Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors
Fairhurst, Robin A., Caravatti, Giorgio, Guagnano, Vito, Aichholz, Reiner, Blanz, Joachim, Blasco, Francesca, Wipfli, Peter, Fritsch, Christine, Maira, Sauveur-Michel, Schnell, Christian, Seiler, Frank H.
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
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Journal Article
High Accumulation of Platinum-DNA Adducts in Strial Marginal Cells of the Cochlea Is an Early Event in Cisplatin but Not Carboplatin Ototoxicity
Thomas, Jan Peter, Lautermann, Juergen, Liedert, Bernd, Seiler, Frank, Thomale, Juergen
Published in Molecular pharmacology (01.07.2006)
Published in Molecular pharmacology (01.07.2006)
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Journal Article
Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range
Berghausen, Joerg, Seiler, Frank Hans, Gobeau, Nathalie, Faller, Bernard
Published in ADMET & DMPK (01.04.2016)
Published in ADMET & DMPK (01.04.2016)
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Journal Article
Paper
Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor
Fairhurst, Robin A., Furet, Pascal, Imbach-Weese, Patricia, Stauffer, Frédéric, Rueeger, Heinrich, McCarthy, Clive, Ripoche, Sebastien, Oswald, Susanne, Arnaud, Bertrand, Jary, Aline, Maira, Michel, Schnell, Christian, Guthy, Daniel A., Wartmann, Markus, Kiffe, Michael, Desrayaud, Sandrine, Blasco, Francesca, Widmer, Toni, Seiler, Frank, Gutmann, Sascha, Knapp, Mark, Caravatti, Giorgio
Published in Journal of medicinal chemistry (23.06.2022)
Published in Journal of medicinal chemistry (23.06.2022)
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Journal Article
Evaluation of a Colorimetric Sensor System for Early Fire Detection
Roland Pohle, Teresa Pohl, Carolin Pannek, Karina Tarantik, Marie-Luise Bauersfeld, Jürgen Wöllenstein, Stefan Raible, Frank Seiler
Published in Proceedings (01.12.2018)
Published in Proceedings (01.12.2018)
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Journal Article
Abstract 1922: 2-Aminothiazoles as potent and selective PI3Kalpha inhibitors: Discovery of NVP-BYL719 and structural basis for the isoform selectivity
Caravatti, Giorgio, Guagnano, Vito, Fairhurst, Robin, Imbach, Patricia, Bruce, Ian, Knapp, Mark, Furet, Pascal, Fritsch, Christine, Pover, Alain De, Blasco, Francesca, Blanz, Joachim, Seiler, Frank H., Fabbro, Doriano, Lang, Marc
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
OXAZOLIDIN-2-ONE COMPOUNDS AND USES THEREOF AS PI3KS INHIBITORS
STAUFFER FREDERIC, SEILER FRANK HANS, RUEEGER HEINRICH, CARAVATTI GIORGIO, FURET PASCAL, FAIRHURST ROBIN ALEC, MCCARTHY CLIVE
Year of Publication 07.10.2014
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Year of Publication 07.10.2014
Patent
Neutrophils cause oxidative DNA damage in alveolar epithelial cells
Knaapen, Ad M, Seiler, Frank, Schilderman, Pauline A.E.L, Nehls, Peter, Bruch, Joachim, Schins, Roel P.F, Borm, Paul J.A
Published in Free radical biology & medicine (01.07.1999)
Published in Free radical biology & medicine (01.07.1999)
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Journal Article
Interindividual Variability of Lymph Drainages in Patients with Cervical Cancer
Marnitz Simone, Köhler Christhardt, Schneider, Achim, Seiler, Frank, Hinkelbein, Wolfgang
Published in Strahlentherapie und Onkologie (01.02.2006)
Published in Strahlentherapie und Onkologie (01.02.2006)
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Journal Article
Proton or stereotactic photon irradiation for posterior uveal melanoma? A planning intercomparison
Höcht, Stefan, Stark, Roland, Seiler, Frank, Heufelder, Jens, Bechrakis, Nikolaos E, Cordini, Dino, Marnitz, Simone, Kluge, Heinz, Foerster, Michael H, Hinkelbein, Wolfgang
Published in Strahlentherapie und Onkologie (01.12.2005)
Published in Strahlentherapie und Onkologie (01.12.2005)
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Journal Article
Quartz Exposure of the Rat Lung Leads to a Linear Dose Response in Inflammation but Not in Oxidative DNA Damage and Mutagenicity
Seiler, Frank, Rehn, Bernd, Rehn, S, Hermann, Martina, Bruch, Joachim
Published in American journal of respiratory cell and molecular biology (01.04.2001)
Published in American journal of respiratory cell and molecular biology (01.04.2001)
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Journal Article
Significant differences in the cellular and molecular reactions of rat and hamster lung after quartz exposure
Seiler, Frank, Rehn, Bernd, Rehn, Stefanie, Bruchs, Joachim
Published in Toxicology letters (03.02.2001)
Published in Toxicology letters (03.02.2001)
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Journal Article
Evidence of a no-effect level in silica-induced rat lung mutagenicity but not in fibrogenicity
SEILER, Frank, REHN, Bernd, REHN, Stefanie, BRUCH, Joachim
Published in Archives of toxicology (01.01.2001)
Published in Archives of toxicology (01.01.2001)
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Journal Article
Mass spectrometric identification and confirmation of 16-methylprednisone acetate in Mexican pills
Urich, R W, Bowerman, D L, Levisky, J A, Pflug, J L, Seiler, F J
Published in Journal of analytical toxicology (01.03.1980)
Published in Journal of analytical toxicology (01.03.1980)
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Journal Article
FORMULATION COMPRISING OXAZOLIDIN-2-ONE-PYRIMIDINE DERIVATIVE
AUBIN, Eric, TIEMESSEN, Henricus Lambertus Gerardus Maria, DE MARCO, Paolo, KUMAR, Rajesh A, LERCHNER, Andreas, RAULT, Isabelle, SVEDBERG, Karin, RIEBESEHL, Bernd Ulrich, SEILER, Frank Hans
Year of Publication 20.06.2019
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Year of Publication 20.06.2019
Patent
FORMULATION COMPRISING OXAZOLIDIN-2-ONE-PYRIMIDINE DERIVATIVE
AUBIN, Eric, TIEMESSEN, Henricus Lambertus Gerardus Maria, DE MARCO, Paolo, KUMAR, Rajesh A, LERCHNER, Andreas, RAULT, Isabelle, SVEDBERG, Karin, RIEBESEHL, Bernd Ulrich, SEILER, Frank Hans
Year of Publication 09.05.2019
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Year of Publication 09.05.2019
Patent
OXAZOLIDIN-2-ONE COMPOUNDS AND USES THEREOF AS PI3KS INHIBITORS
SEILER FRANK HANS, RUEEGER HEINRICH, CARAVATTI GIORGIO, FURET PASCAL, FAIRHURST ROBIN ALEC, STAUFFER FRÉDÉRIC, MCCARTHY CLIVE
Year of Publication 31.01.2017
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Year of Publication 31.01.2017
Patent