Multiple Plasma Biomarkers for Risk Stratification in Patients With Heart Failure and Preserved Ejection Fraction
Chirinos, Julio A., Orlenko, Alena, Zhao, Lei, Basso, Michael D., Cvijic, Mary Ellen, Li, Zhuyin, Spires, Thomas E., Yarde, Melissa, Wang, Zhaoqing, Seiffert, Dietmar A., Prenner, Stuart, Zamani, Payman, Bhattacharya, Priyanka, Kumar, Anupam, Margulies, Kenneth B., Car, Bruce D., Gordon, David A., Moore, Jason H., Cappola, Thomas P.
Published in Journal of the American College of Cardiology (24.03.2020)
Published in Journal of the American College of Cardiology (24.03.2020)
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Clinical Phenogroups in Heart Failure With Preserved Ejection Fraction: Detailed Phenotypes, Prognosis, and Response to Spironolactone
Cohen, Jordana B, Schrauben, Sarah J, Zhao, Lei, Basso, Michael D, Cvijic, Mary Ellen, Li, Zhuyin, Yarde, Melissa, Wang, Zhaoqing, Bhattacharya, Priyanka T, Chirinos, Diana A, Prenner, Stuart, Zamani, Payman, Seiffert, Dietmar A, Car, Bruce D, Gordon, David A, Margulies, Kenneth, Cappola, Thomas, Chirinos, Julio A
Published in JACC. Heart failure (01.03.2020)
Published in JACC. Heart failure (01.03.2020)
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Safety, pharmacokinetics, and pharmacodynamics of milvexian in healthy Japanese participants
Perera, Vidya, Wang, Zhaoqing, Lubin, Susan, Ueno, Takayo, Shiozaki, Tomomi, Chen, Wei, Xu, Xiaohui, Seiffert, Dietmar, DeSouza, Mary, Murthy, Bindu
Published in Scientific reports (25.03.2022)
Published in Scientific reports (25.03.2022)
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Journal Article
Effects of rifampin on the pharmacokinetics and pharmacodynamics of milvexian, a potent, selective, oral small molecule factor XIa inhibitor
Perera, Vidya, Wang, Zhaoqing, Lubin, Susan, Christopher, Lisa J., Chen, Wei, Xu, Sophia, Seiffert, Dietmar, DeSouza, Mary, Murthy, Bindu
Published in Scientific reports (23.12.2022)
Published in Scientific reports (23.12.2022)
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Factor XIa Inhibitors as New Anticoagulants
Quan, Mimi L, Pinto, Donald J. P, Smallheer, Joanne M, Ewing, William R, Rossi, Karen A, Luettgen, Joseph M, Seiffert, Dietmar A, Wexler, Ruth R
Published in Journal of medicinal chemistry (13.09.2018)
Published in Journal of medicinal chemistry (13.09.2018)
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Journal Article
Proteomic Analysis of Effects of Spironolactone in Heart Failure With Preserved Ejection Fraction
Javaheri, Ali, Diab, Ahmed, Zhao, Lei, Qian, Chenao, Cohen, Jordana B, Zamani, Payman, Kumar, Anupam, Wang, Zhaoqing, Ebert, Christina, Maranville, Joseph, Kvikstad, Erika, Basso, Michael, van Empel, Vanessa, Richards, A Mark, Doughty, Robert N, Rietzschel, Ernst, Kammerhoff, Karl, Gogain, Joseph, Schafer, Peter, Seiffert, Dietmar A, Gordon, David A, Ramirez-Valle, Francisco, Mann, Douglas L, Cappola, Thomas P, Chirinos, Julio A
Published in Circulation. Heart failure (01.09.2022)
Published in Circulation. Heart failure (01.09.2022)
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Journal Article
Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure
Chirinos, Julio A, Zhao, Lei, Jia, Yi, Frej, Cecilia, Adamo, Luigi, Mann, Douglas, Shewale, Swapnil V, Millar, John S, Rader, Daniel J, French, Benjamin, Brandimarto, Jeff, Margulies, Kenneth B, Parks, John S, Wang, Zhaoqing, Seiffert, Dietmar A, Fang, James, Sweitzer, Nancy, Chistoffersen, Christina, Dahlbäck, Björn, Car, Bruce D, Gordon, David A, Cappola, Thomas P, Javaheri, Ali
Published in Circulation (New York, N.Y.) (05.05.2020)
Published in Circulation (New York, N.Y.) (05.05.2020)
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First-in-human study to assess the safety, pharmacokinetics, and pharmacodynamics of BMS-986141, a novel, reversible, small-molecule, PAR4 agonist in non-Japanese and Japanese healthy participants
Merali, Samira, Wang, Zhaoqing, Frost, Charles, Meadows-Shropshire, Stephanie, Hawthorne, Dara, Yang, Jing, Seiffert, Dietmar
Published in Platelets (Edinburgh) (31.12.2023)
Published in Platelets (Edinburgh) (31.12.2023)
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Journal Article
Body Composition, Natriuretic Peptides, and Adverse Outcomes in Heart Failure With Preserved and Reduced Ejection Fraction
Selvaraj, Senthil, Kim, Jessica, Ansari, Bilal A., Zhao, Lei, Cvijic, Mary Ellen, Fronheiser, Matthew, Mohan-Rao Vanjarapu, Jagan, Kumar, Anupam A., Suri, Arpita, Yenigalla, Sowjanya, Satija, Vaibhav, Ans, Armghan Haider, Narvaez-Guerra, Offdan, Herrera-Enriquez, Karela, Obeid, Mary Jo, Lee, Jonathan J., Jehangir, Qasim, Seiffert, Dietmar A., Car, Bruce D., Gordon, David A., Chirinos, Julio A.
Published in JACC. Cardiovascular imaging (01.01.2021)
Published in JACC. Cardiovascular imaging (01.01.2021)
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An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay
Yang, Jing, Mapelli, Claudio, Wang, Zhaoqing, Sum, Chi Shing, Hua, Ji, Lawrence, R. Michael, Ni, Yan, Seiffert, Dietmar A.
Published in Platelets (Edinburgh) (03.10.2022)
Published in Platelets (Edinburgh) (03.10.2022)
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Proteomic Correlates of the Urinary Protein/Creatinine Ratio in Heart Failure With Preserved Ejection Fraction
Gan, Sushrima, Zhao, Lei, Salman, Oday, Wang, Zhaoqing, Ebert, Christina, Azzo, Joe David, Dib, Marie Joe, Zamani, Payman, Cohen, Jordana B., Kammerhoff, Karl, Schafer, Peter, Seiffert, Dietmar A., Ramirez-Valle, Francisco, Gordon, David A., Cvijic, Mary Ellen, Gunawardhana, Kushan, Liu, Laura, Chang, Ching-Pin, Cappola, Thomas P., Chirinos, Julio A.
Published in The American journal of cardiology (01.11.2023)
Published in The American journal of cardiology (01.11.2023)
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Inhibition of Factor XIa as a New Approach to Anticoagulation
Schumacher, William A, Luettgen, Joseph M, Quan, Mimi L, Seiffert, Dietmar A
Published in Arteriosclerosis, thrombosis, and vascular biology (01.03.2010)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.03.2010)
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Factor XIIa inhibition by Infestin-4: in vitro mode of action and in vivo antithrombotic benefit
Xu, Yiming, Cai, Tian-Quan, Castriota, Gino, Zhou, Yuchen, Hoos, Lizbeth, Jochnowitz, Nina, Loewrigkeit, Christopher, Cook, John A, Wickham, Alexandra, Metzger, Joseph M, Ogletree, Martin L, Seiffert, Dietmar A, Chen, Zhu
Published in Thrombosis and haemostasis (01.04.2014)
Published in Thrombosis and haemostasis (01.04.2014)
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Journal Article
Proteomic Associations of NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) in Heart Failure With Preserved Ejection Fraction
Azzo, Joe David, Dib, Marie-Joe, Zagkos, Loukas, Zhao, Lei, Wang, Zhaoqing, Chang, Ching-Pin, Ebert, Christina, Salman, Oday, Gan, Sushrima, Zamani, Payman, Cohen, Jordana B, van Empel, Vanessa, Richards, A Mark, Javaheri, Ali, Mann, Douglas L, Rietzschel, Ernst R, Schafer, Peter H, Seiffert, Dietmar A, Gill, Dipender, Burgess, Stephen, Ramirez-Valle, Francisco, Gordon, David A, Cappola, Thomas P, Chirinos, Julio A
Published in Circulation. Heart failure (01.02.2024)
Published in Circulation. Heart failure (01.02.2024)
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Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker
Corte, James R, Fang, Tianan, Osuna, Honey, Pinto, Donald J. P, Rossi, Karen A, Myers, Joseph E, Sheriff, Steven, Lou, Zhen, Zheng, Joanna J, Harper, Timothy W, Bozarth, Jeffrey M, Wu, Yiming, Luettgen, Joseph M, Seiffert, Dietmar A, Decicco, Carl P, Wexler, Ruth R, Quan, Mimi L
Published in Journal of medicinal chemistry (09.02.2017)
Published in Journal of medicinal chemistry (09.02.2017)
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Journal Article
Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species
Yang, Wu, Wang, Yufeng, Lai, Amy, Clark, Charles G, Corte, James R, Fang, Tianan, Gilligan, Paul J, Jeon, Yoon, Pabbisetty, Kumar B, Rampulla, Richard A, Mathur, Arvind, Kaspady, Mahammed, Neithnadka, Premsai Rai, Arumugam, Arunachalam, Raju, Sivashankaran, Rossi, Karen A, Myers, Joseph E, Sheriff, Steven, Lou, Zhen, Zheng, Joanna J, Chacko, Silvi A, Bozarth, Jeffrey M, Wu, Yiming, Crain, Earl J, Wong, Pancras C, Seiffert, Dietmar A, Luettgen, Joseph M, Lam, Patrick Y. S, Wexler, Ruth R, Ewing, William R
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Journal Article
Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups
Corte, James R, Pinto, Donald J. P, Fang, Tianan, Osuna, Honey, Yang, Wu, Wang, Yufeng, Lai, Amy, Clark, Charles G, Sun, Jung-Hui, Rampulla, Richard, Mathur, Arvind, Kaspady, Mahammed, Neithnadka, Premsai Rai, Li, Yi-Xin Cindy, Rossi, Karen A, Myers, Joseph E, Sheriff, Steven, Lou, Zhen, Harper, Timothy W, Huang, Christine, Zheng, Joanna J, Bozarth, Jeffrey M, Wu, Yiming, Wong, Pancras C, Crain, Earl J, Seiffert, Dietmar A, Luettgen, Joseph M, Lam, Patrick Y. S, Wexler, Ruth R, Ewing, William R
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
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Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors
Hu, Zilun, Wang, Cailan, Han, Wei, Rossi, Karen A., Bozarth, Jeffrey M., Wu, Yiming, Sheriff, Steven, Myers, Joseph E., Luettgen, Joseph M., Seiffert, Dietmar A., Wexler, Ruth R., Quan, Mimi L.
Published in Bioorganic & medicinal chemistry letters (01.04.2018)
Published in Bioorganic & medicinal chemistry letters (01.04.2018)
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Journal Article
Factor XIIa as a Novel Target for Thrombosis: Target Engagement Requirement and Efficacy in a Rabbit Model of Microembolic Signals
Barbieri, Christopher M, Wang, Xinkang, Wu, Weizhen, Zhou, Xueping, Ogawa, Aimie M, O'Neill, Kim, Chu, Donald, Castriota, Gino, Seiffert, Dietmar A, Gutstein, David E, Chen, Zhu
Published in The Journal of pharmacology and experimental therapeutics (01.03.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2017)
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