal Article
Characterization of an N‐terminal secreted domain of the type‐1 human metabotropic glutamate receptor produced by a mammalian cell line
Selkirk, Julie V., Challiss, R. A. John, Rhodes, Andrew, McIlhinney, R. A. Jeffrey
Published in Journal of neurochemistry (01.01.2002)
Published in Journal of neurochemistry (01.01.2002)
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Journal Article
Complex Involvement of Pertussis Toxin-Sensitive G Proteins in the Regulation of Type 1α Metabotropic Glutamate Receptor Signaling in Baby Hamster Kidney Cells
Hermans, Emmanuel, Saunders, Ruth, Selkirk, Julie V., Mistry, Rajendra, Nahorski, Stefan R., Challiss, R. A. John
Published in Molecular pharmacology (01.08.2000)
Published in Molecular pharmacology (01.08.2000)
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Journal Article
SB-236057, a selective 5-HT1B receptor inverse agonist, blocks the 5-HT human terminal autoreceptor
MIDDLEMISS, D. N, GÖTHERT, M, SCHLICKER, E, SCOTT, C. M, SELKIRK, J. V, WATSON, J, GASTER, L. M, WYMAN, P, RILEY, G, PRICE, G. W
Published in European journal of pharmacology (30.06.1999)
Published in European journal of pharmacology (30.06.1999)
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Conference Proceeding
Journal Article
Complex Involvement of Pertussis Toxin-Sensitive G Proteins in the Regulation of Type 1α Metabotropic Glutamate Receptor Signaling in Baby Hamster Kidney Cells
Emmanuel Hermans, Ruth Saunders, Julie V. Selkirk, Rajendra Mistry, Stefan R. Nahorski, R. A. John Challiss
Published in Molecular pharmacology (01.08.2000)
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Published in Molecular pharmacology (01.08.2000)
Journal Article
Enhanced inducible mGlu1α receptor expression in Chinese hamster ovary cells
Nash, Mark S., Selkirk, Julie V., Gaymer, Caroline E., Challiss, R. A. John, Nahorski, Stefan R.
Published in Journal of neurochemistry (01.06.2001)
Published in Journal of neurochemistry (01.06.2001)
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Journal Article