Advances in the Genetic Basis and Pathogenesis of Sarcomere Cardiomyopathies
Yotti, Raquel, Seidman, Christine E, Seidman, Jonathan G
Published in Annual review of genomics and human genetics (31.08.2019)
Published in Annual review of genomics and human genetics (31.08.2019)
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Genomic frontiers in congenital heart disease
Morton, Sarah U., Quiat, Daniel, Seidman, Jonathan G., Seidman, Christine E.
Published in Nature reviews cardiology (01.01.2022)
Published in Nature reviews cardiology (01.01.2022)
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Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands
Jin, Sheng Chih, Homsy, Jason, Zaidi, Samir, Lu, Qiongshi, Morton, Sarah, DePalma, Steven R, Zeng, Xue, Qi, Hongjian, Chang, Weni, Sierant, Michael C, Hung, Wei-Chien, Haider, Shozeb, Zhang, Junhui, Knight, James, Bjornson, Robert D, Castaldi, Christopher, Tikhonoa, Irina R, Bilguvar, Kaya, Mane, Shrikant M, Sanders, Stephan J, Mital, Seema, Russell, Mark W, Gaynor, J William, Deanfield, John, Giardini, Alessandro, Porter, George A, Srivastava, Deepak, Lo, Cecelia W, Shen, Yufeng, Watkins, W Scott, Yandell, Mark, Yost, H Joseph, Tristani-Firouzi, Martin, Newburger, Jane W, Roberts, Amy E, Kim, Richard, Zhao, Hongyu, Kaltman, Jonathan R, Goldmuntz, Elizabeth, Chung, Wendy K, Seidman, Jonathan G, Gelb, Bruce D, Seidman, Christine E, Lifton, Richard P, Brueckner, Martina
Published in Nature genetics (01.11.2017)
Published in Nature genetics (01.11.2017)
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A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
Green, Eric M., Wakimoto, Hiroko, Anderson, Robert L., Evanchik, Marc J., Gorham, Joshua M., Harrison, Brooke C., Henze, Marcus, Kawas, Raja, Oslob, Johan D., Rodriguez, Hector M., Song, Yonghong, Wan, William, Leinwand, Leslie A., Spudich, James A., McDowell, Robert S., Seidman, J. G., Seidman, Christine E.
Published in Science (American Association for the Advancement of Science) (05.02.2016)
Published in Science (American Association for the Advancement of Science) (05.02.2016)
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Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy
Hinson, John T., Chopra, Anant, Nafissi, Navid, Polacheck, William J., Benson, Craig C., Swist, Sandra, Gorham, Joshua, Yang, Luhan, Schafer, Sebastian, Sheng, Calvin C., Haghighi, Alireza, Homsy, Jason, Hubner, Norbert, Church, George, Cook, Stuart A., Linke, Wolfgang A., Chen, Christopher S., Seidman, J. G., Seidman, Christine E.
Published in Science (American Association for the Advancement of Science) (28.08.2015)
Published in Science (American Association for the Advancement of Science) (28.08.2015)
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Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease
Schlotter, Florian, Halu, Arda, Goto, Shinji, Blaser, Mark C, Body, Simon C, Lee, Lang H, Higashi, Hideyuki, DeLaughter, Daniel M, Hutcheson, Joshua D, Vyas, Payal, Pham, Tan, Rogers, Maximillian A, Sharma, Amitabh, Seidman, Christine E, Loscalzo, Joseph, Seidman, Jonathan G, Aikawa, Masanori, Singh, Sasha A, Aikawa, Elena
Published in Circulation (New York, N.Y.) (24.07.2018)
Published in Circulation (New York, N.Y.) (24.07.2018)
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A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy
Davis, Jennifer, Davis, L. Craig, Correll, Robert N., Makarewich, Catherine A., Schwanekamp, Jennifer A., Moussavi-Harami, Farid, Wang, Dan, York, Allen J., Wu, Haodi, Houser, Steven R., Seidman, Christine E., Seidman, Jonathan G., Regnier, Michael, Metzger, Joseph M., Wu, Joseph C., Molkentin, Jeffery D.
Published in Cell (19.05.2016)
Published in Cell (19.05.2016)
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Titin-truncating variants affect heart function in disease cohorts and the general population
Schafer, Sebastian, de Marvao, Antonio, Adami, Eleonora, Fiedler, Lorna R, Ng, Benjamin, Khin, Ester, Rackham, Owen J L, van Heesch, Sebastiaan, Pua, Chee J, Kui, Miao, Walsh, Roddy, Tayal, Upasana, Prasad, Sanjay K, Dawes, Timothy J W, Ko, Nicole S J, Sim, David, Chan, Laura L H, Chin, Calvin W L, Mazzarotto, Francesco, Barton, Paul J, Kreuchwig, Franziska, de Kleijn, Dominique P V, Totman, Teresa, Biffi, Carlo, Tee, Nicole, Rueckert, Daniel, Schneider, Valentin, Faber, Allison, Regitz-Zagrosek, Vera, Seidman, Jonathan G, Seidman, Christine E, Linke, Wolfgang A, Kovalik, Jean-Paul, O'Regan, Declan, Ware, James S, Hubner, Norbert, Cook, Stuart A
Published in Nature genetics (01.01.2017)
Published in Nature genetics (01.01.2017)
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Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes
Alamo, Lorenzo, Ware, James S, Pinto, Antonio, Gillilan, Richard E, Seidman, Jonathan G, Seidman, Christine E, Padrón, Raúl
Published in eLife (13.06.2017)
Published in eLife (13.06.2017)
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Genetic and Phenotypic Landscape of Peripartum Cardiomyopathy
Goli, Rahul, Li, Jian, Brandimarto, Jeff, Levine, Lisa D, Riis, Valerie, McAfee, Quentin, DePalma, Steven, Haghighi, Alireza, Seidman, J G, Seidman, Christine E, Jacoby, Daniel, Macones, George, Judge, Daniel P, Rana, Sarosh, Margulies, Kenneth B, Cappola, Thomas P, Alharethi, Rami, Damp, Julie, Hsich, Eileen, Elkayam, Uri, Sheppard, Richard, Alexis, Jeffrey D, Boehmer, John, Kamiya, Chizuko, Gustafsson, Finn, Damm, Peter, Ersbøll, Anne S, Goland, Sorel, Hilfiker-Kleiner, Denise, McNamara, Dennis M, Arany, Zolt
Published in Circulation (New York, N.Y.) (11.05.2021)
Published in Circulation (New York, N.Y.) (11.05.2021)
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SarcTrack
Toepfer, Christopher N, Sharma, Arun, Cicconet, Marcelo, Garfinkel, Amanda C, Mücke, Michael, Neyazi, Meraj, Willcox, Jon A L, Agarwal, Radhika, Schmid, Manuel, Rao, Jyoti, Ewoldt, Jourdan, Pourquié, Olivier, Chopra, Anant, Chen, Christopher S, Seidman, Jonathan G, Seidman, Christine E
Published in Circulation research (12.04.2019)
Published in Circulation research (12.04.2019)
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Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
Delgado-Olguín, Paul, Huang, Yu, Li, Xue, Christodoulou, Danos, Seidman, Christine E, Seidman, J G, Tarakhovsky, Alexander, Bruneau, Benoit G
Published in Nature genetics (01.03.2012)
Published in Nature genetics (01.03.2012)
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Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy
Margara, Francesca, Psaras, Yiangos, Wang, Zhinuo Jenny, Schmid, Manuel, Doste, Ruben, Garfinkel, Amanda C., Repetti, Giuliana G., Seidman, Jonathan G., Seidman, Christine E., Rodriguez, Blanca, Toepfer, Christopher N., Bueno-Orovio, Alfonso
Published in Scientific reports (28.12.2022)
Published in Scientific reports (28.12.2022)
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Genetic Basis of Hypertrophic Cardiomyopathy: From Bench to the Clinics
ALCALAI, RONNY, SEIDMAN, JONATHAN G., SEIDMAN, CHRISTINE E.
Published in Journal of cardiovascular electrophysiology (01.01.2008)
Published in Journal of cardiovascular electrophysiology (01.01.2008)
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Myocardial Fibrosis as an Early Manifestation of Hypertrophic Cardiomyopathy
Ho, Carolyn Y, López, Begoña, Coelho-Filho, Otavio R, Lakdawala, Neal K, Cirino, Allison L, Jarolim, Petr, Kwong, Raymond, González, Arantxa, Colan, Steven D, Seidman, J.G, Seidman, Christine E, Díez, Javier
Published in The New England journal of medicine (05.08.2010)
Published in The New England journal of medicine (05.08.2010)
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Activin type II receptor signaling in cardiac aging and heart failure
Roh, Jason D, Hobson, Ryan, Chaudhari, Vinita, Quintero, Pablo, Yeri, Ashish, Benson, Mark, Xiao, Chunyang, Zlotoff, Daniel, Bezzerides, Vassilios, Houstis, Nicholas, Platt, Colin, Damilano, Federico, Lindman, Brian R, Elmariah, Sammy, Biersmith, Michael, Lee, Se-Jin, Seidman, Christine E, Seidman, Jonathan G, Gerszten, Robert E, Lach-Trifilieff, Estelle, Glass, David J, Rosenzweig, Anthony
Published in Science translational medicine (06.03.2019)
Published in Science translational medicine (06.03.2019)
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Journal Article
Genetic Pathogenesis of Hypertrophic and Dilated Cardiomyopathy
Garfinkel, Amanda C, Seidman, Jonathan G, Seidman, Christine E
Published in Heart failure clinics (01.04.2018)
Published in Heart failure clinics (01.04.2018)
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Journal Article
Spectrum of somatic mitochondrial mutations in five cancers
Larman, Tatianna C, DePalma, Steven R, Hadjipanayis, Angela G, Protopopov, Alexei, Zhang, Jianhua, Gabriel, Stacey B, Chin, Lynda, Seidman, Christine E, Kucherlapati, Raju, Seidman, J. G
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2012)
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Genetic Evaluation of Cardiomyopathy—A Heart Failure Society of America Practice Guideline
Hershberger, Ray E., MD, Lindenfeld, Joann, MD, Mestroni, Luisa, MD, Seidman, Christine E., MD, Taylor, Matthew R.G., MD, PhD, Towbin, Jeffrey A., MD
Published in Journal of cardiac failure (01.03.2009)
Published in Journal of cardiac failure (01.03.2009)
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