Mechanistic Study of Diketopiperazine Formation during Solid-Phase Peptide Synthesis of Tirzepatide
Wang, Jingyao, Berglund, Mark R., Braden, Timothy, Embry, Matthew C., Johnson, Martin D., Groskreutz, Stephen R., Sayyed, Fareed Bhasha, Tsukanov, Sergey Vladimirovich, White, Timothy D., Jalan, Ankur, Seibert, Kevin D., Kopach, Michael E.
Published in ACS omega (20.12.2022)
Published in ACS omega (20.12.2022)
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Journal Article
Quality by design of solid‐phase peptide/protein coupling reaction via mechanistic reaction kinetics modeling approach
Wang, Jingyao, Agrawal, Paridhi, Berglund, Mark R., Groh, Jennifer McClary, Kopach, Michael E., Seibert, Kevin D., Viswanath, Shekhar K.
Published in AIChE journal (01.08.2024)
Published in AIChE journal (01.08.2024)
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Journal Article
Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing
Frederick, Michael O, Boyse, Raymond A, Braden, Timothy M, Calvin, Joel R, Campbell, Bradley M, Changi, Shujauddin M, Coffin, Stephanie R, Condon, Carmel, Gowran, Olivia, McClary Groh, Jennifer, Groskreutz, Stephen R, Harms, Zachary D, Humenik, Ashley A, Kallman, Neil J, Klitzing, Nicholas D, Kopach, Michael E, Kretsinger, Juliana K, Lambertus, Gordon R, Lampert, Jeffrey T, Maguire, Laura M, Moynihan, Humphrey A, Mullane, Nessa S, Murphy, John D, O’Mahony, Marie E, Richey, Rachel N, Seibert, Kevin D, Spencer, Richard D, Strege, Mark A, Tandogan, Nil, Torres Torres, Frank L, Tsukanov, Sergey V, Xia, Han
Published in Organic process research & development (16.07.2021)
Published in Organic process research & development (16.07.2021)
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Journal Article
Synthesis, Optimization, and Large-Scale Preparation of the Low-Dose Central Nervous System-Penetrant BACE1 Inhibitor LY3202626 via a [3 + 2] Nitrone Cycloaddition
Garcia-Losada, Pablo, DeBaillie, Amy C, Eugenio de Diego, Jose, Green, Steven J, Hansen, Marvin M, Jaramillo, Carlos, Johnson, Matt, Kaoudi, Talbi, Li, Jiuyuan, Lindsay-Scott, Peter J, Mateos, Carlos, Mergott, Dustin J, Rincon, Juan Antonio, Rothhaar, Roger R, Seibert, Kevin D, Watson, Brian M, Winneroski, Leonard L, Gangula, Srinivas, Jing, Dajiang, Sun, Hao, Zhang, Lei, Frederick, Michael O
Published in Organic process research & development (21.02.2020)
Published in Organic process research & development (21.02.2020)
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Journal Article
Case Studies in the Applicability of Drug Substance Design Spaces Developed on the Laboratory Scale to Commercial Manufacturing
Thomson, Nicholas M, Seibert, Kevin D, Tummala, Srinivas, Bordawekar, Shailendra, Kiesman, William F, Irdam, Erwin A, Phenix, Brian, Kumke, Daniel
Published in Organic process research & development (21.08.2015)
Published in Organic process research & development (21.08.2015)
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Journal Article
Case Studies in the Development of Drug Substance Control Strategies
Thomson, Nicholas M, Singer, Robert, Seibert, Kevin D, Luciani, Carla V, Srivastava, Sushil, Kiesman, William F, Irdam, Erwin A, Lepore, John V, Schenck, Luke
Published in Organic process research & development (21.08.2015)
Published in Organic process research & development (21.08.2015)
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Journal Article
MILLING OPERATIONS IN THE PHARMACEUTICAL INDUSTRY
Seibert, Kevin D, Collins, Paul C, Luciani, Carla V, Fisher, Elizabeth S
Published in Chemical Engineering in the Pharmaceutical Industry (29.03.2019)
Published in Chemical Engineering in the Pharmaceutical Industry (29.03.2019)
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Book Chapter
Part 3: Enhanced Approaches to the Development of the Control Strategy and its Implementation in the Manufacturing Process Description
Popkin, Matt E., Omer, Batool Ahmed, Seibert, Kevin D., Luciani, Carla V., Srivastava, Sushil, Hobson, Lindsay, Lepore, John V.
Published in Journal of pharmaceutical innovation (15.03.2019)
Published in Journal of pharmaceutical innovation (15.03.2019)
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Journal Article
The Delivery of Flexibility from the Application of QbD to API Development
Popkin, Matt E., Borman, Phil J., Omer, Batool Ahmed, Seibert, Kevin D., Srivastava, Sushil, Lepore, John V., Hobson, Lindsay, Donaubauer, John, Curran, Timothy, Ide, Nathan, Tymonko, Steven, Looker, Adam, Kallemeyn, Jeffrey M.
Published in Journal of pharmaceutical innovation (01.12.2018)
Published in Journal of pharmaceutical innovation (01.12.2018)
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Journal Article
The Use of Routine Process Capability for the Determination of Process Parameter Criticality in Small-molecule API Synthesis
Seibert, Kevin D., Sethuraman, Shanthi, Mitchell, Jerry D., Griffiths, Kristi L., McGarvey, Bernard
Published in Journal of pharmaceutical innovation (01.06.2008)
Published in Journal of pharmaceutical innovation (01.06.2008)
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Journal Article
PROCESSES AND INTERMEDIATES FOR PREPARING TIRZEPATIDE
BERGLUND, Mark R, RICHEY, Rachel Nicole, SEIBERT, Kevin D, KOPACH, Michael E, MURZINSKI, Emily
Year of Publication 04.07.2024
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Year of Publication 04.07.2024
Patent