Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease
Lacy, Michael, Bürger, Christina, Shami, Annelie, Ahmadsei, Maiwand, Winkels, Holger, Nitz, Katrin, van Tiel, Claudia M., Seijkens, Tom T. P., Kusters, Pascal J. H., Karshovka, Ela, Prange, Koen H. M., Wu, Yuting, Brouns, Sanne L. N., Unterlugauer, Sigrid, Kuijpers, Marijke J. E., Reiche, Myrthe E., Steffens, Sabine, Edsfeldt, Andreas, Megens, Remco T. A., Heemskerk, Johan W. M., Goncalves, Isabel, Weber, Christian, Gerdes, Norbert, Atzler, Dorothee, Lutgens, Esther
Published in Nature communications (18.06.2021)
Published in Nature communications (18.06.2021)
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Journal Article
Diet-induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow
van den Berg, Susan M, Seijkens, Tom T P, Kusters, Pascal J H, Beckers, Linda, den Toom, Myrthe, Smeets, Esther, Levels, Johannes, de Winther, Menno P J, Lutgens, Esther
Published in The FASEB journal (01.05.2016)
Published in The FASEB journal (01.05.2016)
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Journal Article
Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis
Seijkens, Tom T.P., van Tiel, Claudia M., Kusters, Pascal J.H., Atzler, Dorothee, Soehnlein, Oliver, Zarzycka, Barbara, Aarts, Suzanne A.B.M., Lameijer, Marnix, Gijbels, Marion J., Beckers, Linda, den Toom, Myrthe, Slütter, Bram, Kuiper, Johan, Duchene, Johan, Aslani, Maria, Megens, Remco T.A., van ‘t Veer, Cornelis, Kooij, Gijs, Schrijver, Roy, Hoeksema, Marten A., Boon, Louis, Fay, Francois, Tang, Jun, Baxter, Samantha, Jongejan, Aldo, Moerland, Perry D., Vriend, Gert, Bleijlevens, Boris, Fisher, Edward A., Duivenvoorden, Raphael, Gerdes, Norbert, de Winther, Menno P.J., Nicolaes, Gerry A., Mulder, Willem J.M., Weber, Christian, Lutgens, Esther
Published in Journal of the American College of Cardiology (06.02.2018)
Published in Journal of the American College of Cardiology (06.02.2018)
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Journal Article
Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates
Lameijer, Marnix, Binderup, Tina, van Leent, Mandy M. T., Senders, Max L., Fay, Francois, Malkus, Joost, Sanchez-Gaytan, Brenda L., Teunissen, Abraham J. P., Karakatsanis, Nicolas, Robson, Philip, Zhou, Xianxiao, Ye, Yuxiang, Wojtkiewicz, Gregory, Tang, Jun, Seijkens, Tom T. P., Kroon, Jeffrey, Stroes, Erik S. G., Kjaer, Andreas, Ochando, Jordi, Reiner, Thomas, Pérez-Medina, Carlos, Calcagno, Claudia, Fisher, Edward A., Zhang, Bin, Temel, Ryan E., Swirski, Filip K., Nahrendorf, Matthias, Fayad, Zahi A., Lutgens, Esther, Mulder, Willem J. M., Duivenvoorden, Raphaël
Published in Nature biomedical engineering (01.05.2018)
Published in Nature biomedical engineering (01.05.2018)
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Journal Article
Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice
Poels, Kikkie, van Leent, Mandy M T, Reiche, Myrthe E, Kusters, Pascal J H, Huveneers, Stephan, de Winther, Menno P J, Mulder, Willem J M, Lutgens, Esther, Seijkens, Tom T P
Published in Cells (Basel, Switzerland) (29.08.2020)
Published in Cells (Basel, Switzerland) (29.08.2020)
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Journal Article
Immune checkpoint inhibitor treatment and atherosclerotic cardiovascular disease: an emerging clinical problem
Poels, Kikkie, Neppelenbroek, Suzanne I.M., Kersten, Marie José, Antoni, M. Louisa, Lutgens, Esther, Seijkens, Tom T.P.
Published in Journal for immunotherapy of cancer (01.06.2021)
Published in Journal for immunotherapy of cancer (01.06.2021)
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Journal Article
Inhibition of PFKFB3 Hampers the Progression of Atherosclerosis and Promotes Plaque Stability
Poels, Kikkie, Schnitzler, Johan G, Waissi, Farahnaz, Levels, Johannes H M, Stroes, Erik S G, Daemen, Mat J A P, Lutgens, Esther, Pennekamp, Anne-Marije, De Kleijn, Dominique P V, Seijkens, Tom T P, Kroon, Jeffrey
Published in Frontiers in cell and developmental biology (12.11.2020)
Published in Frontiers in cell and developmental biology (12.11.2020)
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Journal Article
Author Correction: Ablation of CD8α+ dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice
Legein, Bart, Janssen, Edith M., Theelen, Thomas L., Gijbels, Marion J., Walraven, Joep, Klarquist, Jared S., Hennies, Cassandra M., Wouters, Kristiaan, Seijkens, Tom T. P., Wijnands, Erwin, Sluimer, Judith C., Lutgens, Esther, Zenke, Martin, Hildner, Kai, Biessen, Erik A. L., Temmerman, Lieve
Published in Scientific reports (26.05.2020)
Published in Scientific reports (26.05.2020)
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Journal Article
Immuno-PET Imaging of Atherosclerotic Plaques with [ 89 Zr]Zr-Anti-CD40 mAb-Proof of Concept
Poels, Kikkie, Schreurs, Maxime, Jansen, Matthijs, Vugts, Danielle J, Seijkens, Tom T P, van Dongen, Guus A M S, Lutgens, Esther, Beaino, Wissam
Published in Biology (Basel, Switzerland) (06.03.2022)
Published in Biology (Basel, Switzerland) (06.03.2022)
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Journal Article
Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation
Aarts, Suzanne A B M, Seijkens, Tom T P, Kusters, Pascal J H, van der Pol, Susanne M A, Zarzycka, Barbara, Heijnen, Priscilla D A M, Beckers, Linda, den Toom, Myrthe, Gijbels, Marion J J, Boon, Louis, Weber, Christian, de Vries, Helga E, Nicolaes, Gerry A F, Dijkstra, Christine D, Kooij, Gijs, Lutgens, Esther
Published in Journal of neuroinflammation (12.05.2017)
Published in Journal of neuroinflammation (12.05.2017)
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Journal Article
E3 Ubiquitin Ligases as Immunotherapeutic Target in Atherosclerotic Cardiovascular Disease
Poels, Kikkie, Vos, Winnie G., Lutgens, Esther, Seijkens, Tom T. P.
Published in Frontiers in cardiovascular medicine (05.06.2020)
Published in Frontiers in cardiovascular medicine (05.06.2020)
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Journal Article
Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis
Aarts, Suzanne ABM, Seijkens, Tom TP, Kusters, Pascal JH, van Tiel, Claudia M, Reiche, Myrthe E, den Toom, Myrthe, Beckers, Linda, van Roomen, Cindy PAA, de Winther, Menno PJ, Kooij, Gijs, Lutgens, Esther
Published in The Journal of pathology (01.04.2019)
Published in The Journal of pathology (01.04.2019)
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Journal Article
Ablation of CD8α+ dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice
Legein, Bart, Janssen, Edith M., Theelen, Thomas L., Gijbels, Marion J., Walraven, Joep, Klarquist, Jared S., Hennies, Cassandra M., Wouters, Kristiaan, Seijkens, Tom T.P., Wijnands, Erwin, Sluimer, Judith C., Lutgens, Esther, Zenke, Martin, Hildner, Kai, Biessen, Erik A.L., Temmerman, Lieve
Published in Scientific reports (21.10.2015)
Published in Scientific reports (21.10.2015)
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Journal Article
Exploring immune checkpoints as potential therapeutic targets in atherosclerosis
Kusters, Pascal J H, Lutgens, Esther, Seijkens, Tom T P
Published in Cardiovascular research (01.03.2018)
Published in Cardiovascular research (01.03.2018)
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Journal Article